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Search results 101 to 123 out of 123 for Insc

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Type Details Score
Allele
Insc<tm1.2Cayo> | MGI:5588153
Name: INSC spindle orientation adaptor protein; targeted mutation 1.2, Michel Cayouette
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Insc<tm1e(EUCOMM)Hmgu> | MGI:4452738
Name: INSC spindle orientation adaptor protein; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Insc<tm1a(EUCOMM)Hmgu> | MGI:4455917
Name: INSC spindle orientation adaptor protein; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Insc<tm1Jakn> | MGI:5304348
Name: INSC spindle orientation adaptor protein; targeted mutation 1, Juergen A Knoblich
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Strain
MGI:5697637 | B6.129(SJL)-Insc<tm1.2Cayo>
Attribute String: congenic, mutant strain, targeted mutation
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Allele
Insc<em1Gpt> | MGI:7300854
Name: INSC spindle orientation adaptor protein; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Insc<em2Gpt> | MGI:7300855
Name: INSC spindle orientation adaptor protein; endonuclease-mediated mutation 2, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Insc/Insc
Background: B6.129(SJL)-Insc
Zygosity: hm
Has Mutant Allele: true
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GO Term
GO:1990499 | raps-insc complex
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Genotype
Genotype
Symbol: Insc/Insc Tg(Nes-cre)1Wmz/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
22977735 | -
First Author: Mapelli M
Year: 2012
Journal: Open Biol
Title: On the inscrutable role of Inscuteable: structural basis and functional implications for the competitive binding of NuMA and Inscuteable to LGN.
Volume: 2
Issue: 8
Pages: 120102
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Publication
23516018 | -
First Author: Culurgioni S
Year: 2013
Journal: Cell Mol Life Sci
Title: Going vertical: functional role and working principles of the protein Inscuteable in asymmetric cell divisions.
Volume: 70
Issue: 21
Pages: 4039-46
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Protein Domain
IPR039921 | Inscuteable
Type: Family
Description: Inscuteable (Insc) is a key regulator of spindle orientation in asymmetric divisions in both Drosophila and mammals [, ]. Insc is a competitive interactor of LGN [, ].
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Publication
21816348 | -
First Author: Zhu J
Year: 2011
Journal: Mol Cell
Title: LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gαi/LGN/NuMA pathways.
Volume: 43
Issue: 3
Pages: 418-31
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Publication
16458856 | -
First Author: Izaki T
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3.
Volume: 341
Issue: 4
Pages: 1001-6
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Protein Domain
IPR045789 | Insc_C
Type: Domain
Description: This entry represents the C-terminal region of protein Inscuteable (Insc) containing four putative armadillo repeats and the conserved extreme C-terminal tetrapeptide Glu-Ser-Phe-Val which is in agreement with the class I PDZ-binding motif X-Ser/Thr-X-/ (X and / are unspecified and hydrophobic residues, respectively). Insc functions as an adaptor protein that binds simultaneously with Partner of Insc (Pins, consisting of alpha subunit (Ga) of heterotrimeric G proteins and its guanine nucleotide dissociation inhibitor) and Par3 (PDZ-containing proteins) to regulate their apical localisation in neuroblasts, which is required for the correct execution of the asymmetric division [, ].
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Protein
A0A0U1RNN4
Organism: Mus musculus/domesticus
Length: 135  
Fragment?: true
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Protein
D3Z267
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: true
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Protein
D3Z5D7
Organism: Mus musculus/domesticus
Length: 53  
Fragment?: true
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Publication
28231465 | J:256059
First Author: Falk S
Year: 2017
Journal: Neuron
Title: Time-Specific Effects of Spindle Positioning on Embryonic Progenitor Pool Composition and Adult Neural Stem Cell Seeding.
Volume: 93
Issue: 4
Pages: 777-791.e3
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Publication
21887730 | J:205032
First Author: Zhao Y
Year: 2012
Journal: Inflamm Bowel Dis
Title: Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1.
Volume: 18
Issue: 4
Pages: 603-12
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Protein
Q3HNM7
Organism: Mus musculus/domesticus
Length: 579  
Fragment?: false
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Protein
G3UW77
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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