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Search results 101 to 136 out of 136 for Fuz

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Type Details Score
Protein Domain
IPR043970 | FUZ/MON1/HPS1_longin_3
Type: Domain
Description: Longin domains are evolutionarily conserved regions widely distributed among eukaryotes, involved in membrane dynamic regulation and exhibit similarities in primary sequence and secondary structure. Longin-like domains are found in FUZ and related proteins, such as the MON1 and HPS1 proteins [, , ]. The MON1/CCZ1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking []. The HPS1/HPS4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules []. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia [, ]. Structurally, these domains are composed of an alpha/beta fold which contains five anti-parallel β-strands organised as a central β-sheet and around it, two α-helices [].This entry represents the third Longin domain of FUZ, MON1 and HPS1 proteins.
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Protein Domain
IPR043971 | FUZ/MON1/HPS1_longin_2
Type: Domain
Description: Longin domains are evolutionarily conserved regions widely distributed among eukaryotes, involved in membrane dynamic regulation and exhibit similarities in primary sequence and secondary structure. Longin-like domains are found in FUZ and related proteins, such as the MON1 and HPS1 proteins [, , ]. The MON1/CCZ1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking []. The HPS1/HPS4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules []. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia [, ]. Structurally, these domains are composed of an alpha/beta fold which contains five anti-parallel β-strands organised as a central β-sheet and around it, two α-helices [].This entry represents the second Longin domain found in FUZ, MON1 and HPS1 proteins.
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Publication
17075139 | -
First Author: Kinch LN
Year: 2006
Journal: Protein Sci
Title: Longin-like folds identified in CHiPS and DUF254 proteins: vesicle trafficking complexes conserved in eukaryotic evolution.
Volume: 15
Issue: 11
Pages: 2669-74
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Publication
28051187 | -
 
First Author: Kiontke S
Year: 2017
Journal: Nat Commun
Title: Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1-Ccz1.
Volume: 8
Pages: 14034
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Publication
31562761 | -
First Author: Sanchez-Pulido L
Year: 2020
Journal: Bioinformatics
Title: Hexa-Longin domain scaffolds for inter-Rab signalling.
Volume: 36
Issue: 4
Pages: 990-993
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Protein
Q8C1Y8
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Protein
Q6PDG8
Organism: Mus musculus/domesticus
Length: 556  
Fragment?: false
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Protein
Q3UYI6
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
O08983
Organism: Mus musculus/domesticus
Length: 704  
Fragment?: false
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Protein
Q8BMQ8
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: false
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Protein
Q3U309
Organism: Mus musculus/domesticus
Length: 712  
Fragment?: false
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Protein
Q5FWJ4
Organism: Mus musculus/domesticus
Length: 634  
Fragment?: false
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Protein
A0A0R4J0D5
Organism: Mus musculus/domesticus
Length: 556  
Fragment?: false
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Protein
E9Q045
Organism: Mus musculus/domesticus
Length: 635  
Fragment?: false
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Protein
A0A140LIC9
Organism: Mus musculus/domesticus
Length: 387  
Fragment?: false
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Protein
Q8CD56
Organism: Mus musculus/domesticus
Length: 635  
Fragment?: false
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Protein
E9PYL0
Organism: Mus musculus/domesticus
Length: 627  
Fragment?: false
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Protein
A0A140LJD3
Organism: Mus musculus/domesticus
Length: 379  
Fragment?: false
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Protein
Q80VD7
Organism: Mus musculus/domesticus
Length: 634  
Fragment?: true
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Protein
Q3TBI2
Organism: Mus musculus/domesticus
Length: 703  
Fragment?: false
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Protein
E9QL29
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
A0A0R4J062
Organism: Mus musculus/domesticus
Length: 704  
Fragment?: false
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Publication
23084991 | -
First Author: Gerondopoulos A
Year: 2012
Journal: Curr Biol
Title: BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor.
Volume: 22
Issue: 22
Pages: 2135-9
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Protein
A0A140LI55
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
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Protein
A0A140LIH3
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: true
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Protein
A0A0R4J2D4
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
A0A140LI92
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: true
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Protein
A0A140LI68
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
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Protein
A0A140LJ73
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: false
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Protein
A0A0N4SUY7
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: true
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Protein
Q99KG7
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: false
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Protein
Q3TAF8
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: false
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Protein
Q541V2
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: true
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Protein
Q6P568
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: false
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Protein
Q059U7
Organism: Mus musculus/domesticus
Length: 942  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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