Type |
Details |
Score |
Publication |
First Author: |
Kibar Z |
Year: |
2001 |
Journal: |
Nat Genet |
Title: |
Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail. |
Volume: |
28 |
Issue: |
3 |
Pages: |
251-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Doudney K |
Year: |
2001 |
Journal: |
Genomics |
Title: |
Comparative physical and transcript maps of approximately 1 Mb around loop-tail, a gene for severe neural tube defects on distal mouse chromosome 1 and human chromosome 1q22-q23. |
Volume: |
72 |
Issue: |
2 |
Pages: |
180-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eddleston J |
Year: |
1999 |
Journal: |
Genomics |
Title: |
Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). |
Volume: |
56 |
Issue: |
2 |
Pages: |
149-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ko MS |
Year: |
2000 |
Journal: |
Development |
Title: |
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. |
Volume: |
127 |
Issue: |
8 |
Pages: |
1737-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
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•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1131
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
31
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
300
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
580
 |
Fragment?: |
true |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Allele |
Name: |
coatomer protein complex subunit alpha; targeted mutation 1.1, Anthony K Shum |
Allele Type: |
Targeted |
Attribute String: |
Humanized sequence |
|
•
•
•
•
•
|
Publication |
First Author: |
Hsiao YM |
Year: |
2011 |
Journal: |
J Agric Food Chem |
Title: |
Functional characterization of copA gene encoding multicopper oxidase in Xanthomonas campestris pv. campestris. |
Volume: |
59 |
Issue: |
17 |
Pages: |
9290-302 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vece TJ |
Year: |
2016 |
Journal: |
J Clin Immunol |
Title: |
Copa Syndrome: a Novel Autosomal Dominant Immune Dysregulatory Disease. |
Volume: |
36 |
Issue: |
4 |
Pages: |
377-387 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Copa/Copa<+> |
Background: |
B6(CBA)-Copa |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Blomberg P |
Year: |
1992 |
Journal: |
EMBO J |
Title: |
Replication control of plasmid R1: RepA synthesis is regulated by CopA RNA through inhibition of leader peptide translation. |
Volume: |
11 |
Issue: |
7 |
Pages: |
2675-83 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Copa/Copa |
Background: |
B6(CBA)-Copa |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Djoko KY |
Year: |
2008 |
Journal: |
Chembiochem |
Title: |
Copper resistance in E. coli: the multicopper oxidase PcoA catalyzes oxidation of copper(I) in Cu(I)Cu(II)-PcoC. |
Volume: |
9 |
Issue: |
10 |
Pages: |
1579-82 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
CopA is a multicopper oxidase (MCO) related to laccase and L-ascorbate oxidase, both copper-containing enzymes [, ]. CopA mutant causes a loss of function including copper tolerance and oxidase activity and copA transcription is inducible in the presence of copper [].Although MCOs have diverse functions, majority of them have three cupredoxin domain repeats that include one mononuclear and one trinuclear copper centre. The copper ions are bound in several sites: Type 1, Type 2, and/or Type 3. The ensemble of types 2 and 3 copper is called a trinuclear cluster. MCOs oxidize their substrate by accepting electrons at a mononuclear copper centre and transferring them to the active site trinuclear copper centre. The cupredoxin domain 2 of 3-domain MCOs has lost the ability to bind copper [, , , ]. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
CopA is a multicopper oxidase (MCO) related to laccase and L-ascorbate oxidase, both copper-containing enzymes [, ]. CopA mutant causes a loss of function including copper tolerance and oxidase activity and copA transcription is inducible in the presence of copper [].Although MCOs have diverse functions, majority of them have three cupredoxin domain repeats that include one mononuclear and one trinuclear copper centre. The copper ions are bound in several sites: Type 1, Type 2, and/or Type 3. The ensemble oftypes 2 and 3 copper is called a trinuclear cluster. MCOs oxidize their substrate by accepting electrons at a mononuclear copper centre and transferring them to the active site trinuclear copper centre. The cupredoxin domain 1 of 3-domain MCOs contains part the trinuclear copper binding site, which is located at the interface of domains 1 and 3 [, , , ]. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
CopA is a multicopper oxidase (MCO) related to laccase and L-ascorbate oxidase, both copper-containing enzymes [, ]. CopA mutant causes a loss of function including copper tolerance and oxidase activity and copA transcription is inducible in the presence of copper [].Although MCOs have diverse functions, majority of them have three cupredoxin domain repeats that include one mononuclear and one trinuclear copper centre. The copper ions are bound in several sites: Type 1, Type 2, and/or Type 3. The ensemble of types 2 and 3 copper is called a trinuclear cluster. MCOs oxidize their substrate by accepting electrons at a mononuclear copper centre and transferring them to the active site trinuclear copper centre. The cupredoxin domain 3 of 3-domain MCOs contains the Type 1 (T1) copper binding site and part the trinuclear copper binding site, which is located at the interface of domains 1 and 3 [, , , ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Cooksey DA |
Year: |
1994 |
Journal: |
FEMS Microbiol Rev |
Title: |
Molecular mechanisms of copper resistance and accumulation in bacteria. |
Volume: |
14 |
Issue: |
4 |
Pages: |
381-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Radford DS |
Year: |
2003 |
Journal: |
FEMS Microbiol Lett |
Title: |
CopZ from Bacillus subtilis interacts in vivo with a copper exporting CPx-type ATPase CopA. |
Volume: |
220 |
Issue: |
1 |
Pages: |
105-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bayle D |
Year: |
1998 |
Journal: |
J Bacteriol |
Title: |
Properties of the P-type ATPases encoded by the copAP operons of Helicobacter pylori and Helicobacter felis. |
Volume: |
180 |
Issue: |
2 |
Pages: |
317-29 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Proteins in this family are copper ion-binding proteins, including copper chaperone CopZ and COP-associated protein (COPP). They contain a conserved 30-residue HMA domain, which has been found in a number of other heavy metal transport or detoxification proteins []. CopZ is a chaperone that serves for the intracellular sequestration and transport of Cu+, and delivers copper ions to the copper-transporting ATPase CopA []. COPP is part of a cation-transporting system which is associated with copper export out of the cells []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Gaballa A |
Year: |
2003 |
Journal: |
Microbiology |
Title: |
Two MerR homologues that affect copper induction of the Bacillus subtilis copZA operon. |
Volume: |
149 |
Issue: |
Pt 12 |
Pages: |
3413-21 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the N-terminal HTH (helix-turn-helix) domain of YfmP and related proteins. YfmP is a a transcription regulator that regulates the multidrug efflux protein, YfmO, and indirectly regulates the expression of the Bacillus subtilis copZA operon encoding a metallochaperone, CopZ, and a CPx-type ATPase efflux protein, CopA []. These proteins belong to the MerR superfamily of transcription regulators that promote expression of several stress regulon genes by reconfiguring the spacer between the -35 and -10 promoter elements. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Quek HH |
Year: |
1997 |
Journal: |
Cytogenet Cell Genet |
Title: |
Genomic organization and mapping of the human HEP-COP gene (COPA) to 1q. |
Volume: |
76 |
Issue: |
3-4 |
Pages: |
139-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mukai K |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Homeostatic regulation of STING by retrograde membrane traffic to the ER. |
Volume: |
12 |
Issue: |
1 |
Pages: |
61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Messerschmidt A |
Year: |
1992 |
Journal: |
J Mol Biol |
Title: |
Refined crystal structure of ascorbate oxidase at 1.9 A resolution. |
Volume: |
224 |
Issue: |
1 |
Pages: |
179-205 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bento I |
Year: |
2005 |
Journal: |
Dalton Trans |
Title: |
Dioxygen reduction by multi-copper oxidases; a structural perspective. |
|
Issue: |
21 |
Pages: |
3507-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ouzounis C |
Year: |
1991 |
Journal: |
FEBS Lett |
Title: |
A structure-derived sequence pattern for the detection of type I copper binding domains in distantly related proteins. |
Volume: |
279 |
Issue: |
1 |
Pages: |
73-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Messerschmidt A |
Year: |
1990 |
Journal: |
Eur J Biochem |
Title: |
The blue oxidases, ascorbate oxidase, laccase and ceruloplasmin. Modelling and structural relationships. |
Volume: |
187 |
Issue: |
2 |
Pages: |
341-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bull PC |
Year: |
1994 |
Journal: |
Trends Genet |
Title: |
Wilson disease and Menkes disease: new handles on heavy-metal transport. |
Volume: |
10 |
Issue: |
7 |
Pages: |
246-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brown NL |
Year: |
2003 |
Journal: |
FEMS Microbiol Rev |
Title: |
The MerR family of transcriptional regulators. |
Volume: |
27 |
Issue: |
2-3 |
Pages: |
145-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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•
•
•
•
•
|