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Search results 101 to 131 out of 131 for Doc2b

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Type Details Score
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
19410553 | -
First Author: Miyazaki M
Year: 2009
Journal: Biochem Biophys Res Commun
Title: DOC2b is a SNARE regulator of glucose-stimulated delayed insulin secretion.
Volume: 384
Issue: 4
Pages: 461-5
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Allele
Doc2b<em1(folA/cre)Guru> | MGI:6718299
Name: double C2, beta; endonuclease-mediated mutation 1, Channabasavaiah Gurumurthy
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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Allele
Igs2<em18(CAG-folA/cre)Smoc> | MGI:7626524
Name: intergenic site 2; endonuclease-mediated mutation 18, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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Strain
MGI:6354502 | C57BL/6JSmoc-Igs2<em18(CAG-folA/cre)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Publication
22036572 | J:178686
First Author: Yao J
Year: 2011
Journal: Cell
Title: Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release.
Volume: 147
Issue: 3
Pages: 666-77
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Publication
20403080 | -
First Author: Sato M
Year: 2010
Journal: J Neurochem
Title: Role of the polybasic sequence in the Doc2alpha C2B domain in dense-core vesicle exocytosis in PC12 cells.
Volume: 114
Issue: 1
Pages: 171-81
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Protein Domain
IPR030535 | Doc2a/b
Type: Family
Description: Doc2a (double C2-like domain-containing protein alpha) and Doc2b (double C2-like domain-containing protein beta) are members of the double C2 domain protein family. Doc2a is expressed in neuronal cells and has been implicated in Ca2+-dependent neurotransmitter release [, ]. Doc2a exhibits Ca2+-dependent phospholipid-binding activity through its C2A domain, which is thought to be important for the regulation of Ca2+-dependent exocytosis. The C2B domain is required for binding of syntaxin-1a/synaptosome-associated protein of 25kDa (SNAP-25) heterodimer []. Doc2a is also expressed in pancreatic islets, and has been implicated together with Doc2b in the synergistic regulation of glucose-stimulated insulin secretion [].Doc2b contains two calcium and phospholipid binding domains in its C terminus []. It interacts with the SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) complex composed of SNAP25, STX1A and VAMP2. Doc2b regulates SNARE-dependent fusion of vesicles with membranes in a calcium-dependent manner. It is involved in calcium-dependent spontaneous release of neurotransmitter, with a function analogous to synaptotagmin-1, but with a higher Ca2+ sensitivity []. Doc2b is a positive SNARE regulator for glucose transporter GLUT4 vesicle fusion and mediates insulin-stimulated glucose transport in adipocytes []. It is involved in both insulin-stimulated glucose uptake in adipocytes and glucose-stimulated insulin secretion in pancreatic cells, as well as insulin responsiveness in skeletal muscle [, ].
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Protein
D3Z126
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: true
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Publication
11371549 | -
First Author: Fukuda M
Year: 2001
Journal: J Biol Chem
Title: The C2A domain of double C2 protein gamma contains a functional nuclear localization signal.
Volume: 276
Issue: 27
Pages: 24441-4
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Protein Domain
IPR030536 | Doc2g
Type: Family
Description: This entry represents double C2-like domain-containing protein gamma (Doc2g). The Doc2 (double C2) family members Doc2a and Doc2b are characterised by an N-terminal Munc13-1 interacting domain, and two C2 domains that interact with Ca(2+) and phospholipid at the C terminus. In contrast, the C2 domains of Doc2g impair Ca(2+)-dependent phospholipid binding activity. The Ca2+-independent C2A domain of Doc2g seems to have a nuclear localisation function []. Doc2g may also function as an effector for Munc13-1, and it may be involved in the regulation of vesicular trafficking [].
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Genotype
Genotype
Symbol: Doc2b/Doc2b<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Publication
9115738 | J:39082
First Author: Verhage M
Year: 1997
Journal: Neuron
Title: DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion.
Volume: 18
Issue: 3
Pages: 453-61
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Protein
D3YZ51
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: true
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Protein
Q7TNF0
Organism: Mus musculus/domesticus
Length: 405  
Fragment?: false
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Protein
P70169
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: false
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Publication
11027523 | J:64801
First Author: Fukuda M
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Doc2gamma, a third isoform of double C2 protein, lacking calcium-dependent phospholipid binding activity.
Volume: 276
Issue: 2
Pages: 626-32
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Protein
H3BJT3
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: true
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Protein
D3YYV2
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: true
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Protein
O35527
Organism: Mus musculus/domesticus
Length: 405  
Fragment?: true
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Protein
D3Z1K1
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: true
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Protein
A0A494BAY3
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: true
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Protein
Q9ESN1
Organism: Mus musculus/domesticus
Length: 387  
Fragment?: false
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Protein
A0A0R4J053
Organism: Mus musculus/domesticus
Length: 387  
Fragment?: false
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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