Type |
Details |
Score |
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
163
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
163
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
157
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
251
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Phan L |
Year: |
2001 |
Journal: |
EMBO J |
Title: |
A subcomplex of three eIF3 subunits binds eIF1 and eIF5 and stimulates ribosome binding of mRNA and tRNA(i)Met. |
Volume: |
20 |
Issue: |
11 |
Pages: |
2954-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bandyopadhyay A |
Year: |
1999 |
Journal: |
Nucleic Acids Res |
Title: |
Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 (eIF3): demonstration that eIF3 interacts with eIF5 in mammalian cells. |
Volume: |
27 |
Issue: |
5 |
Pages: |
1331-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Asano K |
Year: |
1999 |
Journal: |
EMBO J |
Title: |
Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2. |
Volume: |
18 |
Issue: |
6 |
Pages: |
1673-88 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
66
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
The largest of the mammalian translation initiation factors, eIF3, consists of at least eight subunits ranging in mass from 35 to 170kDa. eIF3 binds to the 40 S ribosome in an early step of translation initiation and promotes the binding of methionyl-tRNAi and mRNA []. The N-terminal domain of eukaryotic translation initiation factor 3 subunit C mediates eIF3 binding to eIF1 and eIF5 []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
268
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
241
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
241
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
121
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
249
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Karásková M |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
Functional characterization of the role of the N-terminal domain of the c/Nip1 subunit of eukaryotic initiation factor 3 (eIF3) in AUG recognition. |
Volume: |
287 |
Issue: |
34 |
Pages: |
28420-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kouba T |
Year: |
2012 |
Journal: |
Nucleic Acids Res |
Title: |
The eIF3c/NIP1 PCI domain interacts with RNA and RACK1/ASC1 and promotes assembly of translation preinitiation complexes. |
Volume: |
40 |
Issue: |
6 |
Pages: |
2683-99 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Eukaryotic translation initiation factor 3 subunit C (EIF3C) is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. EIF3C appears to be important for eIF3 activity []. Its N-terminal domain mediates eIF3 binding to eIF1 and eIF5 [], and its C-terminal PCI domain forms an important intermolecular bridge between eIF3 and the 40S ribosome []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Bohnsack MT |
Year: |
2002 |
Journal: |
EMBO J |
Title: |
Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. |
Volume: |
21 |
Issue: |
22 |
Pages: |
6205-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Das S |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
Specific interaction of eukaryotic translation initiation factor 5 (eIF5) with the beta-subunit of eIF2. |
Volume: |
272 |
Issue: |
50 |
Pages: |
31712-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dong DJ |
Year: |
2009 |
Journal: |
BMC Dev Biol |
Title: |
A eukaryotic initiation factor 5C is upregulated during metamorphosis in the cotton bollworm, Helicoverpa armigera. |
Volume: |
9 |
|
Pages: |
19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee S |
Year: |
2007 |
Journal: |
Development |
Title: |
The F-actin-microtubule crosslinker Shot is a platform for Krasavietz-mediated translational regulation of midline axon repulsion. |
Volume: |
134 |
Issue: |
9 |
Pages: |
1767-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Loughran G |
Year: |
2018 |
Journal: |
PLoS One |
Title: |
Translational autoregulation of BZW1 and BZW2 expression by modulating the stringency of start codon selection. |
Volume: |
13 |
Issue: |
2 |
Pages: |
e0192648 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chiou J |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Overexpression of BZW1 is an independent poor prognosis marker and its down-regulation suppresses lung adenocarcinoma metastasis. |
Volume: |
9 |
Issue: |
1 |
Pages: |
14624 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
The eIF5-mimic protein 1/2 (also known as basic leucine zipper and W2 domain-containing proteins 2 and 1 (BZW2 and BZW1), respectively), are paralogous human proteins containing C-terminal HEAT domains that resemble the HEAT domain of eIF5 []. BZW1 plays an important role in the cell cycle and transcriptionally control the histone H4 gene during G1/S phase []. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal W2 domain resembles that of a set of concatenated HEAT repeats [, , ].The W2 domain has a globular fold and is exclusively composed out of α-helices [, , ]. The structure can be divided into a structural C-terminalcore onto which the two N-terminal helices are attached. The core contains two aromatic/acidic residue-rich regions (AA boxes), which are important for mediating protein-protein interactions. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
911
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
402
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
323
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Boesen T |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Structure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residue. |
Volume: |
279 |
Issue: |
11 |
Pages: |
10584-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wei Z |
Year: |
2006 |
Journal: |
J Mol Biol |
Title: |
Crystal structure of the C-terminal domain of S.cerevisiae eIF5. |
Volume: |
359 |
Issue: |
1 |
Pages: |
1-9 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
419
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
419
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
419
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
451
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Masutani M |
Year: |
2007 |
Journal: |
EMBO J |
Title: |
Reconstitution reveals the functional core of mammalian eIF3. |
Volume: |
26 |
Issue: |
14 |
Pages: |
3373-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bieniossek C |
Year: |
2006 |
Journal: |
J Mol Biol |
Title: |
The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5. |
Volume: |
360 |
Issue: |
2 |
Pages: |
457-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aravind L |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Eukaryote-specific domains in translation initiation factors: implications for translation regulation and evolution of the translation system. |
Volume: |
10 |
Issue: |
8 |
Pages: |
1172-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Asano K |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
Conservation and diversity of eukaryotic translation initiation factor eIF3. |
Volume: |
272 |
Issue: |
2 |
Pages: |
1101-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|