Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:5795881 |
Assay Type: |
Northern blot |
Annotation Date: |
2016-09-29 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1775928 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5796134 |
Age: |
postnatal |
|
|
Specimen Label: |
5dpp +/+ |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5795881 |
Assay Type: |
Northern blot |
Annotation Date: |
2016-09-29 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1775928 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5796134 |
Age: |
postnatal |
|
|
Specimen Label: |
5dpp -/- |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6384224 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-01-10 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:3790128 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6384229 |
Age: |
postnatal week 5 |
Image: |
1 |
|
Specimen Label: |
Fat pad |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6384224 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-01-10 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1775928 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6384229 |
Age: |
postnatal week 6 |
Image: |
1 |
|
Specimen Label: |
6 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6384224 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-01-10 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1775928 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6384229 |
Age: |
postnatal week 8 |
Image: |
1 |
|
Specimen Label: |
8 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6384224 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-01-10 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1775928 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6384229 |
Age: |
postnatal adult |
Image: |
1 |
|
Specimen Label: |
2.5 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6384224 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-01-10 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1775928 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6384229 |
Age: |
postnatal adult |
Image: |
1 |
|
Specimen Label: |
4.5 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6384224 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-01-10 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1775928 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6384229 |
Age: |
postnatal adult |
Image: |
1 |
|
Specimen Label: |
8.5 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6384224 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-01-10 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1775928 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6384229 |
Age: |
postnatal adult |
Image: |
1 |
|
Specimen Label: |
12.5 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6384224 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-01-10 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1775928 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6384229 |
Age: |
postnatal adult |
Image: |
1 |
|
Specimen Label: |
17.5 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6384224 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-01-10 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1775928 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6384229 |
Age: |
postnatal adult |
Image: |
1 |
|
Specimen Label: |
2 days lact. |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6384224 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-01-10 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1775928 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6384229 |
Age: |
postnatal adult |
Image: |
1 |
|
Specimen Label: |
7 days invol. |
Detected: |
false |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6384224 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-01-10 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3553622 |
|
Stage: |
TS22 |
Assay Id: |
MGI:6384229 |
Age: |
embryonic day 14.0 |
Image: |
1 |
|
Specimen Label: |
14 day embryo |
Detected: |
false |
Specimen Num: |
12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shekar PC |
Year: |
2006 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
kappa-casein-deficient mice fail to lactate. |
Volume: |
103 |
Issue: |
21 |
Pages: |
8000-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gatesy J |
Year: |
1996 |
Journal: |
Mol Biol Evol |
Title: |
Evidence from milk casein genes that cetaceans are close relatives of hippopotamid artiodactyls. |
Volume: |
13 |
Issue: |
7 |
Pages: |
954-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kolb AF |
Year: |
2002 |
Journal: |
Biochim Biophys Acta |
Title: |
Structure and regulation of the murine gamma-casein gene. |
Volume: |
1579 |
Issue: |
2-3 |
Pages: |
101-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Streuli CH |
Year: |
1995 |
Journal: |
J Cell Biol |
Title: |
Laminin mediates tissue-specific gene expression in mammary epithelia. |
Volume: |
129 |
Issue: |
3 |
Pages: |
591-603 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rijnkels M |
Year: |
1995 |
Journal: |
Biochem J |
Title: |
Expression analysis of the individual bovine beta-, alpha s2- and kappa-casein genes in transgenic mice. |
Volume: |
311 ( Pt 3) |
|
Pages: |
929-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gupta P |
Year: |
1982 |
Journal: |
J Cell Biol |
Title: |
Localization of the casein gene family to a single mouse chromosome. |
Volume: |
93 |
Issue: |
1 |
Pages: |
199-204 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hennighausen LG |
Year: |
1982 |
Journal: |
Eur J Biochem |
Title: |
Characterization and cloning of the mRNAs specific for the lactating mouse mammary gland. |
Volume: |
125 |
Issue: |
1 |
Pages: |
131-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tomlinson AM |
Year: |
1996 |
Journal: |
Mamm Genome |
Title: |
Restriction map of two yeast artificial chromosomes spanning the murine casein locus. |
Volume: |
7 |
Issue: |
7 |
Pages: |
542-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
George S |
Year: |
1997 |
Journal: |
DNA Cell Biol |
Title: |
Physical mapping of the murine casein locus reveals the gene order as alpha-beta-gamma-epsilon-kappa. |
Volume: |
16 |
Issue: |
4 |
Pages: |
477-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dong B |
Year: |
2007 |
Journal: |
Biochem J |
Title: |
Involvement of the ubiquitous Oct-1 transcription factor in hormonal induction of beta-casein gene expression. |
Volume: |
401 |
Issue: |
1 |
Pages: |
57-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Triplett AA |
Year: |
2005 |
Journal: |
Genesis |
Title: |
Expression of the whey acidic protein (Wap) is necessary for adequate nourishment of the offspring but not functional differentiation of mammary epithelial cells. |
Volume: |
43 |
Issue: |
1 |
Pages: |
1-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Iavnilovitch E |
Year: |
2002 |
Journal: |
Mol Cancer Res |
Title: |
Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis. |
Volume: |
1 |
Issue: |
1 |
Pages: |
32-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schoenenberger CA |
Year: |
1988 |
Journal: |
EMBO J |
Title: |
Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription. |
Volume: |
7 |
Issue: |
1 |
Pages: |
169-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rijnkels M |
Year: |
1997 |
Journal: |
Mamm Genome |
Title: |
Structure and expression of the mouse casein gene locus. |
Volume: |
8 |
Issue: |
1 |
Pages: |
9-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aoki N |
Year: |
1997 |
Journal: |
Biochim Biophys Acta |
Title: |
Stage specific expression of milk fat globule membrane glycoproteins in mouse mammary gland: comparison of MFG-E8, butyrophilin, and CD36 with a major milk protein, beta-casein. |
Volume: |
1334 |
Issue: |
2-3 |
Pages: |
182-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rijnkels M |
Year: |
2003 |
Journal: |
Genomics |
Title: |
Multispecies comparative analysis of a mammalian-specific genomic domain encoding secretory proteins. |
Volume: |
82 |
Issue: |
4 |
Pages: |
417-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rogers RL |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
Transcript profiling of Elf5+/- mammary glands during pregnancy identifies novel targets of Elf5. |
Volume: |
5 |
Issue: |
10 |
Pages: |
e13150 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vogel WF |
Year: |
2001 |
Journal: |
Mol Cell Biol |
Title: |
Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development. |
Volume: |
21 |
Issue: |
8 |
Pages: |
2906-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marquis ST |
Year: |
1995 |
Journal: |
Nat Genet |
Title: |
The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues. |
Volume: |
11 |
Issue: |
1 |
Pages: |
17-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Geissler EN |
Year: |
1988 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Genetic analysis of the dominant white-spotting (W) region on mouse chromosome 5: identification of cloned DNA markers near W. |
Volume: |
85 |
Issue: |
24 |
Pages: |
9635-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chellaiah M |
Year: |
2000 |
Journal: |
J Cell Biol |
Title: |
Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength. |
Volume: |
148 |
Issue: |
4 |
Pages: |
665-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bentley E |
Year: |
1996 |
Journal: |
Mamm Genome |
Title: |
D5Ucl1 and Els1 are closely linked to W on mouse chromosome 5 but lie distal to the W19H deletion. |
Volume: |
7 |
Issue: |
9 |
Pages: |
691-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
King DP |
Year: |
1997 |
Journal: |
Genetics |
Title: |
The mouse Clock mutation behaves as an antimorph and maps within the W19H deletion, distal of Kit. |
Volume: |
146 |
Issue: |
3 |
Pages: |
1049-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin H |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion. |
Volume: |
12 |
Issue: |
1 |
Pages: |
2461 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kurpios NA |
Year: |
2009 |
Journal: |
Dev Biol |
Title: |
The Pea3 Ets transcription factor regulates differentiation of multipotent progenitor cells during mammary gland development. |
Volume: |
325 |
Issue: |
1 |
Pages: |
106-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Phippard DJ |
Year: |
1996 |
Journal: |
Development |
Title: |
Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development. |
Volume: |
122 |
Issue: |
9 |
Pages: |
2729-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Asselin-Labat ML |
Year: |
2007 |
Journal: |
Nat Cell Biol |
Title: |
Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation. |
Volume: |
9 |
Issue: |
2 |
Pages: |
201-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hadsell DL |
Year: |
2003 |
Journal: |
Mol Endocrinol |
Title: |
Diminished milk synthesis in upstream stimulatory factor 2 null mice is associated with decreased circulating oxytocin and decreased mammary gland expression of eukaryotic initiation factors 4E and 4G. |
Volume: |
17 |
Issue: |
11 |
Pages: |
2251-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stephenson DA |
Year: |
1994 |
Journal: |
Mamm Genome |
Title: |
Mouse rump-white mutation associated with an inversion of chromosome 5. |
Volume: |
5 |
Issue: |
6 |
Pages: |
342-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Seagroves TN |
Year: |
2010 |
Journal: |
Am J Pathol |
Title: |
VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis. |
Volume: |
176 |
Issue: |
5 |
Pages: |
2269-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oliver CH |
Year: |
2012 |
Journal: |
Genes Dev |
Title: |
The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. |
Volume: |
26 |
Issue: |
10 |
Pages: |
1086-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elias S |
Year: |
2014 |
Journal: |
Stem Cell Reports |
Title: |
Huntingtin regulates mammary stem cell division and differentiation. |
Volume: |
2 |
Issue: |
4 |
Pages: |
491-506 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takahashi N |
Year: |
1993 |
Journal: |
Genomics |
Title: |
The short 3'-end region of complementary DNAs as PCR-based polymorphic markers for an expression map of the mouse genome. |
Volume: |
16 |
Issue: |
1 |
Pages: |
161-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gritli-Linde A |
Year: |
2007 |
Journal: |
Dev Cell |
Title: |
Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. |
Volume: |
12 |
Issue: |
1 |
Pages: |
99-112 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lahbib-Mansais Y |
Year: |
2000 |
Journal: |
Mamm Genome |
Title: |
Comparative mapping between humans and pigs: localization of 58 anchorage markers (TOASTs) by use of porcine somatic cell and radiation hybrid panels. |
Volume: |
11 |
Issue: |
12 |
Pages: |
1098-106 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Freeman TC |
Year: |
1998 |
Journal: |
MGI Direct Data Submission |
Title: |
Expression Mapping of Mouse Genes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Sapranauskas R |
Year: |
2011 |
Journal: |
Nucleic Acids Res |
Title: |
The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli. |
Volume: |
39 |
Issue: |
21 |
Pages: |
9275-82 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
This entry represents the Csn2 superfamily of Cas proteins, which are found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas loci. The species range so far for this subtype is animal pathogens and commensals only. This protein is present in some but not all NMENI CRISPR/Cas loci [].The structure of Csn2 contains two domains: an alpha/beta domain and an α-helical domain with significant hinge motion between these two domains []. Sn2 is a ds-DNA-binding protein functioning at the quaternary structure level and regulated by Ca(2+) ions []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Protein Domain |
Type: |
Family |
Description: |
This is a family of Csn2 CRISPR-associated (Cas) proteins found in Firmicutes, largely Streptococcus and Enterococcus. CRISPR-associated (Cas) proteins are the main executioners of the process whereby prokaryotes acquire immunity against foreign genetic material. Cas allow short segments of this DNA, called spacer, to become incorporated into chromosomal loci as clustered regularly interspaced short palindromic repeats or CRISPRs; the resulting encoded RNAs are then processed into small fragments that guide the silencing of the invading genetic elements. Thus Cas are involved in the acquisition of new spacers.Proteins in this family are usually longer than the canonical Csn2 () through the addition of a large C-terminal domain. The central domain present in both families appears to be a channel that selectively interacts with dsDNA []. |
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Publication |
First Author: |
Lykke-Andersen K |
Year: |
2003 |
Journal: |
Mol Cell Biol |
Title: |
Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. |
Volume: |
23 |
Issue: |
19 |
Pages: |
6790-7 |
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Regulatory Region |
Type: |
enhancer |
Organism: |
mouse, laboratory |
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Regulatory Region |
Type: |
enhancer |
Organism: |
mouse, laboratory |
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Regulatory Region |
Type: |
enhancer |
Organism: |
mouse, laboratory |
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Allele |
Name: |
casein beta; targeted mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Targeted |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
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Allele |
Name: |
casein beta; targeted mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Targeted |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
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Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
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Allele |
Name: |
regulatory region 481; endonuclease-mediated mutation 1, Lothar Hennighausen |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Modified regulatory region |
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•
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Allele |
Name: |
deletion, chr 5, Lothar Hennighausen 2; deletion, Chr 5, Lothar Hennighausen 2 |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Modified regulatory region |
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•
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Allele |
Name: |
regulatory region 491; endonuclease-mediated mutation 1, Lothar Hennighausen |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Modified regulatory region |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
443
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
450
 |
Fragment?: |
false |
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Allele |
Name: |
regulatory region 484; endonuclease-mediated mutation 2, Lothar Hennighausen |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Modified regulatory region |
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Allele |
Name: |
transgene insertion, Jakub Abramson |
Allele Type: |
Transgenic |
Attribute String: |
Recombinase |
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•
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Allele |
Name: |
deletion, chr 5, Lothar Hennighausen 3; deletion, Chr 5, Lothar Hennighausen 3 |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Modified regulatory region |
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Allele |
Name: |
deletion, chr 5, Lothar Hennighausen 4; deletion, Chr 5, Lothar Hennighausen 4 |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Modified regulatory region |
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Genotype |
Symbol: |
Rr491/Rr491 |
Background: |
involves: C57BL/6N |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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HT Experiment |
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Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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Publication |
First Author: |
Lee HK |
Year: |
2023 |
Journal: |
Nat Commun |
Title: |
Cell-specific and shared regulatory elements control a multigene locus active in mammary and salivary glands. |
Volume: |
14 |
Issue: |
1 |
Pages: |
4992 |
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Genotype |
Symbol: |
Del(5Rr481-Rr490)3Mam/Del(5Rr481-Rr490)3Mam |
Background: |
involves: C57BL/6N |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Del(5Rr491-Rr490)4Mam/Del(5Rr491-Rr490)4Mam |
Background: |
involves: C57BL/6N |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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•
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Publication |
First Author: |
Tenbaum SP |
Year: |
2003 |
Journal: |
Dev Biol |
Title: |
Alien/CSN2 gene expression is regulated by thyroid hormone in rat brain. |
Volume: |
254 |
Issue: |
1 |
Pages: |
149-60 |
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Publication |
First Author: |
Broad TE |
Year: |
1994 |
Journal: |
Mamm Genome |
Title: |
Seven loci on human chromosome 4 map onto sheep chromosome 6: a proposal to restore the original nomenclature of this sheep chromosome. |
Volume: |
5 |
Issue: |
7 |
Pages: |
429-33 |
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Publication |
First Author: |
Montgomery GW |
Year: |
1994 |
Journal: |
Genomics |
Title: |
The Booroola fecundity (FecB) gene maps to sheep chromosome 6. |
Volume: |
22 |
Issue: |
1 |
Pages: |
148-53 |
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•
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•
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Publication |
First Author: |
Wellberg E |
Year: |
2010 |
Journal: |
Development |
Title: |
The bHLH/PAS transcription factor singleminded 2s promotes mammary gland lactogenic differentiation. |
Volume: |
137 |
Issue: |
6 |
Pages: |
945-52 |
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