|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 200 out of 218 for Hip1

0.029s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
First Author: Reed JC
Year: 2003
Journal: Genome Res
Title: Comparative analysis of apoptosis and inflammation genes of mice and humans.
Volume: 13
Issue: 6B
Pages: 1376-88
Publication        
First Author: Mouse Genome Sequence and Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Mouse Genome Sequence Project Annotation
Publication  
First Author: Ahuja N
Year: 2022
Journal: Dev Biol
Title: Endothelial Cyp26b1 restrains murine heart valve growth during development.
Volume: 486
Pages: 81-95
Publication
First Author: Strausberg RL
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Volume: 99
Issue: 26
Pages: 16899-903
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication      
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
Publication
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
Publication
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
Publication      
First Author: The Jackson Laboratory Backcross DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX BSS Panel Mapping Data
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Means AL
Year: 1992
Journal: Mol Cell Biol
Title: The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter.
Volume: 12
Issue: 3
Pages: 1054-63
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
QTL
Type: QTL
Organism: mouse, laboratory
QTL
Type: QTL
Organism: mouse, laboratory
Allele
Name: huntingtin interacting protein 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Interaction Experiment
Description: Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain.
Publication
First Author: Vandenbol M
Year: 1989
Journal: Gene
Title: Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases.
Volume: 83
Issue: 1
Pages: 153-9
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Allele
Name: huntingtin interacting protein 1; targeted mutation 4, Theodora S Ross
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, No functional change
Allele
Name: huntingtin interacting protein 1; targeted mutation 5.2, Theodora S Ross
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence, Null/knockout, Reporter
Strain
Attribute String: congenic, mutant strain, targeted mutation
Allele
Name: huntingtin interacting protein 1; targeted mutation 5.1, Theodora S Ross
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Null/knockout, Reporter
Strain
Attribute String: mutant strain, coisogenic, targeted mutation
Genotype
Symbol: Hip1/Hip1<+>
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Hip1/Hip1
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Hip1/Hip1
Background: involves: C57BL/6 * SJL
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Ybe JA
Year: 2007
Journal: J Mol Biol
Title: Crystal structure at 2.8 A of the DLLRKN-containing coiled-coil domain of huntingtin-interacting protein 1 (HIP1) reveals a surface suitable for clathrin light chain binding.
Volume: 367
Issue: 1
Pages: 8-15
Publication
First Author: Wilbur JD
Year: 2010
Journal: Acta Crystallogr D Biol Crystallogr
Title: Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain.
Volume: 66
Issue: Pt 3
Pages: 314-8
Protein Domain
Type: Domain
Description: This entry represents the coiled-coil region of Huntingtin-interacting protein 1 (HIP1). It carries a highly conserved HADLLRKN sequence motif at its N terminus which effects the binding of HIP1R to clathrin light-chain EED regulatory site. This binding then stimulates clathrin lattice assembly. HIP1 is an obligate binding partner for Huntingtin, and loss of this interaction triggers the cascade of events that results in the apoptosis of neuronal cells and the onset of Huntington's disease []. Clathrin light-chain binds to a flexible coiled-coil domain in HIP1 and induces a compact state that is refractory to actin binding [].
Genotype
Symbol: Hip1/Hip1<+> Tg(Mx1-cre)1Cgn/?
Background: involves: 129X1/SvJ * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Hip1/Hip1 Tg(Mx1-cre)1Cgn/?
Background: involves: C57BL/6 * C57BL/6J * CBA/J
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gdpd3/Gdpd3 Hip1/Hip1
Background: involves: C57BL/6 * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Hip1/Hip1 Hip1r/Hip1r
Background: involves: 129X1/SvJ * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Hip1/Hip1 Tg(GFAP-cre)25Mes/?
Background: involves: C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Okano A
Year: 2003
Journal: Brain Res
Title: Huntingtin-interacting protein-1-related protein of rat (rHIP1R) is localized in the postsynaptic regions.
Volume: 967
Issue: 1-2
Pages: 210-25
Publication
First Author: Vogt A
Year: 2004
Journal: J Exp Med
Title: Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting protein.
Volume: 199
Issue: 6
Pages: 753-61
Publication
First Author: Miletich I
Year: 2005
Journal: Arch Oral Biol
Title: Expression of the Hedgehog antagonists Rab23 and Slimb/betaTrCP during mouse tooth development.
Volume: 50
Issue: 2
Pages: 147-51
Publication
First Author: Khan M
Year: 2007
Journal: Gene Expr Patterns
Title: Hedgehog pathway gene expression during early development of the molar tooth root in the mouse.
Volume: 7
Issue: 3
Pages: 239-43
Publication
First Author: Bradley SV
Year: 2007
Journal: Cancer Res
Title: Aberrant Huntingtin interacting protein 1 in lymphoid malignancies.
Volume: 67
Issue: 18
Pages: 8923-31
Genotype
Symbol: Hip1/Hip1<+> Runx1/Runx1<+> Tg(Mx1-cre)1Cgn/?
Background: involves: 129X1/SvJ * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Mishra SK
Year: 2002
Journal: EMBO J
Title: Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor.
Volume: 21
Issue: 18
Pages: 4915-26
Publication
First Author: Rao DS
Year: 2002
Journal: J Clin Invest
Title: Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival.
Volume: 110
Issue: 3
Pages: 351-60
Publication
First Author: Chen CY
Year: 2005
Journal: J Biol Chem
Title: Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo.
Volume: 280
Issue: 7
Pages: 6109-17
Protein
Organism: Mus musculus/domesticus
Length: 682  
Fragment?: true
Publication
First Author: McCann RO
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Functional genomic analysis reveals the utility of the I/LWEQ module as a predictor of protein:actin interaction.
Volume: 266
Issue: 1
Pages: 135-40
Publication
First Author: Brett TJ
Year: 2006
Journal: Nat Struct Mol Biol
Title: Structural definition of the F-actin-binding THATCH domain from HIP1R.
Volume: 13
Issue: 2
Pages: 121-30
Publication
First Author: Hickey DD
Year: 1983
Journal: Undersea Biomed Res
Title: Influence of exercise on maximal voluntary ventilation and forced expiratory flow at depth.
Volume: 10
Issue: 3
Pages: 241-54
Protein
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: true
Protein Domain
Type: Domain
Description: The I/LWEQ domain is a ~250-residue actin-binding module that is found in theC termini of functionally diverse proteins from yeast to mammals. The I/LWEQdomain contains four conserved blocks and has been named after the conservedinitial residues of blocks 1-4. The I/LWEQ domain is generally found near theC terminus and in association with other domains, such as FERM or ENTH. The I/LWEQ domain has been shown to bind to F-actin and to bundle actin filaments [, , ].The I/LWEQ domain contains a proteolysis resistant-core that has an all-α-helical structure composed of five long down-up-down-up-down antiparallelhelices connected by short loops and one short connecting alpha helix arranged in a progressive topology. The proteolysis-resistant core isfollowed by a C-terminal latch region that adopts an α-helicalconformation. The latch region can mediate oligomerization of I/LWEQ domains,possibly as dimers, and this seems to enhance the F-actin-binding ability ofthe proteolysis-resistant core [].It's worth noting that the I/LWEQ domain has also been called the talin-HIP1/R/Slap2p actin- tethering C-terminal homology (THATCH) domain (HIP1/R/Slap2p denotes similarity of Slap2p to HIP1 and HIP1R) [].
Protein Domain
Type: Homologous_superfamily
Description: The I/LWEQ domain is a ~250-residue actin-binding module that is found in theC termini of functionally diverse proteins from yeast to mammals. The I/LWEQdomain contains four conserved blocks and has been named after the conservedinitial residues of blocks 1-4. The I/LWEQ domain is generally found near theC terminus and in association with other domains, such as FERM or ENTH. The I/LWEQ domain has been shown to bind to F-actin and to bundle actin filaments [, , ].The I/LWEQ domain contains a proteolysis resistant-core that has an all-α-helical structure composed of five long down-up-down-up-down antiparallelhelices connected by short loops and one short connecting alpha helix arranged in a progressive topology. The proteolysis-resistant core isfollowed by a C-terminal latch region that adopts an α-helicalconformation. The latch region can mediate oligomerization of I/LWEQ domains,possibly as dimers, and this seems to enhance the F-actin-binding ability ofthe proteolysis-resistant core [].It's worth noting that the I/LWEQ domain has also been called the talin-HIP1/R/Slap2p actin- tethering C-terminal homology (THATCH) domain (HIP1/R/Slap2p denotes similarity of Slap2p to HIP1 and HIP1R) [].
Publication
First Author: Aston-Mourney K
Year: 2007
Journal: Diabetologia
Title: Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes.
Volume: 50
Issue: 12
Pages: 2476-85
Protein
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 547  
Fragment?: true
Publication
First Author: McCann RO
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: The I/LWEQ module: a conserved sequence that signifies F-actin binding in functionally diverse proteins from yeast to mammals.
Volume: 94
Issue: 11
Pages: 5679-84
Publication
First Author: Kim JH
Year: 2009
Journal: Cell Physiol Biochem
Title: HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death.
Volume: 23
Issue: 1-3
Pages: 43-52
Protein Domain
Type: Family
Description: Huntingtin-interacting protein 1-related protein (HIP1R, also known as HIP-12) belongs to the Sla2 family. HIP1R is the only known mammalian relative of huntingtin-interacting protein 1 (HIP1) []. HIP1R may have a role in actin regulation during endocytosis and is shown to promote clathrin assembly. It may also be involved in the apoptotic pathway through its interaction with a member of the Bcl-2 pro-apoptotic family [].The Sla2 family, also known as Sla2p/HIP1/HIP1R family, including Sla2p from budding yeasts [], End4 from fission yeasts [], Huntingtin-interacting protein 1 (HIP1) and HIP1-related (HIP1R) from humans and mice []. They are adaptor proteins that link actin to clathrin and endocytosis in the clathrin-mediated endocytosis (CME) pathway. They contain the ENTH and ANTH (E/ANTH) domain that binds both inositol phospholipids and proteins that contribute to the nucleation and formation of clathrin coats on membranes []. They also contain an I/LWEQ (talin-like) domain, which is an actin-binding domain found in proteins that serve as linkers between the actin cytoskeleton and cellular compartments []. The talin-like domains of Sla2p and HIP1R have been shown to bind F-actin (filamentous actin), however, the same level of actin binding has not been observed with HIP1 []. The central domain of the Sla2p/HIP1/HIP1R proteins contains a coiled-coil domain and several consensus sequences enabling protein-protein interactions []. Yeast Sla2p has been extensively studied: Sla2p arrives at existing endocytic patches with a ~25 seconds delay relative to clathrin and dissociates simultaneously with clathrin upon recruitment of actin-related proteins [, ]. It serves as a bridge, connecting the endocytic patch to the cortical actin cytoskeleton [].
Protein
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1068  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1068  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1068  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1083  
Fragment?: true