| Type |
Details |
Score |
| Publication |
| First Author: |
Campbell IK |
| Year: |
2001 |
| Journal: |
J Clin Invest |
| Title: |
Severe inflammatory arthritis and lymphadenopathy in the absence of TNF. |
| Volume: |
107 |
| Issue: |
12 |
| Pages: |
1519-27 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sundar IK |
| Year: |
2011 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation. |
| Volume: |
406 |
| Issue: |
1 |
| Pages: |
127-33 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sundar IK |
| Year: |
2017 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
The nuclear receptor and clock gene REV-ERBα regulates cigarette smoke-induced lung inflammation. |
| Volume: |
493 |
| Issue: |
4 |
| Pages: |
1390-1395 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Takeuchi IK |
| Year: |
1987 |
| Journal: |
Acta Neuropathol |
| Title: |
Absence of subcommissural organ in the cerebral aqueduct of congenital hydrocephalus spontaneously occurring in MT/HokIdr mice. |
| Volume: |
73 |
| Issue: |
4 |
| Pages: |
320-2 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Campbell IK |
| Year: |
2000 |
| Journal: |
J Leukoc Biol |
| Title: |
The colony-stimulating factors and collagen-induced arthritis: exacerbation of disease by M-CSF and G-CSF and requirement for endogenous M-CSF. |
| Volume: |
68 |
| Issue: |
1 |
| Pages: |
144-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Park IK |
| Year: |
2017 |
| Journal: |
Leukemia |
| Title: |
E3 ubiquitin ligase Cbl-b activates the p53 pathway by targeting Siva1, a negative regulator of ARF, in FLT3 inhibitor-resistant acute myeloid leukemia. |
| Volume: |
31 |
| Issue: |
2 |
| Pages: |
502-505 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kwon IK |
| Year: |
2015 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Mitochondrial function contributes to oxysterol-induced osteogenic differentiation in mouse embryonic stem cells. |
| Volume: |
1853 |
| Issue: |
3 |
| Pages: |
561-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Iqbal IK |
| Year: |
2021 |
| Journal: |
Autophagy |
| Title: |
Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy. |
|
|
| Pages: |
1-19 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1335
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
1 |
| Description: |
Phospholipid-transporting ATPase IK |
| Type: |
chain |
| End: |
1335 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mullarky IK |
| Year: |
2005 |
| Journal: |
Infect Immun |
| Title: |
Infection-stimulated fibrin deposition controls hemorrhage and limits hepatic bacterial growth during listeriosis. |
| Volume: |
73 |
| Issue: |
7 |
| Pages: |
3888-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cann IK |
| Year: |
1999 |
| Journal: |
J Bacteriol |
| Title: |
Functional interactions of a homolog of proliferating cell nuclear antigen with DNA polymerases in Archaea. |
| Volume: |
181 |
| Issue: |
21 |
| Pages: |
6591-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Feil IK |
| Year: |
2001 |
| Journal: |
J Biol Chem |
| Title: |
A novel quaternary structure of the dimeric alpha-crystallin domain with chaperone-like activity. |
| Volume: |
276 |
| Issue: |
15 |
| Pages: |
12024-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim IK |
| Year: |
2012 |
| Journal: |
Nat Struct Mol Biol |
| Title: |
Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element. |
| Volume: |
19 |
| Issue: |
6 |
| Pages: |
653-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hwang IK |
| Year: |
2007 |
| Journal: |
J Neurosci Res |
| Title: |
Aquaporin 9 changes in pyramidal cells before and is expressed in astrocytes after delayed neuronal death in the ischemic hippocampal CA1 region of the gerbil. |
| Volume: |
85 |
| Issue: |
11 |
| Pages: |
2470-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Klein IK |
| Year: |
2000 |
| Journal: |
Cancer Res |
| Title: |
Adenoma-specific alterations of protein kinase C isozyme expression in Apc(MIN) mice. |
| Volume: |
60 |
| Issue: |
8 |
| Pages: |
2077-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
SĆørensen IK |
| Year: |
1998 |
| Journal: |
Cancer Lett |
| Title: |
The effect of soy isoflavones on the development of intestinal neoplasia in ApcMin mouse. |
| Volume: |
130 |
| Issue: |
1-2 |
| Pages: |
217-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gratz IK |
| Year: |
2014 |
| Journal: |
J Immunol |
| Title: |
Cutting edge: Self-antigen controls the balance between effector and regulatory T cells in peripheral tissues. |
| Volume: |
192 |
| Issue: |
4 |
| Pages: |
1351-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
LukiÄ IK |
| Year: |
2005 |
| Journal: |
Clin Exp Immunol |
| Title: |
Alteration of newly induced endochondral bone formation in adult mice without tumour necrosis factor receptor 1. |
| Volume: |
139 |
| Issue: |
2 |
| Pages: |
236-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mullarky IK |
| Year: |
2006 |
| Journal: |
Infect Immun |
| Title: |
Tumor necrosis factor alpha and gamma interferon, but not hemorrhage or pathogen burden, dictate levels of protective fibrin deposition during infection. |
| Volume: |
74 |
| Issue: |
2 |
| Pages: |
1181-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mullarky IK |
| Year: |
2007 |
| Journal: |
Infect Immun |
| Title: |
Gamma interferon suppresses erythropoiesis via interleukin-15. |
| Volume: |
75 |
| Issue: |
5 |
| Pages: |
2630-3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Park IK |
| Year: |
2003 |
| Journal: |
Nature |
| Title: |
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. |
| Volume: |
423 |
| Issue: |
6937 |
| Pages: |
302-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
SĆørensen IK |
| Year: |
1997 |
| Journal: |
Carcinogenesis |
| Title: |
Short-term carcinogenicity testing of a potent murine intestinal mutagen, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), in Apc1638N transgenic mice. |
| Volume: |
18 |
| Issue: |
4 |
| Pages: |
777-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jang IK |
| Year: |
2010 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection. |
| Volume: |
107 |
| Issue: |
23 |
| Pages: |
10620-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Campbell IK |
| Year: |
1998 |
| Journal: |
J Immunol |
| Title: |
Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient mice. |
| Volume: |
161 |
| Issue: |
7 |
| Pages: |
3639-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sundar IK |
| Year: |
2015 |
| Journal: |
Sci Rep |
| Title: |
Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD. |
| Volume: |
4 |
|
| Pages: |
9927 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hornstra IK |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Lysyl oxidase is required for vascular and diaphragmatic development in mice. |
| Volume: |
278 |
| Issue: |
16 |
| Pages: |
14387-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gratz IK |
| Year: |
2013 |
| Journal: |
J Immunol |
| Title: |
Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues. |
| Volume: |
190 |
| Issue: |
9 |
| Pages: |
4483-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sundar IK |
| Year: |
2018 |
| Journal: |
FASEB J |
| Title: |
Genetic ablation of histone deacetylase 2 leads to lung cellular senescence and lymphoid follicle formation in COPD/emphysema. |
| Volume: |
32 |
| Issue: |
9 |
| Pages: |
4955-4971 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Poon IK |
| Year: |
2014 |
| Journal: |
Nature |
| Title: |
Unexpected link between an antibiotic, pannexin channels and apoptosis. |
| Volume: |
507 |
| Issue: |
7492 |
| Pages: |
329-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gogolevskaya IK |
| Year: |
2002 |
| Journal: |
Gene |
| Title: |
U87 RNA, a novel C/D box small nucleolar RNA from mammalian cells. |
| Volume: |
292 |
| Issue: |
1-2 |
| Pages: |
199-204 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hariharan IK |
| Year: |
1989 |
| Journal: |
Mol Cell Biol |
| Title: |
A bcr-v-abl oncogene induces lymphomas in transgenic mice. |
| Volume: |
9 |
| Issue: |
7 |
| Pages: |
2798-805 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Law IK |
| Year: |
2009 |
| Journal: |
Proteomics |
| Title: |
Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins. |
| Volume: |
9 |
| Issue: |
9 |
| Pages: |
2444-56 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Park IK |
| Year: |
2001 |
| Journal: |
J Biol Chem |
| Title: |
Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells. |
| Volume: |
276 |
| Issue: |
2 |
| Pages: |
915-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sur IK |
| Year: |
2012 |
| Journal: |
Science |
| Title: |
Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors. |
| Volume: |
338 |
| Issue: |
6112 |
| Pages: |
1360-3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Campbell IK |
| Year: |
2011 |
| Journal: |
J Immunol |
| Title: |
Differentiation of inflammatory dendritic cells is mediated by NF-ĪŗB1-dependent GM-CSF production in CD4 T cells. |
| Volume: |
186 |
| Issue: |
9 |
| Pages: |
5468-77 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lund IK |
| Year: |
2011 |
| Journal: |
Dev Biol |
| Title: |
Concomitant lack of MMP9 and uPA disturbs physiological tissue remodeling. |
| Volume: |
358 |
| Issue: |
1 |
| Pages: |
56-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sundar IK |
| Year: |
2010 |
| Journal: |
Exp Lung Res |
| Title: |
Peroxiredoxin 6 differentially regulates acute and chronic cigarette smoke–mediated lung inflammatory response and injury. |
| Volume: |
36 |
| Issue: |
8 |
| Pages: |
451-62 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jang IK |
| Year: |
2011 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction. |
| Volume: |
108 |
| Issue: |
19 |
| Pages: |
7926-31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Johnsen IK |
| Year: |
2006 |
| Journal: |
J Endocrinol |
| Title: |
Gonadectomy in mice of the inbred strain CE/J induces proliferation of sub-capsular adrenal cells expressing gonadal marker genes. |
| Volume: |
190 |
| Issue: |
1 |
| Pages: |
47-57 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hwang IK |
| Year: |
2008 |
| Journal: |
Brain Res |
| Title: |
Strain-specific differences in cell proliferation and differentiation in the dentate gyrus of C57BL/6N and C3H/HeN mice fed a high fat diet. |
| Volume: |
1241 |
|
| Pages: |
1-6 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Phospholipid-transporting ATPase IK (also known as ATP8B3 orATP1K) belongs to the subfamily IV of the P-type ATPases family, whose members transport phospholipids across the membrane. The function of ATP8B3 is not clear. Unlike other type IV members (ATP8B1,2,4), ATP8B3 does not seem to interact with either CDC50A or CDC50B []. It is exclusively expressed in the testis where it localises to the acrosomes of spermatids, the organelle which develops in the anterior half of the head of spermatozoa []. However, the disruption of ATP8B3 in mice does not affect sperm morphology or fertilisation rate []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee IK |
| Year: |
2004 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
MAP, a protein interacting with a tumor suppressor, merlin, through the run domain. |
| Volume: |
325 |
| Issue: |
3 |
| Pages: |
774-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vila IK |
| Year: |
2019 |
| Journal: |
JCI Insight |
| Title: |
A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity. |
| Volume: |
4 |
| Issue: |
13 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vila IK |
| Year: |
2017 |
| Journal: |
Cancer Cell |
| Title: |
A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy. |
| Volume: |
31 |
| Issue: |
2 |
| Pages: |
208-224 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kerzeli IK |
| Year: |
2021 |
| Journal: |
PLoS One |
| Title: |
Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations. |
| Volume: |
16 |
| Issue: |
7 |
| Pages: |
e0253178 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Poon IK |
| Year: |
2014 |
| Journal: |
Eur J Immunol |
| Title: |
Mice deficient in heparanase exhibit impaired dendritic cell migration and reduced airway inflammation. |
| Volume: |
44 |
| Issue: |
4 |
| Pages: |
1016-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tan IK |
| Year: |
2010 |
| Journal: |
Genome Res |
| Title: |
A recombination hotspot leads to sequence variability within a novel gene (AK005651) and contributes to type 1 diabetes susceptibility. |
| Volume: |
20 |
| Issue: |
12 |
| Pages: |
1629-38 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Law IK |
| Year: |
2010 |
| Journal: |
Diabetes |
| Title: |
Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity. |
| Volume: |
59 |
| Issue: |
4 |
| Pages: |
872-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Suzuki IK |
| Year: |
2018 |
| Journal: |
Cell |
| Title: |
Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation. |
| Volume: |
173 |
| Issue: |
6 |
| Pages: |
1370-1384.e16 |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Morphine prevents lipopolysaccharide-induced TNF secretion in mast cells blocking IB kinase activation and SNAP-23 phosphorylation: correlation with the formation of a -arrestin/TRAF6 complex. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Choi IK |
| Year: |
2021 |
| Journal: |
Nature |
| Title: |
Mechanism of EBV inducing anti-tumour immunity and its therapeutic use. |
| Volume: |
590 |
| Issue: |
7844 |
| Pages: |
157-162 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim IK |
| Year: |
2015 |
| Journal: |
Nat Med |
| Title: |
Glucocorticoid-induced tumor necrosis factor receptor-related protein co-stimulation facilitates tumor regression by inducing IL-9-producing helper T cells. |
| Volume: |
21 |
| Issue: |
9 |
| Pages: |
1010-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim IK |
| Year: |
2024 |
| Journal: |
Nat Commun |
| Title: |
Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma. |
| Volume: |
15 |
| Issue: |
1 |
| Pages: |
1532 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim IK |
| Year: |
2018 |
| Journal: |
J Exp Med |
| Title: |
Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality. |
| Volume: |
215 |
| Issue: |
3 |
| Pages: |
963-983 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vila IK |
| Year: |
2014 |
| Journal: |
Cell Rep |
| Title: |
Immune cell Toll-like receptor 4 mediates the development of obesity- and endotoxemia-associated adipose tissue fibrosis. |
| Volume: |
7 |
| Issue: |
4 |
| Pages: |
1116-29 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vila IK |
| Year: |
2022 |
| Journal: |
Cell Metab |
| Title: |
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses. |
| Volume: |
34 |
| Issue: |
1 |
| Pages: |
125-139.e8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chiang IK |
| Year: |
2017 |
| Journal: |
Development |
| Title: |
SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. |
| Volume: |
144 |
| Issue: |
14 |
| Pages: |
2629-2639 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Na IK |
| Year: |
2010 |
| Journal: |
J Clin Invest |
| Title: |
The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease. |
| Volume: |
120 |
| Issue: |
1 |
| Pages: |
343-56 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chiang IK |
| Year: |
2023 |
| Journal: |
EMBO Rep |
| Title: |
Sox7-positive endothelial progenitors establish coronary arteries and govern ventricular compaction. |
| Volume: |
24 |
| Issue: |
10 |
| Pages: |
e55043 |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
137
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sachs DH |
| Year: |
1979 |
| Journal: |
J Immunol |
| Title: |
Two new recombinant H-2 haplotypes, one of which juxtaposes Kb and Ik alleles. |
| Volume: |
123 |
| Issue: |
5 |
| Pages: |
1965-9 |
|
•
•
•
•
•
|
| Allele |
| Name: |
IK cytokine; wild type |
|
|
|
•
•
•
•
•
|
| Allele |
| Name: |
IK cytokine; gene trap OST55784, Lexicon Genetics |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
557
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Malashenko AM |
| Year: |
1969 |
| Journal: |
Mouse News Lett |
| Title: |
Cerebellum ataxia. |
| Volume: |
41 |
|
| Pages: |
47-48 |
|
•
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