Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:7662999 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-07-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3603128 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7666111 |
Age: |
postnatal adult |
Image: |
1 |
|
Specimen Label: |
Body m |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7662999 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-07-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7666111 |
Age: |
postnatal adult |
Image: |
1 |
|
Specimen Label: |
Brain m |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:376591 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-08-31 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271122 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7522932 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Supplementary table 2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:376591 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-08-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271122 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7711551 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Supplementary Table 3 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:376591 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-08-31 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7522932 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Supplementary table 2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:376591 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-08-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7711551 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Supplementary Table 3 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Watanabe Y |
Year: |
2014 |
Journal: |
Cell Rep |
Title: |
Dendrite development regulated by the schizophrenia-associated gene FEZ1 involves the ubiquitin proteasome system. |
Volume: |
7 |
Issue: |
2 |
Pages: |
552-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Verdin E |
Year: |
2003 |
Journal: |
Trends Genet |
Title: |
Class II histone deacetylases: versatile regulators. |
Volume: |
19 |
Issue: |
5 |
Pages: |
286-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ferreira RC |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
Histone Deacetylase 1 Is Essential for Rod Photoreceptor Differentiation by Regulating Acetylation at Histone H3 Lysine 9 and Histone H4 Lysine 12 in the Mouse Retina. |
Volume: |
292 |
Issue: |
6 |
Pages: |
2422-2440 |
|
•
•
•
•
•
|
Publication |
First Author: |
Izzi L |
Year: |
2007 |
Journal: |
EMBO J |
Title: |
Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. |
Volume: |
26 |
Issue: |
13 |
Pages: |
3132-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pang AL |
Year: |
2003 |
Journal: |
J Androl |
Title: |
Identification of differentially expressed genes in mouse spermatogenesis. |
Volume: |
24 |
Issue: |
6 |
Pages: |
899-911 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nam K-H |
Year: |
2016 |
Journal: |
MGI Direct Data Submission |
Title: |
Direct Data Submission for Alleles from the KRIBB Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Witt O |
Year: |
2009 |
Journal: |
Cancer Lett |
Title: |
HDAC family: What are the cancer relevant targets? |
Volume: |
277 |
Issue: |
1 |
Pages: |
8-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tiwari S |
Year: |
2014 |
Journal: |
BMC Dev Biol |
Title: |
Histone deacetylase expression patterns in developing murine optic nerve. |
Volume: |
14 |
|
Pages: |
30 |
|
•
•
•
•
•
|
Publication |
First Author: |
An CI |
Year: |
2011 |
Journal: |
BMC Dev Biol |
Title: |
Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6. |
Volume: |
11 |
|
Pages: |
59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kuninger D |
Year: |
2004 |
Journal: |
Genomics |
Title: |
Gene discovery by microarray: identification of novel genes induced during growth factor-mediated muscle cell survival and differentiation. |
Volume: |
84 |
Issue: |
5 |
Pages: |
876-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elsen GE |
Year: |
2018 |
Journal: |
Front Neurosci |
Title: |
The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1. |
Volume: |
12 |
|
Pages: |
571 |
|
•
•
•
•
•
|
Publication |
First Author: |
Strausberg RL |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
Volume: |
99 |
Issue: |
26 |
Pages: |
16899-903 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Tang F |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Deterministic and stochastic allele specific gene expression in single mouse blastomeres. |
Volume: |
6 |
Issue: |
6 |
Pages: |
e21208 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Yokoyama S |
Year: |
2009 |
Journal: |
Dev Cell |
Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
Volume: |
17 |
Issue: |
6 |
Pages: |
836-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators, MGI curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation based on Enzyme Commission mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
Data Curation Using Mouse Genome Assembly |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bi L |
Year: |
2021 |
Journal: |
Cancer Res |
Title: |
HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness. |
Volume: |
81 |
Issue: |
8 |
Pages: |
2015-2028 |
|
•
•
•
•
•
|
Publication |
First Author: |
Buglio D |
Year: |
2011 |
Journal: |
Blood |
Title: |
HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma. |
Volume: |
117 |
Issue: |
10 |
Pages: |
2910-7 |
|
•
•
•
•
•
|
Allele |
Name: |
histone deacetylase 11; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Allele |
Name: |
histone deacetylase 11; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao L |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. |
Volume: |
277 |
Issue: |
28 |
Pages: |
25748-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Voelter-Mahlknecht S |
Year: |
2005 |
Journal: |
Int J Mol Med |
Title: |
Chromosomal organization and localization of the novel class IV human histone deacetylase 11 gene. |
Volume: |
16 |
Issue: |
4 |
Pages: |
589-98 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents a domain found in class IV histone deacetylases (), also known as histone deacetylase 11 (HDAC11) [, ]. This class includes animal HDAC11, plant HDA2 and related bacterial deacetylases. Enzymes in this subfamily participate in regulation of a number of different processes through protein modification (deacetylation) []. HDAC11 and HDAC6 interact with each other in the cytoplasm and nuclei of APCs (antigen presenting cells) and are recruited to the IL-10 gene promoter to regulate its transcriptional activity [].In mammals, HDAC11 proteins are known to be involved in progression of various tumours. HDAC11 plays an essential role in regulating OX40 ligand (OX40L) expression in Hodgkin lymphoma (HL); selective inhibition of HDAC11 expression significantly up-regulates OX40L and induces apoptosis in HL cell lines. Thus, inhibition of HDAC11 could be a therapeutic drug option for antitumor immune response in HL patients []. |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion HO220, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
347
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
347
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Leipe DD |
Year: |
1997 |
Journal: |
Nucleic Acids Res |
Title: |
Histone deacetylases, acetoin utilization proteins and acetylpolyamine amidohydrolases are members of an ancient protein superfamily. |
Volume: |
25 |
Issue: |
18 |
Pages: |
3693-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vengoji R |
Year: |
2021 |
Journal: |
J Exp Clin Cancer Res |
Title: |
Differential gene expression-based connectivity mapping identified novel drug candidate and improved Temozolomide efficacy for Glioblastoma. |
Volume: |
40 |
Issue: |
1 |
Pages: |
335 |
|
•
•
•
•
•
|
Publication |
First Author: |
Torres OV |
Year: |
2016 |
Journal: |
Neurotox Res |
Title: |
An Acute Methamphetamine Injection Downregulates the Expression of Several Histone Deacetylases (HDACs) in the Mouse Nucleus Accumbens: Potential Regulatory Role of HDAC2 Expression. |
Volume: |
30 |
Issue: |
1 |
Pages: |
32-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
|
|
|
|
•
•
•
•
•
|