|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 113 out of 113 for Farp2

<< First    < Previous  |  Next >    Last >>
0.016s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
29992992 | -
First Author: Kuo YC
Year: 2018
Journal: Sci Rep
Title: Structural analyses of FERM domain-mediated membrane localization of FARP1.
Volume: 8
Issue: 1
Pages: 10477
•
•
•
•
•
Publication
23946638 | -
 
First Author: Liu Z
Year: 2013
Journal: Mol Vis
Title: A novel missense mutation in the FERM domain containing 7 (FRMD7) gene causing X-linked idiopathic congenital nystagmus in a Chinese family.
Volume: 19
Pages: 1834-40
•
•
•
•
•
Protein Domain
IPR041788 | FARP1/FARP2/FRMD7_FERM_C
Type: Domain
Description: Proteins containing this domain include FARP1, FARP2 and FRMD7. FARP1 and FARP2 are members of the Dbl family guanine nucleotide exchange factors (GEFs) which are upstream positive regulators of Rho GTPases []. FARP1 has increased expression in differentiated chondrocytes. FARP2 is thought to regulate neurite remodeling by mediating the signaling pathways from membrane proteins to Rac. It is found in brain, lung, and testis, as well as embryonic hippocampal and cortical neurons []. They are composed of a N-terminal FERM domain, a proline-rich (PR) domain, Dbl-homology (DH), and two C-terminal PH domains.FRMD7 (FERM domain-containing protein 7) and Caenorhabditis elegans CFRM3 have a FERM domain that is closely related to that in FARP1 and FARP2. Both have unknown functions. They contain an N-terminal FERM domain, a PH domain, followed by a FA (FERM adjacent) domain []. FRMD7 has been linked to Idiopathic congenital nystagmus , an infant-onset disease with the typical features of bilateral ocular oscillations, visual impairment, and abnormal head movement []. The FERM domain has a cloverleaf tripart structure composed of: (1) FERM_N (A-lobe or F1); (2) FERM_M (B-lobe, or F2); and (3) FERM_C (C-lobe or F3). The C-lobe/F3 within the FERM domain is part of the PH domain family. Like most other ERM members they have a phosphoinositide-binding site in their FERM domain. The FERM C domain is the third structural domain within the FERM domain. The FERM domain is found in the cytoskeletal-associated proteins such as ezrin, moesin, radixin, 4.1R, and merlin. These proteins provide a link between the membrane and cytoskeleton and are involved in signal transduction pathways. The FERM domain is also found in protein tyrosine phosphatases (PTPs) , the tyrosine kinases FAK and JAK, in addition to other proteins involved in signaling. This domain is structurally similar to the PH and PTB domains and consequently is capable of binding to both peptides and phospholipids at different sites [, ].
•
•
•
•
•
Publication
24619647 | J:260303
First Author: Mlechkovich G
Year: 2014
Journal: Sci Signal
Title: Distinct cytoplasmic domains in Plexin-A4 mediate diverse responses to semaphorin 3A in developing mammalian neurons.
Volume: 7
Issue: 316
Pages: ra24
•
•
•
•
•
Publication
16582480 | J:222683
First Author: Kitano K
Year: 2006
Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun
Title: Structure of dimerized radixin FERM domain suggests a novel masking motif in C-terminal residues 295-304.
Volume: 62
Issue: Pt 4
Pages: 340-5
•
•
•
•
•
Protein
Q8K2R0
Organism: Mus musculus/domesticus
Length: 835  
Fragment?: true
•
•
•
•
•
Publication
19596566 | -
First Author: Tepass U
Year: 2009
Journal: Curr Opin Genet Dev
Title: FERM proteins in animal morphogenesis.
Volume: 19
Issue: 4
Pages: 357-67
•
•
•
•
•
Protein
Q91VS8
Organism: Mus musculus/domesticus
Length: 1065  
Fragment?: false
•
•
•
•
•
Protein
F8VPU2
Organism: Mus musculus/domesticus
Length: 1048  
Fragment?: false
•
•
•
•
•
Protein
A2AD83
Organism: Mus musculus/domesticus
Length: 703  
Fragment?: false
•
•
•
•
•
Protein
D3Z4C0
Organism: Mus musculus/domesticus
Length: 795  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom