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Search results 101 to 134 out of 134 for Defb1

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0.023s

Type

Details

Score

Protein Coding Gene

MGP_FVBNJ_G0033177 | -

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGP_LPJ_G0033322 | -

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGP_NODShiLtJ_G0033214 | -

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGP_NZOHlLtJ_G0033918 | -

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGP_PWKPhJ_G0032137 | -

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGP_WSBEiJ_G0032540 | -

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGP_PahariEiJ_G0021331 | -

Type:	protein_coding_gene
Organism:	Mus pahari

•

Protein Coding Gene

MGP_SPRETEiJ_G0031978 | -

Type:	protein_coding_gene
Organism:	Mus spretus

•

Publication

28468965 | J:283906

First Author:	Saxena V
Year:	2018
Journal:	Am J Physiol Renal Physiol
Title:	Cell-specific qRT-PCR of renal epithelial cells reveals a novel innate immune signature in murine collecting duct.
Volume:	315
Issue:	4
Pages:	F812-F823

•

Publication

20421464 | J:160305

First Author:	Peyrin-Biroulet L
Year:	2010
Journal:	Proc Natl Acad Sci U S A
Title:	Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon.
Volume:	107
Issue:	19
Pages:	8772-7

•

Publication

20068036 | J:233575

First Author:	Röhrl J
Year:	2010
Journal:	J Biol Chem
Title:	Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells.
Volume:	285
Issue:	10
Pages:	7028-34

•

Publication

25122636 | -

First Author:	Diao R
Year:	2014
Journal:	Sci Transl Med
Title:	Deficient human β-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection.
Volume:	6
Issue:	249
Pages:	249ra108

•

Publication

9169459 | -

First Author:	Baba M
Year:	1997
Journal:	J Biol Chem
Title:	Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC.
Volume:	272
Issue:	23
Pages:	14893-8

•

Publication

9886385 | -

First Author:	Liao F
Year:	1999
Journal:	J Immunol
Title:	CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha.
Volume:	162
Issue:	1
Pages:	186-94

•

Publication

9294137 | -

First Author:	Power CA
Year:	1997
Journal:	J Exp Med
Title:	Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells.
Volume:	186
Issue:	6
Pages:	825-35

•

Publication

17486092 | -

First Author:	Acosta-Rodriguez EV
Year:	2007
Journal:	Nat Immunol
Title:	Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells.
Volume:	8
Issue:	6
Pages:	639-46

•

Publication

10521347 | -

First Author:	Yang D
Year:	1999
Journal:	Science
Title:	Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6.
Volume:	286
Issue:	5439
Pages:	525-8

•

Publication

19249008 | -

First Author:	Wang K
Year:	2009
Journal:	Am J Hum Genet
Title:	Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.
Volume:	84
Issue:	3
Pages:	399-405

•

Protein Domain

IPR004067 | Chemokine_CCR6

Type:

Family

Description:

Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten members of the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.This entry represents CC chemokine receptor 6 (CCR6). It is expressed on unactivated memory T-cells [, ]and some dendritic cells [, ]. CCR6 is also expressed on Th17 cells [], but is down-regulated in activated T-cells []. The receptor is noted as playing a role in Crohn's disease []. CCR6 major ligand is CCL20, also known as Liver and Activation-Regulated Chemokine but it can also bind non-chemokine ligands such as beta-defensines [, ]. Binding to beta-defensine 1 (DEFB1) is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity []and it mediates the chemotactic effects of defensins DEFB4 and DEFB4A/B [].

•

Publication

14718547 | J:93238

First Author:	Zaballos A
Year:	2004
Journal:	J Biol Chem
Title:	Identification on mouse chromosome 8 of new beta-defensin genes with regionally specific expression in the male reproductive organ.
Volume:	279
Issue:	13
Pages:	12421-6

•

Protein

O54689

Organism:	Mus musculus/domesticus
Length:	367
Fragment?:	false

•

Protein

Q3U467

Organism:	Mus musculus/domesticus
Length:	143
Fragment?:	true

•

Protein

Q9R1V0

Organism:	Mus musculus/domesticus
Length:	367
Fragment?:	false

•

Protein

Q542B6

Organism:	Mus musculus/domesticus
Length:	367
Fragment?:	false

•

Publication

9689100 | J:49070

First Author:	Ma Q
Year:	1998
Journal:	Proc Natl Acad Sci U S A
Title:	Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
Volume:	95
Issue:	16
Pages:	9448-53

•

Publication

11544102 | -

First Author:	Horuk R
Year:	2001
Journal:	Cytokine Growth Factor Rev
Title:	Chemokine receptors.
Volume:	12
Issue:	4
Pages:	313-35

•

Publication

10601351 | -

First Author:	Charbonnier AS
Year:	1999
Journal:	J Exp Med
Title:	Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells.
Volume:	190
Issue:	12
Pages:	1755-68

•

Publication

9500790 | -

First Author:	Sallusto F
Year:	1998
Journal:	J Exp Med
Title:	Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
Volume:	187
Issue:	6
Pages:	875-83

•

Publication

7592998 | -

First Author:	Strieter RM
Year:	1995
Journal:	J Biol Chem
Title:	The functional role of the ELR motif in CXC chemokine-mediated angiogenesis.
Volume:	270
Issue:	45
Pages:	27348-57

•

Publication

10714678 | -

First Author:	Zlotnik A
Year:	2000
Journal:	Immunity
Title:	Chemokines: a new classification system and their role in immunity.
Volume:	12
Issue:	2
Pages:	121-7

•

Publication

- | J:342604

First Author:	UniProt-GOA
Year:	2012

Title:	Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

•

Publication

- | J:85000

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2003

Title:	MGI Sequence Curation Reference

•

Publication

- | J:78475

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2002

Title:	Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database

•

Publication

- | J:60000

First Author:	UniProt-GOA
Year:	2012

Title:	Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

•

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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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