| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:3812175 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2008-10-28 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:3525728 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3812194 |
| Age: |
postnatal week 12-15 |
|
|
| Specimen Label: |
1F KO |
| Detected: |
false |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3812175 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2008-10-28 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:3525728 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:3812194 |
| Age: |
postnatal week 12-15 |
|
| Note: |
Expression is present in GABA-ergic inhibitory neurons. |
| Specimen Label: |
1F WT |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3812175 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2008-10-28 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:1909528 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3812194 |
| Age: |
postnatal week 12-15 |
|
|
| Specimen Label: |
1G KO |
| Detected: |
false |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3812175 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2008-10-28 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1909528 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:3812194 |
| Age: |
postnatal week 12-15 |
|
| Note: |
Expression is present in GABA-ergic inhibitory neurons. |
| Specimen Label: |
1G WT |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3812175 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2008-10-28 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:3276828 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3812194 |
| Age: |
postnatal week 12-15 |
|
|
| Specimen Label: |
1E KO |
| Detected: |
false |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3812175 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2008-10-28 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:3276828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:3812194 |
| Age: |
postnatal week 12-15 |
|
| Note: |
Expression is present in GABA-ergic inhibitory neurons. |
| Specimen Label: |
1E WT |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3812175 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2008-10-28 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:3278928 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:3812194 |
| Age: |
postnatal week 12-15 |
|
| Note: |
There is no expression in dopaminergic axon fibers projecting to the nucleus accumbens (although there is expression in GABA-ergic inhibitory neurons). |
| Specimen Label: |
1I WT lower |
| Detected: |
true |
| Specimen Num: |
12 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3812175 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2008-10-28 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:3278928 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3812194 |
| Age: |
postnatal week 12-15 |
|
|
| Specimen Label: |
1H KO |
| Detected: |
false |
| Specimen Num: |
10 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3812175 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2008-10-28 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:3278928 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:3812194 |
| Age: |
postnatal week 12-15 |
|
| Note: |
Expression is present in GABA-ergic inhibitory neurons. |
| Specimen Label: |
1H WT |
| Detected: |
true |
| Specimen Num: |
9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6514419 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2021-04-02 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689617 |
| Pattern: |
Regionally restricted |
| Stage: |
TS17 |
| Assay Id: |
MGI:6514720 |
| Age: |
embryonic day 10.5 |
|
| Note: |
Expression was detected in the developing hypothalamus. |
| Specimen Label: |
6B |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6514419 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2021-04-02 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689617 |
| Pattern: |
Regionally restricted |
| Stage: |
TS17 |
| Assay Id: |
MGI:6514720 |
| Age: |
embryonic day 10.5 |
|
| Note: |
Expression was detected in the developing hypothalamus. |
| Specimen Label: |
6D |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3812175 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2008-10-28 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:3277028 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3812194 |
| Age: |
postnatal week 12-15 |
|
|
| Specimen Label: |
1C KO |
| Detected: |
false |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3812175 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2008-10-28 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:3277028 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:3812194 |
| Age: |
postnatal week 12-15 |
|
| Note: |
Expression is present in axon bundles that form the mossy fiber pathway. |
| Specimen Label: |
1C WT |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3812175 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2008-10-28 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:3583628 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3812194 |
| Age: |
postnatal week 12-15 |
|
| Note: |
There is no expression in the somata of dopaminergic neurons. |
| Specimen Label: |
1I WT upper |
| Detected: |
false |
| Specimen Num: |
11 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3812175 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2008-10-28 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:3527628 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3812194 |
| Age: |
postnatal week 12-15 |
|
|
| Specimen Label: |
1C KO |
| Detected: |
false |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3812175 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2008-10-28 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:3527628 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:3812194 |
| Age: |
postnatal week 12-15 |
|
| Note: |
Expression is present in axon bundles that form the mossy fiber pathway. |
| Specimen Label: |
1C WT |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3812175 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2008-10-28 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:3525628 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3812194 |
| Age: |
postnatal week 12-15 |
|
|
| Specimen Label: |
1F KO |
| Detected: |
false |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3812175 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2008-10-28 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:3525628 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:3812194 |
| Age: |
postnatal week 12-15 |
|
| Note: |
Expression is present in GABA-ergic inhibitory neurons. |
| Specimen Label: |
1F WT |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gobé C |
| Year: |
2019 |
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PLoS Genet |
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Dual role of DMXL2 in olfactory information transmission and the first wave of spermatogenesis. |
| Volume: |
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e1007909 |
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•
•
•
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Mouse Genome Informatics Scientific Curators |
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2002 |
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MGC Data curation in Mouse Genome Informatics |
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•
•
•
•
•
|
| Publication |
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Mouse Genome Informatics Scientific Curators |
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2003 |
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Data Curation Using Mouse Genome Assembly |
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•
•
•
•
•
|
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2014 |
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A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
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•
•
•
•
•
|
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Wellcome Trust Sanger Institute |
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2010 |
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MGI Direct Data Submission |
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Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
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•
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•
•
•
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2008 |
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Genome Res |
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Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
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•
•
•
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The Gene Ontology Consortium |
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2014 |
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Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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•
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•
•
•
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UniProt-GOA |
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2012 |
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| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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•
•
•
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| Publication |
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Magdaleno S |
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2006 |
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PLoS Biol |
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BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
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•
•
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Mouse Genome Informatics Scientific Curators |
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2002 |
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Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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Carninci P |
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Science |
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The transcriptional landscape of the mammalian genome. |
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MGD Nomenclature Committee |
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Nomenclature Committee Use |
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•
•
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2003 |
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Proc Natl Acad Sci U S A |
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
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•
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Skarnes WC |
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2011 |
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Nature |
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A conditional knockout resource for the genome-wide study of mouse gene function. |
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Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
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Mouse Gene Trap Data Load from dbGSS |
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Mouse Genome Informatics Scientific Curators |
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Database Download |
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Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
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2010 |
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Database Download |
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Mouse Genome Informatics Group |
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| Year: |
1999 |
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Database Release |
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Mouse Genome Informatics Scientific Curators |
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| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
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•
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Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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| First Author: |
Okumura F |
| Year: |
2004 |
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J Biol Chem |
| Title: |
Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. |
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51 |
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53533-43 |
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•
•
•
•
•
|
| Publication |
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Ishii H |
| Year: |
1999 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. |
| Volume: |
96 |
| Issue: |
7 |
| Pages: |
3928-33 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
599
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Dendrite Development Regulated by the Schizophrenia-Associated Gene FEZ1 Involves the Ubiquitin Proteasome System. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Boguski MS |
| Year: |
1993 |
| Journal: |
Nat Genet |
| Title: |
dbEST--database for "expressed sequence tags". |
| Volume: |
4 |
| Issue: |
4 |
| Pages: |
332-3 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
The first member of the FEZ (fasciculation and elongation protein zeta) family identified was unc-76, from C. elegans. The protein is necessary for normal axon fasciculation and is required for axon-axon interactions []. Later, two human homologues, FEZ1 and FEZ2, were identified []. FEZ1 and FEZ2 interact with PKCzeta and have been shown to induce neurite extension of PC12 cells when co-expressed with a constitutively active mutant of PKCzeta []. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
125
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
47
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
35
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McKnight NC |
| Year: |
2012 |
| Journal: |
EMBO J |
| Title: |
Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. |
| Volume: |
31 |
| Issue: |
8 |
| Pages: |
1931-46 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents short coiled-coil protein (SCOC). In human, SCOC is required for autophagosome formation during amino acid starvation. It forms a starvation-sensitive trimeric complex with UVRAG (UV radiation resistance associated gene) and FEZ1 and may regulate ULK1 and Beclin 1 complex activities []. |
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•
•
•
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
392
 |
| Fragment?: |
false |
|
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•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
348
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
348
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
322
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
78
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
331
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
375
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
123
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
373
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
169
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
91
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
53
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
167
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
47
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
345
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bloom L |
| Year: |
1997 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. |
| Volume: |
94 |
| Issue: |
7 |
| Pages: |
3414-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ren J |
| Year: |
2016 |
| Journal: |
Brain Res |
| Title: |
Interaction between DISC1 and CHL1 in regulation of neurite outgrowth. |
| Volume: |
1648 |
| Issue: |
Pt A |
| Pages: |
290-297 |
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