Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
101
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
56
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
53
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Atanassov BS |
Year: |
2016 |
Journal: |
Mol Cell |
Title: |
ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth. |
Volume: |
62 |
Issue: |
4 |
Pages: |
558-71 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
Enhancer of yellow 2 (EnY2) is a small transcription factor which is conserved from protozoa to humans []. In insects it is known as enhancer of yellow 2 transcription factor, but in other organisms is known as transcription and mRNA export factor SUS1 or ENY2. It is involved in mRNA export coupled transcription activation by association with both the TREX-2 complex and the transcription regulatory histone acetylation complex SAGA [, , , ]. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B [, ]. The TREX-2 complex participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery []. |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
Transcription and mRNA export factor ENY2 |
Type: |
chain |
End: |
101 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
51
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Allele |
Name: |
ENY2 transcription and export complex 2 subunit; wild type |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Köhler A |
Year: |
2006 |
Journal: |
Mol Biol Cell |
Title: |
The mRNA export factor Sus1 is involved in Spt/Ada/Gcn5 acetyltransferase-mediated H2B deubiquitinylation through its interaction with Ubp8 and Sgf11. |
Volume: |
17 |
Issue: |
10 |
Pages: |
4228-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
RodrÃguez-Navarro S |
Year: |
2004 |
Journal: |
Cell |
Title: |
Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery. |
Volume: |
116 |
Issue: |
1 |
Pages: |
75-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lang G |
Year: |
2011 |
Journal: |
Mol Cell Biol |
Title: |
The tightly controlled deubiquitination activity of the human SAGA complex differentially modifies distinct gene regulatory elements. |
Volume: |
31 |
Issue: |
18 |
Pages: |
3734-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pascual-GarcÃa P |
Year: |
2008 |
Journal: |
Genes Dev |
Title: |
Sus1 is recruited to coding regions and functions during transcription elongation in association with SAGA and TREX2. |
Volume: |
22 |
Issue: |
20 |
Pages: |
2811-22 |
|
•
•
•
•
•
|
Allele |
Name: |
ENY2 transcription and export complex 2 subunit; gene trap OST244689, Lexicon Genetics |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
ENY2 transcription and export complex 2 subunit; gene trap OST276051, Lexicon Genetics |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
ENY2 transcription and export complex 2 subunit; gene trap OST400170, Lexicon Genetics |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
ENY2 transcription and export complex 2 subunit; targeted mutation 1e, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
ENY2 transcription and export complex 2 subunit; endonuclease-mediated mutation 1, Baylor College of Medicine |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Kurshakova MM |
Year: |
2007 |
Journal: |
EMBO J |
Title: |
SAGA and a novel Drosophila export complex anchor efficient transcription and mRNA export to NPC. |
Volume: |
26 |
Issue: |
24 |
Pages: |
4956-65 |
|
•
•
•
•
•
|
Allele |
Name: |
ENY2 transcription and export complex 2 subunit; gene trap IST13621A5, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Eny2/Eny2 |
Background: |
C57BL/6N-Eny2/BayMmucd |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Eny2/Eny2 |
Background: |
C57BL/6NJ-Eny2/Mmnc |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
97
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Rajakulendran S |
Year: |
2013 |
Journal: |
J Neurol Neurosurg Psychiatry |
Title: |
Deletion of chromosome 12q21 affecting KCNC2 and ATXN7L3B in a family with neurodevelopmental delay and ataxia. |
Volume: |
84 |
Issue: |
11 |
Pages: |
1255-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li W |
Year: |
2016 |
Journal: |
Mol Cell Biol |
Title: |
Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module. |
Volume: |
36 |
Issue: |
22 |
Pages: |
2855-2866 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Ataxin-7-like protein 3B (ATXN7L3B) interacts with ENY2, a SAGA component. It regulates histone H2Bub1 levels and SAGA deubiquitinase activity through competition for ENY2 binding []. It has been linked to neurodegenerative disease []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Jani D |
Year: |
2012 |
Journal: |
Nucleic Acids Res |
Title: |
Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export. |
Volume: |
40 |
Issue: |
10 |
Pages: |
4562-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
|
•
•
•
•
•
|