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Search results 101 to 120 out of 120 for Fan1

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0.017s

Type

Details

Score

Protein

B2RSU4

Organism:	Mus musculus/domesticus
Length:	1450
Fragment?:	false

•

Protein

Q3U202

Organism:	Mus musculus/domesticus
Length:	1429
Fragment?:	true

•

Protein

Q3TLN3

Organism:	Mus musculus/domesticus
Length:	1144
Fragment?:	true

•

Protein

A0A0N4SV29

Organism:	Mus musculus/domesticus
Length:	1437
Fragment?:	false

•

Protein

A0A0N4SVS0

Organism:	Mus musculus/domesticus
Length:	84
Fragment?:	true

•

Protein

Q3UQJ0

Organism:	Mus musculus/domesticus
Length:	1450
Fragment?:	false

•

Publication

23444773 | -

First Author:	Yao CJ
Year:	2013
Journal:	Pharmazie
Title:	Fanconi anemia pathway--the way of DNA interstrand cross-link repair.
Volume:	68
Issue:	1
Pages:	5-11

•

Publication

11530803 | -

First Author:	Yamashita T
Year:	2001
Journal:	Int J Hematol
Title:	Current knowledge on the pathophysiology of Fanconi anemia: from genes to phenotypes.
Volume:	74
Issue:	1
Pages:	33-41

•

Publication

20603073 | -

First Author:	Smogorzewska A
Year:	2010
Journal:	Mol Cell
Title:	A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
Volume:	39
Issue:	1
Pages:	36-47

•

Publication

20603016 | -

First Author:	Kratz K
Year:	2010
Journal:	Cell
Title:	Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.
Volume:	142
Issue:	1
Pages:	77-88

•

Publication

20603015 | -

First Author:	MacKay C
Year:	2010
Journal:	Cell
Title:	Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.
Volume:	142
Issue:	1
Pages:	65-76

•

Publication

21464321 | -

First Author:	Yamamoto KN
Year:	2011
Journal:	Proc Natl Acad Sci U S A
Title:	Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway.
Volume:	108
Issue:	16
Pages:	6492-6

•

Publication

22753026 | -

First Author:	Sareen A
Year:	2012
Journal:	Nucleic Acids Res
Title:	Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase.
Volume:	40
Issue:	17
Pages:	8425-39

•

Publication

23658231 | -

First Author:	Chaudhury I
Year:	2013
Journal:	Nucleic Acids Res
Title:	FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery.
Volume:	41
Issue:	13
Pages:	6444-59

•

Publication

24556218 | -

First Author:	Yeo JE
Year:	2014
Journal:	Hum Mol Genet
Title:	CtIP mediates replication fork recovery in a FANCD2-regulated manner.
Volume:	23
Issue:	14
Pages:	3695-705

•

Protein Domain

IPR029448 | FANCD2

Type:

Family

Description:

The Fanconi Anemia (FA) pathway is responsible for interstrand crosslink DNA repair []. The name originates the recessive syndrome known as Fanconi anemia, which causes developmental problems and cancer predisposition []. In this pathway, the FANCI-FANCD2 (ID) complex is ubiquitinated by the FA core complex and then travels to sites of damage to coordinate repair [, ]. FA pathway activation seems to trigger dissociation of FANCD2 from FANCI, coinciding with FANCD2 monoubiquitination which precedes monoubiquitination of FANCI []. This suggests a functional separation for FANCD2 from FANCI [].Monoubiquitinated FANCD2 functions to recruit DNA repair factors FAN1 (Fanconi-associated nuclease 1) []and SLX4 [], suggesting that chromatin-bound FANCD2Ub is a docking platform for certain DNA repair nucleases. FANCD2 has also a role in replication fork recovery [].

•

Protein Domain

IPR040603 | FAN1_SAP

Type:

Domain

Description:

This domain is found in Fanconi-anemia-associated nuclease 1 (FAN1) present in Pseudomonas aeruginosa. FAN1 is a nuclease associated with Fanconi anemia (FA), an autosomal recessive genetic disorder caused by defects in FA genes responsible for processing DNA inter-strand cross-links (ICLs). The domain, known as the SAP domain, helps to augment the overall protein DNA interaction by interacting with the 3' and 5' ends of the template strand. Support of the pre-nick segment binding is crucial as multiple mutations in this domain resulted in hypersensitivity to a cross-linking agent in the SAP domain of Caenorhabditis elegans' FAN1. The helix-hairpin-helix of the SAP recognize three consecutive phosphate groups (C19, A20 and A21) at the 3' end of the template via the basic residues K116, K135 and K117 [].

•

Publication

21115814 | J:167137

First Author:	Yoshikiyo K
Year:	2010
Journal:	Proc Natl Acad Sci U S A
Title:	KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents.
Volume:	107
Issue:	50
Pages:	21553-7

•

Protein

F7CAP1

Organism:	Mus musculus/domesticus
Length:	246
Fragment?:	true

•

Protein

Q69ZT1

Organism:	Mus musculus/domesticus
Length:	1020
Fragment?:	false

•

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Search results 101 to 120 out of 120 for Fan1

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