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Search results 101 to 200 out of 214 for Gnrhr

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Type Details Score
Publication
31724029 | J:286790
First Author: Ongaro L
Year: 2020
Journal: Biol Reprod
Title: Gonadotrope-specific deletion of the BMP type 2 receptor does not affect reproductive physiology in mice†‡.
Volume: 102
Issue: 3
Pages: 639-646
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Publication
35643321 | J:341697
First Author: Schang G
Year: 2022
Journal: J Biol Chem
Title: Transcription factor GATA2 may potentiate follicle-stimulating hormone production in mice via induction of the BMP antagonist gremlin in gonadotrope cells.
Volume: 298
Issue: 7
Pages: 102072
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Publication
38467682 | J:346611
First Author: Banik J
Year: 2024
Journal: Sci Rep
Title: The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs.
Volume: 14
Issue: 1
Pages: 5918
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Publication
25343272 | J:215012
First Author: Boerboom D
Year: 2015
Journal: Endocrinology
Title: β-catenin stabilization in gonadotropes impairs FSH synthesis in male mice in vivo.
Volume: 156
Issue: 1
Pages: 323-33
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Publication
27029473 | J:294378
First Author: Zhou X
Year: 2016
Journal: J Endocrinol
Title: Normal gonadotropin production and fertility in gonadotrope-specific Bmpr1a knockout mice.
Volume: 229
Issue: 3
Pages: 331-41
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Publication
29300908 | J:257093
First Author: Brown JL
Year: 2018
Journal: Endocrinology
Title: Sex- and Age-Specific Impact of ERK Loss Within the Pituitary Gonadotrope in Mice.
Volume: 159
Issue: 3
Pages: 1264-1276
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Publication
18425848 | J:134683
First Author: Tian G
Year: 2008
Journal: Dev Dyn
Title: Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta.
Volume: 237
Issue: 5
Pages: 1517-25
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Publication
29800110 | J:262146
First Author: Li Y
Year: 2018
Journal: Endocrinology
Title: Conditional Deletion of FOXL2 and SMAD4 in Gonadotropes of Adult Mice Causes Isolated FSH Deficiency.
Volume: 159
Issue: 7
Pages: 2641-2655
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Publication
27994055 | J:240719
First Author: Li Y
Year: 2017
Journal: J Biol Chem
Title: SMAD3 Regulates Follicle-stimulating Hormone Synthesis by Pituitary Gonadotrope Cells in Vivo.
Volume: 292
Issue: 6
Pages: 2301-2314
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Publication
23340250 | J:204036
First Author: Tran S
Year: 2013
Journal: Mol Endocrinol
Title: Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout mice.
Volume: 27
Issue: 3
Pages: 407-21
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Publication
34910520 | J:316383
First Author: Brûlé E
Year: 2021
Journal: Sci Adv
Title: TGFBR3L is an inhibin B co-receptor that regulates female fertility.
Volume: 7
Issue: 51
Pages: eabl4391
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Publication
24308975 | J:210699
First Author: Fortin J
Year: 2014
Journal: FASEB J
Title: Follicle-stimulating hormone synthesis and fertility are intact in mice lacking SMAD3 DNA binding activity and SMAD2 in gonadotrope cells.
Volume: 28
Issue: 3
Pages: 1474-85
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Publication
34905605 | J:323855
 
First Author: Lalonde-Larue A
Year: 2022
Journal: Endocrinology
Title: The Hippo Pathway Effectors YAP and TAZ Regulate LH Release by Pituitary Gonadotrope Cells in Mice.
Volume: 163
Issue: 1
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Publication
9593910 | J:47986
First Author: Dellovade TL
Year: 1998
Journal: Brain Res Dev Brain Res
Title: The gonadotropin-releasing hormone system does not develop in Small-Eye (Sey) mouse phenotype.
Volume: 107
Issue: 2
Pages: 233-40
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Publication
14654247 | J:87886
First Author: Kumar TR
Year: 2003
Journal: Mol Cell Endocrinol
Title: Regulation of FSHbeta and GnRH receptor gene expression in activin receptor II knockout male mice.
Volume: 212
Issue: 1-2
Pages: 19-27
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Publication
33475143 | J:302243
 
First Author: Ongaro L
Year: 2021
Journal: Endocrinology
Title: Development of a Highly Sensitive ELISA for Measurement of FSH in Serum, Plasma, and Whole Blood in Mice.
Volume: 162
Issue: 4
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Publication
34864945 | J:324595
 
First Author: Stamatiades GA
Year: 2022
Journal: Endocrinology
Title: Deletion of Gαq/11 or Gαs Proteins in Gonadotropes Differentially Affects Gonadotropin Production and Secretion in Mice.
Volume: 163
Issue: 2
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Publication
32191302 | J:296079
 
First Author: Ongaro L
Year: 2020
Journal: Endocrinology
Title: Human Follicle-Stimulating Hormone ß Subunit Expression Depends on FOXL2 and SMAD4.
Volume: 161
Issue: 5
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Publication
24739304 | J:214944
First Author: Fortin J
Year: 2014
Journal: FASEB J
Title: Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2.
Volume: 28
Issue: 8
Pages: 3396-410
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Publication
32270195 | J:292632
 
First Author: Schang G
Year: 2020
Journal: Endocrinology
Title: Murine FSH Production Depends on the Activin Type II Receptors ACVR2A and ACVR2B.
Volume: 161
Issue: 7
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Publication
25915183 | J:232657
First Author: Xie H
Year: 2015
Journal: Mol Endocrinol
Title: Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development.
Volume: 29
Issue: 6
Pages: 842-55
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Publication
17948256 | J:125764
First Author: Tiong J
Year: 2007
Journal: Dev Dyn
Title: Gonadotropin-releasing hormone-1 (GnRH-1) is involved in tooth maturation and biomineralization.
Volume: 236
Issue: 11
Pages: 2980-92
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Publication
35957608 | J:333151
 
First Author: Lin YF
Year: 2022
Journal: Endocrinology
Title: Steroidogenic Factor 1 Regulates Transcription of the Inhibin B Coreceptor in Pituitary Gonadotrope Cells.
Volume: 163
Issue: 11
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Publication
9388186 | J:44644
First Author: Sheng HZ
Year: 1997
Journal: Science
Title: Multistep control of pituitary organogenesis.
Volume: 278
Issue: 5344
Pages: 1809-12
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Publication
25105693 | J:216309
First Author: Roybal LL
Year: 2014
Journal: Mol Endocrinol
Title: Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ.
Volume: 28
Issue: 10
Pages: 1640-55
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Publication
11944940 | J:76131
First Author: Holley SJ
Year: 2002
Journal: Dev Biol
Title: Complementary expression of IGF-II and IGFBP-5 during anterior pituitary development.
Volume: 244
Issue: 2
Pages: 319-28
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Publication
23143598 | J:190867
First Author: Sun Y
Year: 2012
Journal: Nat Genet
Title: Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement.
Volume: 44
Issue: 12
Pages: 1375-81
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Publication
28911172 | J:248335
First Author: Kreisman MJ
Year: 2017
Journal: Endocrinology
Title: Androgens Mediate Sex-Dependent Gonadotropin Expression During Late Prenatal Development in the Mouse.
Volume: 158
Issue: 9
Pages: 2884-2894
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Publication
17698926 | J:129499
First Author: Ferraro TN
Year: 2007
Journal: Physiol Genomics
Title: Quantitative trait locus for seizure susceptibility on mouse chromosome 5 confirmed with reciprocal congenic strains.
Volume: 31
Issue: 3
Pages: 458-62
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Publication
12943993 | J:85559
First Author: Ellsworth BS
Year: 2003
Journal: Mol Cell Endocrinol
Title: The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein.
Volume: 206
Issue: 1-2
Pages: 93-111
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Publication
29263200 | J:257035
First Author: Kim YJ
Year: 2018
Journal: EMBO Rep
Title: WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome.
Volume: 19
Issue: 2
Pages: 269-289
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Publication
9090387 | J:39356
First Author: Good DJ
Year: 1997
Journal: Nat Genet
Title: Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene.
Volume: 15
Issue: 4
Pages: 397-401
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Publication
11807026 | J:73774
First Author: Suh H
Year: 2002
Journal: Development
Title: Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification.
Volume: 129
Issue: 2
Pages: 329-37
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Publication
29796621 | J:263775
First Author: Stallings CE
Year: 2018
Journal: Endocrinology
Title: Premature Expression of FOXO1 in Developing Mouse Pituitary Results in Anterior Lobe Hypoplasia.
Volume: 159
Issue: 8
Pages: 2891-2904
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Publication
16840533 | J:114717
First Author: Raetzman LT
Year: 2006
Journal: Mol Endocrinol
Title: Persistent expression of Notch2 delays gonadotrope differentiation.
Volume: 20
Issue: 11
Pages: 2898-908
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Publication
10843805 | J:62530
First Author: Tarantino LM
Year: 2000
Journal: Genomics
Title: A high-resolution radiation hybrid map of the proximal portion of mouse chromosome 5.
Volume: 66
Issue: 1
Pages: 55-64
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Publication
29997285 | J:267911
 
First Author: Timmermans S
Year: 2018
Journal: JCI Insight
Title: Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J.
Volume: 3
Issue: 13
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
27101301 | J:343928
First Author: Allen SJ
Year: 2016
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Leptin receptor null mice with reexpression of LepR in GnRHR expressing cells display elevated FSH levels but remain in a prepubertal state.
Volume: 310
Issue: 11
Pages: R1258-66
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Allele
Gnrhr<em1Smoc> | MGI:7289936
Name: gonadotropin releasing hormone receptor; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6428745 | C57BL/6JSmoc-Gnrhr<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Gnrhr<hh> | MGI:3574585
 
Name: gonadotropin releasing hormone receptor; hypogonadotrophic hypogonadism
Allele Type: Chemically induced (ENU)
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Gene
26012 | NSMF
Type: gene
Organism: human
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Genotype
Genotype
Symbol: Gnrhr/Gnrhr
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0090078 | hypogonadotropic hypogonadism 7 with or without anosmia
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HT Experiment
GSE215138 | Fetal origin of sex-bias brain aging [RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Allele
Gnrhr<tm2.1(GNRHR)Djb> | MGI:5908153
Name: gonadotropin releasing hormone receptor; targeted mutation 2.1, Daniel J Bernard
Allele Type: Targeted
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Gnrhr/Gnrhr
Background: involves: 129 * C57BL/6J * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Protein Domain
IPR001658 | GphnRH_fam_rcpt
Type: Family
Description: Gonadotropin-releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH) and luliberin, is synthesized and released from neurons within the hypothalamus []. GnRH is a regulator of reproductive processes, and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary, playing an important role in the control of gonadal function and normal ovarian cyclicity [].There are two major forms of receptor for GnRH, termed GnRHR []and GnRHR2 [], which are members the rhodopsin-like G-protein coupled receptor (GPCR) family. They are expressed on the surface of pituitary gonadotrope cells, as well as lymphocytes, breast, ovary and prostate [, , ]. GnRHR and GnRHR2 couple primarily to Gq/11 []but coupling to Gs and Gi in some systems []. In addition, GnRHR2 may mediate G protein-independent signalling to protein kinases [].Gonadotropin-releasing hormone receptors are of potential therapeutic use in the suppression of prostate cancer and endometriosis, as they have been shown to exert antiproliferative and/or proapoptotic effects on hormone-dependent cancer cells and mediate the effects of cytotoxins [, , , , ]. They may also have application in a number of sex hormone-dependent conditions [, ]. This entry represents the gonadotrophin releasing hormone receptor family and includes GnRHR and GnRHR2.
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Gene
2260 | FGFR1
Type: gene
Organism: human
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Publication
11041448 | -
First Author: Themmen APN
Year: 2000
Journal: Endocr Rev
Title: Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function.
Volume: 21
Issue: 5
Pages: 551-83
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Publication
4938639 | -
First Author: Schally AV
Year: 1971
Journal: Science
Title: Gonadotropin-releasing hormone: one polypeptide regulates secretion of luteinizing and follicle-stimulating hormones.
Volume: 173
Issue: 4001
Pages: 1036-8
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Publication
9894843 | -
First Author: Lovas S
Year: 1998
Journal: J Pept Res
Title: Direct anticancer activity of gonadotropin-releasing hormone-III.
Volume: 52
Issue: 5
Pages: 384-9
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Publication
9419371 | -
First Author: White RB
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Second gene for gonadotropin-releasing hormone in humans.
Volume: 95
Issue: 1
Pages: 305-9
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Publication
7534732 | -
First Author: Kakar SS
Year: 1994
Journal: Mol Cell Endocrinol
Title: The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary.
Volume: 106
Issue: 1-2
Pages: 145-9
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Publication
11713589 | -
First Author: Lau HL
Year: 2001
Journal: Int J Oncol
Title: Detection of mRNA expression of gonadotropin-releasing hormone and its receptor in normal and neoplastic rat prostates.
Volume: 19
Issue: 6
Pages: 1193-201
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Publication
6291912 | -
First Author: Marian J
Year: 1983
Journal: Endocrinology
Title: Subcellular localization of the receptor for gonadotropin-releasing hormone in pituitary and ovarian tissue.
Volume: 112
Issue: 1
Pages: 104-12
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Publication
10734055 | -
First Author: Grosse R
Year: 2000
Journal: J Biol Chem
Title: Gonadotropin-releasing hormone receptor initiates multiple signaling pathways by exclusively coupling to G(q/11) proteins.
Volume: 275
Issue: 13
Pages: 9193-200
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Publication
12591945 | -
First Author: Krsmanovic LZ
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: An agonist-induced switch in G protein coupling of the gonadotropin-releasing hormone receptor regulates pulsatile neuropeptide secretion.
Volume: 100
Issue: 5
Pages: 2969-74
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Publication
15059960 | -
First Author: Caunt CJ
Year: 2004
Journal: Endocrinology
Title: Regulation of gonadotropin-releasing hormone receptors by protein kinase C: inside out signalling and evidence for multiple active conformations.
Volume: 145
Issue: 8
Pages: 3594-602
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Publication
15561800 | -
First Author: Cheng CK
Year: 2005
Journal: Endocr Rev
Title: Molecular biology of gonadotropin-releasing hormone (GnRH)-I, GnRH-II, and their receptors in humans.
Volume: 26
Issue: 2
Pages: 283-306
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Publication
15613448 | -
First Author: Harrison GS
Year: 2004
Journal: Endocr Relat Cancer
Title: Gonadotropin-releasing hormone and its receptor in normal and malignant cells.
Volume: 11
Issue: 4
Pages: 725-48
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Publication
14726258 | -
First Author: Limonta P
Year: 2003
Journal: Front Neuroendocrinol
Title: The biology of gonadotropin hormone-releasing hormone: role in the control of tumor growth and progression in humans.
Volume: 24
Issue: 4
Pages: 279-95
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Publication
17237842 | -
First Author: Engel JB
Year: 2007
Journal: Nat Clin Pract Endocrinol Metab
Title: Drug Insight: clinical use of agonists and antagonists of luteinizing-hormone-releasing hormone.
Volume: 3
Issue: 2
Pages: 157-67
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Publication
12072036 | -
First Author: Kiesel LA
Year: 2002
Journal: Clin Endocrinol (Oxf)
Title: Clinical use of GnRH analogues.
Volume: 56
Issue: 6
Pages: 677-87
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Publication
15306097 | -
First Author: Weckermann D
Year: 2004
Journal: Eur Urol
Title: Hormone therapy in prostate cancer: LHRH antagonists versus LHRH analogues.
Volume: 46
Issue: 3
Pages: 279-83; discussion 283-4
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Publication
10396028 | -
First Author: Millar R
Year: 1999
Journal: J Endocrinol
Title: A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript.
Volume: 162
Issue: 1
Pages: 117-26
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Publication
11352653 | -
First Author: Neill JD
Year: 2001
Journal: Biochem Biophys Res Commun
Title: A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates.
Volume: 282
Issue: 4
Pages: 1012-8
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Publication
11493674 | -
First Author: Millar R
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: A novel mammalian receptor for the evolutionarily conserved type II GnRH.
Volume: 98
Issue: 17
Pages: 9636-41
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Publication
12538601 | -
First Author: Morgan K
Year: 2003
Journal: Endocrinology
Title: A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12.
Volume: 144
Issue: 2
Pages: 423-36
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Publication
16189182 | -
First Author: Eicke N
Year: 2005
Journal: Eur J Endocrinol
Title: GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs.
Volume: 153
Issue: 4
Pages: 605-12
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Publication
11861490 | -
First Author: Neill JD
Year: 2002
Journal: Endocrinology
Title: GnRH and GnRH receptor genes in the human genome.
Volume: 143
Issue: 3
Pages: 737-43
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Protein Domain
IPR027983 | GphnRH_2_rcpt
Type: Family
Description: Gonadotropin-releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH) and luliberin, is synthesized and released from neurons within the hypothalamus []. GnRH is a regulator of reproductive processes, and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary, playing an important role in the control of gonadal function and normal ovarian cyclicity [].There are two major forms of receptor for GnRH, termed GnRHR []and GnRHR2 [], which are members the rhodopsin-like G-protein coupled receptor (GPCR) family. They are expressed on the surface of pituitary gonadotrope cells, as well as lymphocytes, breast, ovary and prostate [, , ]. GnRHR and GnRHR2 couple primarily to Gq/11 []but coupling to Gs and Gi in some systems []. In addition, GnRHR2 may mediate G protein-independent signalling to protein kinases [].Gonadotropin-releasing hormone receptors are of potential therapeutic use in the suppression of prostate cancer and endometriosis, as they have been shown to exert antiproliferative and/or proapoptotic effects on hormone-dependent cancer cells and mediate the effects of cytotoxins [, , , , ]. They may also have application in a number of sex hormone-dependent conditions [, ]. This entry represents GnRHR2. There is currently some conflict regarding GnRHR2 being a functional protein. In non-hominoid primates and non-mammalian vertebrates GnRHR2 encodes a seven-transmembrane G protein-coupled receptor [, , ]. However, in humans, the N terminus of the predicted protein contains a frameshift and prematurestop codon. GnRHR2 transcription occurs but whether the gene produces a functional C-terminal multi-transmembrane protein is currently unresolved [, , ].
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Publication
27402603 | J:256905
 
First Author: Laverrière JN
Year: 2016
Journal: Mol Cell Endocrinol
Title: Epigenetic regulation of alternative promoters and enhancers in progenitor, immature, and mature gonadotrope cell lines.
Volume: 434
Pages: 250-65
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