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Search results 101 to 121 out of 121 for Edem1

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Type Details Score
Interaction Experiment
Marin MB (2012)
Description: Tyrosinase Degradation Is Prevented when EDEM1 Lacks the Intrinsically Disordered Region.
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Publication
25655076 | -
 
First Author: Sokołowska I
Year: 2015
Journal: BMC Cell Biol
Title: Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells.
Volume: 16
Pages: 1
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Publication
22905195 | -
First Author: Marin MB
Year: 2012
Journal: PLoS One
Title: Tyrosinase degradation is prevented when EDEM1 lacks the intrinsically disordered region.
Volume: 7
Issue: 8
Pages: e42998
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Publication
27053108 | -
First Author: Pfeiffer A
Year: 2016
Journal: J Biol Chem
Title: A Complex of Htm1 and the Oxidoreductase Pdi1 Accelerates Degradation of Misfolded Glycoproteins.
Volume: 291
Issue: 23
Pages: 12195-207
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Publication
24737672 | -
First Author: Hüttner S
Year: 2014
Journal: Plant Cell
Title: Arabidopsis Class I α-Mannosidases MNS4 and MNS5 Are Involved in Endoplasmic Reticulum-Associated Degradation of Misfolded Glycoproteins.
Volume: 26
Issue: 4
Pages: 1712-1728
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Protein Domain
IPR044674 | EDEM1/2/3
Type: Family
Description: This entry represents a group of alpha-1,2-specific exomannosidases that are involved in endoplasmic reticulum-associated degradation (ERAD), including EDEM1/2/3 from humans, Mnl1 from yeasts and MNS4/5 from Arabidopsis. Mnl1 forms a complex with Pdi1 to process unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response []. In humans, mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 is performed mainly by EDEM3 and to a lesser extent by EDEM1, while EDEM2 catalyses the first mannose trimming step from Man9GlcNAc2 []. EDEM1 has been shown to recognise and deliver misfolded proteins to the SEL1L-containing ERAD complex []. MNS4/5 function in the formation of unique N-glycan structures that are specifically recognized by components of the endoplasmic reticulum-associated degradation (ERAD) machinery, which leads to the degradation of misfolded glycoproteins [].
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Publication
23650437 | J:198929
First Author: Das I
Year: 2013
Journal: J Exp Med
Title: Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins.
Volume: 210
Issue: 6
Pages: 1201-16
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Publication
25092655 | -
First Author: Ninagawa S
Year: 2014
Journal: J Cell Biol
Title: EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step.
Volume: 206
Issue: 3
Pages: 347-56
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Protein
Q2HXL6
Organism: Mus musculus/domesticus
Length: 931  
Fragment?: false
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Protein
Q925U4
Organism: Mus musculus/domesticus
Length: 652  
Fragment?: false
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Protein
Q8BJT9
Organism: Mus musculus/domesticus
Length: 577  
Fragment?: false
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Protein
B7ZNP0
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein
Q6ZQG3
Organism: Mus musculus/domesticus
Length: 674  
Fragment?: true
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Protein
Q8BYV2
Organism: Mus musculus/domesticus
Length: 539  
Fragment?: true
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Protein
Q8C0J7
Organism: Mus musculus/domesticus
Length: 539  
Fragment?: false
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Protein
Q3UX12
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: true
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Protein
A0A087WQK5
Organism: Mus musculus/domesticus
Length: 917  
Fragment?: false
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Protein
A0A0N4SV08
Organism: Mus musculus/domesticus
Length: 539  
Fragment?: false
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Protein
A0A087WR24
Organism: Mus musculus/domesticus
Length: 947  
Fragment?: false
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Protein
B7ZNN9
Organism: Mus musculus/domesticus
Length: 917  
Fragment?: false
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Protein
Q3U9S2
Organism: Mus musculus/domesticus
Length: 652  
Fragment?: false
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