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Search results 101 to 195 out of 195 for Dcp2

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:7662583
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1784121
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7662603
Age: embryonic day 13.5
Note: Expression was detected in fiber cells in large cytoplasmic granules.
Specimen Label: 3b
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:7662583
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1784122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7662603
Age: embryonic day 14.5
Note: Expression was detected in fiber cells in large cytoplasmic granules.
Specimen Label: 3d
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:7662583
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1784124
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7662603
Age: embryonic day 16.5
Note: In more differentiated fiber cells of the lens cortex, immunoreactivity was associated with nuclei and co-localized with Tob1.
Specimen Label: 2h
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:7662583
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3827924
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7662603
Age: embryonic day 16.5
Note: In transitional zone fiber cells, expression was found in large cytoplasmic complexes with Tob1.
Specimen Label: 2h
Detected: true
Specimen Num: 3
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Publication
33813271 | J:305571
 
First Author: Ibayashi M
Year: 2021
Journal: Biochem Biophys Res Commun
Title: mRNA decapping factor Dcp1a is essential for embryonic growth in mice.
Volume: 555
Pages: 128-133
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Publication
20133598 | J:157579
First Author: Suzuki A
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs.
Volume: 107
Issue: 8
Pages: 3594-9
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Publication
33394034 | J:334500
First Author: Ruthig VA
Year: 2021
Journal: Biol Reprod
Title: A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells†.
Volume: 104
Issue: 4
Pages: 861-874
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Publication
36197846 | J:329565
First Author: Kim J
Year: 2022
Journal: PLoS Genet
Title: The RNA helicase DDX6 controls early mouse embryogenesis by repressing aberrant inhibition of BMP signaling through miRNA-mediated gene silencing.
Volume: 18
Issue: 10
Pages: e1009967
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Publication
26120033 | J:239655
First Author: Zhou Z
Year: 2015
Journal: Dev Cell
Title: RNA Binding Protein Nanos2 Organizes Post-transcriptional Buffering System to Retain Primitive State of Mouse Spermatogonial Stem Cells.
Volume: 34
Issue: 1
Pages: 96-107
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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QTL
MGI:94875 | Dxcp2
Type: QTL
Organism: mouse, laboratory
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GXD Expression
GXD Expression
 
Probe: MGI:7662587
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1784121
Pattern: Punctate
Stage: TS21
Assay Id: MGI:7662602
Age: embryonic day 13.5
Note: Distinct large punctate immunoreactivity was detected in the elongating fiber cells. Co-localization with Dcp2 was observed.
Specimen Label: 2d
Detected: true
Specimen Num: 2
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Publication
24510189 | -
First Author: Chang CT
Year: 2014
Journal: Nucleic Acids Res
Title: The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1.
Volume: 42
Issue: 8
Pages: 5217-33
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GO Term
GO:0098745 | RNA decapping complex
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Publication
15671491 | -
First Author: Sakuno T
Year: 2004
Journal: J Biochem
Title: Decapping reaction of mRNA requires Dcp1 in fission yeast: its characterization in different species from yeast to human.
Volume: 136
Issue: 6
Pages: 805-12
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Publication
12923261 | -
First Author: Piccirillo C
Year: 2003
Journal: RNA
Title: Functional characterization of the mammalian mRNA decapping enzyme hDcp2.
Volume: 9
Issue: 9
Pages: 1138-47
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Publication
12486012 | -
First Author: van Dijk E
Year: 2002
Journal: EMBO J
Title: Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures.
Volume: 21
Issue: 24
Pages: 6915-24
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Protein Domain
IPR044099 | Dcp2_NUDIX
Type: Domain
Description: Dcp2 is the catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay [, ]. Dcp2 contains an all-alpha N-terminal helical domain and a domain which has the Nudix fold. It has been shown that the Nudix domain of both Saccharomyces cerevisiae and S. pombe Dcp2 proteins is sufficient for decapping activity. While decapping is not dependent on the N-terminal of Dcp2, it does affect its efficiency. Dcp1 binds the N-terminal domain of Dcp2 stimulating the decapping activity of Dcp2 [].This entry represents the NUDIX hydrolase domain found in Dcp2. This domain catalyses the mRNA decapping reaction [].
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GXD Expression
GXD Expression
 
Probe: MGI:7662587
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716319
Pattern: Punctate
Stage: TS19
Assay Id: MGI:7662602
Age: embryonic day 11.5
Note: At E11.5, immunoreactivity was found throughout the lens vesicle as fine granular punctate staining, often in association with Dcp2. Larger cytoplasmic complexes of Tob1 and Dcp2 were observed in posterior vesicle cells.
Specimen Label: 2a
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7662587
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3827924
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7662602
Age: embryonic day 16.5
Note: In transitional zone fiber cells, co-localization with DCP2 was found in large cytoplasmic complexes. Expression was also adjacent to DCP2 in large cytoplasmic complexes in fiber cells of the transitional zone.
Specimen Label: 2g
Detected: true
Specimen Num: 3
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Allele
Dcp2<Gt(RRE061)Byg> | MGI:4127248
Name: decapping mRNA 2; gene trap RRE061, BayGenomics
Allele Type: Gene trapped
Attribute String: Hypomorph
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Publication
16341225 | -
First Author: She M
Year: 2006
Journal: Nat Struct Mol Biol
Title: Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe.
Volume: 13
Issue: 1
Pages: 63-70
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Strain
MGI:4840210 | B6;129P2-Dcp2<Gt(RRE061)Byg>/Mmucd
Attribute String: gene trap, mutant stock
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Genotype
Genotype
Symbol: Dcp2/Dcp2
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Publication
18755833 | -
First Author: Jinek M
Year: 2008
Journal: RNA
Title: The C-terminal region of Ge-1 presents conserved structural features required for P-body localization.
Volume: 14
Issue: 10
Pages: 1991-8
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Publication
2165518 | -
First Author: Mawe GM
Year: 1990
Journal: J Neurobiol
Title: Development of synaptic transmission at autonomic synapses in vitro revealed by cytochrome oxidase histochemistry.
Volume: 21
Issue: 4
Pages: 578-91
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Publication
17158604 | -
First Author: Xu J
Year: 2006
Journal: Plant Cell
Title: Arabidopsis DCP2, DCP1, and VARICOSE form a decapping complex required for postembryonic development.
Volume: 18
Issue: 12
Pages: 3386-98
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Protein Domain
IPR044938 | EDC4_C
Type: Homologous_superfamily
Description: This superfamily represents the highly conserved C-terminal region of Enhancer of mRNA-decapping protein 4 (EDC4, also known as Ge-1) which adopts an all α-helical fold [, ]. This domain is necessary and sufficient for P-body targeting and, in plants, it also mediates DCP1 and DCP2 interaction, as well as self-association [].
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Publication
16001405 | -
First Author: Han GW
Year: 2005
Journal: Proteins
Title: Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution.
Volume: 60
Issue: 4
Pages: 797-802
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Protein Domain
IPR011145 | Scavenger_mRNA_decap_enz_N
Type: Homologous_superfamily
Description: This superfamily represents the N-terminal domain of scavenger mRNA decapping enzymes, such as Dcp2 and DcpS. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' mRNA degradation. DcpS uses cap dinucleotides or capped oligonucleotides as substrate to release m(7)GMP (N7-methyl GMP), while Dcp2 uses capped mRNA as substrate in order to hydrolyse the cap to release m(7)GDP (N7-methyl GDP) []. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. DcpS exists as a dimer and each monomer is comprised of an N-terminal and a C-terminal region. The two N-termini form into a domain-swapped dimer and carry out substrate binding, cap dinucleotide, and hydrolysis [].
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Protein Domain
IPR008594 | DcpS/DCS2
Type: Family
Description: This entry represents scavenger mRNA decapping enzymes, such as Dcp2 and DcpS. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' mRNA degradation. DcpS uses cap dinucleotides or capped oligonucleotides as substrate to release m(7)GMP (N7-methyl GMP), while Dcp2 uses capped mRNA as substrate in order to hydrolyse the cap to release m(7)GDP (N7-methyl GDP) []. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The family contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues []. The central histidine within the DcpS HIT motif is critical for decapping activityand defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function. This family is related to ().
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Protein
D6RFQ0
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: false
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Publication
16246173 | -
First Author: Liu H
Year: 2006
Journal: Biochem Soc Trans
Title: Decapping the message: a beginning or an end.
Volume: 34
Issue: Pt 1
Pages: 35-8
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Publication
23142987 | -
First Author: Braun JE
Year: 2012
Journal: Nat Struct Mol Biol
Title: A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation.
Volume: 19
Issue: 12
Pages: 1324-31
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Protein Domain
IPR040587 | XRN1_DBM
Type: Domain
Description: This domain is found in the 5'-3' exonuclease (XRN1) present in Drosophila melanogaster. XRN1 degrades deadenylated mRNA that has recently been decapped by decapping enzyme 2 (DCP2). DCP2 associates with decapping activators DCP1 and EDC4. The direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation. This domain is responsible for binding to DCP1. In particular, the helical C-terminal region of the domain contributes to the binding affinity and the specificity of the interaction [].
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Publication
32366357 | -
   
First Author: Borbolis F
Year: 2020
Journal: Elife
Title: mRNA decapping is an evolutionarily conserved modulator of neuroendocrine signaling that controls development and ageing.
Volume: 9
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Protein Domain
IPR010334 | Dcp1
Type: Family
Description: An essential step in mRNA turnover is decapping. In yeast, two proteins have been identified that are essential for decapping, Dcp1 (this family) and Dcp2. Dcp1 is a coactivator that binds to the decapping enzyme Dcp2 and forms a decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation []. Yeast Dcp1 interact directly with Dcp2, however, the Dcp1-Dcp2 interaction is promoted by an additional factor, EDC4 []. In the nervous system, it promotes neurons' lifespan through the negative regulation of the insulin-like peptide ins-7 expression [].
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Publication
31875550 | J:282288
First Author: Wu H
Year: 2019
Journal: Cell Rep
Title: Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs.
Volume: 29
Issue: 13
Pages: 4422-4434.e13
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Publication
12175488 | J:76635
First Author: Wilanowski T
Year: 2002
Journal: Mech Dev
Title: A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead.
Volume: 114
Issue: 1-2
Pages: 37-50
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Protein
Q3TBW9
Organism: Mus musculus/domesticus
Length: 291  
Fragment?: false
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Publication
23353937 | J:338259
First Author: Song MG
Year: 2013
Journal: RNA
Title: Multiple Nudix family proteins possess mRNA decapping activity.
Volume: 19
Issue: 3
Pages: 390-9
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Publication
32829531 | J:304353
First Author: Lai HC
Year: 2021
Journal: J Leukoc Biol
Title: Regulation of RNA degradation pathways during the lipopolysaccharide response in Macrophages.
Volume: 109
Issue: 3
Pages: 593-603
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Protein
Q9CYC6
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
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Protein
Q3U671
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
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Protein
Q9DAR7
Organism: Mus musculus/domesticus
Length: 338  
Fragment?: false
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Protein
A0A286YCN4
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: true
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•
Protein
A0A286YDC8
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: true
•
•
•
•
•
Protein
Q3TAP6
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: true
•
•
•
•
•
Protein
Q91YD3
Organism: Mus musculus/domesticus
Length: 602  
Fragment?: false
•
•
•
•
•
Protein
Q3U564
Organism: Mus musculus/domesticus
Length: 578  
Fragment?: false
•
•
•
•
•
Protein
B9EIX0
Organism: Mus musculus/domesticus
Length: 578  
Fragment?: false
•
•
•
•
•
Protein
D6RE33
Organism: Mus musculus/domesticus
Length: 1318  
Fragment?: false
•
•
•
•
•
Protein
Q3UJB9
Organism: Mus musculus/domesticus
Length: 1406  
Fragment?: false
•
•
•
•
•
Protein
G5E896
Organism: Mus musculus/domesticus
Length: 1406  
Fragment?: false
•
•
•
•
•
Protein
A0A0R4J1Q0
Organism: Mus musculus/domesticus
Length: 1390  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom