Type |
Details |
Score |
Publication |
First Author: |
Hosoyamada M |
Year: |
1999 |
Journal: |
Am J Physiol |
Title: |
Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. |
Volume: |
276 |
Issue: |
1 Pt 2 |
Pages: |
F122-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
454
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kobayashi Y |
Year: |
2002 |
Journal: |
Mol Pharmacol |
Title: |
Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. |
Volume: |
62 |
Issue: |
1 |
Pages: |
7-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chairoungdua A |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Identification and characterization of a novel member of the heterodimeric amino acid transporter family presumed to be associated with an unknown heavy chain. |
Volume: |
276 |
Issue: |
52 |
Pages: |
49390-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsuo H |
Year: |
2000 |
Journal: |
Chromosome Res |
Title: |
Mouse Asc-1 (asc-type amino acid transporter 1) maps to chromosome 7, region B1-B5. |
Volume: |
8 |
Issue: |
5 |
Pages: |
456 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fukasawa Y |
Year: |
2000 |
Journal: |
J Biol Chem |
Title: |
Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids. |
Volume: |
275 |
Issue: |
13 |
Pages: |
9690-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yanai K |
Year: |
1998 |
Journal: |
Neuroscience |
Title: |
Behavioural characterization and amounts of brain monoamines and their metabolites in mice lacking histamine H1 receptors. |
Volume: |
87 |
Issue: |
2 |
Pages: |
479-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fukuhara D |
Year: |
2007 |
Journal: |
Am J Pathol |
Title: |
Protein characterization of NA+-independent system L amino acid transporter 3 in mice: a potential role in supply of branched-chain amino acids under nutrient starvation. |
Volume: |
170 |
Issue: |
3 |
Pages: |
888-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang D |
Year: |
2011 |
Journal: |
Nucleic Acids Res |
Title: |
A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems. |
Volume: |
39 |
Issue: |
11 |
Pages: |
4532-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tsuchida H |
Year: |
2010 |
Journal: |
Cell Physiol Biochem |
Title: |
Identification of a novel organic anion transporter mediating carnitine transport in mouse liver and kidney. |
Volume: |
25 |
Issue: |
4-5 |
Pages: |
511-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsuo H |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Identification of a novel Na+-independent acidic amino acid transporter with structural similarity to the member of a heterodimeric amino acid transporter family associated with unknown heavy chains. |
Volume: |
277 |
Issue: |
23 |
Pages: |
21017-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakauchi J |
Year: |
2000 |
Journal: |
Neurosci Lett |
Title: |
Cloning and characterization of a human brain Na(+)-independent transporter for small neutral amino acids that transports D-serine with high affinity. |
Volume: |
287 |
Issue: |
3 |
Pages: |
231-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cunningham R |
Year: |
2007 |
Journal: |
J Am Soc Nephrol |
Title: |
Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport. |
Volume: |
18 |
Issue: |
5 |
Pages: |
1419-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shiraya K |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules. |
Volume: |
285 |
Issue: |
29 |
Pages: |
22141-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rosilio C |
Year: |
2015 |
Journal: |
Leukemia |
Title: |
L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia. |
Volume: |
29 |
Issue: |
6 |
Pages: |
1253-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kindler E |
Year: |
2017 |
Journal: |
PLoS Pathog |
Title: |
Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication. |
Volume: |
13 |
Issue: |
2 |
Pages: |
e1006195 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
This entry represents the EndoU-like endoribonucleases from a variety of organisms that range from viruses to humans. The founding member XendoU is a uridylate-specific, divalent cation-dependent enzyme that produces molecules with 2',3'-cyclic phosphate ends [, ]. The human EndoU, known as PP11, is a endoribonuclease with placental tissue specificity [].In human SARS coronavirus, EndoU (also known as NSP15) is part of the replicase-transcriptase complex that plays important roles in virus replication and transcription. NSP15 is a Uridylate-specific endoribonuclease that cleaves the 5'-polyuridines from negative-sense viral RNA, termed PUN RNA [], either upstream or downstream of uridylates, at GUU or GU to produce molecules with 2',3'-cyclic phosphate ends []. PUN RNA is a CoV MDA5-dependent pathogen-associated molecular pattern (PAMP) []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Hackbart M |
Year: |
2020 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors. |
Volume: |
117 |
Issue: |
14 |
Pages: |
8094-8103 |
|
•
•
•
•
•
|