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Search results 101 to 156 out of 156 for Fancm

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Type Details Score
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
22723423 | -
First Author: Lorenz A
Year: 2012
Journal: Science
Title: The fission yeast FANCM ortholog directs non-crossover recombination during meiosis.
Volume: 336
Issue: 6088
Pages: 1585-8
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Publication
18851838 | -
First Author: Sun W
Year: 2008
Journal: Mol Cell
Title: The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair.
Volume: 32
Issue: 1
Pages: 118-28
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Publication
20347428 | -
First Author: Yan Z
Year: 2010
Journal: Mol Cell
Title: A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.
Volume: 37
Issue: 6
Pages: 865-78
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Protein
Q8BGE5
Organism: Mus musculus/domesticus
Length: 2021  
Fragment?: false
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Protein
Q8BGE5-3
Organism: Mus musculus/domesticus
Length: 433  
Fragment?: false
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Protein
Q8BGE5-4
Organism: Mus musculus/domesticus
Length: 1280  
Fragment?: false
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Protein
Q8BGE5-2
Organism: Mus musculus/domesticus
Length: 651  
Fragment?: false
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DO Term
DOID:0111916 | spermatogenic failure 28
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GO Term
GO:0071821 | FANCM-MHF complex
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DO Term
DOID:0080872 | primary ovarian insufficiency 15
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Publication
23932590 | -
First Author: Coulthard R
Year: 2013
Journal: Structure
Title: Architecture and DNA recognition elements of the Fanconi anemia FANCM-FAAP24 complex.
Volume: 21
Issue: 9
Pages: 1648-58
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Protein Domain
IPR040646 | PND
Type: Domain
Description: This entry represents the pseudonuclease domain (PND) from the FANCM protein []. This domain is part of the PD(D/E)XK superfamily but does not appear to have a full set of catalytic residues [].
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Publication
17289582 | J:320165
First Author: Ciccia A
Year: 2007
Journal: Mol Cell
Title: Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.
Volume: 25
Issue: 3
Pages: 331-43
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Publication
22510687 | -
 
First Author: Tao Y
Year: 2012
Journal: Nat Commun
Title: The structure of the FANCM-MHF complex reveals physical features for functional assembly.
Volume: 3
Pages: 782
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Protein Domain
IPR031879 | FANCM-MHF-bd
Type: Domain
Description: This entry represents a structured region found in the Fanconi anemia group M protein (FANCM) that binds to a two-histone-fold-containing protein complex MHF. MHF binds double-strand DNA, stimulates the DNA-binding activity of FANCM, and contributes to the targeting of FANCM to chromatin [].
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Publication
22844101 | -
First Author: Nandi S
Year: 2012
Journal: Nucleic Acids Res
Title: The ATPase activity of Fml1 is essential for its roles in homologous recombination and DNA repair.
Volume: 40
Issue: 19
Pages: 9584-95
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Publication
19995966 | -
First Author: Chen YH
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Interplay between the Smc5/6 complex and the Mph1 helicase in recombinational repair.
Volume: 106
Issue: 50
Pages: 21252-7
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Publication
29281624 | -
First Author: Lafuente-Barquero J
Year: 2017
Journal: PLoS Genet
Title: The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage.
Volume: 13
Issue: 12
Pages: e1007136
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Publication
28673972 | -
First Author: Pan X
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres.
Volume: 114
Issue: 29
Pages: E5940-E5949
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Protein Domain
IPR039686 | FANCM/Mph1-like
Type: Family
Description: This entry includes a group of evolutionarily conserved ATP-dependent DNA helicases/translocases including human FANCM (Fanconi anemia group M protein) and its homologues, such as Mph1 from S. cerevisiae and Fml1/2 from S. pombe. FANCM is part of the FA complex that repair the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination []. It also plays a critical role in the replication stress response []. Mph1 can unwind Rad51 D-loops and extended D-loops []. It has been shown to be regulated by the Smc5/6 complex [, ]. Fml1 promotes Rad51-dependent gene conversion at stalled/blocked replication forks and limits crossing over during mitotic double-strand break repair [, ].
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Publication
36307435 | J:330825
First Author: Yoshinaga M
Year: 2022
Journal: Nat Commun
Title: The N(6)-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity.
Volume: 13
Issue: 1
Pages: 6435
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Protein Coding Gene
MGI:2142208 | Faap24
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8C4X1
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: false
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Protein
A2AC07
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: false
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Protein Domain
IPR018552 | CENP-X
Type: Family
Description: Centromere protein X (CENP-X) is a component of several different complexes, including the multisubunit FA complex, the heterotetrameric CENP-T-W-S-X complex and the APITD1/CENPS complex. The Fanconi anemia (FA) core complex is involved in DNA damage repair and genome maintenance. The FA complex is composed of CENPS, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM, FAAP24 and CENPX. Interacts with CENPS, FANCM and FAAP24 [, ]. Inner kinetochore subunit mhf2 is the dsDNA-binding component of the FANCM-MHF complex, important for gene conversion at blocked replication forks []and non-crossover recombination during mitosis and meiosis [].The CENP-T-W-S-X complex binds, supercoils DNA and plays an important role in kinetochore assembly [].The APITD1/CENPS complex is composed of at least of CENP-S and CENP-X and is essential for the stable assembly of the outer kinetchore [].
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Protein
A0A1Y7VMA3
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: true
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Publication
26920759 | -
First Author: Yimit A
Year: 2016
Journal: Genetics
Title: MTE1 Functions with MPH1 in Double-Strand Break Repair.
Volume: 203
Issue: 1
Pages: 147-57
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Publication
20921626 | J:166938
First Author: Vinciguerra P
Year: 2010
Journal: J Clin Invest
Title: Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells.
Volume: 120
Issue: 11
Pages: 3834-42
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Publication
19620631 | -
First Author: Amano M
Year: 2009
Journal: J Cell Biol
Title: The CENP-S complex is essential for the stable assembly of outer kinetochore structure.
Volume: 186
Issue: 2
Pages: 173-82
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Publication
20347429 | -
First Author: Singh TR
Year: 2010
Journal: Mol Cell
Title: MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM.
Volume: 37
Issue: 6
Pages: 879-86
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Publication
16116422 | -
First Author: Meetei AR
Year: 2005
Journal: Nat Genet
Title: A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.
Volume: 37
Issue: 9
Pages: 958-63
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Publication
19423727 | -
First Author: Singh TR
Year: 2009
Journal: Blood
Title: Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M.
Volume: 114
Issue: 1
Pages: 174-80
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Protein Domain
IPR044749 | FANCM_DEXDc
Type: Domain
Description: This entry represents the N-terminal domain of FANCM. It contains the ATP-binding region.Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex []. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage []. In complex with CENPS and CENPX, it binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA), and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, it efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates []. In vitro, on its own, it strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA []. FANCM is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding [, ].
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Protein
Q8CE63
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
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Protein Coding Gene
MGI:894324 | Cenpx
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1917178 | Cenps
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8BYF4
Organism: Mus musculus/domesticus
Length: 519  
Fragment?: true
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Protein
A0A1Y7VKF2
Organism: Mus musculus/domesticus
Length: 664  
Fragment?: false
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Protein
B2RX10
Organism: Mus musculus/domesticus
Length: 2021  
Fragment?: false
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Publication
21779027 | -
First Author: Linder P
Year: 2011
Journal: Nat Rev Mol Cell Biol
Title: From unwinding to clamping - the DEAD box RNA helicase family.
Volume: 12
Issue: 8
Pages: 505-16
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Protein
Q3TRW6
Organism: Mus musculus/domesticus
Length: 401  
Fragment?: true
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Protein
Q8BHL6
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: false
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Publication
20941364 | -
 
First Author: Schütz P
Year: 2010
Journal: PLoS One
Title: Comparative structural analysis of human DEAD-box RNA helicases.
Volume: 5
Issue: 9
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Publication
22304917 | -
First Author: Nishino T
Year: 2012
Journal: Cell
Title: CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold.
Volume: 148
Issue: 3
Pages: 487-501
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Publication
29017571 | -
First Author: Bhattacharjee S
Year: 2017
Journal: Cell Commun Signal
Title: DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway.
Volume: 15
Issue: 1
Pages: 41
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