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Search results 101 to 200 out of 206 for Cxcr1

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Type Details Score
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
37478375 | J:342667
First Author: Fahimi F
Year: 2023
Journal: J Leukoc Biol
Title: Human CXCR1 knock-in mice infer functional expression of a murine ortholog.
Volume: 114
Issue: 4
Pages: 373-380
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Publication
30883740 | J:283538
First Author: Corrò C
Year: 2019
Journal: J Pathol
Title: IL-8 and CXCR1 expression is associated with cancer stem cell-like properties of clear cell renal cancer.
Volume: 248
Issue: 3
Pages: 377-389
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Publication
11046063 | J:65425
First Author: Godaly G
Year: 2000
Journal: J Immunol
Title: Transepithelial neutrophil migration is CXCR1 dependent in vitro and is defective in IL-8 receptor knockout mice.
Volume: 165
Issue: 9
Pages: 5287-94
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Publication
15170355 | J:91205
First Author: Lee FH
Year: 2004
Journal: Biochemistry
Title: Receptor-ligand binding in the cell-substrate contact zone: a quantitative analysis using CX3CR1 and CXCR1 chemokine receptors.
Volume: 43
Issue: 22
Pages: 7179-86
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Publication
12239185 | -
First Author: Doroshenko T
Year: 2002
Journal: Blood
Title: Phagocytosing neutrophils down-regulate the expression of chemokine receptors CXCR1 and CXCR2.
Volume: 100
Issue: 7
Pages: 2668-71
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Allele
Cxcr1<em1Smoc> | MGI:7289225
Name: C-X-C motif chemokine receptor 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6354720 | C57BL/6JSmoc-Cxcr1<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
10734056 | -
First Author: Richardson RM
Year: 2000
Journal: J Biol Chem
Title: Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2.
Volume: 275
Issue: 13
Pages: 9201-8
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Publication
20610801 | J:165615
First Author: Vukovic J
Year: 2010
Journal: J Leukoc Biol
Title: Bone marrow chimeric mice reveal a role for CX₃CR1 in maintenance of the monocyte-derived cell population in the olfactory neuroepithelium.
Volume: 88
Issue: 4
Pages: 645-54
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Protein Coding Gene
MGI:1097153 | Cx3cl1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR000174 | Chemokine_CXCR_1/2
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The CXC chemokine receptors are a subfamily of chemokine receptors that specifically bind and respond to cytokines of the CXC chemokine family. There are currently seven known CXC chemokine receptors in mammals, CXCR1 through to CXCR7.CXCR1 and CXCR2, also known as interleukin 8 receptor alpha and beta, respectively [], are closely-related receptors. They act as specific receptors for the CXCL8 and CXCL6 chemokines, which have a glutamate-leucine-arginine (ELR) motif in their N-terminal domains []. CXCR2 also binds additional ELR motif-containing CXC chemokines (such as CXCL1, CXCL2, CXCL3, CXCL5 and CXCL7) with high affinity [].CXCR1 and CXCR2 are expressed on all granulocytes, monocytes, and mast cells and on some CD8+ T-cells and CD56+ natural killer (NK) cells []. Equal amounts of CXCR1 and CXCR2 are present on neutrophils [, , , , ], but it appears that monocytes and positive lymphocytes express more CXCR2 than CXCR1 [].This entry represents both CXCR1 and CXCR2.
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Protein Domain
IPR001355 | Chemokine_CXCR1
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The CXC chemokine receptors are a subfamily of chemokine receptors that specifically bind and respond to cytokines of the CXC chemokine family. There are currently seven known CXC chemokine receptors in mammals, CXCR1 through to CXCR7.CXCR1 and CXCR2, also known as interleukin 8 receptor alpha and beta, respectively [], are closely-related receptors. They act as specific receptors for the CXCL8 and CXCL6 chemokines, which have a glutamate-leucine-arginine (ELR) motif in their N-terminal domains []. CXCR2 also binds additional ELR motif-containing CXC chemokines (such as CXCL1, CXCL2, CXCL3, CXCL5 and CXCL7) with high affinity [].CXCR1 and CXCR2 are expressed on all granulocytes, monocytes, and mast cells and on some CD8+ T-cells and CD56+ natural killer (NK) cells []. Equal amounts of CXCR1 and CXCR2 are present on neutrophils [, , , , ], but it appears that monocytes and positive lymphocytes express more CXCR2 than CXCR1 [].This entry represents CXCR1
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Publication
15967374 | -
First Author: Fu W
Year: 2005
Journal: Cytokine
Title: Cloning and characterization of mouse homolog of the CXC chemokine receptor CXCR1.
Volume: 31
Issue: 1
Pages: 9-17
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Publication
8384312 | -
First Author: Cerretti DP
Year: 1993
Journal: Mol Immunol
Title: Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.
Volume: 30
Issue: 4
Pages: 359-67
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Publication
1379593 | -
First Author: Lee J
Year: 1992
Journal: J Biol Chem
Title: Characterization of two high affinity human interleukin-8 receptors.
Volume: 267
Issue: 23
Pages: 16283-7
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Publication
10878382 | -
First Author: Ludwig A
Year: 2000
Journal: J Immunol
Title: Identification of distinct surface-expressed and intracellular CXC-chemokine receptor 2 glycoforms in neutrophils: N-glycosylation is essential for maintenance of receptor surface expression.
Volume: 165
Issue: 2
Pages: 1044-52
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Publication
8955112 | J:37299
First Author: Dunstan CA
Year: 1996
Journal: J Biol Chem
Title: Identification of two rat genes orthologous to the human interleukin-8 receptors.
Volume: 271
Issue: 51
Pages: 32770-6
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Publication
7527448 | -
First Author: Chuntharapai A
Year: 1994
Journal: J Immunol
Title: Monoclonal antibodies detect different distribution patterns of IL-8 receptor A and IL-8 receptor B on human peripheral blood leukocytes.
Volume: 153
Issue: 12
Pages: 5682-8
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Publication
16720046 | -
First Author: Bizzarri C
Year: 2006
Journal: Pharmacol Ther
Title: ELR+ CXC chemokines and their receptors (CXC chemokine receptor 1 and CXC chemokine receptor 2) as new therapeutic targets.
Volume: 112
Issue: 1
Pages: 139-49
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Publication
36862552 | J:334881
First Author: Ikeda N
Year: 2023
Journal: Cell Rep
Title: The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis.
Volume: 42
Issue: 3
Pages: 112165
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Publication
33653774 | J:305553
First Author: Zhang C
Year: 2021
Journal: Cancer Res
Title: Hepatitis B-Induced IL8 Promotes Hepatocellular Carcinoma Venous Metastasis and Intrahepatic Treg Accumulation.
Volume: 81
Issue: 9
Pages: 2386-2398
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Publication
27241286 | J:239915
 
First Author: Zhang T
Year: 2016
Journal: Nat Commun
Title: CXCL1 mediates obesity-associated adipose stromal cell trafficking and function in the tumour microenvironment.
Volume: 7
Pages: 11674
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Publication
12496258 | -
First Author: Heidemann J
Year: 2003
Journal: J Biol Chem
Title: Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2.
Volume: 278
Issue: 10
Pages: 8508-15
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Publication
22719179 | -
 
First Author: Konrad FM
Year: 2012
Journal: Mediators Inflamm
Title: CXCR2 in acute lung injury.
Volume: 2012
Pages: 740987
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Protein Domain
IPR000057 | Chemokine_CXCR2
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The CXC chemokine receptors are a subfamily of chemokine receptors that specifically bind and respond to cytokines of the CXC chemokine family. There are currently seven known CXC chemokine receptors in mammals, CXCR1 through to CXCR7.CXCR1 and CXCR2, also known as interleukin 8 receptor alpha and beta, respectively [], are closely-relatedreceptors. They act as specific receptors for the CXCL8 and CXCL6 chemokines, which have a glutamate-leucine-arginine (ELR) motif in their N-terminal domains []. CXCR2 also binds additional ELR motif-containing CXC chemokines (such as CXCL1, CXCL2, CXCL3, CXCL5 and CXCL7) with high affinity [].CXCR1 and CXCR2 are expressed on all granulocytes, monocytes, and mast cells and on some CD8+ T-cells and CD56+ natural killer (NK) cells []. Equal amounts of CXCR1 and CXCR2 are present on neutrophils [, , , , ], but it appears that monocytes and positive lymphocytes express more CXCR2 than CXCR1 [].This entry represents CXCR2. The angiogenic effects of CXCL8 in intestinal microvascular endothelial cells are mediated by this receptor []. It has been suggested that the receptor may be a potential theraputic target in acute lung injury [].
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Publication
10570306 | J:58649
First Author: Wuyts A
Year: 1999
Journal: J Immunol
Title: NH2- and COOH-terminal truncations of murine granulocyte chemotactic protein-2 augment the in vitro and in vivo neutrophil chemotactic potency.
Volume: 163
Issue: 11
Pages: 6155-63
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Publication
21704645 | J:178566
First Author: Raman D
Year: 2011
Journal: Toxicol Appl Pharmacol
Title: Chemokines, macrophage inflammatory protein-2 and stromal cell-derived factor-1α, suppress amyloid β-induced neurotoxicity.
Volume: 256
Issue: 3
Pages: 300-13
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Publication
21814172 | J:194803
First Author: Svensson M
Year: 2011
Journal: Kidney Int
Title: Acute pyelonephritis and renal scarring are caused by dysfunctional innate immunity in mCxcr2 heterozygous mice.
Volume: 80
Issue: 10
Pages: 1064-72
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Publication
15905535 | J:99016
First Author: Nasser MW
Year: 2005
Journal: J Immunol
Title: Cross-desensitization among CXCR1, CXCR2, and CCR5: role of protein kinase C-epsilon.
Volume: 174
Issue: 11
Pages: 6927-33
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Publication
29323156 | J:260221
First Author: Wang J
Year: 2018
Journal: Sci Rep
Title: Ischemia-induced Neuronal Cell Death Is Mediated by Chemokine Receptor CX3CR1.
Volume: 8
Issue: 1
Pages: 556
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Publication
22880104 | J:189819
First Author: Sato Y
Year: 2012
Journal: PLoS One
Title: Effective elicitation of human effector CD8+ T Cells in HLA-B*51:01 transgenic humanized mice after infection with HIV-1.
Volume: 7
Issue: 8
Pages: e42776
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Publication
22394598 | J:184990
First Author: Dejean E
Year: 2012
Journal: Blood
Title: ALK+ALCLs induce cutaneous, HMGB-1-dependent IL-8/CXCL8 production by keratinocytes through NF-κB activation.
Volume: 119
Issue: 20
Pages: 4698-707
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Publication
27995997 | J:269188
 
First Author: Inoue A
Year: 2016
Journal: Sci Rep
Title: TIARP attenuates autoantibody-mediated arthritis via the suppression of neutrophil migration by reducing CXCL2/CXCR2 and IL-6 expression.
Volume: 6
Pages: 38684
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Publication
23026400 | J:288160
First Author: Stearns TM
Year: 2012
Journal: Exp Mol Pathol
Title: Early gene expression differences in inbred mouse strains with susceptibility to pulmonary adenomas.
Volume: 93
Issue: 3
Pages: 455-61
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Publication
32272490 | J:298114
First Author: Metzemaekers M
Year: 2020
Journal: J Leukoc Biol
Title: Truncation of CXCL8 to CXCL8(9-77) enhances actin polymerization and in vivo migration of neutrophils.
Volume: 107
Issue: 6
Pages: 1167-1173
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Protein
Q810W6
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
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Protein
P35343
Organism: Mus musculus/domesticus
Length: 359  
Fragment?: false
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Publication
18799424 | -
First Author: Veldkamp CT
Year: 2008
Journal: Sci Signal
Title: Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12.
Volume: 1
Issue: 37
Pages: ra4
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Protein Domain
IPR022726 | Chemokine_CXCR4_N_dom
Type: Domain
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The CXC chemokine receptors are a subfamily of chemokine receptors that specifically bind and respond to cytokines of the CXC chemokine family. There are currently seven known CXC chemokine receptors in mammals, CXCR1 through to CXCR7.This entry represents the N-terminal region of the CXC type 4 chemokine receptor. CXCR4 and its ligand stromal cell-derived factor-1 (also known as CXCL12) are essential for proper fetal development. CXCR4 is also the major coreceptor for T-tropicstrains of Human immunodeficiency virus 1, and SDF-1 inhibits HIV-1 infection. Additionally, SDF-1 and CXCR4 mediate cancer cell migration and metastasis. The N-terminal domain of most chemokine receptors is the ligand binding domain and so the N-terminal domain of CXCR4 is the binding site for SDF-1 [].
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Publication
8978608 | J:37126
First Author: Förster R
Year: 1996
Journal: Cell
Title: A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen.
Volume: 87
Issue: 6
Pages: 1037-47
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Protein
A0A1L1SRC9
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: true
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Publication
9463416 | J:172920
First Author: Legler DF
Year: 1998
Journal: J Exp Med
Title: B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5.
Volume: 187
Issue: 4
Pages: 655-60
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Publication
16214223 | -
First Author: Saito R
Year: 2005
Journal: J Neuroimmunol
Title: Altered expression of chemokine receptor CXCR5 on T cells of myasthenia gravis patients.
Volume: 170
Issue: 1-2
Pages: 172-8
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Publication
12171958 | -
First Author: Carlsen HS
Year: 2002
Journal: Gut
Title: B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue.
Volume: 51
Issue: 3
Pages: 364-71
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Publication
12851649 | -
First Author: Müller G
Year: 2003
Journal: Microcirculation
Title: Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking.
Volume: 10
Issue: 3-4
Pages: 325-34
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Publication
12732661 | J:83287
First Author: Ohl L
Year: 2003
Journal: J Exp Med
Title: Cooperating mechanisms of CXCR5 and CCR7 in development and organization of secondary lymphoid organs.
Volume: 197
Issue: 9
Pages: 1199-204
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Publication
23281399 | J:194502
First Author: Slight SR
Year: 2013
Journal: J Clin Invest
Title: CXCR5⁺ T helper cells mediate protective immunity against tuberculosis.
Volume: 123
Issue: 2
Pages: 712-26
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Publication
15969628 | -
First Author: Von Lüttichau I
Year: 2005
Journal: Stem Cells Dev
Title: Human adult CD34- progenitor cells functionally express the chemokine receptors CCR1, CCR4, CCR7, CXCR5, and CCR10 but not CXCR4.
Volume: 14
Issue: 3
Pages: 329-36
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Publication
9166430 | -
First Author: Liao F
Year: 1997
Journal: J Exp Med
Title: STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1.
Volume: 185
Issue: 11
Pages: 2015-23
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Publication
17437534 | -
First Author: Latta M
Year: 2007
Journal: Immunology
Title: CXCR6 is expressed on T cells in both T helper type 1 (Th1) inflammation and allergen-induced Th2 lung inflammation but is only a weak mediator of chemotaxis.
Volume: 121
Issue: 4
Pages: 555-64
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Publication
11714623 | -
 
First Author: Clapham PR
Year: 2001
Journal: Br Med Bull
Title: HIV-1 receptors and cell tropism.
Volume: 58
Pages: 43-59
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Publication
9625760 | -
First Author: Cole KE
Year: 1998
Journal: J Exp Med
Title: Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3.
Volume: 187
Issue: 12
Pages: 2009-21
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Publication
9660793 | -
First Author: Weng Y
Year: 1998
Journal: J Biol Chem
Title: Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
Volume: 273
Issue: 29
Pages: 18288-91
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Publication
9064356 | -
First Author: Loetscher M
Year: 1996
Journal: J Exp Med
Title: Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.
Volume: 184
Issue: 3
Pages: 963-9
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Publication
11310833 | -
First Author: García-López MA
Year: 2001
Journal: Lab Invest
Title: CXCR3 chemokine receptor distribution in normal and inflamed tissues: expression on activated lymphocytes, endothelial cells, and dendritic cells.
Volume: 81
Issue: 3
Pages: 409-18
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Publication
12173928 | -
First Author: Booth V
Year: 2002
Journal: Biochemistry
Title: The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions.
Volume: 41
Issue: 33
Pages: 10418-25
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Publication
10233762 | -
First Author: Tensen CP
Year: 1999
Journal: J Invest Dermatol
Title: Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3).
Volume: 112
Issue: 5
Pages: 716-22
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Publication
12750173 | -
First Author: Smit MJ
Year: 2003
Journal: Blood
Title: CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase.
Volume: 102
Issue: 6
Pages: 1959-65
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Publication
11085753 | J:65916
First Author: Hancock WW
Year: 2000
Journal: J Exp Med
Title: Requirement of the chemokine receptor CXCR3 for acute allograft rejection.
Volume: 192
Issue: 10
Pages: 1515-20
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Publication
10525042 | -
First Author: Mach F
Year: 1999
Journal: J Clin Invest
Title: Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells.
Volume: 104
Issue: 8
Pages: 1041-50
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Publication
15254596 | J:91359
First Author: Jiang D
Year: 2004
Journal: J Clin Invest
Title: Regulation of pulmonary fibrosis by chemokine receptor CXCR3.
Volume: 114
Issue: 2
Pages: 291-9
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Publication
12415259 | J:132575
First Author: Frigerio S
Year: 2002
Journal: Nat Med
Title: Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis.
Volume: 8
Issue: 12
Pages: 1414-20
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Publication
17538187 | J:153194
First Author: Panzer U
Year: 2007
Journal: J Am Soc Nephrol
Title: Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice.
Volume: 18
Issue: 7
Pages: 2071-84
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Publication
9466968 | -
First Author: Qin S
Year: 1998
Journal: J Clin Invest
Title: The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.
Volume: 101
Issue: 4
Pages: 746-54
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Publication
16127166 | -
First Author: Curbishley SM
Year: 2005
Journal: Am J Pathol
Title: CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow.
Volume: 167
Issue: 3
Pages: 887-99
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Publication
10605606 | -
 
First Author: Loetscher P
Year: 2000
Journal: Adv Immunol
Title: Chemokines and their receptors in lymphocyte traffic and HIV infection.
Volume: 74
Pages: 127-80
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Publication
9987599 | -
First Author: Zlotnik A
Year: 1999
Journal: Crit Rev Immunol
Title: Recent advances in chemokines and chemokine receptors.
Volume: 19
Issue: 1
Pages: 1-47
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Publication
17600132 | J:123926
First Author: Yates CC
Year: 2007
Journal: Am J Pathol
Title: Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor.
Volume: 171
Issue: 2
Pages: 484-95
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Publication
12884299 | -
First Author: Xanthou G
Year: 2003
Journal: Eur J Immunol
Title: CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11.
Volume: 33
Issue: 8
Pages: 2241-50
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Protein Domain
IPR004070 | Chemokine_CXCR3
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The CXC chemokine receptors are a subfamily of chemokine receptors that specifically bind and respond to cytokines of the CXC chemokine family. There are currently seven known CXC chemokine receptors in mammals, CXCR1 through to CXCR7.This entry represents CXCR3, which is expressed in natural killer cells and activated T lymphocytes but not in resting T lymphocytes, B lymphocytes, monocytes or granulocytes [, ]. CXCR3 also appears to be constitutively expressed on endothelial cells of medium and large blood vessels []. CXCR3 is able to regulate leukocyte trafficking and binding to various chemokines inducing various cellular responses, most notably integrin activation, cytoskeletal changes and chemotactic migration [, , , ]. The main role of CXCR3 is the selective recruitment of effector T cells in both normal tissues and inflammation []and it is involved in a number of T cell-mediated inflammatory diseases, such as autoimmune diseases, delayed-type hypersensitivity responses, certain viral diseases and acute transplant rejection []. It has been implicated in atherosclerosis [], pulmonary fibrosis [], type 1 diabetes []and nephrotoxic nephritis [], and has been implicated in wound healing [].CXCR3 is the receptor for CXCL9 (Mig), CXCL10 (IP10) and CXCL11 (I-TAC), [, , , ], which are upregulated in response to interferon-gamma and are potent chemoattractants for activated T cells [, ]. All three chemokines elicit an increase in intracellular Ca2+ levels and activate phosphoinositide 3-kinase and mitogen-activated protein kinase (MAPK) []. CXCR3 is also capable of binding a number of CC chemokines with moderate affinity, including CCL11 (eotaxin), CCL13, CCL20, CCL7, CCL5 []. However, it has been reported that CCL11, despite binding with high affinity, may be neither an agonist or an antagonist of the CXCR3 receptor, but sequesters available CCL11 resulting in a lowered response at other receptors [].
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Protein Domain
IPR002235 | Chemokine_CXCR6
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The CXC chemokine receptors are a subfamily of chemokine receptors that specifically bind and respond to cytokines of the CXC chemokine family. There are currently seven known CXC chemokine receptors in mammals, CXCR1 through to CXCR7.This entry represents CXC chemokine receptor 6 (CXCR6) also known as cluster of differentiation 186 and is a receptor for chemokine CXCL16. CXCL16 does not activate any other known chemokine receptor, this interaction is highly specific and unique []. Binding of CXCL16 to CXCR6 causes chemotactic migration in activated T cells [, ]however, CXCR6 is a weak mediator of chemotaxis []. The resultant chemotactic response is sensitive to pertussis toxin and results in calcium mobilisation [, ]. CXCR6 is expressed in lymphoid tissues and activated T cells and is induced in peripheral blood leukocytes []and found on natural killer cells []. A number of roles have been suggested for CXCR6 and subset-specific immune responses may be regulated by cell-cell contacts between activated subsets of T cells expressing CXCR6 and antigen presenting cells expressing CXCL16. CXCR6 may also be involved in cell-cell contacts during chronic inflammation []. Additional roles for the receptor include T cell migration in the splenic red pulp, thymocyte development and effector T cell trafficking []. It has been shown that CXCR6 acts as a coreceptor for T cell line-tropic and macrophage-tropic HIV-1 strains, and may play a role in the establishment and progression of HIV infection [, ].
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Protein Domain
IPR001053 | Chemokine_CXCR5
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The CXC chemokine receptors are a subfamily of chemokine receptors that specifically bind and respond to cytokines of the CXC chemokine family. There are currently seven known CXC chemokine receptors in mammals, CXCR1 through to CXCR7.This entry represents CXC chemokine receptor type 5 (CXCR5), also known as cluster of differentiation 185 or Burkitt lymphoma receptor 1, which acts as a receptor for CXCL13. Upon binding to CXCR5, it causes mobilisation of intracellular calcium and chemotaxis []. CXCR5 is specifically expressed in B cells and lymphatic tissues, as well as in spleen [, ]and is expressed by human CD34(-) mesenchymal progenitor cells and immortalized mesenchymal stem cell lines [].B lymphocytes expressing CXCR5 migrate in a concentration dependent manner in response to CXCL13, which does not induce chemotaxis in T lymphocytes, monocytes or neutrophils. This selectivity for B lymphocytes is unique among the chemokines. CXCR5 also plays an essential role in B cell migration [], lymphocyte homing []and in the development of normal lymphoid tissue [, ]. It has also been shown that CD4+CXCR5+ T cells expressing CXCR5 play a protective role in the immune response against mycobacterium tuberculosis (Mtb) infection, highlighting a potential use for TB vaccine design and therapy [].
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Publication
9689100 | J:49070
First Author: Ma Q
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
Volume: 95
Issue: 16
Pages: 9448-53
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Publication
11544102 | -
First Author: Horuk R
Year: 2001
Journal: Cytokine Growth Factor Rev
Title: Chemokine receptors.
Volume: 12
Issue: 4
Pages: 313-35
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Publication
10601351 | -
First Author: Charbonnier AS
Year: 1999
Journal: J Exp Med
Title: Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells.
Volume: 190
Issue: 12
Pages: 1755-68
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Publication
9500790 | -
First Author: Sallusto F
Year: 1998
Journal: J Exp Med
Title: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
Volume: 187
Issue: 6
Pages: 875-83
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Publication
7592998 | -
First Author: Strieter RM
Year: 1995
Journal: J Biol Chem
Title: The functional role of the ELR motif in CXC chemokine-mediated angiogenesis.
Volume: 270
Issue: 45
Pages: 27348-57
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Protein
Q04683
Organism: Mus musculus/domesticus
Length: 374  
Fragment?: false
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Publication
11017100 | J:65117
First Author: Matloubian M
Year: 2000
Journal: Nat Immunol
Title: A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo.
Volume: 1
Issue: 4
Pages: 298-304
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Protein
Q3V0L2
Organism: Mus musculus/domesticus
Length: 374  
Fragment?: false
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Publication
11290797 | -
First Author: Wilbanks A
Year: 2001
Journal: J Immunol
Title: Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines.
Volume: 166
Issue: 8
Pages: 5145-54
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Publication
10714678 | -
First Author: Zlotnik A
Year: 2000
Journal: Immunity
Title: Chemokines: a new classification system and their role in immunity.
Volume: 12
Issue: 2
Pages: 121-7
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Protein
Q9EQ16
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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