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Search results 101 to 200 out of 209 for Csn2

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Type Details Score
GXD Expression      
Probe: MGI:5795881
Assay Type: Northern blot
Annotation Date: 2016-09-29
Strength: Present
Sex: Female
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:5796134
Age: postnatal
Specimen Label: 5dpp +/+
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:5795881
Assay Type: Northern blot
Annotation Date: 2016-09-29
Strength: Present
Sex: Female
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:5796134
Age: postnatal
Specimen Label: 5dpp -/-
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:6384224
Assay Type: Northern blot
Annotation Date: 2020-01-10
Strength: Absent
Sex: Female
Emaps: EMAPS:3790128
Stage: TS28
Assay Id: MGI:6384229
Age: postnatal week 5
Image: 1
Specimen Label: Fat pad
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:6384224
Assay Type: Northern blot
Annotation Date: 2020-01-10
Strength: Absent
Sex: Female
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:6384229
Age: postnatal week 6
Image: 1
Specimen Label: 6
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:6384224
Assay Type: Northern blot
Annotation Date: 2020-01-10
Strength: Absent
Sex: Female
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:6384229
Age: postnatal week 8
Image: 1
Specimen Label: 8
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:6384224
Assay Type: Northern blot
Annotation Date: 2020-01-10
Strength: Present
Sex: Female
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:6384229
Age: postnatal adult
Image: 1
Specimen Label: 2.5
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6384224
Assay Type: Northern blot
Annotation Date: 2020-01-10
Strength: Present
Sex: Female
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:6384229
Age: postnatal adult
Image: 1
Specimen Label: 4.5
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6384224
Assay Type: Northern blot
Annotation Date: 2020-01-10
Strength: Present
Sex: Female
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:6384229
Age: postnatal adult
Image: 1
Specimen Label: 8.5
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6384224
Assay Type: Northern blot
Annotation Date: 2020-01-10
Strength: Present
Sex: Female
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:6384229
Age: postnatal adult
Image: 1
Specimen Label: 12.5
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6384224
Assay Type: Northern blot
Annotation Date: 2020-01-10
Strength: Present
Sex: Female
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:6384229
Age: postnatal adult
Image: 1
Specimen Label: 17.5
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:6384224
Assay Type: Northern blot
Annotation Date: 2020-01-10
Strength: Present
Sex: Female
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:6384229
Age: postnatal adult
Image: 1
Specimen Label: 2 days lact.
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:6384224
Assay Type: Northern blot
Annotation Date: 2020-01-10
Strength: Absent
Sex: Female
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:6384229
Age: postnatal adult
Image: 1
Specimen Label: 7 days invol.
Detected: false
Specimen Num: 11
GXD Expression    
Probe: MGI:6384224
Assay Type: Northern blot
Annotation Date: 2020-01-10
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3553622
Stage: TS22
Assay Id: MGI:6384229
Age: embryonic day 14.0
Image: 1
Specimen Label: 14 day embryo
Detected: false
Specimen Num: 12
Publication
First Author: Shekar PC
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: kappa-casein-deficient mice fail to lactate.
Volume: 103
Issue: 21
Pages: 8000-5
Publication
First Author: Gatesy J
Year: 1996
Journal: Mol Biol Evol
Title: Evidence from milk casein genes that cetaceans are close relatives of hippopotamid artiodactyls.
Volume: 13
Issue: 7
Pages: 954-63
Publication
First Author: Kolb AF
Year: 2002
Journal: Biochim Biophys Acta
Title: Structure and regulation of the murine gamma-casein gene.
Volume: 1579
Issue: 2-3
Pages: 101-16
Publication
First Author: Streuli CH
Year: 1995
Journal: J Cell Biol
Title: Laminin mediates tissue-specific gene expression in mammary epithelia.
Volume: 129
Issue: 3
Pages: 591-603
Publication  
First Author: Rijnkels M
Year: 1995
Journal: Biochem J
Title: Expression analysis of the individual bovine beta-, alpha s2- and kappa-casein genes in transgenic mice.
Volume: 311 ( Pt 3)
Pages: 929-37
Publication
First Author: Gupta P
Year: 1982
Journal: J Cell Biol
Title: Localization of the casein gene family to a single mouse chromosome.
Volume: 93
Issue: 1
Pages: 199-204
Publication
First Author: Hennighausen LG
Year: 1982
Journal: Eur J Biochem
Title: Characterization and cloning of the mRNAs specific for the lactating mouse mammary gland.
Volume: 125
Issue: 1
Pages: 131-41
Publication
First Author: Tomlinson AM
Year: 1996
Journal: Mamm Genome
Title: Restriction map of two yeast artificial chromosomes spanning the murine casein locus.
Volume: 7
Issue: 7
Pages: 542-4
Publication
First Author: George S
Year: 1997
Journal: DNA Cell Biol
Title: Physical mapping of the murine casein locus reveals the gene order as alpha-beta-gamma-epsilon-kappa.
Volume: 16
Issue: 4
Pages: 477-84
Publication
First Author: Dong B
Year: 2007
Journal: Biochem J
Title: Involvement of the ubiquitous Oct-1 transcription factor in hormonal induction of beta-casein gene expression.
Volume: 401
Issue: 1
Pages: 57-64
Publication
First Author: Triplett AA
Year: 2005
Journal: Genesis
Title: Expression of the whey acidic protein (Wap) is necessary for adequate nourishment of the offspring but not functional differentiation of mammary epithelial cells.
Volume: 43
Issue: 1
Pages: 1-11
Publication
First Author: Iavnilovitch E
Year: 2002
Journal: Mol Cancer Res
Title: Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis.
Volume: 1
Issue: 1
Pages: 32-47
Publication
First Author: Schoenenberger CA
Year: 1988
Journal: EMBO J
Title: Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription.
Volume: 7
Issue: 1
Pages: 169-75
Publication
First Author: Rijnkels M
Year: 1997
Journal: Mamm Genome
Title: Structure and expression of the mouse casein gene locus.
Volume: 8
Issue: 1
Pages: 9-15
Publication
First Author: Aoki N
Year: 1997
Journal: Biochim Biophys Acta
Title: Stage specific expression of milk fat globule membrane glycoproteins in mouse mammary gland: comparison of MFG-E8, butyrophilin, and CD36 with a major milk protein, beta-casein.
Volume: 1334
Issue: 2-3
Pages: 182-90
Publication
First Author: Rijnkels M
Year: 2003
Journal: Genomics
Title: Multispecies comparative analysis of a mammalian-specific genomic domain encoding secretory proteins.
Volume: 82
Issue: 4
Pages: 417-32
Publication
First Author: Rogers RL
Year: 2010
Journal: PLoS One
Title: Transcript profiling of Elf5+/- mammary glands during pregnancy identifies novel targets of Elf5.
Volume: 5
Issue: 10
Pages: e13150
Publication
First Author: Vogel WF
Year: 2001
Journal: Mol Cell Biol
Title: Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development.
Volume: 21
Issue: 8
Pages: 2906-17
Publication
First Author: Marquis ST
Year: 1995
Journal: Nat Genet
Title: The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues.
Volume: 11
Issue: 1
Pages: 17-26
Publication
First Author: Geissler EN
Year: 1988
Journal: Proc Natl Acad Sci U S A
Title: Genetic analysis of the dominant white-spotting (W) region on mouse chromosome 5: identification of cloned DNA markers near W.
Volume: 85
Issue: 24
Pages: 9635-9
Publication
First Author: Chellaiah M
Year: 2000
Journal: J Cell Biol
Title: Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength.
Volume: 148
Issue: 4
Pages: 665-78
Publication
First Author: Bentley E
Year: 1996
Journal: Mamm Genome
Title: D5Ucl1 and Els1 are closely linked to W on mouse chromosome 5 but lie distal to the W19H deletion.
Volume: 7
Issue: 9
Pages: 691-3
Publication
First Author: King DP
Year: 1997
Journal: Genetics
Title: The mouse Clock mutation behaves as an antimorph and maps within the W19H deletion, distal of Kit.
Volume: 146
Issue: 3
Pages: 1049-60
Publication
First Author: Lin H
Year: 2021
Journal: Nat Commun
Title: IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion.
Volume: 12
Issue: 1
Pages: 2461
Publication
First Author: Kurpios NA
Year: 2009
Journal: Dev Biol
Title: The Pea3 Ets transcription factor regulates differentiation of multipotent progenitor cells during mammary gland development.
Volume: 325
Issue: 1
Pages: 106-21
Publication
First Author: Phippard DJ
Year: 1996
Journal: Development
Title: Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development.
Volume: 122
Issue: 9
Pages: 2729-37
Publication
First Author: Asselin-Labat ML
Year: 2007
Journal: Nat Cell Biol
Title: Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation.
Volume: 9
Issue: 2
Pages: 201-9
Publication
First Author: Hadsell DL
Year: 2003
Journal: Mol Endocrinol
Title: Diminished milk synthesis in upstream stimulatory factor 2 null mice is associated with decreased circulating oxytocin and decreased mammary gland expression of eukaryotic initiation factors 4E and 4G.
Volume: 17
Issue: 11
Pages: 2251-67
Publication
First Author: Stephenson DA
Year: 1994
Journal: Mamm Genome
Title: Mouse rump-white mutation associated with an inversion of chromosome 5.
Volume: 5
Issue: 6
Pages: 342-8
Publication
First Author: Seagroves TN
Year: 2010
Journal: Am J Pathol
Title: VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis.
Volume: 176
Issue: 5
Pages: 2269-82
Publication
First Author: Oliver CH
Year: 2012
Journal: Genes Dev
Title: The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3.
Volume: 26
Issue: 10
Pages: 1086-97
Publication
First Author: Elias S
Year: 2014
Journal: Stem Cell Reports
Title: Huntingtin regulates mammary stem cell division and differentiation.
Volume: 2
Issue: 4
Pages: 491-506
Publication
First Author: Takahashi N
Year: 1993
Journal: Genomics
Title: The short 3'-end region of complementary DNAs as PCR-based polymorphic markers for an expression map of the mouse genome.
Volume: 16
Issue: 1
Pages: 161-8
Publication
First Author: Gritli-Linde A
Year: 2007
Journal: Dev Cell
Title: Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling.
Volume: 12
Issue: 1
Pages: 99-112
Publication
First Author: Lahbib-Mansais Y
Year: 2000
Journal: Mamm Genome
Title: Comparative mapping between humans and pigs: localization of 58 anchorage markers (TOASTs) by use of porcine somatic cell and radiation hybrid panels.
Volume: 11
Issue: 12
Pages: 1098-106
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication      
First Author: Freeman TC
Year: 1998
Journal: MGI Direct Data Submission
Title: Expression Mapping of Mouse Genes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Sapranauskas R
Year: 2011
Journal: Nucleic Acids Res
Title: The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli.
Volume: 39
Issue: 21
Pages: 9275-82
Protein Domain
Type: Homologous_superfamily
Description: This entry represents the Csn2 superfamily of Cas proteins, which are found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas loci. The species range so far for this subtype is animal pathogens and commensals only. This protein is present in some but not all NMENI CRISPR/Cas loci [].The structure of Csn2 contains two domains: an alpha/beta domain and an α-helical domain with significant hinge motion between these two domains []. Sn2 is a ds-DNA-binding protein functioning at the quaternary structure level and regulated by Ca(2+) ions [].
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Protein Domain
Type: Family
Description: This is a family of Csn2 CRISPR-associated (Cas) proteins found in Firmicutes, largely Streptococcus and Enterococcus. CRISPR-associated (Cas) proteins are the main executioners of the process whereby prokaryotes acquire immunity against foreign genetic material. Cas allow short segments of this DNA, called spacer, to become incorporated into chromosomal loci as clustered regularly interspaced short palindromic repeats or CRISPRs; the resulting encoded RNAs are then processed into small fragments that guide the silencing of the invading genetic elements. Thus Cas are involved in the acquisition of new spacers.Proteins in this family are usually longer than the canonical Csn2 () through the addition of a large C-terminal domain. The central domain present in both families appears to be a channel that selectively interacts with dsDNA [].
Publication
First Author: Lykke-Andersen K
Year: 2003
Journal: Mol Cell Biol
Title: Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death.
Volume: 23
Issue: 19
Pages: 6790-7
Regulatory Region
Type: enhancer
Organism: mouse, laboratory
Regulatory Region
Type: enhancer
Organism: mouse, laboratory
Regulatory Region
Type: enhancer
Organism: mouse, laboratory
Allele
Name: casein beta; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: casein beta; targeted mutation 2, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
Strain
Attribute String: coisogenic, mutant strain, targeted mutation
Allele
Name: regulatory region 481; endonuclease-mediated mutation 1, Lothar Hennighausen
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
Allele
Name: deletion, chr 5, Lothar Hennighausen 2; deletion, Chr 5, Lothar Hennighausen 2
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
Allele
Name: regulatory region 491; endonuclease-mediated mutation 1, Lothar Hennighausen
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 443  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 450  
Fragment?: false
Allele
Name: regulatory region 484; endonuclease-mediated mutation 2, Lothar Hennighausen
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
Allele
Name: transgene insertion, Jakub Abramson
Allele Type: Transgenic
Attribute String: Recombinase
Allele
Name: deletion, chr 5, Lothar Hennighausen 3; deletion, Chr 5, Lothar Hennighausen 3
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
Allele
Name: deletion, chr 5, Lothar Hennighausen 4; deletion, Chr 5, Lothar Hennighausen 4
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
Genotype
Symbol: Rr491/Rr491
Background: involves: C57BL/6N
Zygosity: hm
Has Mutant Allele: true
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Lee HK
Year: 2023
Journal: Nat Commun
Title: Cell-specific and shared regulatory elements control a multigene locus active in mammary and salivary glands.
Volume: 14
Issue: 1
Pages: 4992
Genotype
Symbol: Del(5Rr481-Rr490)3Mam/Del(5Rr481-Rr490)3Mam
Background: involves: C57BL/6N
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Del(5Rr491-Rr490)4Mam/Del(5Rr491-Rr490)4Mam
Background: involves: C57BL/6N
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Tenbaum SP
Year: 2003
Journal: Dev Biol
Title: Alien/CSN2 gene expression is regulated by thyroid hormone in rat brain.
Volume: 254
Issue: 1
Pages: 149-60
Publication
First Author: Broad TE
Year: 1994
Journal: Mamm Genome
Title: Seven loci on human chromosome 4 map onto sheep chromosome 6: a proposal to restore the original nomenclature of this sheep chromosome.
Volume: 5
Issue: 7
Pages: 429-33
Publication
First Author: Montgomery GW
Year: 1994
Journal: Genomics
Title: The Booroola fecundity (FecB) gene maps to sheep chromosome 6.
Volume: 22
Issue: 1
Pages: 148-53
Publication
First Author: Wellberg E
Year: 2010
Journal: Development
Title: The bHLH/PAS transcription factor singleminded 2s promotes mammary gland lactogenic differentiation.
Volume: 137
Issue: 6
Pages: 945-52