| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1683322 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1700022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1832122 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1876522 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Expression was not detected in the immune system. |
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1741222 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3599822 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3280922 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1833322 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3287022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1752522 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1821522 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3557722 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1702122 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1756322 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1668822 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757722 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757522 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1738322 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1802422 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1768022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Expression was not detected in the skull (base and vault). |
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4427321 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2672022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422376 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Expression was not detected in whisker follicle. |
| Specimen Label: |
EB3439; Specimen B1092 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hernandez D |
| Year: |
2002 |
| Journal: |
GenBank Submission |
| Title: |
Mus musculus flavin-containing monooxygenase 4 mRNA, complete cds |
|
|
| Pages: |
AF461145 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hernandez D |
| Year: |
2009 |
| Journal: |
Pharmacogenet Genomics |
| Title: |
Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine. |
| Volume: |
19 |
| Issue: |
4 |
| Pages: |
289-99 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Veeravalli S |
| Year: |
2014 |
| Journal: |
Biochem Pharmacol |
| Title: |
The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance. |
| Volume: |
90 |
| Issue: |
1 |
| Pages: |
88-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Veeravalli S |
| Year: |
2020 |
| Journal: |
Drug Metab Dispos |
| Title: |
Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine. |
| Volume: |
48 |
| Issue: |
5 |
| Pages: |
378-385 |
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•
•
•
•
•
|
| Publication |
| First Author: |
GO Central curators, GOA curators, Rhea curators |
| Year: |
2020 |
|
| Title: |
Automatic Gene Ontology annotation based on Rhea mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators, MGI curators |
| Year: |
2001 |
|
| Title: |
Gene Ontology annotation based on Enzyme Commission mapping |
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|
|
|
•
•
•
•
•
|
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Mouse Genome Informatics Scientific Curators |
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2002 |
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Function or Process or Component Unknown following Literature Review |
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•
•
•
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Visel A |
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2004 |
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Nucleic Acids Res |
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GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
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Database issue |
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•
•
•
•
•
|
| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2010 |
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MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
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•
•
•
•
•
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| First Author: |
Helmholtz Zentrum Muenchen GmbH |
| Year: |
2010 |
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MGI Direct Data Submission |
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Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
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•
•
•
•
•
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| First Author: |
UniProt-GOA |
| Year: |
2012 |
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| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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DDB, FB, MGI, GOA, ZFIN curators |
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2001 |
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| Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
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Mouse Genome Informatics Scientific Curators |
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2002 |
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| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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Proc Natl Acad Sci U S A |
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Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
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Mouse Gene Trap Data Load from dbGSS |
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•
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•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Flavin-containing monooxygenases (FMOs) constitute a family of xenobiotic-metabolising enzymes []. Using an NADPH cofactor and FAD prosthetic group,these microsomal proteins catalyse the oxygenation of nucleophilic nitrogen,sulphur, phosphorous and selenium atoms in a range of structurally diversecompounds. Five mammalian forms of FMO are now known and have been designatedFMO1-FMO5 [, , , , ].FMO4 mRNA is present in low abundance in several foetal and adult tissuesand the corresponding gene thus appears to be expressed constitutively [].Sequence analysis reveals that FMO4 is 56% identical to FMO3; each isencoded by a single gene []. The deduced amino acid sequence of human FM04 includes the putative FAD- (GxGxxG) and NADP+pyrophosphate-binding (GxGxxA)sites characteristic of mammalian FMOs, a 'FATGY' motif that has also beenobserved in a range of siderphore biosynthetic enzymes [], and a C-terminalhydrophobic segment that is believed to anchor the monooxygenase to themicrosomal membrane []. |
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| Publication |
| First Author: |
Itoh K |
| Year: |
1997 |
| Journal: |
J Toxicol Sci |
| Title: |
Molecular cloning of mouse liver flavin containing monooxygenase (FMO1) cDNA and characterization of the expression product: metabolism of the neurotoxin, 1,2,3,4-tetrahydroisoquinoline (TIQ). |
| Volume: |
22 |
| Issue: |
1 |
| Pages: |
45-56 |
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| Publication |
| First Author: |
Dolphin CT |
| Year: |
1996 |
| Journal: |
Eur J Biochem |
| Title: |
Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FM04. |
| Volume: |
235 |
| Issue: |
3 |
| Pages: |
683-9 |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
560
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| Fragment?: |
false |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
99
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| Fragment?: |
true |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
560
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| Fragment?: |
false |
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| Publication |
| First Author: |
Ozols J |
| Year: |
1990 |
| Journal: |
J Biol Chem |
| Title: |
Covalent structure of liver microsomal flavin-containing monooxygenase form 1. |
| Volume: |
265 |
| Issue: |
18 |
| Pages: |
10289-99 |
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| Publication |
| First Author: |
Stehr M |
| Year: |
1998 |
| Journal: |
Trends Biochem Sci |
| Title: |
A hydrophobic sequence motif common to N-hydroxylating enzymes. |
| Volume: |
23 |
| Issue: |
2 |
| Pages: |
56-7 |
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| Publication |
| First Author: |
Lawton MP |
| Year: |
1994 |
| Journal: |
Arch Biochem Biophys |
| Title: |
A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities. |
| Volume: |
308 |
| Issue: |
1 |
| Pages: |
254-7 |
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| Publication |
| First Author: |
Dolphin CT |
| Year: |
1992 |
| Journal: |
Biochem J |
| Title: |
Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family. |
| Volume: |
287 ( Pt 1) |
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| Pages: |
261-7 |
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| Publication |
| First Author: |
Lawton MP |
| Year: |
1990 |
| Journal: |
J Biol Chem |
| Title: |
The flavin-containing monooxygenase enzymes expressed in rabbit liver and lung are products of related but distinctly different genes. |
| Volume: |
265 |
| Issue: |
10 |
| Pages: |
5855-61 |
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| Publication |
| First Author: |
Dolphin C |
| Year: |
1991 |
| Journal: |
J Biol Chem |
| Title: |
Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1). |
| Volume: |
266 |
| Issue: |
19 |
| Pages: |
12379-85 |
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| Publication |
| First Author: |
Atta-Asafo-Adjei E |
| Year: |
1993 |
| Journal: |
J Biol Chem |
| Title: |
Cloning, sequencing, distribution, and expression in Escherichia coli of flavin-containing monooxygenase 1C1. Evidence for a third gene subfamily in rabbits. |
| Volume: |
268 |
| Issue: |
13 |
| Pages: |
9681-9 |
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| Publication |
| First Author: |
Lomri N |
| Year: |
1992 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver. |
| Volume: |
89 |
| Issue: |
5 |
| Pages: |
1685-9 |
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