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Search results 101 to 175 out of 175 for Dock3

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Type Details Score
Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Interaction Experiment
Bai N (2013)
Description: Dock3 interaction with a glutamate-receptor NR2D subunit protects neurons from excitotoxicity.
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Publication
23641686 | -
 
First Author: Bai N
Year: 2013
Journal: Mol Brain
Title: Dock3 interaction with a glutamate-receptor NR2D subunit protects neurons from excitotoxicity.
Volume: 6
Pages: 22
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Protein Domain
IPR027007 | C2_DOCK-type_domain
Type: Domain
Description: Rho guanosine triphosphatases (GTPases) are critical regulators of cell motility, polarity, adhesion, cytoskeletal organisation, proliferation, geneexpression, and apoptosis. Conversion of these biomolecular switches to the activated GTP-bound state is controlled by two families of guanine nucleotide exchanges factors (GEFs). DH-PH proteins are a large group of Rho GEFs comprising a catalytic Dbl homology (DH) domain with an adjacent pleckstrin homology (PH) domain within the context of functionally diverse signalling modules. The evolutionarily distinct andsmaller family of DOCK (dedicator of cytokinesis) or CDM (CED-5, DOCK1180, Myoblast city) proteins activate either Rac or Cdc42 to control cell migration, morphogenesis, and phagocytosis. DOCK proteins share the DOCK-type C2 domain (also termed the DOCK-homology region (DHR)-1 or CDM-zizimin homology 1 (CZH1) domain and the DHR-2 domain (also termed the CZH2 or DOCKER domain), [, , , , , ].The ~200 residue DOCK-type C2 domain is located toward the N terminus. It adopts a C2-like architecture and interacts with phosphatidylinositol3,4,5-trisphosphate []to mediate signalling and membrane localization. The central core of the DOCK-type C2 domain domain adopts an antiparallel β-sandwich with the "type II"C2 domain fold (a circular permutation of the more common "type I"topology), in which two 4-stranded sheets with strand order 6-5-2-3 and 7-8-1-4 create convex- and concave-exposed faces, respectively [].Some DOCK proteins are listed below:Mammalian Mammalian dedicator of cytokinesis 180 (DOCK180 or DOCK1),important for cell migration.Mammalian DOCK2, important for lymphocyte development, homong, activation,adhesion, polarization and migration processes.Mammalian DOCK3 (also known as MOCA), is expressed predominantly in neuronsand resides in growth cones and membrane ruffles.Mammalian DOCK4, possesses tumor suppressor properties.Mammalian DOCK9 (zizimin1), plays an important role in dendrite growth inhippocampal neurons through activation of Cdc42.Drosophila melanogaster Myoblast city.Caenorhabditis elegans CED-5.
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Protein
A0A0U1RPH6
Organism: Mus musculus/domesticus
Length: 46  
Fragment?: true
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Publication
12172552 | -
First Author: Meller N
Year: 2002
Journal: Nat Cell Biol
Title: Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins.
Volume: 4
Issue: 9
Pages: 639-47
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Publication
19745154 | -
First Author: Yang J
Year: 2009
Journal: Science
Title: Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor.
Volume: 325
Issue: 5946
Pages: 1398-402
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Protein
A0A0U1RNY4
Organism: Mus musculus/domesticus
Length: 811  
Fragment?: true
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Protein
A0A1L1STJ1
Organism: Mus musculus/domesticus
Length: 477  
Fragment?: true
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Publication
20713135 | -
First Author: Zhang D
Year: 2010
Journal: Gene
Title: Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes.
Volume: 469
Issue: 1-2
Pages: 18-30
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Publication
21613211 | -
First Author: Kulkarni K
Year: 2011
Journal: J Biol Chem
Title: Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors.
Volume: 286
Issue: 28
Pages: 25341-51
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Publication
20167601 | -
First Author: Premkumar L
Year: 2010
Journal: J Biol Chem
Title: Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs).
Volume: 285
Issue: 17
Pages: 13211-22
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Protein
Q8VDR9
Organism: Mus musculus/domesticus
Length: 2080  
Fragment?: false
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Protein
Q8R1A4
Organism: Mus musculus/domesticus
Length: 2130  
Fragment?: false
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Protein
A0A1B0GSI1
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
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Protein
A0A1L1SQR4
Organism: Mus musculus/domesticus
Length: 2111  
Fragment?: false
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Protein
Q6ZPS1
Organism: Mus musculus/domesticus
Length: 1909  
Fragment?: true
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Protein
Q6A0A3
Organism: Mus musculus/domesticus
Length: 1567  
Fragment?: true
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Protein
Q8BK93
Organism: Mus musculus/domesticus
Length: 682  
Fragment?: false
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Protein
A0A0R4J2B7
Organism: Mus musculus/domesticus
Length: 1816  
Fragment?: true
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Protein
D6RGU3
Organism: Mus musculus/domesticus
Length: 732  
Fragment?: false
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Protein
A0A0U1RNK7
Organism: Mus musculus/domesticus
Length: 2098  
Fragment?: false
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Protein
A2A9M5
Organism: Mus musculus/domesticus
Length: 2128  
Fragment?: false
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Protein
E9PX48
Organism: Mus musculus/domesticus
Length: 2100  
Fragment?: false
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Protein
A2A9M4
Organism: Mus musculus/domesticus
Length: 2130  
Fragment?: false
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Protein
Q5SRI3
Organism: Mus musculus/domesticus
Length: 1175  
Fragment?: false
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Protein
Q8BZN6
Organism: Mus musculus/domesticus
Length: 2150  
Fragment?: false
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Protein
A2AF47
Organism: Mus musculus/domesticus
Length: 2073  
Fragment?: false
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Protein
Q8BUR4
Organism: Mus musculus/domesticus
Length: 1865  
Fragment?: false
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Protein
Q8C3J5
Organism: Mus musculus/domesticus
Length: 1828  
Fragment?: false
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Protein
B2RY04
Organism: Mus musculus/domesticus
Length: 1868  
Fragment?: false
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Protein
Q8C147
Organism: Mus musculus/domesticus
Length: 2100  
Fragment?: false
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Protein
Q8BIK4
Organism: Mus musculus/domesticus
Length: 2055  
Fragment?: false
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Protein
F8VPN7
Organism: Mus musculus/domesticus
Length: 2113  
Fragment?: false
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Protein
A0A2X0U4P8
Organism: Mus musculus/domesticus
Length: 1942  
Fragment?: true
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Protein
B2RY79
Organism: Mus musculus/domesticus
Length: 2058  
Fragment?: false
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Protein
A0A2X0U2I4
Organism: Mus musculus/domesticus
Length: 2008  
Fragment?: false
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Protein
B9EJ70
Organism: Mus musculus/domesticus
Length: 2100  
Fragment?: false
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Protein
Q7TN11
Organism: Mus musculus/domesticus
Length: 1920  
Fragment?: true
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Protein
A0A1D5RMM1
Organism: Mus musculus/domesticus
Length: 2088  
Fragment?: false
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Protein
A0A1D5RLE0
Organism: Mus musculus/domesticus
Length: 2042  
Fragment?: false
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Protein
E9QMR2
Organism: Mus musculus/domesticus
Length: 2058  
Fragment?: false
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Protein
A2AF67
Organism: Mus musculus/domesticus
Length: 1902  
Fragment?: false
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Protein
A0A5F8MPL9
Organism: Mus musculus/domesticus
Length: 2055  
Fragment?: false
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Protein
B2RXS7
Organism: Mus musculus/domesticus
Length: 2088  
Fragment?: false
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Protein
A0A087WQ86
Organism: Mus musculus/domesticus
Length: 2175  
Fragment?: false
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Protein
E9QM99
Organism: Mus musculus/domesticus
Length: 2187  
Fragment?: false
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Protein
A0A087WRP5
Organism: Mus musculus/domesticus
Length: 2151  
Fragment?: false
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Protein
Q8BMP2
Organism: Mus musculus/domesticus
Length: 1134  
Fragment?: false
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Protein
B2RY08
Organism: Mus musculus/domesticus
Length: 2042  
Fragment?: false
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Protein
B2RWY0
Organism: Mus musculus/domesticus
Length: 2150  
Fragment?: false
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Protein
P59764
Organism: Mus musculus/domesticus
Length: 1978  
Fragment?: false
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Protein
A0A1Y7VLY2
Organism: Mus musculus/domesticus
Length: 1940  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom