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Search results 101 to 171 out of 171 for Git1

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Type Details Score
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
25138700 | -
First Author: Sheu TJ
Year: 2014
Journal: Mol Cell Biochem
Title: Decreased BMP2 signal in GIT1 knockout mice slows bone healing.
Volume: 397
Issue: 1-2
Pages: 67-74
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Publication
26113791 | -
First Author: Mah W
Year: 2015
Journal: Exp Neurobiol
Title: Aberrant Thalamocortical Synchrony Associated with Behavioral Manifestations in Git1 (-/-) Mice.
Volume: 24
Issue: 2
Pages: 126-32
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UniProt Feature
UniProt Feature
Begin: 1
Description: ARF GTPase-activating protein GIT1
Type: chain
End: 770
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Publication
15923189 | -
First Author: Yin G
Year: 2005
Journal: J Biol Chem
Title: GIT1 is a scaffold for ERK1/2 activation in focal adhesions.
Volume: 280
Issue: 30
Pages: 27705-12
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Protein
Q5F258
Organism: Mus musculus/domesticus
Length: 761  
Fragment?: false
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Publication
11896197 | -
First Author: Manabe R
Year: 2002
Journal: J Cell Sci
Title: GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration.
Volume: 115
Issue: Pt 7
Pages: 1497-510
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Publication
24699139 | -
First Author: Totaro A
Year: 2014
Journal: PLoS One
Title: Identification of two tyrosine residues required for the intramolecular mechanism implicated in GIT1 activation.
Volume: 9
Issue: 4
Pages: e93199
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Publication
12153727 | -
First Author: Nishiya N
Year: 2002
Journal: J Biochem
Title: Hic-5 interacts with GIT1 with a different binding mode from paxillin.
Volume: 132
Issue: 2
Pages: 279-89
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Interaction Experiment
Nishiya N (2002)
Description: Hic-5 interacts with GIT1 with a different binding mode from paxillin.
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Interaction Experiment
Smithson LJ (2016)
Description: Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival.
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Interaction Experiment
Fujikawa A (2015)
Description: Specific dephosphorylation at tyr-554 of git1 by ptprz promotes its association with paxillin and hic-5.
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Publication
12695502 | -
First Author: Zhang H
Year: 2003
Journal: J Cell Biol
Title: Synapse formation is regulated by the signaling adaptor GIT1.
Volume: 161
Issue: 1
Pages: 131-42
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Interaction Experiment
Cavet ME (2008)
Description: An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor.
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Publication
19136011 | -
First Author: Schlenker O
Year: 2009
Journal: J Mol Biol
Title: Structures of dimeric GIT1 and trimeric beta-PIX and implications for GIT-PIX complex assembly.
Volume: 386
Issue: 2
Pages: 280-9
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Publication
25742295 | -
First Author: Fujikawa A
Year: 2015
Journal: PLoS One
Title: Specific dephosphorylation at tyr-554 of git1 by ptprz promotes its association with paxillin and hic-5.
Volume: 10
Issue: 3
Pages: e0119361
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Publication
15182672 | -
First Author: Audebert S
Year: 2004
Journal: Curr Biol
Title: Mammalian Scribble forms a tight complex with the betaPIX exchange factor.
Volume: 14
Issue: 11
Pages: 987-95
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Publication
23108400 | J:217270
First Author: Hagemann N
Year: 2013
Journal: Oncogene
Title: The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis.
Volume: 32
Issue: 39
Pages: 4602-13
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Publication
18523162 | -
First Author: Cavet ME
Year: 2008
Journal: FASEB J
Title: An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor.
Volume: 22
Issue: 10
Pages: 3607-16
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Publication
12473661 | -
First Author: Kim S
Year: 2003
Journal: J Biol Chem
Title: The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo.
Volume: 278
Issue: 8
Pages: 6291-300
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Publication
12361575 | -
First Author: van Drogen F
Year: 2002
Journal: Curr Biol
Title: Spa2p functions as a scaffold-like protein to recruit the Mpk1p MAP kinase module to sites of polarized growth.
Volume: 12
Issue: 19
Pages: 1698-703
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Publication
9443897 | -
 
First Author: Roemer T
Year: 1998
Journal: J Cell Sci
Title: The Spa2-related protein, Sph1p, is important for polarized growth in yeast.
Volume: 111 ( Pt 4)
Pages: 479-94
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Protein Domain
IPR013724 | GIT_SHD
Type: Domain
Description: This entry represents the Spa2 homology domain (SHD) domain found in the yeast Spa2/Sph1 protein and the mammalian GIT proteins. Budding yeast Spa2 is a component of the polarisome that functions in actin cytoskeletal organisation during polarized growth []. Its paralogue, Sph1, is involved in shmoo formation and bipolar bud site selection []. GIT is a GTPase-activating protein for the ADP ribosylation factor family. It may serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organisation []. Mutations in the Spa2 homology domain (SHD) domain of GIT1 described here interfere with the association of GIT1 with Piccolo, beta-PIX, and focal adhesion kinase [].
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Protein
Q3V322
Organism: Mus musculus/domesticus
Length: 253  
Fragment?: false
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Protein Domain
IPR022018 | GIT1_C
Type: Domain
Description: This entry represents the C-terminal domain of the ARF GTPase-activating protein GIT1. GIT1 is an ArfGAP and scaffolding protein regulating cell adhesion and migration []. To perform this function, it localises p21-activated kinase (PAK) and PAK-interactive exchange factor to focal adhesions. Its activation is regulated by interaction between its paxillin-binding C-terminal and the LD motifs of paxillin. The C-terminal folds into a four helix bundle.
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Publication
23443560 | J:225063
 
First Author: Nakaya M
Year: 2013
Journal: Nat Commun
Title: GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance.
Volume: 4
Pages: 1532
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Publication
28066185 | J:324367
 
First Author: Franchi SA
Year: 2016
Journal: Front Cell Neurosci
Title: Identification of a Protein Network Driving Neuritogenesis of MGE-Derived GABAergic Interneurons.
Volume: 10
Pages: 289
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Publication
29150658 | J:256939
First Author: Candiello E
Year: 2017
Journal: Sci Rep
Title: Differential regulation of synaptic AP-2/clathrin vesicle uncoating in synaptic plasticity.
Volume: 7
Issue: 1
Pages: 15781
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Protein
F6WV69
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: true
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Publication
16000375 | J:104069
First Author: Brown MC
Year: 2005
Journal: Mol Biol Cell
Title: Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.
Volume: 16
Issue: 9
Pages: 4316-28
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Publication
34787081 | J:314954
   
First Author: Conde-Dusman MJ
Year: 2021
Journal: Elife
Title: Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly.
Volume: 10
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Publication
24928894 | J:216245
First Author: Wilson E
Year: 2014
Journal: J Cell Sci
Title: RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly.
Volume: 127
Issue: Pt 14
Pages: 3039-51
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Publication
31296385 | J:284009
First Author: Kwon Y
Year: 2019
Journal: Biochem Biophys Res Commun
Title: βPix heterozygous mice have defects in neuronal morphology and social interaction.
Volume: 516
Issue: 4
Pages: 1204-1210
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Publication
29061650 | J:250951
First Author: Donnelly SK
Year: 2017
Journal: J Cell Biol
Title: Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation.
Volume: 216
Issue: 12
Pages: 4331-4349
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Protein
F6U8T2
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: true
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Publication
32780989 | -
First Author: Zhu J
Year: 2020
Journal: Mol Cell
Title: GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling.
Volume: 79
Issue: 5
Pages: 782-796.e6
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Publication
10461188 | -
First Author: Bagrodia S
Year: 1999
Journal: Trends Cell Biol
Title: Pak to the future.
Volume: 9
Issue: 9
Pages: 350-5
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Publication
12935897 | -
First Author: Flanders JA
Year: 2003
Journal: FEBS Lett
Title: The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.
Volume: 550
Issue: 1-3
Pages: 119-23
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Publication
11741931 | -
First Author: Feng Q
Year: 2002
Journal: J Biol Chem
Title: Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases.
Volume: 277
Issue: 7
Pages: 5644-50
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Publication
19969308 | -
First Author: Eriguchi M
Year: 2010
Journal: J Neurol Sci
Title: alpha Pix enhances mutant huntingtin aggregation.
Volume: 290
Issue: 1-2
Pages: 80-5
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Protein Domain
IPR046376 | PH_Cool_Pix
Type: Domain
Description: There are two forms of Pix proteins: alpha Pix (also called Rho guanine nucleotide exchange factor (GEF) 6, 90Cool-2 or ARHGEF6) and beta Pix (GEF7, p85Cool-1 or ARHGEF7), which activate small GTPases by exchanging bound GDP for free GTP. betaPix contains an N-terminal SH3 domain, a RhoGEF/DH domain, a PH domain, a GIT1 binding domain (GBD), and a C-terminal coiled-coil (CC) domain []. It acts as a GEF for both Cdc42 and Rac1 [], and plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion [, , , ]. alphaPix differs in that it contains a calponin homology (CH) domain, which interacts with beta-parvin, N-terminal to the SH3 domain. alphaPix is an exchange factor for Rac1 and Cdc42 and mediates Pak activation on cell adhesion to fibronectin. Mutations in alphaPix can cause X-linked mental retardation. alphaPix also interacts with Huntington's disease protein (htt), and enhances the aggregation of mutant htt (muthtt) by facilitating SDS-soluble muthtt-muthtt interactions. The DH-PH domain of a Pix was required for its binding to htt. In the majority of Rho GEF proteins, the DH-PH domain is responsible for the exchange activity [, , , , ].This entry represents the PH domain of ARHGEF6 and ARHGEF7.
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Publication
16472649 | -
 
First Author: Baird D
Year: 2006
Journal: Methods Enzymol
Title: Biochemical characterization of the Cool (Cloned-out-of-Library)/Pix (Pak-interactive exchange factor) proteins.
Volume: 406
Pages: 58-69
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Protein
Q9JLQ2
Organism: Mus musculus/domesticus
Length: 708  
Fragment?: false
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Protein
J3QK07
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
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Protein
Q80XR8
Organism: Mus musculus/domesticus
Length: 679  
Fragment?: false
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Protein
E9PVA6
Organism: Mus musculus/domesticus
Length: 759  
Fragment?: false
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Protein
D3Z1I2
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: false
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Protein
Q5DU47
Organism: Mus musculus/domesticus
Length: 722  
Fragment?: true
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Protein
F7BIK4
Organism: Mus musculus/domesticus
Length: 631  
Fragment?: false
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Publication
21088884 | -
First Author: Momboisse F
Year: 2010
Journal: Cell Mol Neurobiol
Title: The Rho guanine nucleotide exchange factors Intersectin 1L and β-Pix control calcium-regulated exocytosis in neuroendocrine PC12 cells.
Volume: 30
Issue: 8
Pages: 1327-33
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Publication
21472000 | -
First Author: Legg K
Year: 2011
Journal: Nat Rev Mol Cell Biol
Title: Cell migration: keeping young and mobile with β-PIX.
Volume: 12
Issue: 5
Pages: 278
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Publication
22114281 | -
First Author: Sun Y
Year: 2011
Journal: J Neurosci
Title: β-Pix modulates actin-mediated recruitment of synaptic vesicles to synapses.
Volume: 31
Issue: 47
Pages: 17123-33
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Publication
22087847 | -
First Author: Koh SH
Year: 2012
Journal: Stem Cells Dev
Title: β-PIX is critical for transplanted mesenchymal stromal cell migration.
Volume: 21
Issue: 11
Pages: 1989-99
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Publication
21828338 | J:182176
First Author: Kepner EM
Year: 2011
Journal: Am J Physiol Endocrinol Metab
Title: Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion.
Volume: 301
Issue: 6
Pages: E1072-80
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Protein
Q3UGB1
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: false
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Publication
15592455 | -
First Author: Rush J
Year: 2005
Journal: Nat Biotechnol
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Volume: 23
Issue: 1
Pages: 94-101
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Protein
H3BKQ0
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: true
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Protein
A2AFJ8
Organism: Mus musculus/domesticus
Length: 483  
Fragment?: false
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Protein
D3Z0V2
Organism: Mus musculus/domesticus
Length: 636  
Fragment?: true
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Protein
A0A0R4J0X8
Organism: Mus musculus/domesticus
Length: 646  
Fragment?: false
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Publication
18034455 | -
First Author: Ballif BA
Year: 2008
Journal: J Proteome Res
Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
Volume: 7
Issue: 1
Pages: 311-8
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Protein
Q9ES28
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
Q8K4I3
Organism: Mus musculus/domesticus
Length: 771  
Fragment?: false
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Protein
F6WMJ3
Organism: Mus musculus/domesticus
Length: 795  
Fragment?: false
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Publication
19131326 | -
First Author: Sweet SM
Year: 2009
Journal: Mol Cell Proteomics
Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Volume: 8
Issue: 5
Pages: 904-12
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Publication
16452087 | J:263376
First Author: Trinidad JC
Year: 2006
Journal: Mol Cell Proteomics
Title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations.
Volume: 5
Issue: 5
Pages: 914-22
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Publication
17242355 | -
First Author: Villén J
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Large-scale phosphorylation analysis of mouse liver.
Volume: 104
Issue: 5
Pages: 1488-93
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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