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Search results 101 to 176 out of 176 for Cxcl11

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Type Details Score
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
21438871 | J:172254
First Author: Liu Z
Year: 2011
Journal: Clin Exp Immunol
Title: Chemokine CXCL11 links microbial stimuli to intestinal inflammation.
Volume: 164
Issue: 3
Pages: 396-406
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Publication
34205098 | J:335906
 
First Author: Callahan V
Year: 2021
Journal: Viruses
Title: The Pro-Inflammatory Chemokines CXCL9, CXCL10 and CXCL11 Are Upregulated Following SARS-CoV-2 Infection in an AKT-Dependent Manner.
Volume: 13
Issue: 6
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Allele
Cxcl11<em1Smoc> | MGI:7289216
Name: chemokine (C-X-C motif) ligand 11; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6428506 | C57BL/6JSmoc-Cxcl11<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Tg(Cxcl11-EGFP)HE40Gsat | MGI:4846973
Name: transgene insertion HE40, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Tg(Cxcl11-cre)KN257Gsat | MGI:5051777
Name: transgene insertion KN257, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Recombinase
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Strain
MGI:5003680 | STOCK Tg(Cxcl11-EGFP)HE40Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Strain
MGI:5523330 | STOCK Tg(Cxcl11-cre)KN257Gsat/Mmucd
Attribute String: transgenic, mutant stock
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Publication
30305365 | J:267773
First Author: Oh E
Year: 2018
Journal: Diabetes
Title: Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass.
Volume: 67
Issue: 12
Pages: 2626-2639
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Publication
26113803 | J:281352
 
First Author: Li XM
Year: 2015
Journal: J Inflamm (Lond)
Title: Nur77 deficiency leads to systemic inflammation in elderly mice.
Volume: 12
Pages: 40
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Publication
30273603 | J:270521
First Author: Zhang Y
Year: 2018
Journal: Am J Pathol
Title: Reversing CXCL10 Deficiency Ameliorates Kidney Disease in Diabetic Mice.
Volume: 188
Issue: 12
Pages: 2763-2773
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Publication
16778121 | J:127995
First Author: Chen WY
Year: 2006
Journal: Arterioscler Thromb Vasc Biol
Title: IL-20 is expressed in atherosclerosis plaques and promotes atherosclerosis in apolipoprotein E-deficient mice.
Volume: 26
Issue: 9
Pages: 2090-5
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Publication
17898285 | J:126928
First Author: Su SB
Year: 2007
Journal: Invest Ophthalmol Vis Sci
Title: Altered chemokine profile associated with exacerbated autoimmune pathology under conditions of genetic interferon-gamma deficiency.
Volume: 48
Issue: 10
Pages: 4616-25
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Publication
23843024 | J:201671
First Author: Hannesdóttir L
Year: 2013
Journal: Eur J Immunol
Title: Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response.
Volume: 43
Issue: 10
Pages: 2718-29
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Publication
18250471 | J:131976
First Author: Su YC
Year: 2008
Journal: J Immunol
Title: Granulocyte-macrophage colony-stimulating factor is required for bronchial eosinophilia in a murine model of allergic airway inflammation.
Volume: 180
Issue: 4
Pages: 2600-7
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Publication
18521956 | J:137310
First Author: Jin YZ
Year: 2008
Journal: Eur J Immunol
Title: Reciprocal function of Galphai2 and Galphai3 in graft-versus-host disease.
Volume: 38
Issue: 7
Pages: 1988-98
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Publication
24891401 | J:230001
First Author: Saxena A
Year: 2014
Journal: Cardiovasc Res
Title: CXCR3-independent actions of the CXC chemokine CXCL10 in the infarcted myocardium and in isolated cardiac fibroblasts are mediated through proteoglycans.
Volume: 103
Issue: 2
Pages: 217-27
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Publication
29500240 | J:261546
First Author: Kanai K
Year: 2018
Journal: J Immunol
Title: Murine γ-Herpesvirus 68 Induces Severe Lung Inflammation in IL-27-Deficient Mice with Liver Dysfunction Preventable by Oral Neomycin.
Volume: 200
Issue: 8
Pages: 2703-2713
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Publication
19629181 | J:151780
First Author: Benson SA
Year: 2009
Journal: PLoS One
Title: TLR2-dependent inhibition of macrophage responses to IFN-gamma is mediated by distinct, gene-specific mechanisms.
Volume: 4
Issue: 7
Pages: e6329
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Publication
21778049 | J:178813
First Author: Monnier J
Year: 2012
Journal: Eur J Cancer
Title: CXCR7 is up-regulated in human and murine hepatocellular carcinoma and is specifically expressed by endothelial cells.
Volume: 48
Issue: 1
Pages: 138-48
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Publication
27693695 | J:240562
First Author: Peng H
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Blocking CXCR7-mediated adipose tissue macrophages chemotaxis attenuates insulin resistance and inflammation in obesity.
Volume: 479
Issue: 4
Pages: 649-655
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Publication
29601107 | J:264327
First Author: Ameti R
Year: 2018
Journal: J Leukoc Biol
Title: Characterization of a chimeric chemokine as a specific ligand for ACKR3.
Volume: 104
Issue: 2
Pages: 391-400
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Publication
27325565 | J:318385
First Author: Burke SJ
Year: 2016
Journal: Biofactors
Title: Pancreatic β-Cell production of CXCR3 ligands precedes diabetes onset.
Volume: 42
Issue: 6
Pages: 703-715
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Publication
16940167 | J:124566
First Author: Burns JM
Year: 2006
Journal: J Exp Med
Title: A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development.
Volume: 203
Issue: 9
Pages: 2201-13
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Publication
18442043 | J:136246
First Author: Gerrits H
Year: 2008
Journal: Genesis
Title: Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice.
Volume: 46
Issue: 5
Pages: 235-45
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Publication
20161793 | -
First Author: Naumann U
Year: 2010
Journal: PLoS One
Title: CXCR7 functions as a scavenger for CXCL12 and CXCL11.
Volume: 5
Issue: 2
Pages: e9175
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Publication
10623723 | -
First Author: Shimizu N
Year: 2000
Journal: J Virol
Title: A putative G protein-coupled receptor, RDC1, is a novel coreceptor for human and simian immunodeficiency viruses.
Volume: 74
Issue: 2
Pages: 619-26
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Publication
20018651 | -
First Author: Rajagopal S
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7.
Volume: 107
Issue: 2
Pages: 628-32
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Publication
20388803 | -
First Author: Hattermann K
Year: 2010
Journal: Cancer Res
Title: The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects.
Volume: 70
Issue: 8
Pages: 3299-308
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Publication
17898181 | -
First Author: Miao Z
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature.
Volume: 104
Issue: 40
Pages: 15735-40
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Publication
19641136 | -
First Author: Zabel BA
Year: 2009
Journal: J Immunol
Title: Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands.
Volume: 183
Issue: 5
Pages: 3204-11
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Protein Domain
IPR001416 | ACKR3
Type: Family
Description: Just like classical chemokine receptors, atypical chemokine receptors (ACKRs) are seven-transmembrane-helix (7TM) receptors that bind chemokines []. However, they lack the canonical DRYLAIV motif necessary for GPCR coupling to G proteins and induction of classical signalling pathways. Instead, ACKRs internalise their chemokine ligands, which may subsequently affect chemokine availability. The ACKR family comprises five members: Duffy Antigen Receptor for Chemokines (DARC, ACKR1), D6 (ACKR2), CXCR7 (ACKR3), CCRL1 (ACKR4) and CCRL2 (ACKR5) [].Atypical chemokine receptor 3 (ACKR3), previously known as CXC chemokine receptor 7 (CXCR7), is regarded as a scavenger for CXCL12 and, to a lesser extent, for CXCL11 []. Unlike other CXC chemokine receptors, ACKR3 does not elicit classical chemokine receptor signalling via typical G protein-mediated pathways [], but instead induces beta-arrestin recruitment, leading to ligand internalisation and activation of MAPK signaling pathway [, ].ACKR3/CXCR7 has been identified on memory B cells and in mammals is found in bone, brain, heart and kidney [, ]. It has been shown to act as a novel coreceptor for several immunodeficiency virus strains, which infect brain-derived cells []. Studies in zebrafish have also revealed a critical role in vascular formation and angiogenesis during development []. ACKR3/CXCR7 is a functional receptor for CXCL12 in astrocytomas/glioblastomas and mediates resistance to drug-induced apoptosis []. It has been shown to promote growth of tumors formed from breast and lung cancer cells [].
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Publication
37610410 | J:358483
First Author: Batdorf HM
Year: 2023
Journal: Am J Physiol Endocrinol Metab
Title: NOD mice have distinct metabolic and immunologic profiles when compared with genetically similar MHC-matched ICR mice.
Volume: 325
Issue: 4
Pages: E336-E345
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Publication
24319779 | -
First Author: Nibbs RJ
Year: 2013
Journal: Nat Rev Immunol
Title: Immune regulation by atypical chemokine receptors.
Volume: 13
Issue: 11
Pages: 815-29
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Publication
24549061 | -
First Author: Bachelerie F
Year: 2014
Journal: Nat Immunol
Title: New nomenclature for atypical chemokine receptors.
Volume: 15
Issue: 3
Pages: 207-8
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Publication
9660793 | -
First Author: Weng Y
Year: 1998
Journal: J Biol Chem
Title: Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
Volume: 273
Issue: 29
Pages: 18288-91
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Publication
9064356 | -
First Author: Loetscher M
Year: 1996
Journal: J Exp Med
Title: Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.
Volume: 184
Issue: 3
Pages: 963-9
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Publication
11310833 | -
First Author: García-López MA
Year: 2001
Journal: Lab Invest
Title: CXCR3 chemokine receptor distribution in normal and inflamed tissues: expression on activated lymphocytes, endothelial cells, and dendritic cells.
Volume: 81
Issue: 3
Pages: 409-18
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Publication
12173928 | -
First Author: Booth V
Year: 2002
Journal: Biochemistry
Title: The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions.
Volume: 41
Issue: 33
Pages: 10418-25
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Publication
12750173 | -
First Author: Smit MJ
Year: 2003
Journal: Blood
Title: CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase.
Volume: 102
Issue: 6
Pages: 1959-65
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Publication
11085753 | J:65916
First Author: Hancock WW
Year: 2000
Journal: J Exp Med
Title: Requirement of the chemokine receptor CXCR3 for acute allograft rejection.
Volume: 192
Issue: 10
Pages: 1515-20
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Publication
10525042 | -
First Author: Mach F
Year: 1999
Journal: J Clin Invest
Title: Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells.
Volume: 104
Issue: 8
Pages: 1041-50
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Publication
15254596 | J:91359
First Author: Jiang D
Year: 2004
Journal: J Clin Invest
Title: Regulation of pulmonary fibrosis by chemokine receptor CXCR3.
Volume: 114
Issue: 2
Pages: 291-9
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Publication
12415259 | J:132575
First Author: Frigerio S
Year: 2002
Journal: Nat Med
Title: Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis.
Volume: 8
Issue: 12
Pages: 1414-20
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Publication
17538187 | J:153194
First Author: Panzer U
Year: 2007
Journal: J Am Soc Nephrol
Title: Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice.
Volume: 18
Issue: 7
Pages: 2071-84
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Publication
9466968 | -
First Author: Qin S
Year: 1998
Journal: J Clin Invest
Title: The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.
Volume: 101
Issue: 4
Pages: 746-54
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Publication
16127166 | -
First Author: Curbishley SM
Year: 2005
Journal: Am J Pathol
Title: CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow.
Volume: 167
Issue: 3
Pages: 887-99
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Publication
10605606 | -
 
First Author: Loetscher P
Year: 2000
Journal: Adv Immunol
Title: Chemokines and their receptors in lymphocyte traffic and HIV infection.
Volume: 74
Pages: 127-80
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Publication
9987599 | -
First Author: Zlotnik A
Year: 1999
Journal: Crit Rev Immunol
Title: Recent advances in chemokines and chemokine receptors.
Volume: 19
Issue: 1
Pages: 1-47
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Publication
17600132 | J:123926
First Author: Yates CC
Year: 2007
Journal: Am J Pathol
Title: Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor.
Volume: 171
Issue: 2
Pages: 484-95
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Publication
12884299 | -
First Author: Xanthou G
Year: 2003
Journal: Eur J Immunol
Title: CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11.
Volume: 33
Issue: 8
Pages: 2241-50
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Protein Domain
IPR004070 | Chemokine_CXCR3
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The CXC chemokine receptors are a subfamily of chemokine receptors that specifically bind and respond to cytokines of the CXC chemokine family. There are currently seven known CXC chemokine receptors in mammals, CXCR1 through to CXCR7.This entry represents CXCR3, which is expressed in natural killer cells and activated T lymphocytes but not in resting T lymphocytes, B lymphocytes, monocytes or granulocytes [, ]. CXCR3 also appears to be constitutively expressed on endothelial cells of medium and large blood vessels []. CXCR3 is able to regulate leukocyte trafficking and binding to various chemokines inducing various cellular responses, most notably integrin activation, cytoskeletal changes and chemotactic migration [, , , ]. The main role of CXCR3 is the selective recruitment of effector T cells in both normal tissues and inflammation []and it is involved in a number of T cell-mediated inflammatory diseases, such as autoimmune diseases, delayed-type hypersensitivity responses, certain viral diseases and acute transplant rejection []. It has been implicated in atherosclerosis [], pulmonary fibrosis [], type 1 diabetes []and nephrotoxic nephritis [], and has been implicated in wound healing [].CXCR3 is the receptor for CXCL9 (Mig), CXCL10 (IP10) and CXCL11 (I-TAC), [, , , ], which are upregulated in response to interferon-gamma and are potent chemoattractants for activated T cells [, ]. All three chemokines elicit an increase in intracellular Ca2+ levels and activate phosphoinositide 3-kinase and mitogen-activated protein kinase (MAPK) []. CXCR3 is also capable of binding a number of CC chemokines with moderate affinity, including CCL11 (eotaxin), CCL13, CCL20, CCL7, CCL5 []. However, it has been reported that CCL11, despite binding with high affinity, may be neither an agonist or an antagonist of the CXCR3 receptor, but sequesters available CCL11 resulting in a lowered response at other receptors [].
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Protein
P56485
Organism: Mus musculus/domesticus
Length: 362  
Fragment?: false
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Publication
10699158 | -
First Author: Murphy PM
Year: 2000
Journal: Pharmacol Rev
Title: International union of pharmacology. XXII. Nomenclature for chemokine receptors.
Volume: 52
Issue: 1
Pages: 145-76
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Protein
O88410
Organism: Mus musculus/domesticus
Length: 367  
Fragment?: false
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Publication
9689100 | J:49070
First Author: Ma Q
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
Volume: 95
Issue: 16
Pages: 9448-53
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Publication
11544102 | -
First Author: Horuk R
Year: 2001
Journal: Cytokine Growth Factor Rev
Title: Chemokine receptors.
Volume: 12
Issue: 4
Pages: 313-35
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Publication
10601351 | -
First Author: Charbonnier AS
Year: 1999
Journal: J Exp Med
Title: Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells.
Volume: 190
Issue: 12
Pages: 1755-68
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Publication
9500790 | -
First Author: Sallusto F
Year: 1998
Journal: J Exp Med
Title: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
Volume: 187
Issue: 6
Pages: 875-83
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Publication
7592998 | -
First Author: Strieter RM
Year: 1995
Journal: J Biol Chem
Title: The functional role of the ELR motif in CXC chemokine-mediated angiogenesis.
Volume: 270
Issue: 45
Pages: 27348-57
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Publication
10714678 | -
First Author: Zlotnik A
Year: 2000
Journal: Immunity
Title: Chemokines: a new classification system and their role in immunity.
Volume: 12
Issue: 2
Pages: 121-7
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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