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Search results 101 to 200 out of 222 for Cxcr6

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:4883033
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945689
Age: embryonic day 11.5
Image: g01234 E11.5
Specimen Label: g01234 E11.5
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:4883033
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945689
Age: postnatal day 7
Image: g01234 P7
Specimen Label: g01234 P7
Detected: true
Specimen Num: 3
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•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002287
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1832123
Stage: TS23
Assay Id: MGI:5542841
Age: embryonic day 15.5
Image: GUDMAP:8487
Specimen Label: GUDMAP:8487
Detected: false
Specimen Num: 1
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•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002287
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2851823
Stage: TS23
Assay Id: MGI:5542841
Age: embryonic day 15.5
Image: GUDMAP:8487
Specimen Label: GUDMAP:8487
Detected: false
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:4883033
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945689
Age: postnatal day 7
Image: g01234 P7
Specimen Label: g01234 P7
Detected: true
Specimen Num: 3
•
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•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002287
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5542841
Age: embryonic day 15.5
Image: GUDMAP:8487
Specimen Label: GUDMAP:8487
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4883033
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945689
Age: embryonic day 15.5
Image: g01234 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g01234 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4883033
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945689
Age: postnatal day 7
Image: g01234 P7
Specimen Label: g01234 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4883033
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945689
Age: embryonic day 15.5
Image: g01234 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g01234 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002287
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5542841
Age: embryonic day 15.5
Image: GUDMAP:8487
Specimen Label: GUDMAP:8487
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002287
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2874723
Stage: TS23
Assay Id: MGI:5542841
Age: embryonic day 15.5
Image: GUDMAP:8487
Specimen Label: GUDMAP:8487
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4883033
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945689
Age: embryonic day 15.5
Image: g01234 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g01234 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4883033
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945689
Age: postnatal day 7
Image: g01234 P7
Specimen Label: g01234 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002287
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5542841
Age: embryonic day 15.5
Image: GUDMAP:8487
Specimen Label: GUDMAP:8487
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002287
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1796223
Stage: TS23
Assay Id: MGI:5542841
Age: embryonic day 15.5
Image: GUDMAP:8487
Specimen Label: GUDMAP:8487
Detected: false
Specimen Num: 1
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Publication
25436972 | J:222608
First Author: Lynch L
Year: 2015
Journal: Nat Immunol
Title: Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue.
Volume: 16
Issue: 1
Pages: 85-95
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Publication
30559399 | J:268418
First Author: Govindarajan S
Year: 2018
Journal: Nat Commun
Title: Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.
Volume: 9
Issue: 1
Pages: 5340
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Publication
36857453 | J:350798
First Author: Li J
Year: 2023
Journal: Sci Adv
Title: Mechanisms of antigen-induced reversal of CNS inflammation in experimental demyelinating disease.
Volume: 9
Issue: 9
Pages: eabo2810
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Publication
24706879 | J:208876
First Author: Zaid A
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Persistence of skin-resident memory T cells within an epidermal niche.
Volume: 111
Issue: 14
Pages: 5307-12
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Publication
21921158 | J:177038
First Author: Wong CH
Year: 2011
Journal: Science
Title: Functional innervation of hepatic iNKT cells is immunosuppressive following stroke.
Volume: 334
Issue: 6052
Pages: 101-5
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Publication
24833801 | J:223899
First Author: Wu MY
Year: 2014
Journal: Arterioscler Thromb Vasc Biol
Title: Inhibition of the plasma SCUBE1, a novel platelet adhesive protein, protects mice against thrombosis.
Volume: 34
Issue: 7
Pages: 1390-8
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Publication
25205813 | J:216483
First Author: Lee WY
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia.
Volume: 111
Issue: 38
Pages: 13936-41
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Publication
27855783 | J:267393
   
First Author: Qi S
Year: 2016
Journal: Elife
Title: Long-term intravital imaging of the multicolor-coded tumor microenvironment during combination immunotherapy.
Volume: 5
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Publication
30518790 | J:268376
First Author: Burrello C
Year: 2018
Journal: Nat Commun
Title: Therapeutic faecal microbiota transplantation controls intestinal inflammation through IL10 secretion by immune cells.
Volume: 9
Issue: 1
Pages: 5184
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Publication
19884494 | J:154768
First Author: Monticelli LA
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Transcriptional regulator Id2 controls survival of hepatic NKT cells.
Volume: 106
Issue: 46
Pages: 19461-6
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Publication
25007044 | J:216200
First Author: Tong PL
Year: 2015
Journal: J Invest Dermatol
Title: The skin immune atlas: three-dimensional analysis of cutaneous leukocyte subsets by multiphoton microscopy.
Volume: 135
Issue: 1
Pages: 84-93
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Publication
27798616 | J:260264
First Author: Hägglöf T
Year: 2016
Journal: Nat Immunol
Title: Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses.
Volume: 17
Issue: 12
Pages: 1407-1414
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Publication
30220458 | J:267399
First Author: Roediger B
Year: 2018
Journal: Cell
Title: An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis.
Volume: 175
Issue: 2
Pages: 530-543.e24
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Publication
34099917 | J:354562
First Author: Hiltensperger M
Year: 2021
Journal: Nat Immunol
Title: Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity.
Volume: 22
Issue: 7
Pages: 880-892
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Publication
27653688 | J:239120
First Author: Thanabalasuriar A
Year: 2016
Journal: Cell Rep
Title: iNKT Cell Emigration out of the Lung Vasculature Requires Neutrophils and Monocyte-Derived Dendritic Cells in Inflammation.
Volume: 16
Issue: 12
Pages: 3260-3272
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Publication
37392736 | J:338301
First Author: Evrard M
Year: 2023
Journal: Immunity
Title: Single-cell protein expression profiling resolves circulating and resident memory T cell diversity across tissues and infection contexts.
Volume: 56
Issue: 7
Pages: 1664-1680.e9
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Publication
38815582 | J:349353
First Author: Liang Z
Year: 2024
Journal: Immunity
Title: Intestinal CXCR6(+) ILC3s migrate to the kidney and exacerbate renal fibrosis via IL-23 receptor signaling enhanced by PD-1 expression.
Volume: 57
Issue: 6
Pages: 1306-1323.e8
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Publication
22675532 | J:187848
First Author: Gray EE
Year: 2012
Journal: PLoS One
Title: Subcapsular sinus macrophage fragmentation and CD169+ bleb acquisition by closely associated IL-17-committed innate-like lymphocytes.
Volume: 7
Issue: 6
Pages: e38258
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Publication
37562754 | J:350478
First Author: Muñoz-Ruiz M
Year: 2023
Journal: J Allergy Clin Immunol
Title: IFN-γ-dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit allergic contact dermatitis.
Volume: 152
Issue: 6
Pages: 1520-1540
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Publication
22927331 | J:212626
First Author: Borst O
Year: 2012
Journal: Circ Res
Title: The inflammatory chemokine CXC motif ligand 16 triggers platelet activation and adhesion via CXC motif receptor 6-dependent phosphatidylinositide 3-kinase/Akt signaling.
Volume: 111
Issue: 10
Pages: 1297-307
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Publication
36438480 | J:346551
First Author: Dai B
Year: 2022
Journal: Theranostics
Title: Intravital molecular imaging reveals that ROS-caspase-3-GSDME-induced cell punching enhances humoral immunotherapy targeting intracellular tumor antigens.
Volume: 12
Issue: 17
Pages: 7603-7623
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Publication
35366396 | J:328757
First Author: Dähling S
Year: 2022
Journal: Immunity
Title: Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches.
Volume: 55
Issue: 4
Pages: 656-670.e8
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Publication
23352234 | J:194479
First Author: Kastenmüller W
Year: 2013
Journal: Immunity
Title: Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8+ T cell responses in the lymph node.
Volume: 38
Issue: 3
Pages: 502-13
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Publication
33357452 | J:302318
First Author: Srivastava S
Year: 2021
Journal: Cancer Cell
Title: Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade.
Volume: 39
Issue: 2
Pages: 193-208.e10
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Publication
29045904 | J:258615
First Author: Liew PX
Year: 2017
Journal: Immunity
Title: iNKT Cells Orchestrate a Switch from Inflammation to Resolution of Sterile Liver Injury.
Volume: 47
Issue: 4
Pages: 752-765.e5
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Publication
34305911 | J:314908
 
First Author: Mathä L
Year: 2021
Journal: Front Immunol
Title: Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity.
Volume: 12
Pages: 679509
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Publication
33593983 | J:313043
 
First Author: Liu G
Year: 2021
Journal: mBio
Title: IL-27 Negatively Regulates Tip-DC Development during Infection.
Volume: 12
Issue: 1
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Publication
31594939 | J:281372
First Author: Sun D
Year: 2019
Journal: Nat Commun
Title: Fungal dissemination is limited by liver macrophage filtration of the blood.
Volume: 10
Issue: 1
Pages: 4566
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Publication
27487469 | J:267305
   
First Author: Zhang Y
Year: 2016
Journal: Elife
Title: Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node.
Volume: 5
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Publication
34879282 | J:320927
First Author: Hanasoge Somasundara AV
Year: 2021
Journal: Cell Rep
Title: Parity-induced changes to mammary epithelial cells control NKT cell expansion and mammary oncogenesis.
Volume: 37
Issue: 10
Pages: 110099
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Publication
38168955 | J:344204
First Author: Zou D
Year: 2024
Journal: Nat Immunol
Title: CD4(+) T cell immunity is dependent on an intrinsic stem-like program.
Volume: 25
Issue: 1
Pages: 66-76
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Publication
36002023 | J:337135
First Author: Ataide MA
Year: 2022
Journal: Immunity
Title: Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes.
Volume: 55
Issue: 10
Pages: 1813-1828.e9
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Publication
23603794 | J:197353
First Author: Roediger B
Year: 2013
Journal: Nat Immunol
Title: Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells.
Volume: 14
Issue: 6
Pages: 564-73
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Publication
22980983 | J:187962
First Author: Kastenmüller W
Year: 2012
Journal: Cell
Title: A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread.
Volume: 150
Issue: 6
Pages: 1235-48
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Publication
33239787 | J:338001
First Author: Gola A
Year: 2021
Journal: Nature
Title: Commensal-driven immune zonation of the liver promotes host defence.
Volume: 589
Issue: 7840
Pages: 131-136
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Publication
12461651 | J:80594
First Author: Kiss H
Year: 2002
Journal: Mamm Genome
Title: Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3.
Volume: 13
Issue: 11
Pages: 646-55
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Publication
22277947 | J:185240
First Author: Lefebvre S
Year: 2012
Journal: J Invest Dermatol
Title: Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development.
Volume: 132
Issue: 4
Pages: 1094-102
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Publication
34678150 | J:337628
First Author: Xue G
Year: 2021
Journal: Cancer Cell
Title: Adoptive cell therapy with tumor-specific Th9 cells induces viral mimicry to eliminate antigen-loss-variant tumor cells.
Volume: 39
Issue: 12
Pages: 1610-1622.e9
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Publication
23708969 | J:198733
First Author: Lämmermann T
Year: 2013
Journal: Nature
Title: Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo.
Volume: 498
Issue: 7454
Pages: 371-5
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:101977
     
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
28267793 | J:248026
First Author: Koenen A
Year: 2017
Journal: PLoS One
Title: The DRF motif of CXCR6 as chemokine receptor adaptation to adhesion.
Volume: 12
Issue: 3
Pages: e0173486
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Publication
21628524 | J:174974
First Author: Lee LN
Year: 2011
Journal: Infect Immun
Title: CXCR6 is a marker for protective antigen-specific cells in the lungs after intranasal immunization against Mycobacterium tuberculosis.
Volume: 79
Issue: 8
Pages: 3328-37
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Allele
Cxcr6<em1(CXCR6)Smoc> | MGI:7289235
Name: C-X-C motif chemokine receptor 6; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Cxcr6<em2Smoc> | MGI:7289236
Name: C-X-C motif chemokine receptor 6; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7623348 | C57BL/6JSmoc-Cxcr6<em1(CXCR6)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6770680 | C57BL/6JSmoc-Cxcr6<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
17437534 | -
First Author: Latta M
Year: 2007
Journal: Immunology
Title: CXCR6 is expressed on T cells in both T helper type 1 (Th1) inflammation and allergen-induced Th2 lung inflammation but is only a weak mediator of chemotaxis.
Volume: 121
Issue: 4
Pages: 555-64
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CL Term
CL:4047101 | liver-resident natural killer cell
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Publication
9166430 | -
First Author: Liao F
Year: 1997
Journal: J Exp Med
Title: STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1.
Volume: 185
Issue: 11
Pages: 2015-23
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Publication
11714623 | -
 
First Author: Clapham PR
Year: 2001
Journal: Br Med Bull
Title: HIV-1 receptors and cell tropism.
Volume: 58
Pages: 43-59
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Protein Domain
IPR002235 | Chemokine_CXCR6
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The CXC chemokine receptors are a subfamily of chemokine receptors that specifically bind and respond to cytokines of the CXC chemokine family. There are currently seven known CXC chemokine receptors in mammals, CXCR1 through to CXCR7.This entry represents CXC chemokine receptor 6 (CXCR6) also known as cluster of differentiation 186 and is a receptor for chemokine CXCL16. CXCL16 does not activate any other known chemokine receptor, this interaction is highly specific and unique []. Binding of CXCL16 to CXCR6 causes chemotactic migration in activated T cells [, ]however, CXCR6 is a weak mediator of chemotaxis []. The resultant chemotactic response is sensitive to pertussis toxin and results in calcium mobilisation [, ]. CXCR6 is expressed in lymphoid tissues and activated T cells and is induced in peripheral blood leukocytes []and found on natural killer cells []. A number of roles have been suggested for CXCR6 and subset-specific immune responses may be regulated by cell-cell contacts between activated subsets of T cells expressing CXCR6 and antigen presenting cells expressing CXCL16. CXCR6 may also be involved in cell-cell contacts during chronic inflammation []. Additional roles for the receptor include T cell migration in the splenic red pulp, thymocyte development and effector T cell trafficking []. It has been shown that CXCR6 acts as a coreceptor for T cell line-tropic and macrophage-tropic HIV-1 strains, and may play a role in the establishment and progression of HIV infection [, ].
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Publication
11290797 | -
First Author: Wilbanks A
Year: 2001
Journal: J Immunol
Title: Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines.
Volume: 166
Issue: 8
Pages: 5145-54
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HT Experiment
GSE80680 | Global transcriptome analysis reveals aging-related genes in Atp8b1 mutant lungs
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Protein
Q9EQ16
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
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Protein
A0A1L1SVJ3
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: false
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Publication
36630919 | J:333353
First Author: du Halgouet A
Year: 2023
Journal: Immunity
Title: Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing.
Volume: 56
Issue: 1
Pages: 78-92.e6
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Publication
30374017 | J:271282
First Author: Filipovic I
Year: 2018
Journal: Nat Commun
Title: Molecular definition of group 1 innate lymphoid cells in the mouse uterus.
Volume: 9
Issue: 1
Pages: 4492
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Publication
32929273 | J:305304
First Author: Alves de Lima K
Year: 2020
Journal: Nat Immunol
Title: Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons.
Volume: 21
Issue: 11
Pages: 1421-1429
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Publication
18480435 | J:153417
First Author: Jiang JQ
Year: 2008
Journal: J Virol
Title: Qualitative and quantitative characteristics of rotavirus-specific CD8 T cells vary depending on the route of infection.
Volume: 82
Issue: 14
Pages: 6812-9
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Publication
23121668 | J:190984
First Author: Nakano M
Year: 2012
Journal: Clin Exp Immunol
Title: Activated natural killer T cells producing interferon-gamma elicit promoting activity to murine dendritic cell-based autoimmune hepatic inflammation.
Volume: 170
Issue: 3
Pages: 274-82
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