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Search results 101 to 170 out of 170 for Fnip1

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Hits by Pathway

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Hits by Strain

Type Details Score
Protein Coding Gene
MGP_NODShiLtJ_G0027127 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027789 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026210 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026554 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026527 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0026026 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
19137017 | J:175144
First Author: Komori K
Year: 2009
Journal: Oncogene
Title: A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA.
Volume: 28
Issue: 8
Pages: 1142-50
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Publication
36316722 | J:339560
First Author: Fernández LP
Year: 2022
Journal: Genome Biol
Title: Folliculin-interacting protein FNIP2 impacts on overweight and obesity through a polymorphism in a conserved 3' untranslated region.
Volume: 23
Issue: 1
Pages: 230
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2813026
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5540606
Age: postnatal day 84
Image: GUDMAP:14841
Specimen Label: GUDMAP:14841
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3131226
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2794326
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2827826
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1794826
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3131926
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2999526
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1867626
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2824526
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2827526
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2777026
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3000326
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2824826
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3001126
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2775626
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2767826
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1867926
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1927926
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2768126
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3001926
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2825426
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2813626
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2826026
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2814226
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1897626
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2826626
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423312
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2772126
Stage: TS26
Assay Id: MGI:5540606
Age: embryonic day 17.5
Image: GUDMAP:14840
Specimen Label: GUDMAP:14840
Detected: false
Specimen Num: 1
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Protein
Q68FD7
Organism: Mus musculus/domesticus
Length: 1165  
Fragment?: false
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Protein
Q80TD3
Organism: Mus musculus/domesticus
Length: 1108  
Fragment?: false
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Protein
F6RJ64
Organism: Mus musculus/domesticus
Length: 631  
Fragment?: true
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Protein
D3YUC5
Organism: Mus musculus/domesticus
Length: 1138  
Fragment?: false
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Protein
A0A668KLU2
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: true
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Protein
A7E1X7
Organism: Mus musculus/domesticus
Length: 888  
Fragment?: true
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Publication
27617292 | J:236977
First Author: Yang M
Year: 2016
Journal: Sci Adv
Title: A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy.
Volume: 2
Issue: 9
Pages: e1601167
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Publication
27559131 | -
First Author: Amick J
Year: 2016
Journal: Mol Biol Cell
Title: C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling.
Volume: 27
Issue: 20
Pages: 3040-3051
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Protein Domain
IPR032035 | Folliculin_DENN
Type: Domain
Description: Folliculin (FLCN) is a tumor suppressor that enables nutrient-dependent activation of the mechanistic target of rapamycin complex 1 (mTORC1) protein kinase via its guanosine triphosphatase (GTPase) Activating Protein (GAP) activity. It belong to the DENN module family of proteins and contains a divergent DENN module comprised of a N-terminal longin domain (also known as upstream DENN domain, u-DENN), followed by a DENN domain. It forms a complex with its partners, FNIP1 or FNIP2 (Folliculin interacting protein 1 or 2), which directly contacts the Rag GTPases RagC/D to stimulate GTP hydrolysis and thus promote the conversion to the GDP-bound state. FLCN-FNIP2 adopts an extended conformation with two pairs of heterodimerized domains. They contain longin domains that heterodimerize and contact both nucleotide binding domains of the Rag heterodimer, and C-terminal DENN domains which interact at the distal end of the structure [, , ].This is the DENN domain found at the C-terminal of folliculin. This domain shares structural similarity with DENN domain of DENN1B (a Rab GEF). It mediates contact with the longin domain in the heterodimers to ensure a strong intersubunit interaction [, , ].
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Protein Domain
IPR037520 | Folliculin/SMCR8_longin
Type: Domain
Description: Folliculin (FLCN) is a tumor suppressor that enables nutrient-dependent activation of the mechanistic target of rapamycin complex 1 (mTORC1) protein kinase via its guanosine triphosphatase (GTPase) Activating Protein (GAP) activity. It belong to the DENN module family of proteins and contains a divergent DENN module comprised of a N-terminal longin domain (also known as upstream DENN domain, u-DENN), followed by a DENN domain. It forms a complex with its partners, FNIP1 or FNIP2 (Folliculin interacting protein 1 or 2), which directly contacts the Rag GTPases RagC/D to stimulate GTP hydrolysis and thus promote the conversion to the GDP-bound state. FLCN-FNIP2 adopts an extended conformation with two pairs of heterodimerized domains. They contain longin domains that heterodimerize and contact both nucleotide binding domains of the Rag heterodimer, and C-terminal DENN domains which interact at the distal end of the structure [, , ].This is the N-terminal domain of folliculin, the longin domain [, , ]. An arginine residue located in this domain (Arg164) is catalytic residue for GAP activity [, ]. This domain can also be found in SMCR8, a component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy [, , , , , ].
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Publication
20562859 | -
First Author: Behrends C
Year: 2010
Journal: Nature
Title: Network organization of the human autophagy system.
Volume: 466
Issue: 7302
Pages: 68-76
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Protein
Q8QZS3
Organism: Mus musculus/domesticus
Length: 579  
Fragment?: false
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Publication
31704029 | -
First Author: Shen K
Year: 2019
Journal: Cell
Title: Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex.
Volume: 179
Issue: 6
Pages: 1319-1329.e8
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Publication
31672913 | -
First Author: Lawrence RE
Year: 2019
Journal: Science
Title: Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.
Volume: 366
Issue: 6468
Pages: 971-977
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Publication
27193190 | J:240578
First Author: Sullivan PM
Year: 2016
Journal: Acta Neuropathol Commun
Title: The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway.
Volume: 4
Issue: 1
Pages: 51
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Publication
28195531 | -
   
First Author: Jung J
Year: 2017
Journal: Elife
Title: Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator.
Volume: 6
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Publication
23248642 | -
 
First Author: Zhang D
Year: 2012
Journal: Front Genet
Title: Discovery of Novel DENN Proteins: Implications for the Evolution of Eukaryotic Intracellular Membrane Structures and Human Disease.
Volume: 3
Pages: 283
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Protein
Q3UMB5
Organism: Mus musculus/domesticus
Length: 935  
Fragment?: false
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Publication
27103069 | J:233688
First Author: Sellier C
Year: 2016
Journal: EMBO J
Title: Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.
Volume: 35
Issue: 12
Pages: 1276-97
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Publication
22977732 | -
First Author: Nookala RK
Year: 2012
Journal: Open Biol
Title: Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer.
Volume: 2
Issue: 8
Pages: 120071
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Publication
- | J:104881
     
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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