| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:4424600 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3287023 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:4824452 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_011832_09 |
|
| Specimen Label: |
euxassay_011832_09 |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4424600 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3287023 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:4824452 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_011832_10 |
|
| Specimen Label: |
euxassay_011832_10 |
| Detected: |
true |
| Specimen Num: |
9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4424600 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3287023 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:4824452 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_011832_11 |
|
| Specimen Label: |
euxassay_011832_11 |
| Detected: |
true |
| Specimen Num: |
10 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4424600 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3287023 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:4824452 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_011832_12 |
|
| Specimen Label: |
euxassay_011832_12 |
| Detected: |
true |
| Specimen Num: |
11 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4424600 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3287023 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:4824452 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_011832_13 |
|
| Specimen Label: |
euxassay_011832_13 |
| Detected: |
true |
| Specimen Num: |
12 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5001779 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-02-07 |
| Strength: |
Absent |
| Sex: |
Female |
| Emaps: |
EMAPS:2852723 |
|
| Stage: |
TS23 |
| Assay Id: |
MGI:5542333 |
| Age: |
embryonic day 15.5 |
| Image: |
GUDMAP:12355 |
|
| Specimen Label: |
GUDMAP:12355 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5001779 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-02-07 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:2852723 |
|
| Stage: |
TS23 |
| Assay Id: |
MGI:5542333 |
| Age: |
embryonic day 15.5 |
| Image: |
GUDMAP:12356 |
|
| Specimen Label: |
GUDMAP:12356 |
| Detected: |
false |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5001779 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-02-07 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:2874723 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:5542333 |
| Age: |
embryonic day 15.5 |
| Image: |
GUDMAP:12355 |
|
| Specimen Label: |
GUDMAP:12355 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4844644 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-12-22 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1618417 |
| Pattern: |
Not Specified |
| Stage: |
TS17 |
| Assay Id: |
MGI:4848535 |
| Age: |
embryonic day 10.5 |
|
|
| Specimen Label: |
Table S4 - E10.5 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5001779 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-02-07 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:2850023 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:5542333 |
| Age: |
embryonic day 15.5 |
| Image: |
GUDMAP:12355 |
|
| Specimen Label: |
GUDMAP:12355 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5001779 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-02-07 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:2850023 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:5542333 |
| Age: |
embryonic day 15.5 |
| Image: |
GUDMAP:12356 |
|
| Specimen Label: |
GUDMAP:12356 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4424600 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1778223 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4824452 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_011832_06 |
|
| Specimen Label: |
euxassay_011832_06 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4424600 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1778223 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4824452 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_011832_07 |
|
| Specimen Label: |
euxassay_011832_07 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4424600 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1778223 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4824452 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_011832_10 |
|
| Specimen Label: |
euxassay_011832_10 |
| Detected: |
true |
| Specimen Num: |
9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4424600 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1778223 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4824452 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_011832_11 |
|
| Specimen Label: |
euxassay_011832_11 |
| Detected: |
true |
| Specimen Num: |
10 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5001779 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-02-07 |
| Strength: |
Absent |
| Sex: |
Female |
| Emaps: |
EMAPS:1796223 |
|
| Stage: |
TS23 |
| Assay Id: |
MGI:5542333 |
| Age: |
embryonic day 15.5 |
| Image: |
GUDMAP:12355 |
|
| Specimen Label: |
GUDMAP:12355 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Weijts BGMW |
| Year: |
2018 |
| Journal: |
Oncogene |
| Title: |
Atypical E2Fs inhibit tumor angiogenesis. |
| Volume: |
37 |
| Issue: |
2 |
| Pages: |
271-276 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Moreno E |
| Year: |
2022 |
| Journal: |
Liver Int |
| Title: |
Inhibition of polyploidization in Pten-deficient livers reduces steatosis. |
| Volume: |
42 |
| Issue: |
11 |
| Pages: |
2442-2452 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mans DA |
| Year: |
2013 |
| Journal: |
J Pathol |
| Title: |
Regulation of E2F1 by the von Hippel-Lindau tumour suppressor protein predicts survival in renal cell cancer patients. |
| Volume: |
231 |
| Issue: |
1 |
| Pages: |
117-29 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hu T |
| Year: |
2012 |
| Journal: |
Blood |
| Title: |
Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia. |
| Volume: |
119 |
| Issue: |
19 |
| Pages: |
4532-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wenzel PL |
| Year: |
2007 |
| Journal: |
Genes Dev |
| Title: |
Rb is critical in a mammalian tissue stem cell population. |
| Volume: |
21 |
| Issue: |
1 |
| Pages: |
85-97 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang J |
| Year: |
2010 |
| Journal: |
J Neurosci |
| Title: |
Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex. |
| Volume: |
30 |
| Issue: |
15 |
| Pages: |
5219-28 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Otto T |
| Year: |
2017 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. |
| Volume: |
114 |
| Issue: |
40 |
| Pages: |
10660-10665 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nakano T |
| Year: |
2021 |
| Journal: |
Dev Biol |
| Title: |
Effects of Pparγ1 deletion on late-stage murine embryogenesis and cells that undergo endocycle. |
| Volume: |
478 |
|
| Pages: |
222-235 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mayer C |
| Year: |
2018 |
| Journal: |
Nature |
| Title: |
Developmental diversification of cortical inhibitory interneurons. |
| Volume: |
555 |
| Issue: |
7697 |
| Pages: |
457-462 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Campbell GR |
| Year: |
2011 |
| Journal: |
Mol Cell Neurosci |
| Title: |
Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling. |
| Volume: |
46 |
| Issue: |
2 |
| Pages: |
548-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory Backcross DNA Panel Mapping Resource |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
JAX BSS Panel Mapping Data |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ko MS |
| Year: |
2000 |
| Journal: |
Development |
| Title: |
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. |
| Volume: |
127 |
| Issue: |
8 |
| Pages: |
1737-49 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yokoyama S |
| Year: |
2009 |
| Journal: |
Dev Cell |
| Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
| Volume: |
17 |
| Issue: |
6 |
| Pages: |
836-48 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
Data Curation Using Mouse Genome Assembly |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory |
| Year: |
2012 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Friedel RH |
| Year: |
2007 |
| Journal: |
Brief Funct Genomic Proteomic |
| Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
| Volume: |
6 |
| Issue: |
3 |
| Pages: |
180-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Thompson CL |
| Year: |
2014 |
| Journal: |
Neuron |
| Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
| Volume: |
83 |
| Issue: |
2 |
| Pages: |
309-323 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stryke D |
| Year: |
2003 |
| Journal: |
Nucleic Acids Res |
| Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
| Volume: |
31 |
| Issue: |
1 |
| Pages: |
278-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2009 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GUDMAP Consortium |
| Year: |
2004 |
| Journal: |
www.gudmap.org |
| Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hansen GM |
| Year: |
2008 |
| Journal: |
Genome Res |
| Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
| Volume: |
18 |
| Issue: |
10 |
| Pages: |
1670-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
| Year: |
2001 |
|
| Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zambrowicz BP |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
| Volume: |
100 |
| Issue: |
24 |
| Pages: |
14109-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Skarnes WC |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
| Volume: |
474 |
| Issue: |
7351 |
| Pages: |
337-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cyagen Biosciences Inc. |
| Year: |
2022 |
|
| Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
1 |
| Description: |
Transcription factor E2F7 |
| Type: |
chain |
| End: |
904 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
140
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
904
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
219
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
421
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Paik JC |
| Year: |
2010 |
| Journal: |
J Biol Chem |
| Title: |
Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B. |
| Volume: |
285 |
| Issue: |
9 |
| Pages: |
6348-63 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
The E2F family of transcription factors plays a crucial role in the control of cell cycle [, ]and action of tumour suppressor proteins. This family consists of eight members and is divided into activators (E2F1-3) and repressors (E2F4-8) depending on cellular context, target gene and cofactors []. The E2F proteins contain several evolutionarily conserved domains found in most members of the family. These domains include a DNA-binding domain, a dimerisation domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumour suppressor protein association domain which is embedded within the transactivation domain []. Classical E2Fs (E2F1-6) contain one DNA-binding domain which form heterodimers with DP proteins; atypical family members, E2F7 and E2F8, possess two DNA-binding domains, form homodimers or heterodimers, thus regulating transcription in a DP-independent manner []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Maiti B |
| Year: |
2005 |
| Journal: |
J Biol Chem |
| Title: |
Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation. |
| Volume: |
280 |
| Issue: |
18 |
| Pages: |
18211-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun Y |
| Year: |
2015 |
| Journal: |
J Clin Invest |
| Title: |
Mature T cell responses are controlled by microRNA-142. |
| Volume: |
125 |
| Issue: |
7 |
| Pages: |
2825-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Christensen J |
| Year: |
2005 |
| Journal: |
Nucleic Acids Res |
| Title: |
Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription. |
| Volume: |
33 |
| Issue: |
17 |
| Pages: |
5458-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kent LN |
| Year: |
2016 |
| Journal: |
J Clin Invest |
| Title: |
E2f8 mediates tumor suppression in postnatal liver development. |
| Volume: |
126 |
| Issue: |
8 |
| Pages: |
2955-69 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
248
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
224
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim JY |
| Year: |
2022 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
RORα contributes to the maintenance of genome ploidy in the liver of mice with diet-induced nonalcoholic steatohepatitis. |
| Volume: |
322 |
| Issue: |
2 |
| Pages: |
E118-E131 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu CL |
| Year: |
1995 |
| Journal: |
Mol Cell Biol |
| Title: |
In vivo association of E2F and DP family proteins. |
| Volume: |
15 |
| Issue: |
5 |
| Pages: |
2536-46 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
430
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
443
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
457
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
410
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
335
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
860
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
335
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
321
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
336
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
381
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
457
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
340
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
404
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
388
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
385
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
430
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
334
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
272
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
272
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
201
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
237
 |
| Fragment?: |
false |
|
•
•
•
•
•
|