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Search results 101 to 200 out of 201 for Crb3

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945475
Age: postnatal day 7
Image: g00997 P7
Specimen Label: g00997 P7
Detected: true
Specimen Num: 3
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945475
Age: postnatal day 42
Image: g00997 Adult
Specimen Label: g00997 Adult
Detected: true
Specimen Num: 4
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•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4417279
Assay Type: RNA in situ
Annotation Date: 2024-04-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7621774
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945475
Age: postnatal day 7
Image: g00997 P7
Specimen Label: g00997 P7
Detected: true
Specimen Num: 3
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945475
Age: postnatal day 42
Image: g00997 Adult
Specimen Label: g00997 Adult
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
 
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280923
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945475
Age: embryonic day 15.5
Image: g00997 E15.5
Specimen Label: g00997 E15.5
Detected: true
Specimen Num: 2
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945475
Age: postnatal day 7
Image: g00997 P7
Specimen Label: g00997 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945475
Age: postnatal day 42
Image: g00997 Adult
Specimen Label: g00997 Adult
Detected: true
Specimen Num: 4
•
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•
•
•
GXD Expression
GXD Expression
Probe: MGI:7434426
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1779024
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7435351
Age: embryonic day 16.5
Image: 8G
Note: Expressed in the apical junctional complex of neuroepithelium at the ventricular surface continuously.
Specimen Label: 8G
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
   
Probe: MGI:7434426
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-17
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1779024
Stage: TS24
Assay Id: MGI:7435351
Age: embryonic day 16.5
Image: 8H
Specimen Label: 8H
Detected: false
Specimen Num: 2
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•
GXD Expression
GXD Expression
Probe: MGI:7434426
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1779022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7435351
Age: embryonic day 14.5
Image: 8K
Note: Expressed in the apical junctional complex of neuroepithelium at the ventricular surface continuously.
Specimen Label: 8K
Detected: true
Specimen Num: 3
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•
GXD Expression
GXD Expression
Probe: MGI:7434426
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1779022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7435351
Age: embryonic day 14.5
Image: 8L
Note: Loss of apical localization of Crbs correlated with the Yap1-reduced area.
Specimen Label: 8L
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
Probe: MGI:7434426
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1779024
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7435353
Age: embryonic day 16.5
Image: S7C/C'
Note: Expressed in the apical junctional complex of neuroepithelium at the ventricular surface continuously.
Specimen Label: S7C/C'
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
Probe: MGI:7434426
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1779024
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7435353
Age: embryonic day 16.5
Image: S7D/D'
Note: Not expressed at the ventricular surface in some areas.
Specimen Label: S7D/D'
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945475
Age: embryonic day 15.5
Image: g00997 E15.5
Specimen Label: g00997 E15.5
Detected: true
Specimen Num: 2
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•
•
•
GXD Expression
GXD Expression
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945475
Age: embryonic day 15.5
Image: g00997 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g00997 E15.5
Detected: true
Specimen Num: 2
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945475
Age: postnatal day 7
Image: g00997 P7
Specimen Label: g00997 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4886204
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945475
Age: postnatal day 42
Image: g00997 Adult
Specimen Label: g00997 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:6192126
Assay Type: Immunohistochemistry
Annotation Date: 2018-07-31
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Uniform
Stage: TS02
Assay Id: MGI:6192260
Age: embryonic day 1.0
Image: S2 2c
Note: Expression is in the cytoplasm.
Specimen Label: S2 2c
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:3721110
Assay Type: Immunohistochemistry
Annotation Date: 2019-03-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1657719
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:6283607
Age: embryonic day 11.5
Image: 6I
Note: Expression localized to all sub-apical tight junctions.
Specimen Label: 6I
Detected: true
Specimen Num: 1
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•
•
•
GXD Expression
GXD Expression
Probe: MGI:3721110
Assay Type: Immunohistochemistry
Annotation Date: 2019-03-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1657719
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:6283607
Age: embryonic day 11.5
Image: 6M
Note: Authors report expression is dicontinuous within abnormal epithelium of the mutant nephric duct.
Specimen Label: 6M
Detected: true
Specimen Num: 2
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Publication
12697824 | J:83166
First Author: Rubio-Aliaga I
Year: 2003
Journal: Mol Cell Biol
Title: Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney.
Volume: 23
Issue: 9
Pages: 3247-52
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Publication
27435623 | J:241172
 
First Author: Fernando RN
Year: 2016
Journal: Nat Commun
Title: Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway.
Volume: 7
Pages: 12186
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Publication
15177033 | J:92210
First Author: Saotome I
Year: 2004
Journal: Dev Cell
Title: Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine.
Volume: 6
Issue: 6
Pages: 855-64
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Publication
16399075 | J:105283
First Author: Davis MA
Year: 2006
Journal: Dev Cell
Title: Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland.
Volume: 10
Issue: 1
Pages: 21-31
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Publication
16885194 | J:114927
First Author: van Rossum AG
Year: 2006
Journal: Hum Mol Genet
Title: Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Muller glia cells.
Volume: 15
Issue: 18
Pages: 2659-72
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Publication
31391582 | J:283645
First Author: Peng G
Year: 2019
Journal: Nature
Title: Molecular architecture of lineage allocation and tissue organization in early mouse embryo.
Volume: 572
Issue: 7770
Pages: 528-532
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Publication
22410172 | J:184878
First Author: Soofi A
Year: 2012
Journal: Dev Biol
Title: Two novel EGFP insertion alleles reveal unique aspects of Pax2 function in embryonic and adult kidneys.
Volume: 365
Issue: 1
Pages: 241-50
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Publication
32673396 | J:313432
 
First Author: Qi Y
Year: 2020
Journal: J Cell Biol
Title: PTEN dephosphorylates Abi1 to promote epithelial morphogenesis.
Volume: 219
Issue: 9
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Publication
28536193 | J:242275
First Author: Schell C
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier.
Volume: 114
Issue: 23
Pages: E4621-E4630
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Publication
21145499 | J:169049
First Author: Varelas X
Year: 2010
Journal: Dev Cell
Title: The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.
Volume: 19
Issue: 6
Pages: 831-44
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Publication
21880782 | J:178336
First Author: Grosse AS
Year: 2011
Journal: Development
Title: Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis.
Volume: 138
Issue: 20
Pages: 4423-32
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Publication
28552558 | J:241995
First Author: Jossin Y
Year: 2017
Journal: Dev Cell
Title: Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells.
Volume: 41
Issue: 5
Pages: 481-495.e5
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Publication
25371366 | J:316286
First Author: Francou A
Year: 2014
Journal: Development
Title: TBX1 regulates epithelial polarity and dynamic basal filopodia in the second heart field.
Volume: 141
Issue: 22
Pages: 4320-31
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Publication
18403412 | J:134686
First Author: Srinivasan K
Year: 2008
Journal: Development
Title: MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex.
Volume: 135
Issue: 10
Pages: 1781-90
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Publication
37172642 | J:336187
 
First Author: Barlow HR
Year: 2023
Journal: Dev Biol
Title: Rab11 is essential to pancreas morphogenesis, lumen formation and endocrine mass.
Volume: 499
Pages: 59-74
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Publication
17507402 | J:122548
First Author: Lee JD
Year: 2007
Journal: Development
Title: The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo.
Volume: 134
Issue: 11
Pages: 2007-16
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Publication
27647853 | J:307229
First Author: McNeill H
Year: 2017
Journal: J Am Soc Nephrol
Title: Lats1/2 Regulate Yap/Taz to Control Nephron Progenitor Epithelialization and Inhibit Myofibroblast Formation.
Volume: 28
Issue: 3
Pages: 852-861
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Publication
21606200 | J:174237
First Author: Sripathy S
Year: 2011
Journal: Mol Cell Biol
Title: Mammalian Llgl2 is necessary for proper branching morphogenesis during placental development.
Volume: 31
Issue: 14
Pages: 2920-33
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Publication
22398208 | J:184469
First Author: Cho SH
Year: 2012
Journal: Hum Mol Genet
Title: Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis.
Volume: 21
Issue: 12
Pages: 2663-76
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Publication
27870829 | J:238551
First Author: Ramkumar N
Year: 2016
Journal: Nat Cell Biol
Title: Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation.
Volume: 18
Issue: 12
Pages: 1281-1291
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Publication
29058721 | J:246200
First Author: Löf-Öhlin ZM
Year: 2017
Journal: Nat Cell Biol
Title: EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity.
Volume: 19
Issue: 11
Pages: 1313-1325
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Publication
19914171 | J:157396
First Author: Kesavan G
Year: 2009
Journal: Cell
Title: Cdc42-mediated tubulogenesis controls cell specification.
Volume: 139
Issue: 4
Pages: 791-801
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Publication
33332551 | J:306851
 
First Author: Kunii M
Year: 2021
Journal: J Cell Biol
Title: SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarity.
Volume: 220
Issue: 1
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Publication
31586559 | J:283394
First Author: Hughes LJ
Year: 2020
Journal: Dev Biol
Title: Yap/Taz are required for establishing the cerebellar radial glia scaffold and proper foliation.
Volume: 457
Issue: 1
Pages: 150-162
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Publication
33526661 | J:302296
 
First Author: Vong KI
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: SOX9-COL9A3-dependent regulation of choroid plexus epithelial polarity governs blood-cerebrospinal fluid barrier integrity.
Volume: 118
Issue: 6
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Publication
25742799 | J:220469
First Author: Grego-Bessa J
Year: 2015
Journal: Development
Title: Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains.
Volume: 142
Issue: 7
Pages: 1305-14
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Publication
26243870 | J:224142
First Author: Reginensi A
Year: 2015
Journal: Development
Title: Yap and Taz are required for Ret-dependent urinary tract morphogenesis.
Volume: 142
Issue: 15
Pages: 2696-703
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Publication
27616714 | J:237224
First Author: Kim JY
Year: 2016
Journal: Dev Biol
Title: Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye.
Volume: 419
Issue: 2
Pages: 336-347
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Publication
39284539 | J:354796
 
First Author: Cho SH
Year: 2024
Journal: Dev Biol
Title: Perturbed cell cycle phase-dependent positioning and nuclear migration of retinal progenitors along the apico-basal axis underlie global retinal disorganization in the LCA8-like mouse model.
Volume: 517
Pages: 39-54
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Publication
24191021 | J:202984
First Author: Rockich BE
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Sox9 plays multiple roles in the lung epithelium during branching morphogenesis.
Volume: 110
Issue: 47
Pages: E4456-64
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Publication
33737325 | J:306107
 
First Author: Niborski LL
Year: 2021
Journal: Dis Model Mech
Title: Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model.
Volume: 14
Issue: 5
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Publication
27480037 | J:241275
 
First Author: Reginensi A
Year: 2016
Journal: Nat Commun
Title: A critical role for NF2 and the Hippo pathway in branching morphogenesis.
Volume: 7
Pages: 12309
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Publication
21947380 | J:181586
First Author: Hald J
Year: 2012
Journal: Diabetologia
Title: Pancreatic islet and progenitor cell surface markers with cell sorting potential.
Volume: 55
Issue: 1
Pages: 154-65
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Publication
30718289 | J:272613
 
First Author: Koutelou E
Year: 2019
Journal: Development
Title: USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta.
Volume: 146
Issue: 4
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Publication
20562862 | J:161922
First Author: Tang T
Year: 2010
Journal: Nat Biotechnol
Title: A mouse knockout library for secreted and transmembrane proteins.
Volume: 28
Issue: 7
Pages: 749-55
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Publication
- | J:171883
     
First Author: Lexicon Genetics, Inc
Year: 2011
Journal: Database Download
Title: MGI download of Lexicon knockout data
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
25080976 | J:225211
 
First Author: Mojallal M
Year: 2014
Journal: Nat Commun
Title: AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion.
Volume: 5
Pages: 4557
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Publication
20362667 | -
First Author: Yamaguchi M
Year: 2010
Journal: Mech Dev
Title: Mutations in N-cadherin and a Stardust homolog, Nagie oko, affect cell-cycle exit in zebrafish retina.
Volume: 127
Issue: 5-6
Pages: 247-64
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Publication
20861315 | -
First Author: Bulgakova NA
Year: 2010
Journal: Mol Biol Cell
Title: Antagonistic functions of two stardust isoforms in Drosophila photoreceptor cells.
Volume: 21
Issue: 22
Pages: 3915-25
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Publication
22114289 | J:178056
First Author: Park B
Year: 2011
Journal: J Neurosci
Title: PALS1 is essential for retinal pigment epithelium structure and neural retina stratification.
Volume: 31
Issue: 47
Pages: 17230-41
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Publication
28416478 | -
First Author: Das S
Year: 2017
Journal: J Cell Biol
Title: Stardust, the Janus-faced partner of Crumbs.
Volume: 216
Issue: 5
Pages: 1219-1221
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Publication
21479189 | -
First Author: Carvalho G
Year: 2011
Journal: PLoS One
Title: Participation of the cell polarity protein PALS1 to T-cell receptor-mediated NF-κB activation.
Volume: 6
Issue: 3
Pages: e18159
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Protein Domain
IPR035601 | MPP5_SH3
Type: Domain
Description: MPP5, also called PALS1 (protein associated with Lin7) or Nagie oko protein in zebrafish []or Stardust in Drosophila [], is a scaffolding protein which associates with Crumbs homologue 1 (CRB1), CRB2, or CRB3 through its PDZ domain and with PALS1-associated tight junction protein (PATJ) or multi-PDZ domain protein 1 (MUPP1) through its L27 domain []. The resulting tri-protein complexes are core proteins of the Crumb complex, which localizes at tight junctions or subapical regions, and is involved in the maintenance of apical-basal polarity in epithelial cells and the morphogenesis and function of photoreceptor cells []. MPP5 is critical for the proper stratification of the retina and is also expressed in T lymphocytes where it is important for TCR-mediated activation of NFkB []. Drosophila Stardust exists in several isoforms, some of which show opposing functions in photoreceptor cells, which suggests that the relative ratio of different Crumbs complexes regulates photoreceptor homeostasis []. MPP5 belongs to the membrane-associated guanylate kinase (MAGUK) p55 subfamily.The membrane-associated guanylate kinase (MAGUK) p55 subfamily (also known as MPP subfamily) members include the Drosophila Stardust protein and its vertebrate homologues, MPP1-7. They contain the core of three domains characteristic of MAGUK (membrane-associated guanylate kinase) proteins: PDZ, SH3, and guanylate kinase (GuK). In addition, they also contain the Hook (Protein 4.1 Binding) motif in between the SH3 and GuK domains []. MPP2-7 have two additional L27 domains at their N terminus. The GuK domain in MAGUK proteins is enzymatically inactive; instead, the domain mediates protein-protein interactions and associates intramolecularly with the SH3 domain [].
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Publication
15316081 | J:92068
First Author: van de Pavert SA
Year: 2004
Journal: J Cell Sci
Title: Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure.
Volume: 117
Issue: Pt 18
Pages: 4169-77
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Publication
26404741 | J:298908
 
First Author: Paniagua AE
Year: 2015
Journal: Sci Rep
Title: CRB2 completes a fully expressed Crumbs complex in the Retinal Pigment Epithelium.
Volume: 5
Pages: 14504
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Publication
25809849 | J:225273
First Author: Pan X
Year: 2015
Journal: Genesis
Title: A Cre-inducible fluorescent reporter for observing apical membrane dynamics.
Volume: 53
Issue: 3-4
Pages: 285-93
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Publication
28154200 | J:289471
First Author: Weide T
Year: 2017
Journal: J Am Soc Nephrol
Title: Pals1 Haploinsufficiency Results in Proteinuria and Cyst Formation.
Volume: 28
Issue: 7
Pages: 2093-2107
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Publication
16098509 | J:102605
First Author: Satohisa S
Year: 2005
Journal: Exp Cell Res
Title: Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4alpha-induced epithelial polarization.
Volume: 310
Issue: 1
Pages: 66-78
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Publication
26279473 | J:227728
First Author: Zhai Y
Year: 2016
Journal: J Pathol
Title: Arid1a inactivation in an Apc- and Pten-defective mouse ovarian cancer model enhances epithelial differentiation and prolongs survival.
Volume: 238
Issue: 1
Pages: 21-30
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Publication
11414766 | -
First Author: Stöhr H
Year: 2001
Journal: Genomics
Title: Cloning and characterization of the human retina-specific gene MPP4, a novel member of the p55 subfamily of MAGUK proteins.
Volume: 74
Issue: 3
Pages: 377-84
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Publication
17678554 | -
 
First Author: te Velthuis AJ
Year: 2007
Journal: BMC Evol Biol
Title: Molecular evolution of the MAGUK family in metazoan genomes.
Volume: 7
Pages: 129
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Protein
Q9JLB2
Organism: Mus musculus/domesticus
Length: 675  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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