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Search results 101 to 200 out of 200 for Glra3

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Type Details Score
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1860128
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 54
Specimen Label: Mouse 235765
Detected: false
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1928728
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 54
Specimen Label: Mouse 235765
Detected: false
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 54
Specimen Label: Mouse 235765
Detected: false
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Weak
Sex: Female
Emaps: EMAPS:3573928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 54
Image: Mouse 235765 - Image 99184666
Note: There is occasional staining in the ganglion cell layer.
Specimen Label: Mouse 235765 - Image 99184666
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:3599828
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:3599828
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 54
Specimen Label: Mouse 235765
Detected: false
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1857728
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Weak
Sex: Male
Emaps: EMAPS:3579028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Image: Mouse 199335 - Image 99187740
Note: There is scattered expression in the dorsal horns.
Specimen Label: Mouse 199335 - Image 99187740
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425297
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1690623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825080
Age: embryonic day 14.5
Image: euxassay_010858_10
Specimen Label: euxassay_010858_10
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425297
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1690623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825080
Age: embryonic day 14.5
Image: euxassay_010858_11
Specimen Label: euxassay_010858_11
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425297
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1690623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825080
Age: embryonic day 14.5
Image: euxassay_010858_14
Specimen Label: euxassay_010858_14
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425297
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1690623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825080
Age: embryonic day 14.5
Image: euxassay_010858_15
Specimen Label: euxassay_010858_15
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425297
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1690623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825080
Age: embryonic day 14.5
Image: euxassay_010858_16
Specimen Label: euxassay_010858_16
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 54
Specimen Label: Mouse 235765
Detected: false
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425297
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825080
Age: embryonic day 14.5
Image: euxassay_010858_10
Specimen Label: euxassay_010858_10
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4425297
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825080
Age: embryonic day 14.5
Image: euxassay_010858_11
Specimen Label: euxassay_010858_11
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:2991528
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 54
Specimen Label: Mouse 235765
Detected: false
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Weak
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 54
Image: Mouse 235765 - Image 99187732
Note: There is scattered expression in the brain.
Specimen Label: Mouse 235765 - Image 99187732
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
       
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 54
Specimen Label: Mouse 235765
Detected: false
Specimen Num: 11
•
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Publication
- | J:72480
   
First Author: Noegel S
Year: 2001
Journal: GenBank Submission
Title: Mus musculus glycine receptor alpha 3 subunit (Glra3) mRNA, complete cds
Pages: AF362764
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Publication
15131310 | J:89981
First Author: Harvey RJ
Year: 2004
Journal: Science
Title: GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization.
Volume: 304
Issue: 5672
Pages: 884-7
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Publication
20978350 | J:166914
First Author: Manzke T
Year: 2010
Journal: J Clin Invest
Title: Serotonin receptor 1A-modulated phosphorylation of glycine receptor α3 controls breathing in mice.
Volume: 120
Issue: 11
Pages: 4118-28
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Publication
16420443 | J:105396
First Author: Ivanova E
Year: 2006
Journal: Eur J Neurosci
Title: Characterization of the glycinergic input to bipolar cells of the mouse retina.
Volume: 23
Issue: 2
Pages: 350-64
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Publication
21486794 | J:184662
First Author: Graham BA
Year: 2011
Journal: J Physiol
Title: Probing glycine receptor stoichiometry in superficial dorsal horn neurones using the spasmodic mouse.
Volume: 589
Issue: Pt 10
Pages: 2459-74
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Publication
28784756 | J:244005
First Author: McCracken LM
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain.
Volume: 114
Issue: 34
Pages: E7179-E7186
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Publication
22399754 | J:182733
First Author: Nobles RD
Year: 2012
Journal: J Neurosci
Title: Selective glycine receptor α2 subunit control of crossover inhibition between the on and off retinal pathways.
Volume: 32
Issue: 10
Pages: 3321-32
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Publication
17154252 | J:263489
First Author: Heinze L
Year: 2007
Journal: J Comp Neurol
Title: Diversity of glycine receptors in the mouse retina: localization of the alpha4 subunit.
Volume: 500
Issue: 4
Pages: 693-707
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Publication
22585736 | J:189039
First Author: Xiong W
Year: 2012
Journal: J Exp Med
Title: Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.
Volume: 209
Issue: 6
Pages: 1121-34
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Publication
29203410 | J:272151
 
First Author: Mesuret G
Year: 2018
Journal: Respir Physiol Neurobiol
Title: Breathing disturbances in a model of Rett syndrome: A potential involvement of the glycine receptor α3 subunit?
Volume: 248
Pages: 43-47
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Publication
10198177 | J:51381
First Author: Zhu L
Year: 1999
Journal: Genomics
Title: Chromosomal mapping of the tankyrase gene in human and mouse.
Volume: 57
Issue: 2
Pages: 320-1
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Publication
17920294 | J:132622
First Author: Weiss J
Year: 2008
Journal: Mol Cell Neurosci
Title: Glycinergic input of small-field amacrine cells in the retinas of wildtype and glycine receptor deficient mice.
Volume: 37
Issue: 1
Pages: 40-55
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Publication
19528249 | J:176536
First Author: Majumdar S
Year: 2009
Journal: J Physiol
Title: Glycinergic input of widefield, displaced amacrine cells of the mouse retina.
Volume: 587
Issue: Pt 15
Pages: 3831-49
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Publication
7894176 | J:22191
First Author: Kingsmore SF
Year: 1994
Journal: Mamm Genome
Title: Genetic mapping of the glycine receptor alpha 3 subunit on mouse chromosome 8.
Volume: 5
Issue: 12
Pages: 831-2
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Publication
9051263 | J:38407
First Author: Heck S
Year: 1997
Journal: Brain Res Dev Brain Res
Title: Expression and mRNA splicing of glycine receptor subunits and gephyrin during neuronal differentiation of P19 cells in vitro, studied by RT-PCR and immunocytochemistry.
Volume: 98
Issue: 2
Pages: 211-20
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Publication
18721822 | J:147002
First Author: Lynch JW
Year: 2009
Journal: Neuropharmacology
Title: Native glycine receptor subtypes and their physiological roles.
Volume: 56
Issue: 1
Pages: 303-9
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Publication
21486797 | J:185249
First Author: Mordel J
Year: 2011
Journal: J Physiol
Title: Activation of glycine receptor phase-shifts the circadian rhythm in neuronal activity in the mouse suprachiasmatic nucleus.
Volume: 589
Issue: Pt 9
Pages: 2287-300
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Publication
- | J:44385
First Author: Becker CM
Year: 1997
Journal: Neuroscientist
Title: Glycine receptors: Molecular heterogeneity and implications for disease.
Volume: 1
Issue: 3
Pages: 130-41
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Publication
22988142 | J:203021
First Author: Kunz PA
Year: 2012
Journal: J Physiol
Title: Glycine receptors support excitatory neurotransmitter release in developing mouse visual cortex.
Volume: 590
Issue: 22
Pages: 5749-64
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Publication
35535852 | J:324531
   
First Author: Kim H
Year: 2022
Journal: Elife
Title: Rescue of behavioral and electrophysiological phenotypes in a Pitt-Hopkins syndrome mouse model by genetic restoration of Tcf4 expression.
Volume: 11
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Publication
1679744 | J:11417
First Author: Derry JM
Year: 1991
Journal: Genomics
Title: Mapping of the glycine receptor alpha 2-subunit gene and the GABAA alpha 3-subunit gene on the mouse X chromosome.
Volume: 10
Issue: 3
Pages: 593-7
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Publication
22937132 | J:191676
First Author: Manceau V
Year: 2012
Journal: PLoS One
Title: The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice.
Volume: 7
Issue: 8
Pages: e43946
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Publication
27568567 | J:239016
First Author: Kennedy AJ
Year: 2016
Journal: Cell Rep
Title: Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function.
Volume: 16
Issue: 10
Pages: 2666-2685
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Publication
22723691 | J:185665
First Author: Guo Z
Year: 2012
Journal: J Neurosci
Title: Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.
Volume: 32
Issue: 25
Pages: 8509-20
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Publication
21491433 | J:174459
First Author: Boyle MP
Year: 2011
Journal: J Comp Neurol
Title: Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala.
Volume: 519
Issue: 11
Pages: 2061-89
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Publication
- | J:101679
     
First Author: Deltagen Inc
Year: 2005
Journal: MGI Direct Data Submission
Title: NIH initiative supporting placement of Deltagen, Inc. mice into public repositories
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
9677400 | J:49529
First Author: Nikolic Z
Year: 1998
Journal: J Biol Chem
Title: The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcripts.
Volume: 273
Issue: 31
Pages: 19708-14
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Allele
Hprt1<tm1(CAG-Glra3*)Jcme> | MGI:5608589
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Jochen C Meier
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
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Genotype
Genotype
Symbol: Hprt1/? Pvalb/Pvalb<+>
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hprt1/? Tg(Camk2a-cre)2Gsc/?
Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Publication
24430185 | J:207981
First Author: Winkelmann A
Year: 2014
Journal: J Clin Invest
Title: Changes in neural network homeostasis trigger neuropsychiatric symptoms.
Volume: 124
Issue: 2
Pages: 696-711
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Publication
26908632 | J:231517
First Author: Çaliskan G
Year: 2016
Journal: Cereb Cortex
Title: Identification of Parvalbumin Interneurons as Cellular Substrate of Fear Memory Persistence.
Volume: 26
Issue: 5
Pages: 2325-2340
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Protein Domain
IPR008130 | Glycine_rcpt_A3
Type: Family
Description: Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [, ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily:Nicotinic acetylcholine receptor (AchR), an excitatory cation channel in vertebrates and invertebrates; in vertebrate motor endplates it is composed of alpha, beta, gamma and delta/epsilon subunits; in neurons it is composed of alpha and non-alpha (or beta) subunits [].Glycine receptor, an inhibitory chloride ion channel composed of alpha and beta subunits [].Gamma-aminobutyric acid (GABA) receptor, an inhibitory chloride ion channel; at least four types of subunits (alpha, beta, gamma and delta) are known [].Serotonin 5HT3 receptor, of which there are seven major types (5HT3-5HT7) [].Glutamate receptor, an excitatory cation channel of which at least three types have been described (kainate, N-methyl-D-aspartate (NMDA) and quisqualate) [].These receptors possess a pentameric structure (made up of varying subunits), surrounding a central pore. All known sequences of subunits from neurotransmitter-gated ion-channels are structurally related. They are composed of a large extracellular glycosylated N-terminal ligand-binding domain, followed by three hydrophobic transmembrane regions which form the ionic channel, followed by an intracellular region of variable length. A fourth hydrophobic region is found at the C-terminal of the sequence [, ].Glycine is a major inhibitory neurotransmitter (NT) in the adult vertebratecentral nervous system (CNS). Glycinergic synapses have a well-establishedrole in the processing of motor and sensory information that controlsmovement, vision and audition []. This action of glycine is mediatedthrough its interaction with the glycine receptor (GlyR): an intrinsicchloride channel is opened in response to agonist binding. The subsequentinflux of anions prevents membrane depolarisation and neuronal firinginduced by excitatory NTs. Strychnine acts as a competitive antagonist ofglycine binding, thereby reducing the activity of inhibitory neurones.Poisoning with strychnine is characterised by over-excitation, muscle spasmsand convulsions. Whilst glycine is the principal physiological agonist atGlyRs, taurine and beta-alanine also behave as agonists []. Compounds thatmodulate GlyR activity include zinc, some alcohols and anaesthetics,picrotoxin, cocaine and some anticonvulsants. GlyRs were thought for sometime to be localised exclusively in the brain stem and spinal cord, but havesince been found to be expressed more widely, including the cochlear nuclei,cerebellar cortex and forebrain [].GlyRs belong to the ligand-gated ion channel family, which also includes theinhibitory gamma-aminobutyric acid type A (GABAA) and excitatory nicotinicacetylcholine (nACh) and serotonin type 3 (5-HT3) receptors [].Affinity-purified GlyR was found to contain two glycosylated membraneproteins of 48kDa and 56kDa, corresponding to alpha and beta subunits,respectively. Four genes encoding alpha subunits have been identified (GLRA1to 4), together with a single beta polypeptide (GLRB). The heterogeneity ofalpha subunits is further increased by alternative exon splicing, yieldingtwo isoforms of GLRA1 to 3 []. The characteristics of different GlyRsubtypes, therefore, can be largely explained by their GLRA content.GlyRs are generally believed to adopt a pentameric structure in vivo: fivesubunits assemble to form a ring structure with a central pore. Typically, astoichiometry of 3:2 (alpha:beta) is observed []. GlyR subunits share ahigh overall level of sequence similarity both with themselves and with thesubunits of the GABAA and nACh receptors. Four highly conserved segmentshave been proposed to correspond to transmembrane (TM) alpha helices (TM1-4), the second of which is thought to contribute to the pore wall []. A long extracellular N-terminal segment precedes TM1 and a long cytoplasmic loop links TM3 and 4. Short cytoplasmic and extracellular loops join TM1-2 andTM2-3, respectively, and a short C-terminal sequence follows TM4. Studiesusing radiolabelled strychnine have shown the alpha subunit to beresponsible for ligand binding, the critical residues for this interaction lying within the N-terminal domain. The beta subunit plays a structuralrole, contributing one of its TM domains to the pore wall as well as playinga putative role in postsynaptic clustering of the receptor.In several mammalian species, defects in glycinergic transmission areassociated with complex motor disorders. Mutations in the gene encodingGLRA1 give rise to hyperplexia, or startle disease []. This ischaracterised by muscular spasms in response to unexpected light or noisestimuli, similar to the symptoms of sublethal doses of strychnine. Themutations result in amino acid substitutions within the TM1-2 and TM3-4loops, suggesting that these regions are involved in the transduction ofligand binding into channel activation.GLRA3 is expressed in thecerebellum, olfactory bulb and hippocampus. GLRA3 trancripts, together withGLRA1, predominate in the postnatal CNS, replacing GLRA2, which is moreabundant in embryonic and neonatal neurones.
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Protein
Q91XP5
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
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Protein
G5E811
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Publication
10414351 | -
 
First Author: Betz H
Year: 1999
Journal: Ann N Y Acad Sci
Title: Structure and functions of inhibitory and excitatory glycine receptors.
Volume: 868
Pages: 667-76
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Publication
11396606 | -
First Author: López-Corcuera B
Year: 2001
Journal: Mol Membr Biol
Title: Glycine neurotransmitter transporters: an update.
Volume: 18
Issue: 1
Pages: 13-20
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Publication
11437237 | -
First Author: Legendre P
Year: 2001
Journal: Cell Mol Life Sci
Title: The glycinergic inhibitory synapse.
Volume: 58
Issue: 5-6
Pages: 760-93
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Publication
1323284 | -
First Author: Sato C
Year: 1992
Journal: Biochem Biophys Res Commun
Title: Proposed tertiary structure of the sodium channel.
Volume: 186
Issue: 2
Pages: 1158-67
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Publication
11358478 | -
First Author: Leite JF
Year: 2001
Journal: Mol Cell Neurosci
Title: Structure of ligand-gated ion channels: critical assessment of biochemical data supports novel topology.
Volume: 17
Issue: 5
Pages: 777-92
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Publication
1846404 | J:10953
First Author: Kofuji P
Year: 1991
Journal: J Neurochem
Title: Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.
Volume: 56
Issue: 2
Pages: 713-5
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Publication
1721053 | -
First Author: Wagner K
Year: 1991
Journal: J Biol Chem
Title: Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.
Volume: 266
Issue: 35
Pages: 23784-9
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Publication
10026168 | J:53253
First Author: Yan D
Year: 1999
Journal: J Biol Chem
Title: Structural features of the ligand-binding domain of the serotonin 5HT3 receptor.
Volume: 274
Issue: 9
Pages: 5537-41
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Publication
18446614 | -
First Author: Millar NS
Year: 2008
Journal: Mol Membr Biol
Title: Assembly and trafficking of nicotinic acetylcholine receptors (Review).
Volume: 25
Issue: 4
Pages: 279-92
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Publication
15383648 | -
First Author: Lynch JW
Year: 2004
Journal: Physiol Rev
Title: Molecular structure and function of the glycine receptor chloride channel.
Volume: 84
Issue: 4
Pages: 1051-95
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Publication
18760291 | -
First Author: Olsen RW
Year: 2009
Journal: Neuropharmacology
Title: GABA A receptors: subtypes provide diversity of function and pharmacology.
Volume: 56
Issue: 1
Pages: 141-8
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Publication
15165736 | -
First Author: Wollmuth LP
Year: 2004
Journal: Trends Neurosci
Title: Structure and gating of the glutamate receptor ion channel.
Volume: 27
Issue: 6
Pages: 321-8
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