Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1775122 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3274122 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3287422 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1624622 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
Note: |
Expression was strong in the digestive system. |
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1721422 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1646922 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1736222 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1683322 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1700022 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1832122 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-09-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7530794 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Supplementary table 2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876522 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
Note: |
Expression was detected in the immune system. |
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1741222 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754022 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3599822 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3280922 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1833322 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3287022 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752522 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1821522 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3557722 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1702122 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1756322 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1668822 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757722 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757522 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1738322 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1802422 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
MH207; Specimen C910 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1768022 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
Note: |
Expression was weak in the skull (base and vault). |
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354287 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:2672022 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421785 |
Age: |
embryonic day 14.5 |
Image: |
MH207; Specimen C910 |
Note: |
Expression was strong in whisker follicle. |
Specimen Label: |
MH207; Specimen C910 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sansom SN |
Year: |
2009 |
Journal: |
PLoS Genet |
Title: |
The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. |
Volume: |
5 |
Issue: |
6 |
Pages: |
e1000511 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
MGC Data curation in Mouse Genome Informatics |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
Journal: |
Database Download |
Title: |
Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
Data Curation Using Mouse Genome Assembly |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2018 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
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309 |
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5740 |
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1559-63 |
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Title: |
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Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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Title: |
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Mouse T31 Radiation Hybrid Data Load |
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Title: |
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Mouse Genome Informatics Scientific Curators |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Title: |
Annotation inferences using phylogenetic trees |
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Mouse Genome Database and National Center for Biotechnology Information |
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Database Release |
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Allen Institute for Brain Science |
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Allen Institute |
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Database Download |
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Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
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Mouse Genome Informatics Group |
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Bairoch A |
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Mouse Genome Informatics Scientific Curators |
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2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Mouse Genome Informatics |
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2010 |
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Publication |
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Mouse Genome Informatics Scientific Curators |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Mouse Genome Informatics Scientific Curators |
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2009 |
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Database Download |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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HT Experiment |
Series Id: |
E-GEOD-65753 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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Publication |
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Kawamura S |
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2017 |
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Immunity |
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Identification of a Human Clonogenic Progenitor with Strict Monocyte Differentiation Potential: A Counterpart of Mouse cMoPs. |
Volume: |
46 |
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5 |
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835-848.e4 |
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Hérault A |
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2017 |
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Nature |
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Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis. |
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544 |
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7648 |
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53-58 |
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Zhao Y |
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2023 |
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iScience |
Title: |
mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway. |
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26 |
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9 |
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107540 |
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Iwasaki H |
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Genes Dev |
Title: |
The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. |
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20 |
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Immunity |
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Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor. |
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53 |
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303-318.e5 |
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Yáñez A |
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2017 |
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Immunity |
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Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes. |
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47 |
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5 |
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890-902.e4 |
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AhYoung AP |
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2020 |
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Commun Biol |
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Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage. |
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3 |
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Cell Rep |
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Cancer Cell |
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Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells. |
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Year: |
2023 |
Journal: |
Cell Stem Cell |
Title: |
Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal. |
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648-664.e8 |
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MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors. |
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5767 |
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Publication |
First Author: |
Griseri T |
Year: |
2012 |
Journal: |
Immunity |
Title: |
Dysregulated hematopoietic stem and progenitor cell activity promotes interleukin-23-driven chronic intestinal inflammation. |
Volume: |
37 |
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6 |
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Maruoka S |
Year: |
2010 |
Journal: |
J Mol Biol |
Title: |
Crystal structure of the ATPPase subunit and its substrate-dependent association with the GATase subunit: a novel regulatory mechanism for a two-subunit-type GMP synthetase from Pyrococcus horikoshii OT3. |
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395 |
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Grimaldi C |
Year: |
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Journal: |
Curr Microbiol |
Title: |
Genetic organization and polymorphism of the guaA gene encoding the GMP synthetase in Lactobacillus rhamnosus. |
Volume: |
40 |
Issue: |
4 |
Pages: |
245-9 |
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Protein Domain |
Type: |
Domain |
Description: |
Guanosine 5'-monophosphate synthetase (GMPS) is a widespread enzyme seen inall domains of life. GMPS is required for the final step of the de novosynthesis of guanine nucleotides, converting xanthosine 5'-monophosphate (XMP)into guanosine 5'-monophosphate (GMP), a precursor of DNA and RNA. GMPSconsists of two catalytic units, glutamine amidotransferase (GATase) and ATP pyrophosphatase (ATP-PPase). GATase hydrolyzes glutamineto yield glutamate and ammonia, while ATP-PPase utilises ammonia to convertadenyl xanthosine 5'-monophosphate (adenyl-XMP) into GMP. The two catalyticunits are either encoded by a single gene (two-domain type) in eucaryotes,bacteria, and some archaea, or encoded by two separate genes (two-subunittype) in other archaea. In two-domain-type GMPS, the GATase domain is locatedin the N-terminal half, and the ATP-PPase domain is located in the C-terminalhalf; in two-subunit-type GMPS, these two units exist as separatepolypeptides. ATP-PPase consists of two domains (N-domain and C-domain). TheN-domain contains an ATP-binding platform called P-loop,whereas the C-domain contains the XMP-binding site and also contributes tohomodimerisation [, , ].The GMP synthetase ATP-PPase ATP-binding domain is a twisted, five-strandedparallel β-sheet sandwiched between helical layers. Itcontains a glycine rich ATP-binding motif called the "P-loop motif"locatedafter the first β-strand [, ]. |
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Publication |
First Author: |
Khalfin-Rabinovich Y |
Year: |
2011 |
Journal: |
Int Immunol |
Title: |
PML is a key component for the differentiation of myeloid progenitor cells to macrophages. |
Volume: |
23 |
Issue: |
4 |
Pages: |
287-96 |
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Publication |
First Author: |
Wara AK |
Year: |
2011 |
Journal: |
Blood |
Title: |
TGF-β1 signaling and Krüppel-like factor 10 regulate bone marrow-derived proangiogenic cell differentiation, function, and neovascularization. |
Volume: |
118 |
Issue: |
24 |
Pages: |
6450-60 |
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Publication |
First Author: |
Yuan J |
Year: |
2011 |
Journal: |
Leukemia |
Title: |
Bmi1 is essential for leukemic reprogramming of myeloid progenitor cells. |
Volume: |
25 |
Issue: |
8 |
Pages: |
1335-43 |
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Publication |
First Author: |
Zezulin AU |
Year: |
2023 |
Journal: |
Genes Dev |
Title: |
RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils. |
Volume: |
37 |
Issue: |
13-14 |
Pages: |
605-620 |
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Publication |
First Author: |
Böiers C |
Year: |
2010 |
Journal: |
Blood |
Title: |
Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development. |
Volume: |
115 |
Issue: |
24 |
Pages: |
5061-8 |
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Publication |
First Author: |
Kimura A |
Year: |
2009 |
Journal: |
Blood |
Title: |
The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis. |
Volume: |
114 |
Issue: |
21 |
Pages: |
4721-8 |
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Publication |
First Author: |
Satpathy AT |
Year: |
2014 |
Journal: |
Blood |
Title: |
Runx1 and Cbfβ regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder. |
Volume: |
123 |
Issue: |
19 |
Pages: |
2968-77 |
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Publication |
First Author: |
Ohmori K |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen. |
Volume: |
182 |
Issue: |
5 |
Pages: |
2835-41 |
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Publication |
First Author: |
Alemdehy MF |
Year: |
2012 |
Journal: |
Blood |
Title: |
Dicer1 deletion in myeloid-committed progenitors causes neutrophil dysplasia and blocks macrophage/dendritic cell development in mice. |
Volume: |
119 |
Issue: |
20 |
Pages: |
4723-30 |
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Publication |
First Author: |
Nakajima-Takagi Y |
Year: |
2023 |
Journal: |
Elife |
Title: |
Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis. |
Volume: |
12 |
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Publication |
First Author: |
Nutt SL |
Year: |
2005 |
Journal: |
J Exp Med |
Title: |
Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors. |
Volume: |
201 |
Issue: |
2 |
Pages: |
221-31 |
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Publication |
First Author: |
Dougher CWL |
Year: |
2017 |
Journal: |
J Leukoc Biol |
Title: |
The blood-borne sialyltransferase ST6Gal-1 is a negative systemic regulator of granulopoiesis. |
Volume: |
102 |
Issue: |
2 |
Pages: |
507-516 |
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Publication |
First Author: |
Schuster MB |
Year: |
2013 |
Journal: |
Exp Hematol |
Title: |
Lack of the p42 form of C/EBPα leads to spontaneous immortalization and lineage infidelity of committed myeloid progenitors. |
Volume: |
41 |
Issue: |
10 |
Pages: |
882-893.e16 |
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•
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Publication |
First Author: |
Saulnier N |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
ERK1 regulates the hematopoietic stem cell niches. |
Volume: |
7 |
Issue: |
1 |
Pages: |
e30788 |
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Publication |
First Author: |
Zhang Y |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Suppression of cytochrome p450 reductase enhances long-term hematopoietic stem cell repopulation efficiency in mice. |
Volume: |
8 |
Issue: |
7 |
Pages: |
e69913 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
693
 |
Fragment?: |
false |
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