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Search results 101 to 200 out of 314 for Cul3

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Type Details Score
Publication
25401743 | J:225134
First Author: Ren K
Year: 2014
Journal: PLoS One
Title: KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development.
Volume: 9
Issue: 11
Pages: e112275
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Publication
19056892 | J:142037
First Author: Miranda-Carboni GA
Year: 2008
Journal: Genes Dev
Title: A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors.
Volume: 22
Issue: 22
Pages: 3121-34
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Publication
28794184 | J:244911
     
First Author: Zhang M
Year: 2017
Journal: Genes Dev
Title: Post-transcriptional regulation of mouse neurogenesis by Pumilio proteins.
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Publication
23055941 | J:193640
First Author: Lo JC
Year: 2012
Journal: PLoS Genet
Title: RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.
Volume: 8
Issue: 10
Pages: e1002969
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
25995385 | J:225608
First Author: Dorr C
Year: 2015
Journal: Mol Cancer Res
Title: Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor.
Volume: 13
Issue: 8
Pages: 1238-47
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Publication
17296727 | -
First Author: Ribar B
Year: 2007
Journal: Mol Cell Biol
Title: ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells.
Volume: 27
Issue: 8
Pages: 3211-6
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Publication
28743001 | -
First Author: Pae J
Year: 2017
Journal: Dev Cell
Title: GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK.
Volume: 42
Issue: 2
Pages: 130-142.e7
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Publication
23349464 | -
First Author: Canning P
Year: 2013
Journal: J Biol Chem
Title: Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.
Volume: 288
Issue: 11
Pages: 7803-14
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Interaction Experiment
He X (2006)
Description: Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer.
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HT Experiment
GSE144046 | Autism-linked Cullin3 germline haploinsufficiency severely impacts mouse brain development and cortical neurogenesis through RhoA signaling
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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GO Term
GO:0031463 | Cul3-RING ubiquitin ligase complex
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Publication
19818708 | -
First Author: Zhuang M
Year: 2009
Journal: Mol Cell
Title: Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Volume: 36
Issue: 1
Pages: 39-50
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Publication
16524876 | -
First Author: Kwon JE
Year: 2006
Journal: J Biol Chem
Title: BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.
Volume: 281
Issue: 18
Pages: 12664-72
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Publication
23999291 | -
First Author: van Geersdaele LK
Year: 2013
Journal: Acta Crystallogr D Biol Crystallogr
Title: Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP.
Volume: 69
Issue: Pt 9
Pages: 1677-84
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Protein Domain
IPR034089 | SPOP_C
Type: Domain
Description: This entry represents the C-terminal BACK (BTB and C-terminal Kelch) domain of speckle-type POZ protein (SPOP, also known as HIB homologue 1 or Roadkill homologue 1). This domain contains a pair of α-helices which seem to be conserved among Cul3 adaptors [].SPOP is an adaptor protein that forms a complex with Cul3, cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, and is involved in ubiquitination of BMI1, H2AFY, and the death-associated protein 6 (DAXX) []. The C-terminal BACK domain of SPOP, may be involved in oligomer formation and in recruiting Cul3 (together with the adjacent BTB domain), whereas the N-terminal MATH domain recruits substrates [, ].
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Publication
11864988 | -
First Author: Hyman LE
Year: 2002
Journal: J Biol Chem
Title: Binding to Elongin C inhibits degradation of interacting proteins in yeast.
Volume: 277
Issue: 18
Pages: 15586-91
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Publication
18817898 | -
First Author: Lejeune D
Year: 2009
Journal: DNA Repair (Amst)
Title: Yeast Elc1 plays an important role in global genomic repair but not in transcription coupled repair.
Volume: 8
Issue: 1
Pages: 40-50
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Publication
19782033 | -
First Author: Chen Y
Year: 2009
Journal: Mol Cell
Title: Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement.
Volume: 35
Issue: 6
Pages: 841-55
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Publication
29085068 | -
First Author: Mao H
Year: 2017
Journal: Nat Plants
Title: Arabidopsis BTB/POZ protein-dependent PENETRATION3 trafficking and disease susceptibility.
Volume: 3
Issue: 11
Pages: 854-858
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Protein Domain
IPR039948 | ELC1
Type: Family
Description: Elongin-C is a highly conserved protein found in a variety of multiprotein complexes in human, rat, fly, worm, and yeast cells []. Budding yeast elongin-C homologue, Elc1, forms a complex with Cul3 that is required for Pol II polyubiquitylation and degradation []. Elc1 also plays a role in global genomic repair []. In humans, elongin-C works as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL) [].
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Protein Domain
IPR045068 | BACURD1-3
Type: Family
Description: This entry represents a group of BTB/POZ domain-containing proteins, such as BACURD1-3 from humans. They act as the substrate-specific adapters of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of RhoA, leading to its degradation by the proteasome []. This entry also includes EAP3 from Arabidopsis. The BTB/POZ domain of EAP3 displays poor conservation of the residues required for CUL3 binding and is not likely to function as an E3 ligase adaptor [].
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Publication
15367669 | J:279946
First Author: Cullinan SB
Year: 2004
Journal: Mol Cell Biol
Title: The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase.
Volume: 24
Issue: 19
Pages: 8477-86
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Publication
22466964 | J:245285
First Author: den Besten W
Year: 2012
Journal: Nat Struct Mol Biol
Title: NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.
Volume: 19
Issue: 5
Pages: 511-6, S1
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Publication
33409479 | J:311524
First Author: Madison JM
Year: 2021
Journal: iScience
Title: Regulation of purine metabolism connects KCTD13 to a metabolic disorder with autistic features.
Volume: 24
Issue: 1
Pages: 101935
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Publication
37339955 | J:340706
First Author: Cai C
Year: 2023
Journal: Nat Commun
Title: USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice.
Volume: 14
Issue: 1
Pages: 3648
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Protein Coding Gene
MGI:1917632 | Kctd2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2685141 | Kbtbd7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914113 | Lztr1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914705 | Klhl13
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2442829 | Klhl4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR029959 | NPH3-like
Type: Family
Description: Root phototropism protein 3 (RPT3), also known as nonphototropic hypocotyl 3 (NPH3), and root phototropism 2 (RPT2) () represent the founding members of a novel plant-specific family []. Three domains define the members of this family: an N-terminal BTB (broad complex, tramtrack, bric a brac) domain (), a centrally located NPH3 domain (), and a C-terminal coiled-coil domain.NPH3 assembles with CUL3 to form a E3 complex that ubiquitinates phototropin 1 (phot1) and modulates phototropic responsiveness [, ]. NPH3 is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening or chloroplast relocation []. Coleoptile phototropism protein 1 (CPT1) is a rice orthologue of Arabidopsis NPH3 also required for phototropism []. This entry also includes DOT3 (AT5G10250) that is involved in shoot and primary root growth; DOT3 mutants produce an aberrant parallel venation pattern in juvenile leaves [].
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Publication
15282312 | J:279942
First Author: Kobayashi A
Year: 2004
Journal: Mol Cell Biol
Title: Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
Volume: 24
Issue: 16
Pages: 7130-9
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Publication
18268004 | J:133900
First Author: Yamamoto T
Year: 2008
Journal: Mol Cell Biol
Title: Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity.
Volume: 28
Issue: 8
Pages: 2758-70
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Publication
23576762 | J:197369
First Author: Shibata S
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.
Volume: 110
Issue: 19
Pages: 7838-43
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Publication
30146013 | J:283921
First Author: López-Cayuqueo KI
Year: 2018
Journal: Kidney Int
Title: A mouse model of pseudohypoaldosteronism type II reveals a novel mechanism of renal tubular acidosis.
Volume: 94
Issue: 3
Pages: 514-523
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Publication
30301860 | J:292543
First Author: Cornelius RJ
Year: 2018
Journal: J Am Soc Nephrol
Title: Renal COP9 Signalosome Deficiency Alters CUL3-KLHL3-WNK Signaling Pathway.
Volume: 29
Issue: 11
Pages: 2627-2640
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Publication
30148674 | J:284284
First Author: Lin CM
Year: 2019
Journal: FASEB J
Title: Generation and analysis of a mouse model of pseudohypoaldosteronism type II caused by KLHL3 mutation in BTB domain.
Volume: 33
Issue: 1
Pages: 1051-1061
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Publication
19256485 | J:148999
First Author: Plafker KS
Year: 2009
Journal: Biochemistry
Title: The ubiquitin conjugating enzyme, UbcM2, engages in novel interactions with components of cullin-3 based E3 ligases.
Volume: 48
Issue: 15
Pages: 3527-37
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Publication
31515271 | J:282843
First Author: Frendo-Cumbo S
Year: 2019
Journal: J Biol Chem
Title: Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation.
Volume: 294
Issue: 44
Pages: 16172-16185
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Publication
23454126 | J:201235
First Author: Baird L
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells.
Volume: 433
Issue: 1
Pages: 58-65
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Publication
26100637 | J:224601
First Author: Ibeawuchi SR
Year: 2015
Journal: J Biol Chem
Title: Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors.
Volume: 290
Issue: 31
Pages: 19208-17
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Publication
34803491 | J:314766
First Author: Zhao M
Year: 2021
Journal: Int J Biol Sci
Title: Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific Smad4/Pten mutant mice.
Volume: 17
Issue: 15
Pages: 4176-4191
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Publication
35687106 | J:326771
     
First Author: Lao L
Year: 2022
Journal: Nucleic Acids Res
Title: ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.
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Protein
A0JLP8
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true
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Publication
18643975 | -
First Author: Petricka JJ
Year: 2008
Journal: Plant J
Title: Vein patterning screens and the defectively organized tributaries mutants in Arabidopsis thaliana.
Volume: 56
Issue: 2
Pages: 251-63
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Publication
15749712 | -
First Author: Gingerich DJ
Year: 2005
Journal: J Biol Chem
Title: Cullins 3a and 3b assemble with members of the broad complex/tramtrack/bric-a-brac (BTB) protein family to form essential ubiquitin-protein ligases (E3s) in Arabidopsis.
Volume: 280
Issue: 19
Pages: 18810-21
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Protein Coding Gene
MGI:2181067 | Klhl10
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3643058 | Kbtbd6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1920094 | Kctd17
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2686922 | Klhl6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916509 | Kctd5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1924107 | Spopl
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2180122 | Klhl9
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96581 | Ipp
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2179430 | Klhl8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2444786 | Klhl42
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2668031 | Klhl25
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1890619 | Gan
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2143315 | Klhl18
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923400 | Klhl15
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
25878247 | -
First Author: Weems JC
Year: 2015
Journal: J Biol Chem
Title: Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses.
Volume: 290
Issue: 24
Pages: 15030-41
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Publication
19995937 | -
First Author: Maerki S
Year: 2009
Journal: J Cell Biol
Title: The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.
Volume: 187
Issue: 6
Pages: 791-800
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Publication
31279627 | -
First Author: Chen Z
Year: 2019
Journal: Structure
Title: Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase.
Volume: 27
Issue: 9
Pages: 1395-1404.e4
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