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Search results 101 to 167 out of 167 for Dhx58

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Type Details Score
Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: ATP-dependent RNA helicase DHX58
Type: chain
End: 678
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Publication
33909701 | J:314224
First Author: Xu J
Year: 2021
Journal: PLoS Pathog
Title: The RNA helicase DDX5 promotes viral infection via regulating N6-methyladenosine levels on the DHX58 and NFκB transcripts to dampen antiviral innate immunity.
Volume: 17
Issue: 4
Pages: e1009530
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Protein
Q99J87
Organism: Mus musculus/domesticus
Length: 678  
Fragment?: false
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Publication
17473309 | -
First Author: Vitour D
Year: 2007
Journal: Sci STKE
Title: Regulation of interferon production by RIG-I and LGP2: a lesson in self-control.
Volume: 2007
Issue: 384
Pages: pe20
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Publication
21481967 | -
First Author: Eisenächer K
Year: 2012
Journal: Eur J Cell Biol
Title: Regulation of RLR-mediated innate immune signaling--it is all about keeping the balance.
Volume: 91
Issue: 1
Pages: 36-47
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Allele
Dhx58<em1Smoc> | MGI:7289338
Name: DExH-box helicase 58; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6475125 | C57BL/6JSmoc-Dhx58<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
21496944 | -
First Author: Schmidt A
Year: 2012
Journal: Eur J Cell Biol
Title: Sensing of viral nucleic acids by RIG-I: from translocation to translation.
Volume: 91
Issue: 1
Pages: 78-85
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Publication
21616437 | -
First Author: Loo YM
Year: 2011
Journal: Immunity
Title: Immune signaling by RIG-I-like receptors.
Volume: 34
Issue: 5
Pages: 680-92
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Publication
31006531 | -
First Author: Cadena C
Year: 2019
Journal: Cell
Title: Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity.
Volume: 177
Issue: 5
Pages: 1187-1200.e16
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Publication
33727702 | -
First Author: Liu G
Year: 2021
Journal: Nat Microbiol
Title: ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity.
Volume: 6
Issue: 4
Pages: 467-478
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Publication
32169843 | -
First Author: Wu XM
Year: 2020
Journal: J Immunol
Title: NOD1 Promotes Antiviral Signaling by Binding Viral RNA and Regulating the Interaction of MDA5 and MAVS.
Volume: 204
Issue: 8
Pages: 2216-2231
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Protein Domain
IPR041204 | RIG-I-like_C
Type: Domain
Description: This entry represents the C-terminal domain of RIG-I and RIG-I-like receptors, which are key cytosolic pattern-recognition receptors of the vertebrate innate immune system that forms the first line of defence against RNA viral infection [, , ]. ATP-dependent RNA helicase DHX58 (also known as RIG-I-like receptor LGP2) acts as a regulator of RIG-I and IFIH1/MDA5 mediated antiviral signaling as it cannot initiate antiviral signalling due to the lack of the CARD domain required for activating MAVS/IPS1-dependent signalling events. RNA binding to RIG-I is mediated both by the C-terminal domain and by the helicase domain. The C-terminal domain specifically binds the 5'-triphosphate end with a 10-fold higher affinity compared to 5'OH-dsRNA [].
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Publication
16753150 | -
First Author: Law PY
Year: 2006
Journal: FEBS Lett
Title: Expression and functional characterization of the putative protein 8b of the severe acute respiratory syndrome-associated coronavirus.
Volume: 580
Issue: 15
Pages: 3643-8
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Publication
16876844 | -
First Author: Keng CT
Year: 2006
Journal: Virology
Title: The human severe acute respiratory syndrome coronavirus (SARS-CoV) 8b protein is distinct from its counterpart in animal SARS-CoV and down-regulates the expression of the envelope protein in infected cells.
Volume: 354
Issue: 1
Pages: 132-42
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Publication
32890763 | -
 
First Author: Pereira F
Year: 2020
Journal: Infect Genet Evol
Title: Evolutionary dynamics of the SARS-CoV-2 ORF8 accessory gene.
Volume: 85
Pages: 104525
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Publication
32015508 | -
First Author: Wu F
Year: 2020
Journal: Nature
Title: A new coronavirus associated with human respiratory disease in China.
Volume: 579
Issue: 7798
Pages: 265-269
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Publication
32825438 | -
 
First Author: Mohammad S
Year: 2020
Journal: Pathogens
Title: SARS-CoV-2 ORF8 and SARS-CoV ORF8ab: Genomic Divergence and Functional Convergence.
Volume: 9
Issue: 9
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Publication
31986261 | -
First Author: Chan JF
Year: 2020
Journal: Lancet
Title: A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.
Volume: 395
Issue: 10223
Pages: 514-523
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Publication
34021074 | -
 
First Author: Zhang Y
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι.
Volume: 118
Issue: 23
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Publication
34177923 | -
 
First Author: Geng H
Year: 2021
Journal: Front Immunol
Title: SARS-CoV-2 ORF8 Forms Intracellular Aggregates and Inhibits IFNγ-Induced Antiviral Gene Expression in Human Lung Epithelial Cells.
Volume: 12
Pages: 679482
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Publication
22000019 | -
First Author: Kowalinski E
Year: 2011
Journal: Cell
Title: Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA.
Volume: 147
Issue: 2
Pages: 423-35
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Protein Domain
IPR022722 | ORF8_betacoronavirus
Type: Family
Description: This entry includes the ORF8 gene products (also known as NS8, accessory protein 8) from human SARS coronavirus (SARS-CoV), SARS-CoV-2, Bat coronavirus HKU3 and pangolin coronaviruses [].ORF8 is an accessory protein that is not shared by all members of subgenus sarbecovirus. The presence and location of ORF8 in the SARS-CoV-2 genome has led its classification with SARS-CoV [, ]. ORF8 is a potential pathogenicity factor which evolves rapidly to counter the immune response and facilitate the transmission between hosts []. ORF8 has been suggested to be one of the relevant genes in the study of human adaptation of the virus [, ].The ORF8 protein is a fast-evolving protein in SARS-related CoVs, with a tendency to recombine and undergo deletions. During the early phases of the SARS (SARS-CoV) epidemic in 2002, human isolates were found to possess a unique continuous ORF8 with 366 nucleotides and a predicted protein with 122 amino acids. During the middle and late phases of the SARS epidemic, two functional ORFs (ORF8a and ORF8b) were emerged; they are predicted to encode two small proteins, 8a with 39 amino acids and 8b with 84 amino acids. Interestingly, SARS-CoV-2 ORF8 has not undergone any significantly measurable deletion events, so its function as a full-length protein might be more important to its pathogenicity []. ORF8 plays a role in modulating host immune response []which may act by down-regulating major histocompatibility complex class I (MHC-I) []. It may inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58 []. ORF8 also binds to IL17RA receptor, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors, contributing to cytokine storm during COVID-19 infection [].
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Protein Domain
IPR044391 | ORF8_SARS-CoV-2-like
Type: Family
Description: This entry represents the ORF8 immunoglobulin (Ig) domain protein of Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2, also known as a 2019 novel coronavirus, 2019-nCoV) and related Sarbecovirus ORF8 proteins.ORF8 is an accessory protein that is not shared by all members of subgenus sarbecovirus. The presence and location of ORF8 in the SARS-CoV-2 genome has led its classification with SARS-CoV [, ]. ORF8 is a potential pathogenicity factor which evolves rapidly to counter the immune response and facilitate the transmission between hosts []. ORF8 has been suggested to be one of the relevant genes in the study of human adaptation of the virus [, ].The ORF8 protein is a fast-evolving protein in SARS-related CoVs, with a tendency to recombine and undergo deletions. During the early phases of the SARS (SARS-CoV) epidemic in 2002, human isolates were found to possess a unique continuous ORF8 with 366 nucleotides and a predicted protein with 122 amino acids. During the middle and late phases of the SARS epidemic, two functional ORFs (ORF8a and ORF8b) were emerged; they are predicted to encode two small proteins, 8a with 39 amino acids and 8b with 84 amino acids. Interestingly, SARS-CoV-2 ORF8 has not undergone any significantly measurable deletion events, so its function as a full-length protein might be more important to its pathogenicity []. ORF8 plays a role in modulating host immune response []which may act by down-regulating major histocompatibility complex class I (MHC-I) []. It may inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58 []. ORF8 also binds to IL17RA receptor, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors, contributing to cytokine storm during COVID-19 infection [].
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Protein Domain
IPR044392 | ORF8_Bat_SARS_CoV_Rf1-like
Type: Family
Description: This subfamily includes the ORF8 immunoglobulin (Ig) domain proteins of bat coronavirus Rf1 (Bat SARS CoV Rf1) and Bat CoV 273/2005, which have been classified previously as type II ORF8 proteins.ORF8 is an accessory protein that is not shared by all members of subgenus sarbecovirus. The presence and location of ORF8 in the SARS-CoV-2 genome has led its classification with SARS-CoV [, ]. ORF8 is a potential pathogenicity factor which evolves rapidly to counter the immune response and facilitate the transmission between hosts []. ORF8 has been suggested to be one of the relevant genes in the study of human adaptation of the virus [, ].The ORF8 protein is a fast-evolving protein in SARS-related CoVs, with a tendency to recombine and undergo deletions. During the early phases of the SARS (SARS-CoV) epidemic in 2002, human isolates were found to possess a unique continuous ORF8 with 366 nucleotides and a predicted protein with 122 amino acids. During the middle and late phases of the SARS epidemic, two functional ORFs (ORF8a and ORF8b) were emerged; they are predicted to encode two small proteins, 8a with 39 amino acids and 8b with 84 amino acids. Interestingly, SARS-CoV-2 ORF8 has not undergone any significantly measurable deletion events, so its function as a full-length protein might be more important to its pathogenicity []. ORF8 plays a role in modulating host immune response []which may act by down-regulating major histocompatibility complex class I (MHC-I) []. It may inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58 []. ORF8 also binds to IL17RA receptor, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors, contributing to cytokine storm during COVID-19 infection [].
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Protein Domain
IPR044393 | ORF8_bat_SARS-CoV_HKU3-1-like
Type: Family
Description: This entry includes the ORF8 immunoglobulin (Ig) domain proteins of Bat SARS coronavirus HKU3-1, which have been classified previously as type III ORF8's.ORF8 is an accessory protein that is not shared by all members of subgenus sarbecovirus. The presence and location of ORF8 in the SARS-CoV-2 genome has led its classification with SARS-CoV [, ]. ORF8 is a potential pathogenicity factor which evolves rapidly to counter the immune response and facilitate the transmission between hosts []. ORF8 has been suggested to be one of the relevant genes in the study of human adaptation of the virus [, ].The ORF8 protein is a fast-evolving protein in SARS-related CoVs, with a tendency to recombine and undergo deletions. During the early phases of the SARS (SARS-CoV) epidemic in 2002, human isolates were found to possess a unique continuous ORF8 with 366 nucleotides and a predicted protein with 122 amino acids. During the middle and late phases of the SARS epidemic, two functional ORFs (ORF8a and ORF8b) were emerged; they are predicted to encode two small proteins, 8a with 39 amino acids and 8b with 84 amino acids. Interestingly, SARS-CoV-2 ORF8 has not undergone any significantly measurable deletion events, so its function as a full-length protein might be more important to its pathogenicity []. ORF8 plays a role in modulating host immune response []which may act by down-regulating major histocompatibility complex class I (MHC-I) []. It may inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58 []. ORF8 also binds to IL17RA receptor, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors, contributing to cytokine storm during COVID-19 infection [].
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Publication
33723527 | J:304178
First Author: Lin X
Year: 2021
Journal: iScience
Title: ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway.
Volume: 24
Issue: 4
Pages: 102293
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Publication
26433221 | -
First Author: Wu Z
Year: 2016
Journal: J Infect Dis
Title: ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus.
Volume: 213
Issue: 4
Pages: 579-83
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Protein
Q3U605
Organism: Mus musculus/domesticus
Length: 444  
Fragment?: true
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Protein
Q8R5F7
Organism: Mus musculus/domesticus
Length: 1025  
Fragment?: false
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Protein
Q3U1I9
Organism: Mus musculus/domesticus
Length: 733  
Fragment?: false
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Protein
D2CGM4
Organism: Mus musculus/domesticus
Length: 1025  
Fragment?: false
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Protein
Q05CC6
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: true
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Protein
A2AP29
Organism: Mus musculus/domesticus
Length: 707  
Fragment?: true
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Protein
Q3KQQ7
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: true
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Protein
Q3U606
Organism: Mus musculus/domesticus
Length: 672  
Fragment?: false
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Protein
D2CGM5
Organism: Mus musculus/domesticus
Length: 1025  
Fragment?: false
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Protein
Q6Q899
Organism: Mus musculus/domesticus
Length: 926  
Fragment?: false
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Protein
A1L0V6
Organism: Mus musculus/domesticus
Length: 924  
Fragment?: true
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Protein
A7YY79
Organism: Mus musculus/domesticus
Length: 925  
Fragment?: true
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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