Type |
Details |
Score |
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
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Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Kirk R |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor. |
Volume: |
283 |
Issue: |
32 |
Pages: |
22325-35 |
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Interaction Experiment |
Description: |
Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells. |
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DO Term |
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Allele |
Name: |
F-box protein 7; targeted mutation 1a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Hypomorph, Null/knockout, Reporter |
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Strain |
Attribute String: |
coisogenic, targeted mutation |
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Genotype |
Symbol: |
Fbxo7/Fbxo7 |
Background: |
involves: C57BL/6N |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Fbxo7/Fbxo7 |
Background: |
C57BL/6N-Fbxo7/Wtsi |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
45
 |
Fragment?: |
false |
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Protein Domain |
Type: |
Family |
Description: |
PI31 is a regulatory subunit of the immunoproteasome which is an inhibitor of the 20S proteasome in vitro. PI31 is also an Fbxo7.Skp1 binding partner. Fbxo7 is an F-box protein, which are the substrate-recognition components of the Skp1-Cul1-F box protein (SCF) E3 ubiquitin ligases. The interaction between PI31 and Fbxo7.Skp1 occurs via the beta sheets of a N-terminal domain present in both proteins and known as FP(Fbxo7/PI31) domain. The structure of PI31 FP domain contains a novel alpha/β-fold and two intermolecular contact surfaces []. |
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Protein Domain |
Type: |
Domain |
Description: |
PI31 is a regulatory subunit of the immunoproteasome which is an inhibitor of the 20S proteasome in vitro. PI31 is also an Fbxo7.Skp1 binding partner. Fbxo7 is an F-box protein, which are the substrate-recognition components of the Skp1-Cul1-F box protein (SCF) E3 ubiquitin ligases. The interaction between PI31 and Fbxo7.Skp1 occurs via the beta sheets of a N-terminal domain present in both proteins and known as FP(Fbxo7/PI31) domain. The structure of PI31 FP domain contains a novel alpha/β-fold and two intermolecular contact surfaces [].This entry represents the N-terminal domain of the PI31 proteasome regulator. |
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Strain |
Attribute String: |
mutant strain, targeted mutation |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
271
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
238
 |
Fragment?: |
true |
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•
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
271
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
278
 |
Fragment?: |
false |
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Publication |
First Author: |
Li G |
Year: |
2018 |
Journal: |
Autophagy |
Title: |
PTENα regulates mitophagy and maintains mitochondrial quality control. |
Volume: |
14 |
Issue: |
10 |
Pages: |
1742-1760 |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
442
 |
Fragment?: |
false |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
444
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
523
 |
Fragment?: |
false |
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