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Search results 101 to 125 out of 125 for Fkbp6

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Type

Details

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HT Experiment

E-GEOD-39203 | A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing

Series Id:	GSE39203
Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	ArrayExpress

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Publication

23284302 | -

First Author:	Raudsepp T
Year:	2012
Journal:	PLoS Genet
Title:	Genome-wide association study implicates testis-sperm specific FKBP6 as a susceptibility locus for impaired acrosome reaction in stallions.
Volume:	8
Issue:	12
Pages:	e1003139

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GXD Expression

Probe:	MGI:5471969
Assay Type:	Immunohistochemistry
Annotation Date:	2013-04-04
Strength:	Present
Sex:	Male
Emaps:	EMAPS:1797526
Pattern:	Regionally restricted
Stage:	TS26
Assay Id:	MGI:5471982
Age:	embryonic day 18.5

Note:	Authors report a reduced nuclear accumulation in Fkbp6 mutant male germ cells.
Specimen Label:	2J Fkbp6-/- Miwi2
Detected:	true
Specimen Num:	2

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Allele

Fkbp6<em1Smoc> | MGI:7289706

Name:	FK506 binding protein 6; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Null/knockout

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Strain

MGI:6475289 | C57BL/6JSmoc-Fkbp6<em1Smoc>/Smoc

Attribute String:

coisogenic, endonuclease-mediated mutation, mutant strain

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DO Term

DOID:0070576 | spermatogenic failure 77

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Protein

Q61576

Organism:	Mus musculus/domesticus
Length:	581
Fragment?:	false

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Allele

Del(5Limk1-Trim50)2Uta | MGI:5317121

Name:	deletion, Chr 5, Uta Francke 2
Allele Type:	Targeted
Attribute String:	Null/knockout

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Publication

10978289 | -

First Author:	Munn K
Year:	2000
Journal:	Genetics
Title:	The shut-down gene of Drosophila melanogaster encodes a novel FK506-binding protein essential for the formation of germline cysts during oogenesis.
Volume:	156
Issue:	1
Pages:	245-56

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Publication

22753781 | -

First Author:	Preall JB
Year:	2012
Journal:	RNA
Title:	shutdown is a component of the Drosophila piRNA biogenesis machinery.
Volume:	18
Issue:	8
Pages:	1446-57

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Protein Domain

IPR042282 | FKBP6/shu

Type:

Family

Description:

This entry includes FKBP6 from mammals and protein shutdown (shu) from flies. FKBP6 is a testis-sperm specific protein that belongs to the immunophilins FKBP family known to be involved in meiosis, calcium homeostasis, clathrin-coated vesicles, and membrane fusions []. FKBP6 contains a PPIase FKBP-type domain and a TPR domain. However, it is inactive as an isomerase and associates with Hsp90 via its TPR domain []. Protein shutdown is essential for the formation of germline cysts during oogenesis []and is a component of the Drosophila piRNA biogenesis machinery [].

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Protein Coding Gene

MGI:104769 | Fkbp10

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Strain

MGI:5516339 | B6;129S7-Del(5Limk1-Trim50)2Uta/J

Attribute String:

targeted mutation, deletion, mutant stock

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Genotype

Symbol:	Del(5Limk1-Trim50)2Uta/+
Background:	involves: 129S7/SvEvBrd * C57BL/6J
Zygosity:	ht
Has Mutant Allele:	true

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Genotype

Symbol:	Del(5Gtf2i-Limk1)1Uta/? Del(5Limk1-Trim50)2Uta/?
Background:	involves: 129S7/SvEvBrd * C57BL/6J
Zygosity:	cx
Has Mutant Allele:	true

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Publication

20926892 | J:182794

First Author:	Goergen CJ
Year:	2011
Journal:	J Vasc Res
Title:	Induced chromosome deletion in a Williams-Beuren syndrome mouse model causes cardiovascular abnormalities.
Volume:	48
Issue:	2
Pages:	119-29

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Publication

22319452 | J:181479

First Author:	Campuzano V
Year:	2012
Journal:	PLoS Genet
Title:	Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome.
Volume:	8
Issue:	2
Pages:	e1002458

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HT Experiment

E-GEOD-54515 | Small RNA analysis for fetal testes of Hsp90-alpha knockout mice

Series Id:	GSE54515
Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	ArrayExpress

•

Publication

25262350 | J:356915

First Author:	Ichiyanagi T
Year:	2014
Journal:	Nucleic Acids Res
Title:	HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse.
Volume:	42
Issue:	19
Pages:	11903-11

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Publication

20049703 | J:182796

First Author:	Li HH
Year:	2009
Journal:	EMBO Mol Med
Title:	Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice.
Volume:	1
Issue:	1
Pages:	50-65

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Publication

36152627 | J:334324

First Author:	Davenport CM
Year:	2022
Journal:	Cell
Title:	Innate frequency-discrimination hyperacuity in Williams-Beuren syndrome mice.
Volume:	185
Issue:	21
Pages:	3877-3895.e21

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Publication

16141072 | J:99680

First Author:	Carninci P
Year:	2005
Journal:	Science
Title:	The transcriptional landscape of the mammalian genome.
Volume:	309
Issue:	5740
Pages:	1559-63

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

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Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

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