Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:3615619 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-24 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753627 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3617511 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615619 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3617511 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
Note: |
Expression was detected in precortical tissue. |
Specimen Label: |
E13.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615619 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754427 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617511 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3584875 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3284528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585481 |
Age: |
postnatal day 6 |
|
|
Specimen Label: |
CNS |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615619 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3284527 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617511 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3584875 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1647024 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:3585481 |
Age: |
embryonic day 16.0 |
|
|
Specimen Label: |
Embryo |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1988340 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603923 |
Pattern: |
Ubiquitous |
Stage: |
TS23 |
Assay Id: |
MGI:4825537 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_006316_13 |
|
Specimen Label: |
euxassay_006316_13 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7469442 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-05-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603919 |
Pattern: |
Widespread |
Stage: |
TS19 |
Assay Id: |
MGI:7469580 |
Age: |
embryonic day 11.5 |
Image: |
1H |
Note: |
There is broad expression in the nervous system as well as in other tissues. |
Specimen Label: |
1H |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3584875 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915726 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:3585481 |
Age: |
embryonic day 18.0 |
Image: |
E18 |
Note: |
Expression was detected in the outer neuroblastic layer. |
Specimen Label: |
E18 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3584875 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915727 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:3585481 |
Age: |
postnatal day 0-1 |
Image: |
P0/1 |
Note: |
Expression was detected in the vitreal outer neuroblastic layer. |
Specimen Label: |
P0/1 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3584875 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915727 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:3585481 |
Age: |
postnatal day 2-3 |
Image: |
P2/3 |
Note: |
Expression was detected in the vitreal outer neuroblastic layer. |
Specimen Label: |
P2/3 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3584875 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585481 |
Age: |
postnatal day 6-7 |
Image: |
P6/7 |
|
Specimen Label: |
P6/7 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3584875 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1915728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585481 |
Age: |
postnatal adult |
Image: |
Adult |
|
Specimen Label: |
Adult |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6720355 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-07-27 |
Strength: |
Weak |
Sex: |
Female |
Emaps: |
EMAPS:3647428 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:6726375 |
Age: |
postnatal adult |
|
Note: |
Expression is in the granulosa cells of small and growing follicles. |
Specimen Label: |
4A Female |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3584875 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684624 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:3585481 |
Age: |
embryonic day 16.0 |
|
|
Specimen Label: |
Embryo |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3584875 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1859224 |
Pattern: |
Regionally restricted |
Stage: |
TS24 |
Assay Id: |
MGI:3585481 |
Age: |
embryonic day 16.0 |
Image: |
E16 |
Note: |
Expression was detected in the outer neuroblastic layer. |
Specimen Label: |
E16 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6720355 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-07-27 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:360355 |
Pattern: |
Not Specified |
Stage: |
TS05 |
Assay Id: |
MGI:6726385 |
Age: |
embryonic day 4.0 |
|
Note: |
There is cytoplasmic staining with a granular appearance. |
Specimen Label: |
5C |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6720355 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-07-27 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797222 |
Pattern: |
Ubiquitous |
Stage: |
TS22 |
Assay Id: |
MGI:6726375 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
not shown Male |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6720355 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-07-27 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797220 |
Pattern: |
Ubiquitous |
Stage: |
TS20 |
Assay Id: |
MGI:6726375 |
Age: |
embryonic day 12.5 |
|
|
Specimen Label: |
3A Male |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3584875 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3287424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:3585481 |
Age: |
embryonic day 16.0 |
|
|
Specimen Label: |
Embryo |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7469442 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-05-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1609219 |
Pattern: |
Widespread |
Stage: |
TS19 |
Assay Id: |
MGI:7469580 |
Age: |
embryonic day 11.5 |
Image: |
1H |
|
Specimen Label: |
1H |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7469442 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-05-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1646919 |
Pattern: |
Widespread |
Stage: |
TS19 |
Assay Id: |
MGI:7469580 |
Age: |
embryonic day 11.5 |
Image: |
1H |
|
Specimen Label: |
1H |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3505900 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-06 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1666917 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:3510329 |
Age: |
embryonic day 10.5 |
Image: |
2J |
Note: |
Otic vesicle; dorsally restricted expression. |
Specimen Label: |
2J |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6720355 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-07-27 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797524 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6726375 |
Age: |
embryonic day 16.5 |
|
|
Specimen Label: |
3C Male |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615619 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679727 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617511 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615619 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-24 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754027 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617511 |
Age: |
postnatal day 0 |
Image: |
P0 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
P0 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615619 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-24 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3280927 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617511 |
Age: |
postnatal day 0 |
Image: |
P0 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
P0 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615619 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3267921 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3617511 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
|
Specimen Label: |
E13.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6720355 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-07-27 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3102528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6726375 |
Age: |
postnatal adult |
|
Note: |
Expression is in the cytoplasm of both resting and growing oocytes. |
Specimen Label: |
4A Female |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6720355 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-07-27 |
Strength: |
Strong |
Sex: |
Female |
Emaps: |
EMAPS:3102528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6726385 |
Age: |
postnatal adult |
|
Note: |
There is cytoplasmic staining with a granular appearance. |
Specimen Label: |
not shown |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615619 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3617511 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
|
Specimen Label: |
E13.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615619 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-24 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757727 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617511 |
Age: |
postnatal day 0 |
Image: |
P0 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
P0 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3505900 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-06 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1699417 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:3510329 |
Age: |
embryonic day 10.5 |
Image: |
2J |
Note: |
Endolymphatic duct. |
Specimen Label: |
2J |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6720355 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-07-27 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796222 |
Pattern: |
Ubiquitous |
Stage: |
TS22 |
Assay Id: |
MGI:6726375 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
not shown Female |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6720355 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-07-27 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796220 |
Pattern: |
Ubiquitous |
Stage: |
TS20 |
Assay Id: |
MGI:6726375 |
Age: |
embryonic day 12.5 |
|
|
Specimen Label: |
3A Female |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grenov AC |
Year: |
2021 |
Journal: |
J Exp Med |
Title: |
The germinal center reaction depends on RNA methylation and divergent functions of specific methyl readers. |
Volume: |
218 |
Issue: |
10 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hammer NA |
Year: |
2005 |
Journal: |
Reproduction |
Title: |
Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer. |
Volume: |
130 |
Issue: |
2 |
Pages: |
203-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Duh JL |
Year: |
1995 |
Journal: |
J Biol Chem |
Title: |
The Y-box motif mediates redox-dependent transcriptional activation in mouse cells. |
Volume: |
270 |
Issue: |
51 |
Pages: |
30499-507 |
|
•
•
•
•
•
|
Publication |
First Author: |
Degrauwe N |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing. |
Volume: |
15 |
Issue: |
8 |
Pages: |
1634-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dai N |
Year: |
2011 |
Journal: |
Genes Dev |
Title: |
mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry. |
Volume: |
25 |
Issue: |
11 |
Pages: |
1159-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Runge S |
Year: |
2000 |
Journal: |
J Biol Chem |
Title: |
H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein. |
Volume: |
275 |
Issue: |
38 |
Pages: |
29562-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brants JR |
Year: |
2004 |
Journal: |
FEBS Lett |
Title: |
Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2. |
Volume: |
569 |
Issue: |
1-3 |
Pages: |
277-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Anderson MG |
Year: |
2002 |
Journal: |
Nat Genet |
Title: |
Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice. |
Volume: |
30 |
Issue: |
1 |
Pages: |
81-5 |
|
•
•
•
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Mouse Genome Informatics Scientific Curators |
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The Jackson Laboratory |
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MGI Direct Data Submission |
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Alleles produced for the KOMP project by The Jackson Laboratory |
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Friedel RH |
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Brief Funct Genomic Proteomic |
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EUCOMM--the European conditional mouse mutagenesis program. |
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6 |
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3 |
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180-5 |
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Lennon G |
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Database Download |
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WashU-HHMI Mouse EST Project |
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Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
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2014 |
Journal: |
Database Release |
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Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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Publication |
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Mouse Genome Informatics Scientific Curators |
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Proc Natl Acad Sci U S A |
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
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First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
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Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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Year: |
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Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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UniProt-GOA |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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The Jackson Laboratory Mouse Radiation Hybrid Database |
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Mouse T31 Radiation Hybrid Data Load |
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First Author: |
The Gene Ontology Consortium |
Year: |
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Mouse Genome Informatics Computational Sequence to Gene Associations |
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Mouse Genome Database and National Center for Biotechnology Information |
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Allen Institute for Brain Science |
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2004 |
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Mouse Genome Informatics Scientific Curators |
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Database Download |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
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Database Download |
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Database Procedure |
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First Author: |
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Database Release |
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Mouse Genome Informatics Scientific Curators |
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2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Mouse Genome Informatics |
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Mouse Genome Informatics Scientific Curators |
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Mouse Genome Informatics Scientific Curators |
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Database Download |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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Allele |
Name: |
insulin-like growth factor 2 mRNA binding protein 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
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•
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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•
•
•
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Publication |
First Author: |
Suvasini R |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Insulin growth factor-2 binding protein 3 (IGF2BP3) is a glioblastoma-specific marker that activates phosphatidylinositol 3-kinase/mitogen-activated protein kinase (PI3K/MAPK) pathways by modulating IGF-2. |
Volume: |
286 |
Issue: |
29 |
Pages: |
25882-90 |
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•
•
•
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the RNA recognition motif 2 (RRM2) of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3).IGF2BP3 plays an important role in the differentiation process during early embryogenesis. It is known to bind to and repress the translation of IGF2 leader 3 mRNA []. IGF2BP3 also acts as a Glioblastoma-specific proproliferative and proinvasive marker acting through IGF2 resulting in the activation of oncogenic phosphatidylinositol 3-kinase/mitogen-activated protein kinase (PI3K/MAPK) pathways []. IGF2BP3 contains four hnRNP K-homology (KH) domains, two RNA recognition motifs (RRMs) and a RGG RNA-binding domain.IGF2BP3 belongs to the IGF2BP family (includes IGF2BP1, IGF2BP2, IGF2BP3). They have different functions, such as cell polarisation, migration, morphology, metabolism, proliferation and differentiation []. |
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Publication |
First Author: |
Nguyen LH |
Year: |
2014 |
Journal: |
Cancer Cell |
Title: |
Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models. |
Volume: |
26 |
Issue: |
2 |
Pages: |
248-61 |
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•
•
•
•
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Publication |
First Author: |
Nie D |
Year: |
2024 |
Journal: |
Adv Sci (Weinh) |
Title: |
Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre-mRNA Splicing as a Noncanonical Mechanism to Suppress Hepatocellular Carcinoma Metastasis. |
Volume: |
11 |
Issue: |
5 |
Pages: |
e2305374 |
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•
•
•
•
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Publication |
First Author: |
Bell JL |
Year: |
2013 |
Journal: |
Cell Mol Life Sci |
Title: |
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? |
Volume: |
70 |
Issue: |
15 |
Pages: |
2657-75 |
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•
•
•
•
|
Publication |
First Author: |
Chen CL |
Year: |
2013 |
Journal: |
J Clin Invest |
Title: |
Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells. |
Volume: |
123 |
Issue: |
7 |
Pages: |
2832-49 |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
579
 |
Fragment?: |
false |
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•
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