| Type |
Details |
Score |
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
380
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
380
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
411
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
380
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
380
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
378
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Allele |
| Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 9, Shanghai Model Organisms Center |
| Allele Type: |
Targeted |
| Attribute String: |
Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Allele |
| Name: |
flap structure specific endonuclease 1; targeted mutation 2.1, Binghui Shen |
| Allele Type: |
Targeted |
| Attribute String: |
Not Specified |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Fen1/Fen1 |
| Background: |
involves: 129S1/Sv |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Fen1/Fen1<+> |
| Background: |
involves: 129S1/Sv |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
46
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pandolfini L |
| Year: |
2019 |
| Journal: |
Mol Cell |
| Title: |
METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation. |
| Volume: |
74 |
| Issue: |
6 |
| Pages: |
1278-1290.e9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang LS |
| Year: |
2019 |
| Journal: |
Mol Cell |
| Title: |
Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA. |
| Volume: |
74 |
| Issue: |
6 |
| Pages: |
1304-1316.e8 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit Trm82 and its homologues, wuho from flies and WDR4 from humans. In Saccharomyces cerevisiae, Trm82 is the non-catalytic subunit of the tRNA methyltransferase complex which consists of Trm8 and Trm82 [, ]. It is essential for the enzyme activity and may function in regulating the the Trm8 protein []. In humans, WDR4 forms the tRNA methyltransferase complex with METTL1 (Trm8 homologue). It is required to stabilise and induce conformational changes of the catalytic subunit METTL1 []. It is required for the formation of N7-methylguanine at position 46 (m7G46) in tRNA [, ]and also for the formation of N7-methylguanine at internal sites in a subset of mRNAs []. WDR4 is also involved in the methylation of a specific subset of miRNAs, such as let-7 []. Independently of METTL1, it also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Prasad R |
| Year: |
2007 |
| Journal: |
Mol Cell |
| Title: |
HMGB1 is a cofactor in mammalian base excision repair. |
| Volume: |
27 |
| Issue: |
5 |
| Pages: |
829-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim K |
| Year: |
1998 |
| Journal: |
J Biol Chem |
| Title: |
Involvement of flap endonuclease 1 in base excision DNA repair. |
| Volume: |
273 |
| Issue: |
15 |
| Pages: |
8842-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hanzlikova H |
| Year: |
2018 |
| Journal: |
Mol Cell |
| Title: |
The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication. |
| Volume: |
71 |
| Issue: |
2 |
| Pages: |
319-331.e3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Leulliot N |
| Year: |
2008 |
| Journal: |
Structure |
| Title: |
Structure of the yeast tRNA m7G methylation complex. |
| Volume: |
16 |
| Issue: |
1 |
| Pages: |
52-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Matsumoto K |
| Year: |
2007 |
| Journal: |
FEBS Lett |
| Title: |
RNA recognition mechanism of eukaryote tRNA (m7G46) methyltransferase (Trm8-Trm82 complex). |
| Volume: |
581 |
| Issue: |
8 |
| Pages: |
1599-604 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marquardt A |
| Year: |
2000 |
| Journal: |
Genomics |
| Title: |
cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. |
| Volume: |
66 |
| Issue: |
2 |
| Pages: |
175-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dan Y |
| Year: |
2008 |
| Journal: |
DNA Repair (Amst) |
| Title: |
Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus. |
| Volume: |
7 |
| Issue: |
9 |
| Pages: |
1437-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Risinger JI |
| Year: |
1996 |
| Journal: |
Nat Genet |
| Title: |
Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. |
| Volume: |
14 |
| Issue: |
1 |
| Pages: |
102-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jónsson ZO |
| Year: |
1998 |
| Journal: |
EMBO J |
| Title: |
Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen. |
| Volume: |
17 |
| Issue: |
8 |
| Pages: |
2412-25 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
107
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cooper PR |
| Year: |
1998 |
| Journal: |
Genomics |
| Title: |
Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes. |
| Volume: |
49 |
| Issue: |
3 |
| Pages: |
419-29 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
413
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
426
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
456
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
120
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Alexandrov A |
| Year: |
2002 |
| Journal: |
RNA |
| Title: |
Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. |
| Volume: |
8 |
| Issue: |
10 |
| Pages: |
1253-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shanghai Model Organisms Center |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|