Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_02 |
|
Specimen Label: |
euxassay_008199_02 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_03 |
|
Specimen Label: |
euxassay_008199_03 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_04 |
|
Specimen Label: |
euxassay_008199_04 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_05 |
|
Specimen Label: |
euxassay_008199_05 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_06 |
|
Specimen Label: |
euxassay_008199_06 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_07 |
|
Specimen Label: |
euxassay_008199_07 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_08 |
|
Specimen Label: |
euxassay_008199_08 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_09 |
|
Specimen Label: |
euxassay_008199_09 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_10 |
|
Specimen Label: |
euxassay_008199_10 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_20 |
|
Specimen Label: |
euxassay_008199_20 |
Detected: |
true |
Specimen Num: |
20 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_21 |
|
Specimen Label: |
euxassay_008199_21 |
Detected: |
true |
Specimen Num: |
21 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_22 |
|
Specimen Label: |
euxassay_008199_22 |
Detected: |
true |
Specimen Num: |
22 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_23 |
|
Specimen Label: |
euxassay_008199_23 |
Detected: |
true |
Specimen Num: |
23 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_24 |
|
Specimen Label: |
euxassay_008199_24 |
Detected: |
true |
Specimen Num: |
24 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1763923 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_06 |
|
Specimen Label: |
euxassay_008199_06 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1763923 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_07 |
|
Specimen Label: |
euxassay_008199_07 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1763923 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_08 |
|
Specimen Label: |
euxassay_008199_08 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1763923 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_09 |
|
Specimen Label: |
euxassay_008199_09 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1763923 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_10 |
|
Specimen Label: |
euxassay_008199_10 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1763923 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_11 |
|
Specimen Label: |
euxassay_008199_11 |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1763923 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_12 |
|
Specimen Label: |
euxassay_008199_12 |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1763923 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_19 |
|
Specimen Label: |
euxassay_008199_19 |
Detected: |
true |
Specimen Num: |
19 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1763923 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_20 |
|
Specimen Label: |
euxassay_008199_20 |
Detected: |
true |
Specimen Num: |
20 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1763923 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_21 |
|
Specimen Label: |
euxassay_008199_21 |
Detected: |
true |
Specimen Num: |
21 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1763923 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_22 |
|
Specimen Label: |
euxassay_008199_22 |
Detected: |
true |
Specimen Num: |
22 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1763923 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_23 |
|
Specimen Label: |
euxassay_008199_23 |
Detected: |
true |
Specimen Num: |
23 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1059113 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1763923 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4824231 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_008199_24 |
|
Specimen Label: |
euxassay_008199_24 |
Detected: |
true |
Specimen Num: |
24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hao L |
Year: |
2009 |
Journal: |
Biol Reprod |
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The unfolded protein response contributes to preimplantation mouse embryo death in the DDK syndrome. |
Volume: |
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Pages: |
944-53 |
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•
•
•
•
•
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Publication |
First Author: |
Strausberg RL |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
Volume: |
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•
•
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Publication |
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Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP) |
Year: |
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Database Release |
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•
•
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Publication |
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Year: |
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Publication |
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University of California, Davis |
Year: |
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Alleles produced for the KOMP project by the University of California, Davis |
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Publication |
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Mouse Genome Informatics Scientific Curators |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Inbal B |
Year: |
1997 |
Journal: |
Nature |
Title: |
DAP kinase links the control of apoptosis to metastasis. |
Volume: |
390 |
Issue: |
6656 |
Pages: |
180-4 |
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Publication |
First Author: |
Friedrich ML |
Year: |
2005 |
Journal: |
Int Immunol |
Title: |
DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection. |
Volume: |
17 |
Issue: |
11 |
Pages: |
1379-90 |
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•
•
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•
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Publication |
First Author: |
Guenebeaud C |
Year: |
2010 |
Journal: |
Mol Cell |
Title: |
The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. |
Volume: |
40 |
Issue: |
6 |
Pages: |
863-76 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
93
 |
Fragment?: |
false |
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•
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•
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Publication |
First Author: |
Yang H |
Year: |
2015 |
Journal: |
Apoptosis |
Title: |
Activation of NOD1 by DAP contributes to myocardial ischemia/reperfusion injury via multiple signaling pathways. |
Volume: |
20 |
Issue: |
4 |
Pages: |
512-22 |
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Publication |
First Author: |
Kamal M |
Year: |
2010 |
Journal: |
FEBS Lett |
Title: |
C-mip interacts with the p85 subunit of PI3 kinase and exerts a dual effect on ERK signaling via the recruitment of Dip1 and DAP kinase. |
Volume: |
584 |
Issue: |
3 |
Pages: |
500-6 |
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Interaction Experiment |
Description: |
The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
448
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1442
 |
Fragment?: |
false |
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•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1430
 |
Fragment?: |
false |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
372
 |
Fragment?: |
false |
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•
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GO Term |
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Publication |
First Author: |
Kögel D |
Year: |
2001 |
Journal: |
Bioessays |
Title: |
The DAP kinase family of pro-apoptotic proteins: novel players in the apoptotic game. |
Volume: |
23 |
Issue: |
4 |
Pages: |
352-8 |
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•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
370
 |
Fragment?: |
false |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
489
 |
Fragment?: |
false |
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•
•
•
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Publication |
First Author: |
Tanos BE |
Year: |
2013 |
Journal: |
Genes Dev |
Title: |
Centriole distal appendages promote membrane docking, leading to cilia initiation. |
Volume: |
27 |
Issue: |
2 |
Pages: |
163-8 |
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Protein Domain |
Type: |
Family |
Description: |
PrpF is a protein found in the 2-methylcitrate pathway. It is structurally similar to DAP epimerase and proline racemase. This protein is an aconitate- isomerise converting trans-aconitate to cis-aconitate [, ]. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
692
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
319
 |
Fragment?: |
false |
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•
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Publication |
First Author: |
Joo K |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
CCDC41 is required for ciliary vesicle docking to the mother centriole. |
Volume: |
110 |
Issue: |
15 |
Pages: |
5987-92 |
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Protein Domain |
Type: |
Family |
Description: |
Centriole distal appendages (DAPs) anchor cilia to the plasma membrane and are thought to initiate primary cilium assembly through ciliary vesicles docking to the mother centriole. Centrosomal protein of 83kDa (Cep83), previously known as coiled-coil domain-containing protein 41 or CCDC41, is a DAP component required for the docking of ciliary vesicles []. Cep38 has been shown to recruit SCLT1 and Cep89, also DAP components, to centrioles []. |
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Publication |
First Author: |
Garvey GS |
Year: |
2007 |
Journal: |
Protein Sci |
Title: |
The three-dimensional crystal structure of the PrpF protein of Shewanella oneidensis complexed with trans-aconitate: insights into its biological function. |
Volume: |
16 |
Issue: |
7 |
Pages: |
1274-84 |
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Publication |
First Author: |
Das NK |
Year: |
2020 |
Journal: |
Cell Metab |
Title: |
Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis. |
Volume: |
31 |
Issue: |
1 |
Pages: |
115-130.e6 |
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Publication |
First Author: |
Fritz JD |
Year: |
1995 |
Journal: |
Pediatr Res |
Title: |
Expression of deletion-containing dystrophins in mdx muscle: implications for gene therapy and dystrophin function. |
Volume: |
37 |
Issue: |
6 |
Pages: |
693-700 |
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Protein Domain |
Type: |
Domain |
Description: |
Aminotransferases share certain mechanistic features with other pyridoxal-phosphate dependent enzymes, such as the covalent binding of the pyridoxal-phosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped []into class I and class II. This entry includes proteins from both subfamilies, including class I LL-diaminopimelate aminotransferase, chloroplastic from Arabidopsis thaliana (Dap) and class II Histidinol-phosphate aminotransferase from Listeria welshimeri (HisC). Dap consists of two domains, a large domain and a small domain. This entry represents the large domain, which has a 3-layer α/β/α sandwich topology []. |
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Publication |
First Author: |
Cheggour A |
Year: |
2000 |
Journal: |
Mol Microbiol |
Title: |
The dppA gene of Bacillus subtilis encodes a new D-aminopeptidase. |
Volume: |
38 |
Issue: |
3 |
Pages: |
504-13 |
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•
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•
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Publication |
First Author: |
Mathiopoulos C |
Year: |
1991 |
Journal: |
Mol Microbiol |
Title: |
A Bacillus subtilis dipeptide transport system expressed early during sporulation. |
Volume: |
5 |
Issue: |
8 |
Pages: |
1903-13 |
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•
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Protein Domain |
Type: |
Family |
Description: |
This entry contains the D-aminopeptidase dipeptide-binding protein (dppA; DAP dppA; MEROPS identifier M55.001). Peptide transport systems are found in many bacterial species and generally function to accumulate intact peptides in the cell, where they are hydrolyzed []. The dipeptide-binding protein (dppA) of Bacillus subtilis belongs to the dipeptide ABC transport (dpp) operon expressed early during sporulation. It is a binuclear zinc-dependent, D-specific aminopeptidase. The biologically active enzyme is a homodecamer with active sites buried in its channel. These self-compartmentalizing proteases are characterized by a SXDXEG motif []. D-Ala-D-Ala and D-Ala-Gly-Gly are the preferred substrates []. Bacillus subtilis dppA is thought to function as an adaptation to nutrient deficiency; hydrolysis of its substrate releases D-Ala which can be used subsequently as metabolic fuel []. |
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Protein Domain |
Type: |
Homologous_superfamily |
Description: |
Beta-Lactam antibiotics interfere with the biosynthesis of peptidoglycans in the bacterial cell wall by inactivating the penicillin-binding proteins DD-transpeptidases. Bacterial resistance to beta-lactam occurs through the synthesis of beta-lactmases that hydrolyse beta-lactam rings. D-aminopeptidase (DAP; peptidase family S12) is inhibited by beta-lactam antibiotics, and shares a low sequence identity with class C beta-lactamases and R61 DD-carboxypeptidase. DAP consists of three domains: the N-terminal domain A contains catalytic residues and displays a beta-lactamase-like fold (), domains B (middle) and C (C-terminal) domains are structurally similar, displaying an eight-stranded beta barrel []. Domain C is responsible for substrate and inhibitor specificity.This superfamily represents a structurally similar domain to domains B and C of D-aminopeptidase. Proteins in this entry include D-aminopeptidases and some uncharacterised hypothetical lipoproteins from Streptococcus. |
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Publication |
First Author: |
Moukhles H |
Year: |
2001 |
Journal: |
J Neurochem |
Title: |
Dystroglycan contributes to the formation of multiple dystrophin-like complexes in brain. |
Volume: |
78 |
Issue: |
4 |
Pages: |
824-34 |
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•
•
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•
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Publication |
First Author: |
Kawai T |
Year: |
1998 |
Journal: |
Mol Cell Biol |
Title: |
ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. |
Volume: |
18 |
Issue: |
3 |
Pages: |
1642-51 |
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•
•
•
•
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Publication |
First Author: |
Kawai T |
Year: |
2003 |
Journal: |
Mol Cell Biol |
Title: |
ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. |
Volume: |
23 |
Issue: |
17 |
Pages: |
6174-86 |
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•
•
•
•
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Publication |
First Author: |
Kawai T |
Year: |
1999 |
Journal: |
Oncogene |
Title: |
Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity. |
Volume: |
18 |
Issue: |
23 |
Pages: |
3471-80 |
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•
•
•
•
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Publication |
First Author: |
Guo Q |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4. |
Volume: |
279 |
Issue: |
6 |
Pages: |
4596-603 |
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•
•
•
•
|
Publication |
First Author: |
Crawford GE |
Year: |
2000 |
Journal: |
J Cell Biol |
Title: |
Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain. |
Volume: |
150 |
Issue: |
6 |
Pages: |
1399-410 |
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•
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•
•
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