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Search results 101 to 178 out of 178 for Dok1

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Type Details Score
Publication
10051670 | J:53335
First Author: Encinas JA
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family.
Volume: 96
Issue: 5
Pages: 2491-6
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Publication
18422655 | J:137549
First Author: Warner N
Year: 2008
Journal: FEBS J
Title: Analysis of EphA4 receptor tyrosine kinase substrate specificity using peptide-based arrays.
Volume: 275
Issue: 10
Pages: 2561-73
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Publication
10585470 | J:58900
First Author: Berg KL
Year: 1999
Journal: J Biol Chem
Title: SHP-1 regulation of p62(DOK) tyrosine phosphorylation in macrophages.
Volume: 274
Issue: 50
Pages: 35855-65
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Publication
27450811 | J:238874
First Author: Waseda M
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Loss of Dok-1 and Dok-2 in mice causes severe experimental colitis accompanied by reduced expression of IL-17A and IL-22.
Volume: 478
Issue: 1
Pages: 135-142
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Publication
11585923 | J:242479
First Author: Elowe S
Year: 2001
Journal: Mol Cell Biol
Title: Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction.
Volume: 21
Issue: 21
Pages: 7429-41
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Publication
10567556 | J:58605
First Author: Cong F
Year: 1999
Journal: Mol Cell Biol
Title: Characterization of a novel member of the DOK family that binds and modulates Abl signaling.
Volume: 19
Issue: 12
Pages: 8314-25
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Publication
9927484 | J:52798
First Author: Jang W
Year: 1999
Journal: Genome Res
Title: Comparative sequence of human and mouse BAC clones from the mnd2 region of chromosome 2p13.
Volume: 9
Issue: 1
Pages: 53-61
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Publication
9806835 | J:50420
First Author: Weber JS
Year: 1998
Journal: Genomics
Title: High-resolution genetic, physical, and transcript map of the mnd2 region of mouse chromosome 6.
Volume: 54
Issue: 1
Pages: 107-15
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Publication
20697350 | J:164892
First Author: Titz B
Year: 2010
Journal: Oncogene
Title: The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.
Volume: 29
Issue: 44
Pages: 5895-910
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Publication
11970986 | J:112147
First Author: Ott VL
Year: 2002
Journal: J Immunol
Title: Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signaling.
Volume: 168
Issue: 9
Pages: 4430-9
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Publication
11470823 | J:70544
First Author: Grimm J
Year: 2001
Journal: J Cell Biol
Title: Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation.
Volume: 154
Issue: 2
Pages: 345-54
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Publication
27926878 | J:241670
First Author: Davidson D
Year: 2016
Journal: Cell Rep
Title: The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.
Volume: 17
Issue: 10
Pages: 2776-2788
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Publication
25859222 | J:237754
 
First Author: Maga AM
Year: 2015
Journal: Front Physiol
Title: Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico.
Volume: 6
Pages: 92
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Dok1<em1Smoc> | MGI:7289385
Name: docking protein 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Pathway
R-MMU-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
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Protein Coding Gene
MGI:1202710 | Art4
Type: protein_coding_gene
Organism: mouse, laboratory
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Strain
MGI:6475151 | C57BL/6JSmoc-Dok1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
10822173 | -
First Author: Dunant NM
Year: 2000
Journal: Cell Signal
Title: The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells.
Volume: 12
Issue: 5
Pages: 317-26
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Publication
14747716 | -
First Author: Shi N
Year: 2004
Journal: Acta Crystallogr D Biol Crystallogr
Title: Expression, crystallization and preliminary X-ray studies of the recombinant PTB domain of mouse dok1 protein.
Volume: 60
Issue: Pt 2
Pages: 334-6
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Interaction Experiment
Sattler M (2001)
Description: SHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKL.
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Protein
P97465
Organism: Mus musculus/domesticus
Length: 482  
Fragment?: false
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Protein Coding Gene
MGI:1916960 | Arap1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q4LDD4
Organism: Mus musculus/domesticus
Length: 1452  
Fragment?: false
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Protein Coding Gene
MGI:99683 | Ptk6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q64434
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
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Protein Coding Gene
MGI:88279 | Cbl
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P22682
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Publication
11836526 | J:83415
First Author: Fujita Y
Year: 2002
Journal: Nat Cell Biol
Title: Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex.
Volume: 4
Issue: 3
Pages: 222-31
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Publication
22252131 | J:200486
First Author: Mukherjee M
Year: 2012
Journal: EMBO J
Title: Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin.
Volume: 31
Issue: 5
Pages: 1308-19
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Publication
25074933 | -
First Author: Mukherjee M
Year: 2014
Journal: J Biol Chem
Title: Dimeric switch of Hakai-truncated monomers during substrate recognition: insights from solution studies and NMR structure.
Volume: 289
Issue: 37
Pages: 25611-23
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Publication
22349934 | -
First Author: Aparicio LA
Year: 2012
Journal: Cancer Metastasis Rev
Title: Biological influence of Hakai in cancer: a 10-year review.
Volume: 31
Issue: 1-2
Pages: 375-86
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Publication
20657603 | -
First Author: Liu YQ
Year: 2010
Journal: Asian J Androl
Title: Human RING finger protein ZNF645 is a novel testis-specific E3 ubiquitin ligase.
Volume: 12
Issue: 5
Pages: 658-66
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Protein Domain
IPR040383 | HAKAI/CBLL2
Type: Family
Description: Hakai is an E3 ubiquitin ligase that disrupts cell-cell contacts in epithelial cells and is upregulated in human colon and gastric adenocarcinomas. It was identified to mediate the posttranslational downregulation of E-cadherin (CDH1), a major component of adherens junctions in epithelial cells and a potent tumour suppressor [, , ]. It also promotes ubiquitination of several other tyrosine-phosphorylated Src substrates, including cortactin (CTTN) and DOK1 []. Hakai acts as a homodimer with a novel HYB (Hakai pTyr-binding) domain that forms a phosphotyrosine-binding pocket upon, and consists of a pair of monomers arranged in an anti-parallel configuration. Each monomer contains a C3HC4-type RING-HC finger and a short pTyr-B domain that incorporates a novel, atypical C2H2-type Zn-finger coordination motif. Both domains are important for dimerization [, ]. ZNF645, also known as CBLL2, is a novel testis-specific E3 ubiquitin-protein ligase that plays a role in sperm production and quality control []. It has a structure similar to that of the c-Cbl-like protein Hakai. In contrast to Hakai, its HYB domain demonstrates different target specificities. It interacts with v-Src-phosphorylated E-cadherin, but not to cortactin [].
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Protein Domain
IPR040380 | HAKAI-like_RING-HC
Type: Domain
Description: Hakai is an E3 ubiquitin ligase that disrupts cell-cell contacts in epithelial cells and is upregulated in human colon and gastric adenocarcinomas. It was identified to mediate the posttranslational downregulation of E-cadherin (CDH1), a major component of adherens junctions in epithelial cells and a potent tumour suppressor [, , ]. It also promotes ubiquitination of several other tyrosine-phosphorylated Src substrates, including cortactin (CTTN) and DOK1 []. Hakai acts as a homodimer with a novel HYB (Hakai pTyr-binding) domain that forms a phosphotyrosine-binding pocket upon, and consists of a pair of monomers arranged in an anti-parallel configuration. Each monomer contains a C3HC4-type RING-HC finger and a short pTyr-B domain that incorporates a novel, atypical C2H2-type Zn-finger coordination motif. Both domains are important for dimerization [, ]. ZNF645, also known as CBLL2, is a novel testis-specific E3 ubiquitin-protein ligase that plays a role in sperm production and quality control []. It has a structure similar to that of the c-Cbl-like protein Hakai. In contrast to Hakai, its HYB domain demonstrates different target specificities. It interacts with v-Src-phosphorylated E-cadherin, but not to cortactin [].
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Publication
11477403 | J:227397
First Author: Latour S
Year: 2001
Journal: Nat Immunol
Title: Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product.
Volume: 2
Issue: 8
Pages: 681-90
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Publication
20565848 | J:225030
 
First Author: Li Wq
Year: 2010
Journal: BMC Biol
Title: Downstream of tyrosine kinase/docking protein 6, as a novel substrate of tropomyosin-related kinase C receptor, is involved in neurotrophin 3-mediated neurite outgrowth in mouse cortex neurons.
Volume: 8
Pages: 86
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Publication
15557172 | J:94359
First Author: Zhang S
Year: 2004
Journal: J Immunol
Title: Molecular mechanisms of CD200 inhibition of mast cell activation.
Volume: 173
Issue: 11
Pages: 6786-93
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Publication
20577653 | J:166304
 
First Author: Ogando DG
Year: 2010
Journal: Mol Vis
Title: Candidate genes for chromosomes 6 and 10 quantitative trait loci for age-related retinal degeneration in mice.
Volume: 16
Pages: 1004-18
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Protein Coding Gene
MGI:87986 | Akt1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P31750
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Protein
Q9JIY2
Organism: Mus musculus/domesticus
Length: 491  
Fragment?: false
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Protein
A0A1X7SB71
Organism: Mus musculus/domesticus
Length: 488  
Fragment?: false
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Protein
E9QM14
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
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Protein Coding Gene
MGI:1925544 | Rps27a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98887 | Uba52
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98888 | Ubb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98889 | Ubc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P62984
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Protein
P0CG50
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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Protein
P62983
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
P0CG49
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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