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Search results 101 to 196 out of 196 for Grm6

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Type Details Score
Publication
- | J:82718
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Download
Title: MGI cDNA Clone Load
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Publication
16332269 | J:156373
First Author: Chang B
Year: 2005
Journal: Vis Neurosci
Title: Mouse models of ocular diseases.
Volume: 22
Issue: 5
Pages: 587-93
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Publication
21052544 | J:166679
 
First Author: Won J
Year: 2011
Journal: J Ophthalmol
Title: Mouse model resources for vision research.
Volume: 2011
Pages: 391384
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Publication
25979088 | J:242531
First Author: Bedogni F
Year: 2016
Journal: Cereb Cortex
Title: Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.
Volume: 26
Issue: 6
Pages: 2517-2529
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Publication
22723691 | J:185665
First Author: Guo Z
Year: 2012
Journal: J Neurosci
Title: Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.
Volume: 32
Issue: 25
Pages: 8509-20
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Allele
Grm6<nob8> | MGI:5754533
Name: glutamate receptor, metabotropic 6; no b wave 8
Allele Type: Spontaneous
Attribute String: Hypomorph
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Allele
Grm6<nob7> | MGI:5754842
Name: glutamate receptor, metabotropic 6; no b wave 7
Allele Type: Spontaneous
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Grm6/Grm6
Background: C57BL/6J-Grm6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Grm6/Grm6
Background: CBA/CaJ
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0110865 | congenital stationary night blindness 1B
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Allele
Tg(Grm6-YFP/TeNT)#Rolw | MGI:6850006
Name: transgene insertion, Rachel O L Wong
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Allele
Tg(Grm6-tdTomato)#Rolw | MGI:6850008
Name: transgene insertion, Rachel O L Wong
Allele Type: Transgenic
Attribute String: Reporter
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Publication
28547795 | J:269903
First Author: Anastassov IA
Year: 2019
Journal: J Comp Neurol
Title: Synaptogenesis and synaptic protein localization in the postnatal development of rod bipolar cell dendrites in mouse retina.
Volume: 527
Issue: 1
Pages: 52-66
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Allele
Grm6<nob4> | MGI:3580353
 
Name: glutamate receptor, metabotropic 6; no b wave 4
Allele Type: Chemically induced (ENU)
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Allele
Tg(Grm6-icre)1Rlbn | MGI:4411993
Name: transgene insertion 1, R Lane Brown
Allele Type: Transgenic
Attribute String: Recombinase
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Publication
19693082 | J:151917
First Author: Kerschensteiner D
Year: 2009
Journal: Nature
Title: Neurotransmission selectively regulates synapse formation in parallel circuits in vivo.
Volume: 460
Issue: 7258
Pages: 1016-20
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Genotype
Genotype
Symbol: Tg(Grm6-icre)1Rlbn/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Strain
MGI:3622784 | C57BL/6J-Grm6<nob4>/Nwu
Attribute String: coisogenic, chemically induced mutation, mutant strain
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Strain
MGI:3580431 | C57BL/6J-Grm6<nob4>
Attribute String: coisogenic, mutant strain, chemically induced mutation
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Publication
33088174 | J:356113
 
First Author: Fadl BR
Year: 2020
Journal: Mol Vis
Title: An optimized protocol for retina single-cell RNA sequencing.
Volume: 26
Pages: 705-717
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Genotype
Genotype
Symbol: Grm6/Grm6
Background: C57BL/6J-Grm6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Grm6/Grm6
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Publication
8188265 | J:16767
First Author: Kuramoto T
Year: 1994
Journal: Genomics
Title: Gene mapping of NMDA receptors and metabotropic glutamate receptors in the rat (Rattus norvegicus).
Volume: 19
Issue: 2
Pages: 358-61
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Publication
28746305 | J:253063
First Author: Jorstad NL
Year: 2017
Journal: Nature
Title: Stimulation of functional neuronal regeneration from Müller glia in adult mice.
Volume: 548
Issue: 7665
Pages: 103-107
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Genotype
Genotype
Symbol: Grm6/Grm6
Background: involves: C57BL/6J * C57BL/10 * DBA/2
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CAG-Bgeo/GFP)21Lbe/? Tg(Grm6-icre)1Rlbn/?
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Publication
22325362 | J:185567
First Author: Peachey NS
Year: 2012
Journal: Am J Hum Genet
Title: GPR179 is required for depolarizing bipolar cell function and is mutated in autosomal-recessive complete congenital stationary night blindness.
Volume: 90
Issue: 2
Pages: 331-9
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Publication
18667607 | J:139494
First Author: Kim DS
Year: 2008
Journal: J Neurosci
Title: A core paired-type and POU homeodomain-containing transcription factor program drives retinal bipolar cell gene expression.
Volume: 28
Issue: 31
Pages: 7748-64
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Publication
33922602 | J:308356
 
First Author: Orhan E
Year: 2021
Journal: Int J Mol Sci
Title: A New Mouse Model for Complete Congenital Stationary Night Blindness Due to Gpr179 Deficiency.
Volume: 22
Issue: 9
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Publication
19861548 | J:154776
First Author: Morgans CW
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells.
Volume: 106
Issue: 45
Pages: 19174-8
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Publication
36385954 | J:331438
 
First Author: Procyk CA
Year: 2022
Journal: Front Cell Neurosci
Title: Quantitative characterisation of ipRGCs in retinal degeneration using a computation platform for extracting and reconstructing single neurons in 3D from a multi-colour labeled population.
Volume: 16
Pages: 1009321
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Publication
36630957 | J:332915
First Author: Rodgers J
Year: 2023
Journal: Curr Biol
Title: Functional integrity of visual coding following advanced photoreceptor degeneration.
Volume: 33
Issue: 3
Pages: 474-486.e5
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Publication
30463000 | J:270519
First Author: Yu WQ
Year: 2018
Journal: Cell Rep
Title: Synaptic Convergence Patterns onto Retinal Ganglion Cells Are Preserved despite Topographic Variation in Pre- and Postsynaptic Territories.
Volume: 25
Issue: 8
Pages: 2017-2026.e3
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Publication
23583111 | J:326645
First Author: Schubert T
Year: 2013
Journal: Neuron
Title: Developmental regulation and activity-dependent maintenance of GABAergic presynaptic inhibition onto rod bipolar cell axonal terminals.
Volume: 78
Issue: 1
Pages: 124-37
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Publication
26420868 | J:225574
First Author: Hoon M
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Neurotransmission plays contrasting roles in the maturation of inhibitory synapses on axons and dendrites of retinal bipolar cells.
Volume: 112
Issue: 41
Pages: 12840-5
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Publication
32521255 | J:304137
First Author: Care RA
Year: 2020
Journal: Cell Rep
Title: Mature Retina Compensates Functionally for Partial Loss of Rod Photoreceptors.
Volume: 31
Issue: 10
Pages: 107730
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Publication
31092821 | J:275568
First Author: Okawa H
Year: 2019
Journal: Nat Commun
Title: Dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system.
Volume: 10
Issue: 1
Pages: 2167
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Publication
8840028 | -
First Author: Makoff A
Year: 1996
Journal: Brain Res Mol Brain Res
Title: Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS.
Volume: 40
Issue: 1
Pages: 165-70
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Publication
8288585 | -
First Author: Okamoto N
Year: 1994
Journal: J Biol Chem
Title: Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction.
Volume: 269
Issue: 2
Pages: 1231-6
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Protein Domain
IPR001883 | GPCR_3_mGluR7
Type: Family
Description: G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].GPCR family 3 receptors (also known as family C) are structurally similar to other GPCRs, but do not show any significant sequence similarity and thus represent a distinct group. Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length []. Family 3 members include the metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors [, , , ]. As these receptors regulate many important physiological processes they are potentially promising targets for drug development.The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+intracellular signalling pathway [, , , ]. At least eight sub-types of metabotropic receptor (GRM1-8) have been identified in cloning studies. The sub-types differ in their agonist pharmacology and signal transduction pathways.GRM7 mRNA has a widespread distribution in many neuronal cells of the central nervoussystem, with highest levels in the hippocampal formation, cerebral cortexand cerebellum [, ]; it is thus different from the more limitedly expressedGRM4 or GRM6 mRNA []. GRM7 and GRM4 are believed to correspond to theputative L-2-amino-4-phosphonobutyrate receptor, which plays an importantrole in modulation of glutamate transmission in the CNS [].
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Publication
34433078 | J:314267
First Author: Sinha R
Year: 2021
Journal: Curr Biol
Title: Transient expression of a GABA receptor subunit during early development is critical for inhibitory synapse maturation and function.
Volume: 31
Issue: 19
Pages: 4314-4326.e5
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Publication
31974009 | J:291953
First Author: Sinha R
Year: 2020
Journal: Neuron
Title: LRRTM4: A Novel Regulator of Presynaptic Inhibition and Ribbon Synapse Arrangements of Retinal Bipolar Cells.
Volume: 105
Issue: 6
Pages: 1007-1017.e5
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Protein
G3UZU3
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: false
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Protein
Q8BL09
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Protein
Q8BKZ1
Organism: Mus musculus/domesticus
Length: 381  
Fragment?: true
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Protein
Q8BKE3
Organism: Mus musculus/domesticus
Length: 361  
Fragment?: false
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Protein
Q68ED2
Organism: Mus musculus/domesticus
Length: 915  
Fragment?: false
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Protein
G5E8D5
Organism: Mus musculus/domesticus
Length: 922  
Fragment?: false
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Publication
1320017 | -
First Author: Abe T
Year: 1992
Journal: J Biol Chem
Title: Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.
Volume: 267
Issue: 19
Pages: 13361-8
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Publication
1847995 | -
First Author: Masu M
Year: 1991
Journal: Nature
Title: Sequence and expression of a metabotropic glutamate receptor.
Volume: 349
Issue: 6312
Pages: 760-5
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Publication
1656524 | -
First Author: Houamed KM
Year: 1991
Journal: Science
Title: Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain.
Volume: 252
Issue: 5010
Pages: 1318-21
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Publication
10773016 | -
First Author: Sullivan R
Year: 2000
Journal: J Pharmacol Exp Ther
Title: Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.
Volume: 293
Issue: 2
Pages: 460-7
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Publication
9292726 | J:42626
First Author: Ryba NJ
Year: 1997
Journal: Neuron
Title: A new multigene family of putative pheromone receptors.
Volume: 19
Issue: 2
Pages: 371-9
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Publication
17266540 | -
First Author: Bräuner-Osborne H
Year: 2007
Journal: Curr Drug Targets
Title: Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors.
Volume: 8
Issue: 1
Pages: 169-84
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Publication
8255296 | -
First Author: Brown EM
Year: 1993
Journal: Nature
Title: Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid.
Volume: 366
Issue: 6455
Pages: 575-80
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Publication
1309649 | -
First Author: Tanabe Y
Year: 1992
Journal: Neuron
Title: A family of metabotropic glutamate receptors.
Volume: 8
Issue: 1
Pages: 169-79
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
12679517 | J:83410
First Author: Vassilatis DK
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: The G protein-coupled receptor repertoires of human and mouse.
Volume: 100
Issue: 8
Pages: 4903-8
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Publication
8170923 | -
First Author: Attwood TK
Year: 1994
Journal: Protein Eng
Title: Fingerprinting G-protein-coupled receptors.
Volume: 7
Issue: 2
Pages: 195-203
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Publication
8081729 | -
First Author: Kolakowski LF Jr
Year: 1994
Journal: Receptors Channels
Title: GCRDb: a G-protein-coupled receptor database.
Volume: 2
Issue: 1
Pages: 1-7
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Publication
15914470 | -
First Author: Foord SM
Year: 2005
Journal: Pharmacol Rev
Title: International Union of Pharmacology. XLVI. G protein-coupled receptor list.
Volume: 57
Issue: 2
Pages: 279-88
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Publication
18948278 | -
First Author: Harmar AJ
Year: 2009
Journal: Nucleic Acids Res
Title: IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels.
Volume: 37
Issue: Database issue
Pages: D680-5
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Publication
16753280 | J:115055
First Author: Bjarnadóttir TK
Year: 2006
Journal: Genomics
Title: Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse.
Volume: 88
Issue: 3
Pages: 263-73
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Publication
23020293 | -
 
First Author: Civelli O
Year: 2013
Journal: Annu Rev Pharmacol Toxicol
Title: G protein-coupled receptor deorphanizations.
Volume: 53
Pages: 127-46
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