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Search results 101 to 200 out of 200 for Fndc5

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0.016s
Type Details Score
GXD Expression    
Probe: MGI:6885829
Assay Type: RT-PCR
Annotation Date: 2022-03-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3278228
Stage: TS28
Assay Id: MGI:6886069
Age: postnatal adult
Image: S1
Specimen Label: CMV;IRS
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:6885829
Assay Type: RT-PCR
Annotation Date: 2022-03-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273028
Stage: TS28
Assay Id: MGI:6886070
Age: postnatal adult
Image: S1
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6885829
Assay Type: RT-PCR
Annotation Date: 2022-03-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273028
Stage: TS28
Assay Id: MGI:6886070
Age: postnatal adult
Image: S1
Specimen Label: IRS
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6885829
Assay Type: RT-PCR
Annotation Date: 2022-03-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273028
Stage: TS28
Assay Id: MGI:6886070
Age: postnatal adult
Image: S1
Specimen Label: CMVIRS<-/->
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6885829
Assay Type: RT-PCR
Annotation Date: 2022-03-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3273028
Stage: TS28
Assay Id: MGI:6886070
Age: postnatal adult
Image: S1
Specimen Label: CMV;IRS
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:6885829
Assay Type: RT-PCR
Annotation Date: 2022-03-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3290628
Stage: TS28
Assay Id: MGI:6886071
Age: postnatal adult
Image: S1
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6885829
Assay Type: RT-PCR
Annotation Date: 2022-03-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3290628
Stage: TS28
Assay Id: MGI:6886071
Age: postnatal adult
Image: S1
Specimen Label: IRS
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6885829
Assay Type: RT-PCR
Annotation Date: 2022-03-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3290628
Stage: TS28
Assay Id: MGI:6886071
Age: postnatal adult
Image: S1
Specimen Label: CMVIRS<-/->
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6885829
Assay Type: RT-PCR
Annotation Date: 2022-03-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3290628
Stage: TS28
Assay Id: MGI:6886071
Age: postnatal adult
Image: S1
Specimen Label: CMV;IRS
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:6885829
Assay Type: RT-PCR
Annotation Date: 2022-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271528
Stage: TS28
Assay Id: MGI:6886232
Age: postnatal adult
Image: S1
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6885829
Assay Type: RT-PCR
Annotation Date: 2022-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271528
Stage: TS28
Assay Id: MGI:6886232
Age: postnatal adult
Image: S1
Specimen Label: IRS
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6885829
Assay Type: RT-PCR
Annotation Date: 2022-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271528
Stage: TS28
Assay Id: MGI:6886232
Age: postnatal adult
Image: S1
Specimen Label: CMVIRS<-/->
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6885829
Assay Type: RT-PCR
Annotation Date: 2022-03-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3271528
Stage: TS28
Assay Id: MGI:6886232
Age: postnatal adult
Image: S1
Specimen Label: CMV;IRS
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:5472005
Assay Type: RNA in situ
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5473323
Age: embryonic day 10.5
Specimen Label: E10.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5472005
Assay Type: RNA in situ
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689519
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:5473323
Age: embryonic day 11.5
Specimen Label: E11.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5472005
Assay Type: RNA in situ
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5473323
Age: embryonic day 10.5
Specimen Label: E10.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5472005
Assay Type: RNA in situ
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:5473323
Age: embryonic day 11.5
Specimen Label: E11.5
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3586600
Assay Type: RNA in situ
Annotation Date: 2005-09-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1774821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3586607
Age: embryonic day 13.5
Image: 6A
Specimen Label: 6A
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3586600
Assay Type: RNA in situ
Annotation Date: 2005-09-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1774821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3586607
Age: embryonic day 13.5
Image: 6B
Specimen Label: 6B
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3586600
Assay Type: RNA in situ
Annotation Date: 2005-09-01
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1770121
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3586607
Age: embryonic day 13.5
Image: 6A
Specimen Label: 6A
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3586600
Assay Type: RNA in situ
Annotation Date: 2005-09-01
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1770121
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3586607
Age: embryonic day 13.5
Image: 6B
Specimen Label: 6B
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6885828
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3514927
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6885830
Age: postnatal day 1
Image: 1A D1
Note: Expression was detected throughout all zones of the cartilage.
Specimen Label: 1A D1
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:6885828
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3514928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6885830
Age: postnatal day 4
Image: 1A D4
Note: Expression was detected throughout all zones of the cartilage.
Specimen Label: 1A D4
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:6885828
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3514928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6885830
Age: postnatal day 7
Image: 1A D7
Note: Expression was mainly in the superficial zone and less in the middle zone.
Specimen Label: 1A D7
Detected: true
Specimen Num: 5
GXD Expression
Probe: MGI:6885828
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3514928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6885830
Age: postnatal day 28
Image: 1A D28
Note: Expression was mainly in the superficial zone and less in the middle zone.
Specimen Label: 1A D28
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:5472005
Assay Type: RNA in situ
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5473323
Age: embryonic day 9.5
Specimen Label: E9.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3586600
Assay Type: RNA in situ
Annotation Date: 2005-09-01
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1774521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3586607
Age: embryonic day 13.5
Image: 6A
Specimen Label: 6A
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3586600
Assay Type: RNA in situ
Annotation Date: 2005-09-01
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1774521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3586607
Age: embryonic day 13.5
Image: 6B
Specimen Label: 6B
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:3586600
Assay Type: RNA in situ
Annotation Date: 2005-09-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3185821
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:3586607
Age: embryonic day 13.5
Image: 6A
Note: Expression is in the head muscles.
Specimen Label: 6A
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5472005
Assay Type: RNA in situ
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5473323
Age: embryonic day 9.5
Specimen Label: E9.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3586600
Assay Type: RNA in situ
Annotation Date: 2005-09-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1718521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3586607
Age: embryonic day 13.5
Image: 6A
Specimen Label: 6A
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3586600
Assay Type: RNA in situ
Annotation Date: 2005-09-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1718521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3586607
Age: embryonic day 13.5
Image: 6B
Specimen Label: 6B
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4424620
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1788323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824893
Age: embryonic day 14.5
Image: euxassay_011781_10
Specimen Label: euxassay_011781_10
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4424620
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1788323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824893
Age: embryonic day 14.5
Image: euxassay_011781_11
Specimen Label: euxassay_011781_11
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4424620
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1788323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824893
Age: embryonic day 14.5
Image: euxassay_011781_12
Specimen Label: euxassay_011781_12
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3586600
Assay Type: RNA in situ
Annotation Date: 2005-09-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3270021
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3586607
Age: embryonic day 13.5
Image: 6A
Specimen Label: 6A
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3586600
Assay Type: RNA in situ
Annotation Date: 2005-09-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3270021
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3586607
Age: embryonic day 13.5
Image: 6B
Specimen Label: 6B
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5472005
Assay Type: RNA in situ
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611715
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5473323
Age: embryonic day 9.5
Specimen Label: E9.5
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:6885828
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6885830
Age: embryonic day 14.5
Image: 1A E14.5
Note: Expression was prominent in the prehypertrophic and hypertrophic zones of growth plate cartilage. Expression was absent in the proliferating and resting zones.
Specimen Label: 1A E14.5
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:6885828
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270124
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:6885830
Age: embryonic day 16.5
Image: 1A E16.5
Note: Expression was prominent in the prehypertrophic and hypertrophic zones of growth plate cartilage. Expression was absent in the proliferating and resting zones.
Specimen Label: 1A E16.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3586600
Assay Type: RNA in situ
Annotation Date: 2005-09-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3586607
Age: embryonic day 13.5
Image: 6A
Specimen Label: 6A
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3586600
Assay Type: RNA in situ
Annotation Date: 2005-09-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3586607
Age: embryonic day 13.5
Image: 6B
Specimen Label: 6B
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:3586600
Assay Type: RNA in situ
Annotation Date: 2005-09-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1609821
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:3586607
Age: embryonic day 13.5
Image: 6B
Note: Expression is in the head muscles.
Specimen Label: 6B
Detected: true
Specimen Num: 2
Publication
First Author: Teufel A
Year: 2002
Journal: Gene
Title: Frcp1 and Frcp2, two novel fibronectin type III repeat containing genes.
Volume: 297
Issue: 1-2
Pages: 79-83
Publication
First Author: Lee J
Year: 2019
Journal: PLoS One
Title: Irisin promotes C2C12 myoblast proliferation via ERK-dependent CCL7 upregulation.
Volume: 14
Issue: 9
Pages: e0222559
Publication
First Author: Shan T
Year: 2013
Journal: FASEB J
Title: Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle.
Volume: 27
Issue: 5
Pages: 1981-9
Publication
First Author: Kuninger D
Year: 2004
Journal: Genomics
Title: Gene discovery by microarray: identification of novel genes induced during growth factor-mediated muscle cell survival and differentiation.
Volume: 84
Issue: 5
Pages: 876-89
Publication
First Author: Suzuki H
Year: 2001
Journal: Genome Res
Title: Protein-protein interaction panel using mouse full-length cDNAs.
Volume: 11
Issue: 10
Pages: 1758-65
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication      
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
Publication        
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Xiong XQ
Year: 2015
Journal: Biochim Biophys Acta
Title: FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity.
Volume: 1852
Issue: 9
Pages: 1867-75
Publication  
First Author: Xia DY
Year: 2017
Journal: Front Aging Neurosci
Title: PGC-1α or FNDC5 Is Involved in Modulating the Effects of Aβ1-42 Oligomers on Suppressing the Expression of BDNF, a Beneficial Factor for Inhibiting Neuronal Apoptosis, Aβ Deposition and Cognitive Decline of APP/PS1 Tg Mice.
Volume: 9
Pages: 65
Allele
Name: fibronectin type III domain containing 5; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Allele
Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Jake J Chen
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
Publication
First Author: Schumacher MA
Year: 2013
Journal: J Biol Chem
Title: The structure of irisin reveals a novel intersubunit β-sheet fibronectin type III (FNIII) dimer: implications for receptor activation.
Volume: 288
Issue: 47
Pages: 33738-44
Publication
First Author: Elsen M
Year: 2014
Journal: J Endocrinol
Title: Browning of white fat: does irisin play a role in humans?
Volume: 222
Issue: 1
Pages: R25-38
Publication  
First Author: Kristóf E
Year: 2015
Journal: Sci Rep
Title: Laser-scanning cytometry can quantify human adipocyte browning and proves effectiveness of irisin.
Volume: 5
Pages: 12540
Protein Domain
Type: Domain
Description: This domain is found in fibronectin type III domain-containing protein 5 (FNDC5). FNDC5 is cleaved into Irisin, a putative myokin that stimulates white-to-brown fat conversion in mice [], though this role is disputed in humans [, ]. This domain is found C-terminal to the irisin domain [].
Allele
Name: fibronectin type III domain containing 5; targeted mutation 1.1, Jake J Chen
Allele Type: Targeted
Attribute String: Conditional ready
Allele
Name: fibronectin type III domain containing 5; targeted mutation 1.2, Jake J Chen
Allele Type: Targeted
Attribute String: Null/knockout
Genotype
Symbol: Fndc5/Fndc5
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Fndc5/Fndc5 Tg(CMV-cre)1Cgn/?
Background: involves: C57BL/6J
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Fndc5/Fndc5 Tg(CMV-cre)1Cgn/?
Background: involves: C57BL/6J
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Nie Y
Year: 2017
Journal: Biochem J
Title: N-Glycosylation is required for FDNC5 stabilization and irisin secretion.
Volume: 474
Issue: 18
Pages: 3167-3177
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication  
First Author: Zhang J
Year: 2017
Journal: Bone Res
Title: Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism.
Volume: 5
Pages: 16056
Publication  
First Author: Li H
Year: 2019
Journal: Front Pharmacol
Title: Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis.
Volume: 10
Pages: 548
Publication  
First Author: Hung PL
Year: 2021
Journal: Int J Mol Sci
Title: Music-Based Intervention Ameliorates Mecp2-Loss-Mediated Sociability Repression in Mice through the Prefrontal Cortex FNDC5/BDNF Pathway.
Volume: 22
Issue: 13
Protein
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false