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Search results 101 to 120 out of 120 for Eif3m

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Type Details Score
Protein Coding Gene
MGI:1913335 | Eif3f
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1926966 | Eif3c
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95301 | Eif3a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR045237 | COPS7/eIF3m
Type: Family
Description: This entry includes eIF3m and COPS7A/B. eIF3m is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome []. The COP9 signalosome (CSN) is a conserved protein complex that regulates the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes [], which leads to a decrease in Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 []. Protein kinases CK2 and D, which phosphorylate proteins such as cJun and p53 resulting in their degradation by the ubiquitin-26S proteasome system, also binds to CSN [, ]. The mammalian CSN typically consistis of eight subunits designated CSN1-CSN8. The fission yeast possesses a smaller version of the CSN, consisting only of six subunits, whereas a more distant CSN-like complex has been described in Saccharomyces cerevisiae [].
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Protein
A2A701
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true
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Protein
D6RI85
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: false
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Protein
D6RH36
Organism: Mus musculus/domesticus
Length: 62  
Fragment?: false
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Protein
D3Z6T8
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: true
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Protein
D3Z0S0
Organism: Mus musculus/domesticus
Length: 79  
Fragment?: true
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Protein
Q9CZ04
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: false
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Protein
Q8BV13
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: false
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Protein
D3YVI6
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: true
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Protein
D3Z440
Organism: Mus musculus/domesticus
Length: 226  
Fragment?: true
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Protein
Q3TDL0
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: false
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Protein
A2A702
Organism: Mus musculus/domesticus
Length: 242  
Fragment?: false
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Publication
11337588 | -
First Author: Lyapina S
Year: 2001
Journal: Science
Title: Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.
Volume: 292
Issue: 5520
Pages: 1382-5
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Publication
12732143 | -
First Author: Groisman R
Year: 2003
Journal: Cell
Title: The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.
Volume: 113
Issue: 3
Pages: 357-67
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Publication
12628923 | -
First Author: Uhle S
Year: 2003
Journal: EMBO J
Title: Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.
Volume: 22
Issue: 6
Pages: 1302-12
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Publication
11285227 | -
First Author: Bech-Otschir D
Year: 2001
Journal: EMBO J
Title: COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system.
Volume: 20
Issue: 7
Pages: 1630-9
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Publication
18926707 | -
First Author: Wei N
Year: 2008
Journal: Trends Biochem Sci
Title: The COP9 signalosome: more than a protease.
Volume: 33
Issue: 12
Pages: 592-600
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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