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Search results 101 to 136 out of 136 for Fcf1

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Type Details Score
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: macaque, rhesus
Allele  
Name: FCF1 rRNA processing protein; wild type
Allele Type: Not Specified
Allele  
Name: FCF1 rRNA processing protein; gene trap OST61673, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: FCF1 rRNA processing protein; gene trap OST208334, Lexicon Genetics
Allele Type: Gene trapped
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: dog, domestic
Allele  
Name: FCF1 rRNA processing protein; gene trap E208D12, German Gene Trap Consortium
Allele Type: Gene trapped
Allele
Name: FCF1 rRNA processing protein; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
Allele
Name: FCF1 rRNA processing protein; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele  
Name: FCF1 rRNA processing protein; gene trap IST14045C9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: FCF1 rRNA processing protein; gene trap IST15052D2, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Protein Domain
Type: Domain
Description: Fcf1 (also known as Utp24) is an essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly []. As a component of the small subunit (SSU) processome, Fcf1 is an essential nucleolar protein required for processing of the 18S pre-rRNA at sites A0-A2 [].The PIN (PilT N terminus) domain is a compact RNA-binding protein domain found in all domains of life. Typically, the PIN domain contains three or four conserved acidic residues (putative metal-binding, active site residues) []. The Fcf1 PIN domain has four of these putative active site residues and the Fcf1-Utp23 homologue PIN domain has three of them. Point mutation studies of the conserved acidic residues in the putative active site of Saccharomyces cerevisiae Fcf1 determined they were essential for pre-rRNA processing at sites A1 and A2, whereas the presence of the Fcf1 protein itself is also required for cleavage at site A0 [, ].
Publication
First Author: Rempola B
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing.
Volume: 346
Issue: 2
Pages: 546-54
Publication
First Author: Bleichert F
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation.
Volume: 103
Issue: 25
Pages: 9464-9
Protein
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: false
Protein Domain
Type: Family
Description: Utp23 share homology with PINc domain protein Fcf1. They are components of the small subunit processome (SSU) that are involved in rRNA-processing and ribosome biogenesis [, ]. Depletion of yeast Fcf1 and Fcf2 leads to a decrease in synthesis of the 18S rRNA and results in a deficit in 40S ribosomal subunits [].
Publication
First Author: Senissar M
Year: 2017
Journal: Protein Sci
Title: Structural conservation of the PIN domain active site across all domains of life.
Volume: 26
Issue: 8
Pages: 1474-1492
Protein
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
Publication
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112