Type |
Details |
Score |
Publication |
First Author: |
Reed JC |
Year: |
2003 |
Journal: |
Genome Res |
Title: |
Comparative analysis of apoptosis and inflammation genes of mice and humans. |
Volume: |
13 |
Issue: |
6B |
Pages: |
1376-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Sequence and Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Mouse Genome Sequence Project Annotation |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ahuja N |
Year: |
2022 |
Journal: |
Dev Biol |
Title: |
Endothelial Cyp26b1 restrains murine heart valve growth during development. |
Volume: |
486 |
|
Pages: |
81-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Strausberg RL |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
Volume: |
99 |
Issue: |
26 |
Pages: |
16899-903 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The RIKEN BioResource Center |
Year: |
2006 |
Journal: |
Unpublished |
Title: |
Information obtained from The RIKEN BioResource Center |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Araki K |
Year: |
1999 |
Journal: |
Cell Mol Biol (Noisy-le-grand) |
Title: |
Exchangeable gene trap using the Cre/mutated lox system. |
Volume: |
45 |
Issue: |
5 |
Pages: |
737-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Taniwaki T |
Year: |
2005 |
Journal: |
Dev Growth Differ |
Title: |
Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. |
Volume: |
47 |
Issue: |
3 |
Pages: |
163-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Backcross DNA Panel Mapping Resource |
Year: |
1999 |
Journal: |
Database Release |
Title: |
JAX BSS Panel Mapping Data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
Data Curation Using Mouse Genome Assembly |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2018 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Means AL |
Year: |
1992 |
Journal: |
Mol Cell Biol |
Title: |
The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter. |
Volume: |
12 |
Issue: |
3 |
Pages: |
1054-63 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
QTL |
Type: |
QTL |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
QTL |
Type: |
QTL |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Allele |
Name: |
huntingtin interacting protein 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain. |
|
•
•
•
•
•
|
Publication |
First Author: |
Vandenbol M |
Year: |
1989 |
Journal: |
Gene |
Title: |
Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases. |
Volume: |
83 |
Issue: |
1 |
Pages: |
153-9 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Allele |
Name: |
huntingtin interacting protein 1; targeted mutation 4, Theodora S Ross |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Humanized sequence, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
huntingtin interacting protein 1; targeted mutation 5.2, Theodora S Ross |
Allele Type: |
Targeted |
Attribute String: |
Humanized sequence, Inserted expressed sequence, Null/knockout, Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Allele |
Name: |
huntingtin interacting protein 1; targeted mutation 5.1, Theodora S Ross |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Humanized sequence, Inserted expressed sequence, Null/knockout, Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, coisogenic, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hip1/Hip1<+> |
Background: |
involves: 129X1/SvJ * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hip1/Hip1 |
Background: |
involves: C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hip1/Hip1 |
Background: |
involves: C57BL/6 * SJL |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Ybe JA |
Year: |
2007 |
Journal: |
J Mol Biol |
Title: |
Crystal structure at 2.8 A of the DLLRKN-containing coiled-coil domain of huntingtin-interacting protein 1 (HIP1) reveals a surface suitable for clathrin light chain binding. |
Volume: |
367 |
Issue: |
1 |
Pages: |
8-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilbur JD |
Year: |
2010 |
Journal: |
Acta Crystallogr D Biol Crystallogr |
Title: |
Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain. |
Volume: |
66 |
Issue: |
Pt 3 |
Pages: |
314-8 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the coiled-coil region of Huntingtin-interacting protein 1 (HIP1). It carries a highly conserved HADLLRKN sequence motif at its N terminus which effects the binding of HIP1R to clathrin light-chain EED regulatory site. This binding then stimulates clathrin lattice assembly. HIP1 is an obligate binding partner for Huntingtin, and loss of this interaction triggers the cascade of events that results in the apoptosis of neuronal cells and the onset of Huntington's disease []. Clathrin light-chain binds to a flexible coiled-coil domain in HIP1 and induces a compact state that is refractory to actin binding []. |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hip1/Hip1<+> Tg(Mx1-cre)1Cgn/? |
Background: |
involves: 129X1/SvJ * C57BL/6 * CBA |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hip1/Hip1 Tg(Mx1-cre)1Cgn/? |
Background: |
involves: C57BL/6 * C57BL/6J * CBA/J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gdpd3/Gdpd3 Hip1/Hip1 |
Background: |
involves: C57BL/6 * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hip1/Hip1 Hip1r/Hip1r |
Background: |
involves: 129X1/SvJ * C57BL/6 * SJL |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hip1/Hip1 Tg(GFAP-cre)25Mes/? |
Background: |
involves: C57BL/6 * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Okano A |
Year: |
2003 |
Journal: |
Brain Res |
Title: |
Huntingtin-interacting protein-1-related protein of rat (rHIP1R) is localized in the postsynaptic regions. |
Volume: |
967 |
Issue: |
1-2 |
Pages: |
210-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vogt A |
Year: |
2004 |
Journal: |
J Exp Med |
Title: |
Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting protein. |
Volume: |
199 |
Issue: |
6 |
Pages: |
753-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miletich I |
Year: |
2005 |
Journal: |
Arch Oral Biol |
Title: |
Expression of the Hedgehog antagonists Rab23 and Slimb/betaTrCP during mouse tooth development. |
Volume: |
50 |
Issue: |
2 |
Pages: |
147-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Khan M |
Year: |
2007 |
Journal: |
Gene Expr Patterns |
Title: |
Hedgehog pathway gene expression during early development of the molar tooth root in the mouse. |
Volume: |
7 |
Issue: |
3 |
Pages: |
239-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bradley SV |
Year: |
2007 |
Journal: |
Cancer Res |
Title: |
Aberrant Huntingtin interacting protein 1 in lymphoid malignancies. |
Volume: |
67 |
Issue: |
18 |
Pages: |
8923-31 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hip1/Hip1<+> Runx1/Runx1<+> Tg(Mx1-cre)1Cgn/? |
Background: |
involves: 129X1/SvJ * C57BL/6 * CBA |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Mishra SK |
Year: |
2002 |
Journal: |
EMBO J |
Title: |
Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor. |
Volume: |
21 |
Issue: |
18 |
Pages: |
4915-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rao DS |
Year: |
2002 |
Journal: |
J Clin Invest |
Title: |
Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival. |
Volume: |
110 |
Issue: |
3 |
Pages: |
351-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen CY |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo. |
Volume: |
280 |
Issue: |
7 |
Pages: |
6109-17 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
682
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
McCann RO |
Year: |
1999 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Functional genomic analysis reveals the utility of the I/LWEQ module as a predictor of protein:actin interaction. |
Volume: |
266 |
Issue: |
1 |
Pages: |
135-40 |
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Publication |
First Author: |
Brett TJ |
Year: |
2006 |
Journal: |
Nat Struct Mol Biol |
Title: |
Structural definition of the F-actin-binding THATCH domain from HIP1R. |
Volume: |
13 |
Issue: |
2 |
Pages: |
121-30 |
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Publication |
First Author: |
Hickey DD |
Year: |
1983 |
Journal: |
Undersea Biomed Res |
Title: |
Influence of exercise on maximal voluntary ventilation and forced expiratory flow at depth. |
Volume: |
10 |
Issue: |
3 |
Pages: |
241-54 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
122
 |
Fragment?: |
true |
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Protein Domain |
Type: |
Domain |
Description: |
The I/LWEQ domain is a ~250-residue actin-binding module that is found in theC termini of functionally diverse proteins from yeast to mammals. The I/LWEQdomain contains four conserved blocks and has been named after the conservedinitial residues of blocks 1-4. The I/LWEQ domain is generally found near theC terminus and in association with other domains, such as FERM or ENTH. The I/LWEQ domain has been shown to bind to F-actin and to bundle actin filaments [, , ].The I/LWEQ domain contains a proteolysis resistant-core that has an all-α-helical structure composed of five long down-up-down-up-down antiparallelhelices connected by short loops and one short connecting alpha helix arranged in a progressive topology. The proteolysis-resistant core isfollowed by a C-terminal latch region that adopts an α-helicalconformation. The latch region can mediate oligomerization of I/LWEQ domains,possibly as dimers, and this seems to enhance the F-actin-binding ability ofthe proteolysis-resistant core [].It's worth noting that the I/LWEQ domain has also been called the talin-HIP1/R/Slap2p actin- tethering C-terminal homology (THATCH) domain (HIP1/R/Slap2p denotes similarity of Slap2p to HIP1 and HIP1R) []. |
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Protein Domain |
Type: |
Homologous_superfamily |
Description: |
The I/LWEQ domain is a ~250-residue actin-binding module that is found in theC termini of functionally diverse proteins from yeast to mammals. The I/LWEQdomain contains four conserved blocks and has been named after the conservedinitial residues of blocks 1-4. The I/LWEQ domain is generally found near theC terminus and in association with other domains, such as FERM or ENTH. The I/LWEQ domain has been shown to bind to F-actin and to bundle actin filaments [, , ].The I/LWEQ domain contains a proteolysis resistant-core that has an all-α-helical structure composed of five long down-up-down-up-down antiparallelhelices connected by short loops and one short connecting alpha helix arranged in a progressive topology. The proteolysis-resistant core isfollowed by a C-terminal latch region that adopts an α-helicalconformation. The latch region can mediate oligomerization of I/LWEQ domains,possibly as dimers, and this seems to enhance the F-actin-binding ability ofthe proteolysis-resistant core [].It's worth noting that the I/LWEQ domain has also been called the talin-HIP1/R/Slap2p actin- tethering C-terminal homology (THATCH) domain (HIP1/R/Slap2p denotes similarity of Slap2p to HIP1 and HIP1R) []. |
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Publication |
First Author: |
Aston-Mourney K |
Year: |
2007 |
Journal: |
Diabetologia |
Title: |
Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes. |
Volume: |
50 |
Issue: |
12 |
Pages: |
2476-85 |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
529
 |
Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
547
 |
Fragment?: |
true |
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•
•
•
•
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Publication |
First Author: |
McCann RO |
Year: |
1997 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The I/LWEQ module: a conserved sequence that signifies F-actin binding in functionally diverse proteins from yeast to mammals. |
Volume: |
94 |
Issue: |
11 |
Pages: |
5679-84 |
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Publication |
First Author: |
Kim JH |
Year: |
2009 |
Journal: |
Cell Physiol Biochem |
Title: |
HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death. |
Volume: |
23 |
Issue: |
1-3 |
Pages: |
43-52 |
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Protein Domain |
Type: |
Family |
Description: |
Huntingtin-interacting protein 1-related protein (HIP1R, also known as HIP-12) belongs to the Sla2 family. HIP1R is the only known mammalian relative of huntingtin-interacting protein 1 (HIP1) []. HIP1R may have a role in actin regulation during endocytosis and is shown to promote clathrin assembly. It may also be involved in the apoptotic pathway through its interaction with a member of the Bcl-2 pro-apoptotic family [].The Sla2 family, also known as Sla2p/HIP1/HIP1R family, including Sla2p from budding yeasts [], End4 from fission yeasts [], Huntingtin-interacting protein 1 (HIP1) and HIP1-related (HIP1R) from humans and mice []. They are adaptor proteins that link actin to clathrin and endocytosis in the clathrin-mediated endocytosis (CME) pathway. They contain the ENTH and ANTH (E/ANTH) domain that binds both inositol phospholipids and proteins that contribute to the nucleation and formation of clathrin coats on membranes []. They also contain an I/LWEQ (talin-like) domain, which is an actin-binding domain found in proteins that serve as linkers between the actin cytoskeleton and cellular compartments []. The talin-like domains of Sla2p and HIP1R have been shown to bind F-actin (filamentous actin), however, the same level of actin binding has not been observed with HIP1 []. The central domain of the Sla2p/HIP1/HIP1R proteins contains a coiled-coil domain and several consensus sequences enabling protein-protein interactions []. Yeast Sla2p has been extensively studied: Sla2p arrives at existing endocytic patches with a ~25 seconds delay relative to clathrin and dissociates simultaneously with clathrin upon recruitment of actin-related proteins [, ]. It serves as a bridge, connecting the endocytic patch to the cortical actin cytoskeleton []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
165
 |
Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
316
 |
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1068
 |
Fragment?: |
false |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1068
 |
Fragment?: |
false |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1068
 |
Fragment?: |
false |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1083
 |
Fragment?: |
true |
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•
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