Type |
Details |
Score |
Publication |
First Author: |
Matkovic T |
Year: |
2013 |
Journal: |
J Cell Biol |
Title: |
The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles. |
Volume: |
202 |
Issue: |
4 |
Pages: |
667-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohara-Imaizumi M |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
ELKS/Voltage-Dependent Ca2+ Channel-β Subunit Module Regulates Polarized Ca2+ Influx in Pancreatic β Cells. |
Volume: |
26 |
Issue: |
5 |
Pages: |
1213-1226.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hagiwara A |
Year: |
2018 |
Journal: |
J Cell Biol |
Title: |
Cytomatrix proteins CAST and ELKS regulate retinal photoreceptor development and maintenance. |
Volume: |
217 |
Issue: |
11 |
Pages: |
3993-4006 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mochida S |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
SAD-B Phosphorylation of CAST Controls Active Zone Vesicle Recycling for Synaptic Depression. |
Volume: |
16 |
Issue: |
11 |
Pages: |
2901-2913 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawabe H |
Year: |
2017 |
Journal: |
J Cell Biol |
Title: |
ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones. |
Volume: |
216 |
Issue: |
4 |
Pages: |
1143-1161 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang SSH |
Year: |
2016 |
Journal: |
Neuron |
Title: |
Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking. |
Volume: |
91 |
Issue: |
4 |
Pages: |
777-791 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nyitrai H |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals. |
Volume: |
31 |
Issue: |
10 |
Pages: |
107712 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dong W |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse. |
Volume: |
24 |
Issue: |
2 |
Pages: |
284-293.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu ZH |
Year: |
2010 |
Journal: |
Mol Cell |
Title: |
ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress. |
Volume: |
40 |
Issue: |
1 |
Pages: |
75-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tan C |
Year: |
2022 |
Journal: |
Elife |
Title: |
Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones. |
Volume: |
11 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Tan C |
Year: |
2022 |
Journal: |
Neuron |
Title: |
Rebuilding essential active zone functions within a synapse. |
Volume: |
110 |
Issue: |
9 |
Pages: |
1498-1515.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu C |
Year: |
2018 |
Journal: |
Cell |
Title: |
Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites. |
Volume: |
172 |
Issue: |
4 |
Pages: |
706-718.e15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Proszynski TJ |
Year: |
2013 |
Journal: |
J Cell Sci |
Title: |
Amotl2 interacts with LL5β, localizes to podosomes and regulates postsynaptic differentiation in muscle. |
Volume: |
126 |
Issue: |
Pt 10 |
Pages: |
2225-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fischer M |
Year: |
2009 |
Journal: |
Mol Cell Neurosci |
Title: |
P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons. |
Volume: |
42 |
Issue: |
2 |
Pages: |
134-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Emperador-Melero J |
Year: |
2024 |
Journal: |
Nat Neurosci |
Title: |
Distinct active zone protein machineries mediate Ca(2+) channel clustering and vesicle priming at hippocampal synapses. |
Volume: |
27 |
Issue: |
9 |
Pages: |
1680-1694 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cao Y |
Year: |
2022 |
Journal: |
Curr Biol |
Title: |
Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors. |
Volume: |
32 |
Issue: |
22 |
Pages: |
4783-4796.e3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen J |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones. |
Volume: |
31 |
Issue: |
2 |
Pages: |
512-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Albrecht NE |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
Rapid and Integrative Discovery of Retina Regulatory Molecules. |
Volume: |
24 |
Issue: |
9 |
Pages: |
2506-2519 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wentzel C |
Year: |
2013 |
Journal: |
Neuron |
Title: |
mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking. |
Volume: |
78 |
Issue: |
6 |
Pages: |
1012-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Revil T |
Year: |
2010 |
Journal: |
BMC Genomics |
Title: |
Alternative splicing is frequent during early embryonic development in mouse. |
Volume: |
11 |
|
Pages: |
399 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schoch S |
Year: |
2006 |
Journal: |
EMBO J |
Title: |
Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release. |
Volume: |
25 |
Issue: |
24 |
Pages: |
5852-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang D |
Year: |
2020 |
Journal: |
J Comp Neurol |
Title: |
Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae. |
Volume: |
528 |
Issue: |
5 |
Pages: |
729-755 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakano Y |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. |
Volume: |
27 |
Issue: |
3 |
Pages: |
860-871.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki N |
Year: |
2003 |
Journal: |
DNA Res |
Title: |
Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. |
Volume: |
10 |
Issue: |
1 |
Pages: |
35-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2005 |
Journal: |
Unpublished |
Title: |
Information obtained from The Jackson Laboratory, Bar Harbor, ME |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
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•
•
•
•
•
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Publication |
First Author: |
Koscielny G |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Volume: |
42 |
Issue: |
Database issue |
Pages: |
D802-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
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•
•
•
•
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Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
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•
•
•
•
•
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Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
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•
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Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
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Title: |
Nomenclature Committee Use |
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•
•
•
•
•
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Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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•
•
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•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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•
•
•
•
•
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
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Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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•
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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•
•
•
•
•
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
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•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
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•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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•
|
Regulatory Region |
Type: |
enhancer |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
720
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
992
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
948
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
285
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Y |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones. |
Volume: |
99 |
Issue: |
22 |
Pages: |
14464-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wagh DA |
Year: |
2006 |
Journal: |
Neuron |
Title: |
Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila. |
Volume: |
49 |
Issue: |
6 |
Pages: |
833-44 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The active zone is the presynaptic region in the nerve terminals that mediates neurotransmitter release and is composed a dense collection of proteins called the cytomatrix at the active zone (CAZ). The CAZ proteins are thought to mediate synapse formation and regulate neurotransmitter release [, ].This entry represents the ELKS family, which are thought to be involved in the organisation of CAZ. Vertebrate ELKS proteins are produced by two genes, ERC1 and ERC2. Caenorhabditis elegans expresses a homologue of ELKS that acts downstream of syd2/liprin-alpha during active zone assembly []. Drosophila melanogaster expresses a related protein termed bruchpilot (brp) that consists of a conserved N terminus and a C-terminal half with no homologous sequences in vertebrates. Brp is required for structural integrity and function of synaptic active zones []. Vertebrate ELKS proteins are enriched at presynaptic active zones []and support Ca2+ influx at nerve terminals of inhibitory hippocampal neurons []. They have a C-terminal PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). These proteins also contain four coiled-coil domains []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
957
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
977
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
969
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
405
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
960
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
270
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
957
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
251
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
347
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
953
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1120
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1116
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1088
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1120
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Dai Y |
Year: |
2006 |
Journal: |
Nat Neurosci |
Title: |
SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS. |
Volume: |
9 |
Issue: |
12 |
Pages: |
1479-87 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
The Rab11 GTPase regulates recycling of internalized plasma membrane receptors and is essential for completion of cytokinesis. A family of Rab11 interacting proteins (FIPs) that conserve a C-terminal Rab-binding domain (RBD) selectively recognise the active form of Rab11. FIPs are diverse in sequence length and composition toward their N-termini, presumably a feature that underpins their specific roles in Rab11-mediated vesicle trafficking. They have been divided into three subfamilies (classe I, II, and III)on the basis of domain architecture. Class I FIPs comprises a subfamily of three proteins (Rip11/pp75/FIP5, Rab-coupling protein (RCP), and FIP2) that possess an N-terminal C2 domain, localize to recycling endosomes, and regulate plasma membrane recycling. The class II subfamily consists of two proteins (FIP3/eferin/arfophilin and FIP4) with tandem EF hands and a proline-rich region. Class II FIPs localize to recycling endosomes, the trans-Golgi network, and have been implicated in the regulation of membrane trafficking during cytokinesis. The class III subfamily consists of a single protein, FIP1, which does not contain obvious homology domains or motifs other than the FIP-RBD [, , , ].The FIP-RBD domain is also found in Rab6-interacting protein Erc1/Elks. Erc1 is the regulatory subunit of the IKK complex and probably recruits IkappaBalpha/NFKBIA to the complex []. It may be involved in the organisation of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. It may also be involved in vesicle trafficking at the CAZ, as well as in Rab-6 regulated endosomes to Golgi transport [].The FIB-RBD domain consists of an N-terminal long α-helix, followed by a 90 degrees bend at a conserved proline residue, a 3(10) helix and a C-terminal short β-strand, adopting an "L"shape. The long α-helix forms a parallel coiled-coil homodimer that symmetrically interacts with two Rab11 molecules on both sides, forming a quaternary Rab11-(FIP)2-Rab11 complex. The Rab11-interacting region of FIP-RBD is confined to the C-terminal 24 amino acids, which cover the C-terminal half of the long α-helix and the short β-strand [, , , ]. This entry represents the FIP-RBD C-terminal domain. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
The Rab11 GTPase regulates recycling of internalized plasma membrane receptors and is essential for completion of cytokinesis. A family of Rab11 interacting proteins (FIPs) that conserve a C-terminal Rab-binding domain (RBD) selectively recognise the active form of Rab11. FIPs are diverse in sequence length and composition toward their N-termini, presumably a feature that underpins their specific roles in Rab11-mediated vesicle trafficking. They have been divided into three subfamilies (classe I, II, and III)on the basis of domain architecture. Class I FIPs comprises a subfamily of three proteins (Rip11/pp75/FIP5, Rab-coupling protein (RCP), and FIP2) that possess an N-terminal C2 domain, localize to recycling endosomes, and regulate plasma membrane recycling. The class II subfamily consists of two proteins (FIP3/eferin/arfophilin and FIP4) with tandem EF hands and a proline-rich region. Class II FIPs localize to recycling endosomes, the trans-Golgi network, and have been implicated in the regulation of membrane trafficking during cytokinesis. The class III subfamily consists of a single protein, FIP1, which does not contain obvious homology domains or motifs other than the FIP-RBD [, , , ].The FIP-RBD domain is also found in Rab6-interacting protein Erc1/Elks. Erc1 is the regulatory subunit of the IKK complex and probably recruits IkappaBalpha/NFKBIA to the complex []. It may be involved in the organisation of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. It may also be involved in vesicle trafficking at the CAZ, as well as in Rab-6 regulated endosomes to Golgi transport [].The FIB-RBD domain consists of an N-terminal long α-helix, followed by a 90 degrees bend at a conserved proline residue, a 3(10) helix and a C-terminal short β-strand, adopting an "L"shape. The long α-helix forms a parallel coiled-coil homodimer that symmetrically interacts with two Rab11 molecules on both sides, forming a quaternary Rab11-(FIP)2-Rab11 complex. The Rab11-interacting region of FIP-RBD is confined to the C-terminal 24 amino acids, which cover the C-terminal half of the long α-helix and the short β-strand [, , , ]. This entry represents the FIP-RBD C-terminal domain. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1047
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
635
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
518
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
163
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
370
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Jagoe WN |
Year: |
2006 |
Journal: |
Structure |
Title: |
Crystal structure of rab11 in complex with rab11 family interacting protein 2. |
Volume: |
14 |
Issue: |
8 |
Pages: |
1273-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eathiraj S |
Year: |
2006 |
Journal: |
J Mol Biol |
Title: |
Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes. |
Volume: |
364 |
Issue: |
2 |
Pages: |
121-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shiba T |
Year: |
2006 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. |
Volume: |
103 |
Issue: |
42 |
Pages: |
15416-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wei J |
Year: |
2009 |
Journal: |
Biochemistry |
Title: |
Disorder and structure in the Rab11 binding domain of Rab11 family interacting protein 2. |
Volume: |
48 |
Issue: |
3 |
Pages: |
549-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ducut Sigala JL |
Year: |
2004 |
Journal: |
Science |
Title: |
Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit. |
Volume: |
304 |
Issue: |
5679 |
Pages: |
1963-7 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
645
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
645
 |
Fragment?: |
false |
|
•
•
•
•
•
|