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Search results 101 to 165 out of 165 for Deptor

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Type Details Score
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
26909318 | J:307118
First Author: Caron A
Year: 2016
Journal: Mol Metab
Title: Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity.
Volume: 5
Issue: 2
Pages: 102-112
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Allele
Deptor<em1Smoc> | MGI:7289316
Name: DEP domain containing MTOR-interacting protein; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6428531 | C57BL/6JSmoc-Deptor<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
28932123 | -
 
First Author: Hu B
Year: 2017
Journal: Onco Targets Ther
Title: Downregulation of DEPTOR inhibits the proliferation, migration, and survival of osteosarcoma through PI3K/Akt/mTOR pathway.
Volume: 10
Pages: 4379-4391
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Allele
Col1a1<tm1(tetO-Deptor)Dmsa> | MGI:5437855
Name: collagen, type I, alpha 1; targeted mutation 1, David M Sabatini
Allele Type: Targeted
Attribute String: Inducible, Inserted expressed sequence, RMCE-ready
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Genotype
Genotype
Symbol: Col1a1/Col1a1<+> Gt(ROSA)26Sor/?
Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Publication
15988011 | -
First Author: Cheng J
Year: 2005
Journal: Mol Cell Biol
Title: Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation.
Volume: 25
Issue: 14
Pages: 5955-64
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Publication
16919458 | -
First Author: Frias MA
Year: 2006
Journal: Curr Biol
Title: mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.
Volume: 16
Issue: 18
Pages: 1865-70
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Publication
23762398 | -
First Author: Wang JQ
Year: 2013
Journal: PLoS One
Title: Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains.
Volume: 8
Issue: 6
Pages: e65586
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Publication
17043309 | J:113443
First Author: Yang Q
Year: 2006
Journal: Genes Dev
Title: Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.
Volume: 20
Issue: 20
Pages: 2820-32
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Protein
A2AVJ5
Organism: Mus musculus/domesticus
Length: 370  
Fragment?: false
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Protein
B0R105
Organism: Mus musculus/domesticus
Length: 95  
Fragment?: true
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Protein
B0R106
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: true
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Protein
B0R102
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: true
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Protein
F6VRG5
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: true
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Protein
B0R103
Organism: Mus musculus/domesticus
Length: 36  
Fragment?: true
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Protein Domain
IPR013745 | Bit61/PRR5
Type: Family
Description: This entry includes PRR5 (also known as PROTOR1) from animals, Bit61 and its paralogue-Bit2 from budding yeasts [, ]. They are part of the Target Of Rapamycin Complex 2 (TORC2) complex, which plays an essential role in signal transduction []. The mammalian TORC2 consists of mTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR [, , , , ]. The budding yeast TORC2 is composed of Avo1, Avo2, Tsc11, Lst8, Bit61, Slm, Slm2 and Tor2 [, ].
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Protein Domain
IPR008828 | Sin1/Avo1
Type: Family
Description: This entry includes MAPKAP1/Sin1 from animals, Sin1 from fission yeast, Avo1 from budding yeast and Rip3 from Slime mold. They are part of the Target Of Rapamycin Complex 2 (TORC2) complex, which plays an essential role in signal transduction []. The mammalian TORC2 consists of mTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR [, , , , ]. Within TORC2, MAPKAP1 is required for complex formation and TORC2 kinase activity []. The budding yeast TORC2 is composed of Avo1, Avo2, Tsc11, Lst8, Bit61, Slm, Slm2 and Tor2 [, ].
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Publication
16962653 | J:125618
First Author: Jacinto E
Year: 2006
Journal: Cell
Title: SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.
Volume: 127
Issue: 1
Pages: 125-37
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Publication
32372061 | J:290823
First Author: Feng J
Year: 2020
Journal: Oncogene
Title: Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide.
Volume: 39
Issue: 23
Pages: 4551-4566
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Publication
12718876 | J:237685
First Author: Kim DH
Year: 2003
Journal: Mol Cell
Title: GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.
Volume: 11
Issue: 4
Pages: 895-904
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Protein
A0A0A6YW60
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: true
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Publication
17461779 | -
First Author: Pearce LR
Year: 2007
Journal: Biochem J
Title: Identification of Protor as a novel Rictor-binding component of mTOR complex-2.
Volume: 405
Issue: 3
Pages: 513-22
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Publication
18076573 | -
First Author: Hayashi T
Year: 2007
Journal: Genes Cells
Title: Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.
Volume: 12
Issue: 12
Pages: 1357-70
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Protein Domain
IPR037588 | MLST8
Type: Family
Description: This entry represents target of rapamycin complex subunit LST8 (MLST8 or GbetaL), a component of both mTORC1 and mTORC2, complexes that regulate cell growth in response to nutrients. The mTORC1 complex consists of MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. The mTORC2 complex contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR []. In mTORC1, MLST8 interacts directly with MTOR and enhances its kinase activity [].This entry also includes the target of rapamycin complex subunit wat1 (pop3 or wat1) from Schizosaccharomyces pombe, which is also a component of yeast TORC1 and TORC2 complexes. The subunits of TORC1 in fission yeasts are known as mip1, pop3/wat1, tco89, toc1 and tor2; and the subunits of the TORC2 complex are bit61, pop3/wat1, sin1, ste20 and tor1 [].
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Publication
17303383 | -
First Author: Schroder WA
Year: 2007
Journal: Cell Signal
Title: Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling.
Volume: 19
Issue: 6
Pages: 1279-89
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Publication
24458360 | J:229282
First Author: Meng ZX
Year: 2014
Journal: Diabetes
Title: The Baf60c/Deptor pathway links skeletal muscle inflammation to glucose homeostasis in obesity.
Volume: 63
Issue: 5
Pages: 1533-45
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Publication
36909232 | J:334978
 
First Author: Zhang M
Year: 2023
Journal: Front Physiol
Title: Delayed denervation-induced muscle atrophy in Opg knockout mice.
Volume: 14
Pages: 1127474
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Publication
30692212 | J:272892
First Author: Saito N
Year: 2019
Journal: J Immunol
Title: Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis.
Volume: 202
Issue: 5
Pages: 1428-1440
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Publication
31406304 | J:293243
First Author: Cui D
Year: 2020
Journal: Cell Death Differ
Title: The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth.
Volume: 27
Issue: 3
Pages: 1119-1133
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Publication
14736892 | -
First Author: Reinke A
Year: 2004
Journal: J Biol Chem
Title: TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae.
Volume: 279
Issue: 15
Pages: 14752-62
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Publication
15689497 | -
First Author: Fadri M
Year: 2005
Journal: Mol Biol Cell
Title: The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2.
Volume: 16
Issue: 4
Pages: 1883-900
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Protein
Q812A5
Organism: Mus musculus/domesticus
Length: 387  
Fragment?: false
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Protein
A2AR15
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: true
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Protein
Q8BKH7
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
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Publication
12408816 | -
First Author: Loewith R
Year: 2002
Journal: Mol Cell
Title: Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.
Volume: 10
Issue: 3
Pages: 457-68
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Publication
26700129 | -
First Author: Hu K
Year: 2016
Journal: Mol Microbiol
Title: Ubiquitin regulates TORC1 in yeast Saccharomyces cerevisiae.
Volume: 100
Issue: 2
Pages: 303-14
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Protein
Q9DCJ1
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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Protein
A0A3Q4EC26
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
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Protein
A0A3Q4L2V5
Organism: Mus musculus/domesticus
Length: 271  
Fragment?: false
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Protein
A0A3Q4L2Y8
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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