| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:3690856 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2006-12-18 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603926 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:3691190 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
E18.5 |
| Detected: |
true |
| Specimen Num: |
12 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1706828 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6692441 |
| Age: |
postnatal adult |
| Image: |
JAX_1305960 |
|
| Specimen Label: |
JAX_1305960 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3690859 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2006-12-14 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1752323 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:3690904 |
| Age: |
embryonic day 15.0 |
|
|
| Specimen Label: |
4H |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1803007 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1752323 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4824828 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002482_13 |
|
| Specimen Label: |
euxassay_002482_13 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1803007 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1752323 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4824828 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002482_14 |
|
| Specimen Label: |
euxassay_002482_14 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1803007 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1752323 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4824828 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002482_15 |
|
| Specimen Label: |
euxassay_002482_15 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1803007 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1752323 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4824828 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002482_16 |
|
| Specimen Label: |
euxassay_002482_16 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1803007 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1752323 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4824828 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002482_17 |
|
| Specimen Label: |
euxassay_002482_17 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1803007 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1752323 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4824828 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002482_18 |
|
| Specimen Label: |
euxassay_002482_18 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3690859 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2006-12-14 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684620 |
| Pattern: |
Non-Uniform |
| Stage: |
TS20 |
| Assay Id: |
MGI:3690904 |
| Age: |
embryonic day 12.0 |
|
| Note: |
Expression was particularly strong in large multinucleated cells, most likely representing megakaryocytes. |
| Specimen Label: |
4B |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3690859 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2006-12-14 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684621 |
| Pattern: |
Non-Uniform |
| Stage: |
TS21 |
| Assay Id: |
MGI:3690904 |
| Age: |
embryonic day 13.0 |
|
| Note: |
Expression was particularly strong in large multinucleated cells, most likely representing megakaryocytes. |
| Specimen Label: |
4D |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3690859 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2006-12-14 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684623 |
| Pattern: |
Non-Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:3690904 |
| Age: |
embryonic day 15.0 |
|
| Note: |
Expression was particularly strong in large multinucleated cells, most likely representing megakaryocytes. |
| Specimen Label: |
4F |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3690865 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2006-12-14 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684622 |
| Pattern: |
Non-Uniform |
| Stage: |
TS22 |
| Assay Id: |
MGI:3690912 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Expression was detected in the liver with particularly high signals in megakaryocytes. |
| Specimen Label: |
5E, 5E' |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1797228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6692441 |
| Age: |
postnatal adult |
| Image: |
JAX_1305961 |
|
| Specimen Label: |
JAX_1305961 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1803007 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-01-24 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3266022 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:7576142 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
Supplementary table 2 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1803007 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-01-24 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754722 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:7576142 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
Supplementary table 2 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1803007 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-01-24 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3518622 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:7576142 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
Supplementary table 2 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1881228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6692441 |
| Age: |
postnatal adult |
| Image: |
JAX_1305959 |
|
| Specimen Label: |
JAX_1305959 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
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Proc Natl Acad Sci U S A |
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Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
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| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
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•
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Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
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2014 |
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Database Release |
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Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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Carninci P |
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2005 |
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Science |
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The transcriptional landscape of the mammalian genome. |
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309 |
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5740 |
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1559-63 |
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Adams DJ |
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2024 |
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Nature |
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Genetic determinants of micronucleus formation in vivo. |
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627 |
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8002 |
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130-136 |
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MGD Nomenclature Committee |
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1995 |
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Nomenclature Committee Use |
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GemPharmatech |
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2020 |
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Skarnes WC |
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2011 |
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Nature |
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A conditional knockout resource for the genome-wide study of mouse gene function. |
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474 |
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AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
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2011 |
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| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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| First Author: |
UniProt-GOA |
| Year: |
2012 |
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| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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The Jackson Laboratory Mouse Radiation Hybrid Database |
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2004 |
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Database Release |
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Mouse T31 Radiation Hybrid Data Load |
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Okazaki Y |
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2002 |
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Nature |
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
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420 |
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6915 |
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563-73 |
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The Gene Ontology Consortium |
| Year: |
2010 |
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| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Diez-Roux G |
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2011 |
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PLoS Biol |
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
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e1000582 |
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Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
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| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
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Database Download |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
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2010 |
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| Title: |
Annotation inferences using phylogenetic trees |
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Mouse Genome Database and National Center for Biotechnology Information |
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2000 |
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Database Release |
| Title: |
Entrez Gene Load |
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Allen Institute for Brain Science |
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2004 |
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Allen Institute |
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Allen Brain Atlas: mouse riboprobes |
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Mouse Genome Informatics Scientific Curators |
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2009 |
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Database Download |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
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Database Download |
| Title: |
Consensus CDS project |
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Mouse Genome Informatics Group |
| Year: |
2003 |
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Database Procedure |
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Automatic Encodes (AutoE) Reference |
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Bairoch A |
| Year: |
1999 |
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Database Release |
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SWISS-PROT Annotated protein sequence database |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
•
•
•
|
| Allele |
| Name: |
fermitin family member 3; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
RAS, guanyl releasing protein 2; targeted mutation 1, Ann M Graybiel |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
fermitin family member 3; targeted mutation 1, Reinhard Fassler |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Rasgrp2/Rasgrp2 |
| Background: |
Not Specified |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Fermt3/Fermt3 |
| Background: |
involves: 129S1/Sv * 129X1/SvJ |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Allele |
| Name: |
integrin beta 2; targeted mutation 1.1, TaconicArtemis |
| Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
fermitin family member 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Savinko TS |
| Year: |
2015 |
| Journal: |
J Invest Dermatol |
| Title: |
Functional Beta2-Integrins Restrict Skin Inflammation In Vivo. |
| Volume: |
135 |
| Issue: |
9 |
| Pages: |
2249-2257 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meakin PJ |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
Mice Lacking beta2-Integrin Function Remain Glucose Tolerant in Spite of Insulin Resistance, Neutrophil Infiltration and Inflammation. |
| Volume: |
10 |
| Issue: |
9 |
| Pages: |
e0138872 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Harjunpää H |
| Year: |
2024 |
| Journal: |
J Immunol |
| Title: |
β2-Integrins Regulate Microglial Responses and the Functional Outcome of Hemorrhagic Stroke In Vivo. |
| Volume: |
213 |
| Issue: |
4 |
| Pages: |
519-525 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Itgb2/Itgb2 |
| Background: |
involves: C57BL/6NTac |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Weinstein EJ |
| Year: |
2003 |
| Journal: |
Biochim Biophys Acta |
| Title: |
URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas. |
| Volume: |
1637 |
| Issue: |
3 |
| Pages: |
207-16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu J |
| Year: |
2011 |
| Journal: |
J Biol Chem |
| Title: |
Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation. |
| Volume: |
286 |
| Issue: |
50 |
| Pages: |
43334-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rozario T |
| Year: |
2014 |
| Journal: |
Mech Dev |
| Title: |
Diverse functions of kindlin/fermitin proteins during embryonic development in Xenopus laevis. |
| Volume: |
133 |
|
| Pages: |
203-17 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Canning CA |
| Year: |
2011 |
| Journal: |
Dev Dyn |
| Title: |
Developmental expression of the fermitin/kindlin gene family in Xenopus laevis embryos. |
| Volume: |
240 |
| Issue: |
8 |
| Pages: |
1958-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ye F |
| Year: |
2014 |
| Journal: |
Front Med |
| Title: |
Talin and kindlin: the one-two punch in integrin activation. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
6-16 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
266
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
93
 |
| Fragment?: |
true |
|
•
•
•
•
•
|