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Search results 101 to 134 out of 134 for Depdc5

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Type Details Score
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
29590090 | -
First Author: Shen K
Year: 2018
Journal: Nature
Title: Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.
Volume: 556
Issue: 7699
Pages: 64-69
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Protein Domain
IPR045838 | DEPDC5_CTD
Type: Domain
Description: This entry represents the C-terminal domain (CTD) (residues 1,291-1,603) of the DEPDC5 protein []. It contains two structurally similar lobes and has a pseudo-2-fold rotational symmetry. Each half consists of a five-stranded β-sheet, with an α-helix covering one side. The CTD is located in the core of DEPDC5 and contacts all the other domains of DEPDC5 except the NTD, making it the central organizer of this multi-domain protein [].
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UniProt Feature
UniProt Feature
Begin: 1
Description: GATOR complex protein DEPDC5
Type: chain
End: 1591
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Protein
A0A0J9YU49
Organism: Mus musculus/domesticus
Length: 44  
Fragment?: true
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Protein
D3Z7M7
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
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Protein
A0A0G2JFM3
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: false
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Protein
E9PWF2
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: true
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Protein
E9QAT3
Organism: Mus musculus/domesticus
Length: 1085  
Fragment?: false
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Protein
D3Z5Y4
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: true
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Protein
F6X8H7
Organism: Mus musculus/domesticus
Length: 657  
Fragment?: true
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Publication
32781001 | J:301371
 
First Author: Iffland PH 2nd
Year: 2020
Journal: Exp Neurol
Title: Dynamic analysis of 4E-BP1 phosphorylation in neurons with Tsc2 or Depdc5 knockout.
Volume: 334
Pages: 113432
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Protein
P61460-2
Organism: Mus musculus/domesticus
Length: 1569  
Fragment?: false
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Protein
A0A0J9YV31
Organism: Mus musculus/domesticus
Length: 35  
Fragment?: true
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Protein
D3Z419
Organism: Mus musculus/domesticus
Length: 31  
Fragment?: true
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Protein
F6XIK0
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: true
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Protein
A0A571BG14
Organism: Mus musculus/domesticus
Length: 26  
Fragment?: true
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Allele
Depdc5<em1Pqt> | MGI:6115603
Name: DEP domain containing 5; endonuclease-mediated mutation 1, Paul Q Thomas
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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DO Term
DOID:0081421 | familial focal epilepsy with variable foci 1
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Protein
Q8BXW3
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: false
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Protein
Q8BVE2
Organism: Mus musculus/domesticus
Length: 1085  
Fragment?: false
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Publication
21900499 | -
First Author: Wu X
Year: 2011
Journal: Mol Biol Cell
Title: Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation.
Volume: 22
Issue: 21
Pages: 4124-33
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Publication
21804352 | -
First Author: Dokudovskaya S
Year: 2011
Journal: Autophagy
Title: A novel coatomer-related SEA complex dynamically associates with the vacuole in yeast and is implicated in the response to nitrogen starvation.
Volume: 7
Issue: 11
Pages: 1392-3
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Publication
25457612 | -
First Author: Parmigiani A
Year: 2014
Journal: Cell Rep
Title: Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
Volume: 9
Issue: 4
Pages: 1281-91
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Protein Domain
IPR027244 | IML1
Type: Family
Description: Proteins in this family contain a DEP domain, which is a globular domain of about 80 residues. This entry includes GTPase-activating proteins (GAPs), such as Iml1 from fungi and GATOR complex protein DEPDC5 from mammals. In Saccharomyces cerevisiae, Iml1 is a GAP subunit of both the SEA (Seh1-associated) and Iml1 complexes (Iml1-Npr2-Npr3). SEA complex is associates dynamically with the vacuole and is involved in autophagy [, , ]. Iml1 complex is required for non-nitrogen-starvation (NNS)-induced autophagy []. In mammals, DEPDC5 is a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway [, ].
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Publication
23716719 | -
First Author: Panchaud N
Year: 2013
Journal: Sci Signal
Title: Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.
Volume: 6
Issue: 277
Pages: ra42
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Publication
29769719 | J:262340
First Author: Chen J
Year: 2018
Journal: Nature
Title: KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.
Volume: 557
Issue: 7706
Pages: 585-589
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Publication
23723238 | -
First Author: Bar-Peled L
Year: 2013
Journal: Science
Title: A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Volume: 340
Issue: 6136
Pages: 1100-6
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Publication
21454883 | -
First Author: Dokudovskaya S
Year: 2011
Journal: Mol Cell Proteomics
Title: A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae.
Volume: 10
Issue: 6
Pages: M110.006478
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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