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Search results 101 to 124 out of 124 for Fastk

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Type Details Score
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
29036396 | -
First Author: Jourdain AA
Year: 2017
Journal: Nucleic Acids Res
Title: The FASTK family of proteins: emerging regulators of mitochondrial RNA biology.
Volume: 45
Issue: 19
Pages: 10941-10947
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GO Term
GO:0033867 | Fas-activated serine/threonine kinase activity
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Allele
Fastk<em1Smoc> | MGI:7289608
Name: Fas-activated serine/threonine kinase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6475252 | C57BL/6JSmoc-Fastk<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Protein
A0A1Y7VJ24
Organism: Mus musculus/domesticus
Length: 101  
Fragment?: true
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Protein
Q6ZQ14
Organism: Mus musculus/domesticus
Length: 606  
Fragment?: true
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Protein Domain
IPR010622 | FAST_Leu-rich
Type: Domain
Description: This entry represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases that contains several conserved leucine residues. This domain can be found in the FASTK family members, including FASTK, FASTKD1, FASTKD2 and FASTKD5. FAST kinase has been shown to be rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis []. However, a critical active site residues are not conserved within the family and their kinase activity has been questioned []. FASTK localizes to nucleus, cytosol and mitochondria. FASTKD1, FASTKD2 and FASTKD5 localizes to mitochondria. FASTK has been shown to bind ND6 mRNA and cooperate with the mitochondrial degradosome to ensure regulated ND6 mRNA biogenesis []. FASTKD1, FASTKD2 and FASTKD5 are involved in mitochondrial RNA stability [].
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Protein Domain
IPR015715 | Ser/Thr_kinase_FAST
Type: Family
Description: This entry consists of proteins related to the eukaryotic Fas-activated serine/threonine (FAST) kinases that contain several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis []. However, a critical active site residues are not conserved within the family and its kinase activity has been questioned. FASTK localizes to nucleus, cytosol and mitochondria. In mitochondria, FASTK concentrates in mitochondrial RNA granules, where it interacts with the G-rich se-quence factor 1 (GRSF1) and MT-ND6 mRNA [].
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Publication
7544399 | -
First Author: Tian Q
Year: 1995
Journal: J Exp Med
Title: Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.
Volume: 182
Issue: 3
Pages: 865-74
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Protein
Q922E6
Organism: Mus musculus/domesticus
Length: 689  
Fragment?: false
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Protein
F2Z402
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: false
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Protein
Q9JIX9
Organism: Mus musculus/domesticus
Length: 511  
Fragment?: false
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Protein
Q91WQ6
Organism: Mus musculus/domesticus
Length: 511  
Fragment?: false
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Protein
Q8CAK5
Organism: Mus musculus/domesticus
Length: 545  
Fragment?: false
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Protein
E9QA06
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
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Protein
D3Z4M5
Organism: Mus musculus/domesticus
Length: 516  
Fragment?: false
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Protein
Q9CTC9
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: true
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Protein
Q8C725
Organism: Mus musculus/domesticus
Length: 545  
Fragment?: false
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Protein
Q6DI86
Organism: Mus musculus/domesticus
Length: 829  
Fragment?: false
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Protein
Q8BSN9
Organism: Mus musculus/domesticus
Length: 661  
Fragment?: false
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Protein
Q7TMV3
Organism: Mus musculus/domesticus
Length: 762  
Fragment?: false
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Protein
A0A0R4J291
Organism: Mus musculus/domesticus
Length: 807  
Fragment?: false
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Protein
Q91YM4
Organism: Mus musculus/domesticus
Length: 630  
Fragment?: false
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