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Search results 101 to 128 out of 128 for Elp3

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Type Details Score
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Elp3<Gt(AQ0461)Wtsi> | MGI:4345664
Name: elongator acetyltransferase complex subunit 3; gene trap AQ0461, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
Attribute String: Null/knockout
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Publication
27811057 | J:237511
First Author: Delaunay S
Year: 2016
Journal: J Exp Med
Title: Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.
Volume: 213
Issue: 11
Pages: 2503-2523
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GXD Expression
GXD Expression
Probe: MGI:6401514
Assay Type: Immunohistochemistry
Annotation Date: 2020-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6401804
Age: embryonic day 14.5
Image: 1B
Note: Co-expressed with Elp3 in cortical neurons.
Specimen Label: 1B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6401514
Assay Type: Immunohistochemistry
Annotation Date: 2020-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6401804
Age: embryonic day 14.5
Image: 1B
Note: Co-expressed with Elp3 in cortical neurons.
Specimen Label: 1B
Detected: true
Specimen Num: 1
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HT Experiment
E-MTAB-6992 | RNA-seq of long-term hematopoietic stem cells and myeloid progenitors of control mice or mice conditionally deficient for Trp53 or Elp3 or both genes in the hematopoietic system
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-MTAB-9628 | Polysome profiling analysis of myeloid progenitors of control mice or mice conditionally deficient for Elp3 in the hematopoietic system
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
25151136 | -
First Author: Selvadurai K
Year: 2014
Journal: Nat Chem Biol
Title: Archaeal Elp3 catalyzes tRNA wobble uridine modification at C5 via a radical mechanism.
Volume: 10
Issue: 10
Pages: 810-2
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GXD Expression
GXD Expression
Probe: MGI:6401514
Assay Type: Immunohistochemistry
Annotation Date: 2020-03-27
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6401804
Age: embryonic day 14.5
Image: 1B
Note: Co-expressed with Elp3 in cortical progenitor cells lining the ventricle.
Specimen Label: 1B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6401514
Assay Type: Immunohistochemistry
Annotation Date: 2020-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Pattern: Punctate
Stage: TS22
Assay Id: MGI:6401804
Age: embryonic day 14.5
Image: 1B
Note: A punctate staining throughout the cortical wall, with a stronger labeling of the ventricular layer cells. Co-expressed with Elp3 in cortical neurons.
Specimen Label: 1B
Detected: true
Specimen Num: 1
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Protein Domain
IPR034687 | ELP3-like
Type: Family
Description: The elongator complex is a major component of the RNA polymerase II (RNAPII) holoenzyme responsible for transcriptional elongation. It binds to both naked and nucleosomal DNA, can acetylate both core and nucleosomal histones, and is involved in chromatin remodelling []. It acetylates histones H3, preferentially at 'Lys-14', and H4, preferentially at 'Lys-8'. ELP3 is required for the complex integrity and for the association of the complex with nascent RNA transcript. ELP3 is thought to act as a highly conserved histone acetyltransferase (HAT) capable of acetylating core histones in vitro, however, it is clearly a multi-domain protein. The HAT activity is thought to be present only in the C-terminal GNAT domain (histone acyltransferase domain). Recent work []suggests that both the histone acetyltransferase and radical S-adenosylmethionine domains are essential for function, although the exact role of the Radical SAM domain is still unclear. The radical SAM domain is important for the structural integrity of the protein complex, and in yeast (previously demonstrated) []. However, an alternative may be that ELP3 binds and cleave SAM, as seen in the archaean M. jannaschii. It has also been shown in previous studies that the mouse ELP3 does not require the histone acyltransferase domain for zygotic paternal genome demethylation [, , , ].The archaeal protein which is the homologue of the third subunit of the eukaryotic elongator complex (Elp3), catalyses the tRNA wobble uridine modification at C5: the same reaction as the eukaryotic elongator complex. The proposed mechanism of action by Elp3 represents an unprecedented chemistry performed on acetyl-CoA in which the methyl group of the acetly-CoA is activated by the 5'-deoxyadenosyl radical. This then adds to the uridine of tRNA []. Some bacterial ELP3 homologues are known as tRNA uridine(34) acetyltransferase [].
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Publication
11714725 | J:99828
First Author: Hawkes NA
Year: 2002
Journal: J Biol Chem
Title: Purification and characterization of the human elongator complex.
Volume: 277
Issue: 4
Pages: 3047-52
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Publication
11435442 | J:71291
First Author: Winkler GS
Year: 2001
Journal: J Biol Chem
Title: RNA polymerase II elongator holoenzyme is composed of two discrete subcomplexes.
Volume: 276
Issue: 35
Pages: 32743-9
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HT Experiment
GSE158595 | E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure protein translation fidelity during neuronal development
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-74683 | A dynamic unfolded protein response contributes to the control of cortical neurogenesis
Series Id: GSE74683
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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