|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 200 out of 221 for Eif5a

<< First    < Previous  |  Next >    Last >>
0.028s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:7329827
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329903
Age: embryonic day 18.5
Image: 6
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7329826
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329904
Age: embryonic day 18.5
Image: 6
Specimen Label: Ptf1a-cre
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7329826
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329904
Age: embryonic day 18.5
Image: 6
Specimen Label: Ptf1a-cre
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7329826
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329904
Age: embryonic day 18.5
Image: 6
Specimen Label: Ptf1a-cre
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7329826
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329904
Age: embryonic day 18.5
Image: 6
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7329826
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329904
Age: embryonic day 18.5
Image: 6
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7329826
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329904
Age: embryonic day 18.5
Image: 6
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5642292
Assay Type: Immunohistochemistry
Annotation Date: 2015-07-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1619821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5642311
Age: embryonic day 13.5
Specimen Label: 3F
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5642292
Assay Type: Immunohistochemistry
Annotation Date: 2015-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5642311
Age: embryonic day 13.5
Note: The mesencephalic region is one of the tissues with higher levels of expression.
Specimen Label: 3D
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5642292
Assay Type: Immunohistochemistry
Annotation Date: 2015-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610321
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5642311
Age: embryonic day 13.5
Note: Organs from abdominal and thoracic regions have higher levels of expression.
Specimen Label: 3E
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5642292
Assay Type: Immunohistochemistry
Annotation Date: 2015-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1626221
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5642311
Age: embryonic day 13.5
Note: The stomatodeum is one of the tissues with higher levels of expression.
Specimen Label: 3B
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4415831
Assay Type: RNA in situ
Annotation Date: 2024-09-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7719041
Age: embryonic day 14.5
Image: S13P
Note: Expression was not enriched in the dorsal telencephalon or are inconclusive, compared with other regions.
Specimen Label: S13P
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5642292
Assay Type: Immunohistochemistry
Annotation Date: 2015-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5642311
Age: embryonic day 13.5
Note: The heart is one of the tissues with higher levels of expression.
Specimen Label: 3E
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5642292
Assay Type: Immunohistochemistry
Annotation Date: 2015-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647021
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5642311
Age: embryonic day 13.5
Note: Regions of the central nervous system have higher levels of expression.
Specimen Label: 3D
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5642292
Assay Type: Immunohistochemistry
Annotation Date: 2015-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Pattern: Widespread
Stage: TS21
Assay Id: MGI:5642311
Age: embryonic day 13.5
Note: Expression is present in all tissues and organs of the body, although some areas have higher expression levels than others.
Specimen Label: not shown
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5642292
Assay Type: Immunohistochemistry
Annotation Date: 2015-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5642311
Age: embryonic day 13.5
Note: The liver is one of the tissues with higher levels of expression.
Specimen Label: 3C
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1405725
Assay Type: RNA in situ
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750322
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7329942
Age: embryonic day 14.5
Image: S3B
Specimen Label: S3B
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5642292
Assay Type: Immunohistochemistry
Annotation Date: 2015-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5642311
Age: embryonic day 13.5
Note: The ectoderm is one of the tissues with higher levels of expression.
Specimen Label: 3D
Detected: true
Specimen Num: 4
•
•
•
•
•
Publication
- | J:68947
   
First Author: Strausberg R
Year: 2001
Journal: GenBank Submission
Title: Mus musculus, eukaryotic trasnlation initiation factor 5A, clone MGC: 6742, mRNA, complete cds
Pages: BC003889
•
•
•
•
•
Publication
36848144 | J:335172
 
First Author: Schultz CR
Year: 2023
Journal: Biol Open
Title: New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape.
Volume: 12
Issue: 3
•
•
•
•
•
Publication
26037925 | J:236582
First Author: Pällmann N
Year: 2015
Journal: J Biol Chem
Title: Biological Relevance and Therapeutic Potential of the Hypusine Modification System.
Volume: 290
Issue: 30
Pages: 18343-60
•
•
•
•
•
Publication
16880268 | J:111226
First Author: Torres-Padilla ME
Year: 2006
Journal: J Cell Biol
Title: Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote.
Volume: 174
Issue: 3
Pages: 329-38
•
•
•
•
•
Publication
22421546 | J:185743
First Author: Cotney J
Year: 2012
Journal: Genome Res
Title: Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb.
Volume: 22
Issue: 6
Pages: 1069-80
•
•
•
•
•
Publication
24165879 | J:210222
First Author: Hupe M
Year: 2014
Journal: Nucleic Acids Res
Title: Evaluation of TRAP-sequencing technology with a versatile conditional mouse model.
Volume: 42
Issue: 2
Pages: e14
•
•
•
•
•
Publication
25211037 | J:263419
First Author: Distler U
Year: 2014
Journal: Proteomics
Title: In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics.
Volume: 14
Issue: 21-22
Pages: 2607-13
•
•
•
•
•
Publication
9811942 | J:50869
First Author: Ko MS
Year: 1998
Journal: Hum Mol Genet
Title: Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Volume: 7
Issue: 12
Pages: 1967-78
•
•
•
•
•
Publication
- | J:29126
     
First Author: The Jackson Laboratory DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX Interspecific Backcross BSS and BSB Public Mapping Data
•
•
•
•
•
Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
•
•
•
•
•
Publication
18554416 | J:139177
First Author: Hoffman BG
Year: 2008
Journal: Genome Biol
Title: Identification of transcripts with enriched expression in the developing and adult pancreas.
Volume: 9
Issue: 6
Pages: R99
•
•
•
•
•
Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
•
•
•
•
•
Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
•
•
•
•
•
Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
•
•
•
•
•
Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
•
•
•
•
•
Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
•
•
•
•
•
Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
•
•
•
•
•
Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
•
•
•
•
•
Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
•
•
•
•
•
Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
•
•
•
•
•
Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
•
•
•
•
•
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7329825
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329902
Age: embryonic day 18.5
Image: 6
Specimen Label: Eif5a PANC
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7329825
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329902
Age: embryonic day 18.5
Image: 6
Specimen Label: Eif5a PANC
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7329825
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329902
Age: embryonic day 18.5
Image: 6
Specimen Label: Eif5a PANC
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7329830
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329905
Age: embryonic day 18.5
Image: 6
Specimen Label: Eif5a PANC
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7329830
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329905
Age: embryonic day 18.5
Image: 6
Specimen Label: Eif5a PANC
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7329830
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329905
Age: embryonic day 18.5
Image: 6
Specimen Label: Eif5a PANC
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7329829
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329906
Age: embryonic day 18.5
Image: 6
Specimen Label: Eif5a PANC
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7329829
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329906
Age: embryonic day 18.5
Image: 6
Specimen Label: Eif5a PANC
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7329829
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329906
Age: embryonic day 18.5
Image: 6
Specimen Label: Eif5a PANC
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5825117
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329907
Age: embryonic day 18.5
Image: 6
Specimen Label: Eif5a PANC
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5825117
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329907
Age: embryonic day 18.5
Image: 6
Specimen Label: Eif5a PANC
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5825117
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329907
Age: embryonic day 18.5
Image: 6
Specimen Label: Eif5a PANC
Detected: true
Specimen Num: 9
•
•
•
•
•
Publication
31474573 | J:283754
First Author: Zhang H
Year: 2019
Journal: Mol Cell
Title: Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.
Volume: 76
Issue: 1
Pages: 110-125.e9
•
•
•
•
•
Publication
32208453 | J:286614
First Author: Mastracci TL
Year: 2020
Journal: PLoS One
Title: Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes.
Volume: 15
Issue: 3
Pages: e0230627
•
•
•
•
•
Publication
30733517 | J:275256
First Author: Imam S
Year: 2019
Journal: Sci Rep
Title: eIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of Type 1 Diabetes.
Volume: 9
Issue: 1
Pages: 1533
•
•
•
•
•
Publication
23727016 | -
First Author: Gutierrez E
Year: 2013
Journal: Mol Cell
Title: eIF5A promotes translation of polyproline motifs.
Volume: 51
Issue: 1
Pages: 35-45
•
•
•
•
•
Publication
19424157 | -
First Author: Saini P
Year: 2009
Journal: Nature
Title: Hypusine-containing protein eIF5A promotes translation elongation.
Volume: 459
Issue: 7243
Pages: 118-21
•
•
•
•
•
Publication
28392174 | -
First Author: Schuller AP
Year: 2017
Journal: Mol Cell
Title: eIF5A Functions Globally in Translation Elongation and Termination.
Volume: 66
Issue: 2
Pages: 194-205.e5
•
•
•
•
•
Allele
Eif5a<em1Smoc> | MGI:7289472
Name: eukaryotic translation initiation factor 5A; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Publication
15377278 | -
First Author: Nishimura K
Year: 2005
Journal: Biochem J
Title: Independent roles of eIF5A and polyamines in cell proliferation.
Volume: 385
Issue: Pt 3
Pages: 779-85
•
•
•
•
•
Strain
MGI:7718042 | C57BL/6JSmoc-Eif5a<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Publication
19546244 | -
First Author: Patel PH
Year: 2009
Journal: J Cell Biol
Title: The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy.
Volume: 185
Issue: 7
Pages: 1181-94
•
•
•
•
•
Publication
26982726 | J:232714
First Author: Liu Y
Year: 2016
Journal: Nature
Title: Deletions linked to TP53 loss drive cancer through p53-independent mechanisms.
Volume: 531
Issue: 7595
Pages: 471-475
•
•
•
•
•
Publication
27089465 | J:236887
 
First Author: Lee WB
Year: 2016
Journal: Nat Commun
Title: Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution.
Volume: 7
Pages: 11322
•
•
•
•
•
Publication
33326776 | J:300705
First Author: Gobert AP
Year: 2020
Journal: Cell Rep
Title: Hypusination Orchestrates the Antimicrobial Response of Macrophages.
Volume: 33
Issue: 11
Pages: 108510
•
•
•
•
•
Publication
34496231 | J:309730
First Author: Anderson-Baucum E
Year: 2021
Journal: Cell Metab
Title: Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype.
Volume: 33
Issue: 9
Pages: 1883-1893.e7
•
•
•
•
•
Publication
31796630 | J:286192
 
First Author: Levasseur EM
Year: 2019
Journal: Sci Signal
Title: Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.
Volume: 12
Issue: 610
•
•
•
•
•
Protein Domain
IPR022847 | Transl_elong_IF5A_arc
Type: Family
Description: Eukaryotic eIF-5A was initially thought to function as a translation initiation factor, based on its ability to stimulate methionyl-puromycin synthesis. However, subsequent work revealed a role for eIF5A in translation elongation [, ]. Depletion or inactivation of eIF-5A in the yeast Saccharomyces cerevisiae (Baker's yeast) resulted in the accumulation of polysomes and an increase in ribosomal transit times. Addition of recombinant eIF-5A from yeast, but not a derivative lacking hypusine, enhanced the rate of tripeptide synthesis in vitro. Moreover, inactivation of eIF-5A mimicked the effects of the eEF2 inhibitor sordarin, indicating that eIF-5A might function together with eEF2 to promote ribosomal translocation. Finally, it was shown that eIF5A is specifically required to promote peptide-bond formation between consecutive proline residues. It has been proposed to stimulate the peptidyl-transferase activity of the ribosome and facilitate the reactivity of poor substrates like proline [].eIF-5A is a cofactor for the Rev and Rex transactivator proteins of human immunodeficiency virus-1 and T-cell leukaemia virus I, respectively [, , ]. IF-5A is the sole protein in eukaryotes and archaea to contain the unusual amino acid hypusine (Ne-(4-amino-2-hydroxybutyl)lysine) that is an absolute functional requirement. The first step in the post-translational modification of lysine to hypusine is catalyzed by the enzyme deoxyhypusine synthase, the structure of which has been reported []. The archaeal IF-5A proteins have not been studied as comprehensively as their eukaryotic homologues, though the crystal structure of the Pyrobaculum aerophilum protein has been determined. Unmodified P. aerophilum IF-5A is found to be a beta structure with two domains and three separate hydrophobic cores. The lysine (Lys42) that is post-translationally modified by deoxyhypusine synthase is found at one end of the IF-5A molecule in a turn between beta strands beta4 and beta5; this lysine residue is freely solvent accessible. The C-terminal domain is found to be homologous to the cold-shock protein CspA of E. coli, which has a well characterised RNA-binding fold, suggesting that IF-5A is involved in RNA binding [].This entry represents the archaeal IF-5A proteins.
•
•
•
•
•
Publication
9405429 | -
First Author: Aoki H
Year: 1997
Journal: J Biol Chem
Title: The gene encoding the elongation factor P protein is essential for viability and is required for protein synthesis.
Volume: 272
Issue: 51
Pages: 32254-9
•
•
•
•
•
Publication
23869404 | -
First Author: Beck J
Year: 2013
Journal: Mol Microbiol
Title: Woronin bodies, their impact on stress resistance and virulence of the pathogenic mould Aspergillus fumigatus and their anchoring at the septal pore of filamentous Ascomycota.
Volume: 89
Issue: 5
Pages: 857-71
•
•
•
•
•
Protein Domain
IPR001884 | IF5A-like
Type: Family
Description: Eukaryotic eIF-5A was initially thought to function as a translation initiation factor, based on its ability to stimulate methionyl-puromycin synthesis. However, subsequent work revealed a role for eIF5A in translation elongation [, ]. Depletion or inactivation of eIF-5A in the yeast Saccharomyces cerevisiae (Baker's yeast) resulted in the accumulation of polysomes and an increase in ribosomal transit times. Addition of recombinant eIF-5A from yeast, but not a derivative lacking hypusine, enhanced the rate of tripeptide synthesis in vitro. Moreover, inactivation of eIF-5A mimicked the effects of the eEF2 inhibitor sordarin, indicating that eIF-5A might function together with eEF2 to promote ribosomal translocation. Finally, it was shown that eIF5A is specifically required to promote peptide-bond formation between consecutive proline residues. It has been proposed to stimulate the peptidyl-transferase activity of the ribosome and facilitate the reactivity of poor substrates like proline [].eIF-5A is a cofactor for the Rev and Rex transactivator proteins of human immunodeficiency virus-1 and T-cell leukaemia virus I, respectively [, , ]. IF-5A is the sole protein in eukaryotes and archaea to contain the unusual amino acid hypusine (Ne-(4-amino-2-hydroxybutyl)lysine) that is an absolute functional requirement. The first step in the post-translational modification of lysine to hypusine is catalyzed by the enzyme deoxyhypusine synthase, the structure of which has been reported []. The archaeal IF-5A proteins have not been studied as comprehensively as their eukaryotic homologues, though the crystal structure of the Pyrobaculum aerophilum protein has been determined. Unmodified P. aerophilum IF-5A is found to be a beta structure with two domains and three separate hydrophobic cores. The lysine (Lys42) that is post-translationally modified by deoxyhypusine synthase is found at one end of the IF-5A molecule in a turn between beta strands beta4 and beta5; this lysine residue is freely solvent accessible.The C-terminal domain is found to be homologous to the cold-shock protein CspA of E. coli, which has a well characterised RNA-binding fold, suggesting that IF-5A is involved in RNA binding [].This family also includes the Woronin body major protein Hex1, whose sequence and structure are similar to eukaryotic initiation factor 5A (eIF5A), suggesting they share a common ancestor during evolution []. Woronin bodies are important for stress resistance and virulence [].
•
•
•
•
•
Publication
24496311 | J:212296
First Author: Imam S
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: Eukaryotic translation initiation factor 5A inhibition alters physiopathology and immune responses in a "humanized" transgenic mouse model of type 1 diabetes.
Volume: 306
Issue: 7
Pages: E791-8
•
•
•
•
•
Publication
38055903 | J:360415
First Author: Connors CT
Year: 2024
Journal: Diabetes
Title: A Translational Regulatory Mechanism Mediated by Hypusinated Eukaryotic Initiation Factor 5A Facilitates β-Cell Identity and Function.
Volume: 73
Issue: 3
Pages: 461-473
•
•
•
•
•
Publication
24196968 | J:207229
First Author: Colvin SC
Year: 2013
Journal: J Biol Chem
Title: Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes.
Volume: 288
Issue: 51
Pages: 36226-35
•
•
•
•
•
Publication
25261239 | J:217192
First Author: Fujimura K
Year: 2014
Journal: Cancer Res
Title: A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer.
Volume: 74
Issue: 22
Pages: 6671-81
•
•
•
•
•
Publication
8347280 | -
First Author: Park MH
Year: 1993
Journal: Biofactors
Title: Hypusine: its post-translational formation in eukaryotic initiation factor 5A and its potential role in cellular regulation.
Volume: 4
Issue: 2
Pages: 95-104
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom