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Search results 101 to 193 out of 193 for Irak2

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Type Details Score
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692592
Age: postnatal adult
Image: MRC Harwell_1312688
Specimen Label: MRC Harwell_1312688
Detected: true
Specimen Num: 3
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Publication
18268037 | J:131437
First Author: Conner JR
Year: 2008
Journal: J Exp Med
Title: Forward genetic analysis of Toll-like receptor responses in wild-derived mice reveals a novel antiinflammatory role for IRAK1BP1.
Volume: 205
Issue: 2
Pages: 305-14
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Publication
11544529 | J:71392
First Author: Fitzgerald KA
Year: 2001
Journal: Nature
Title: Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.
Volume: 413
Issue: 6851
Pages: 78-83
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Publication
28658630 | J:250938
First Author: Mertins P
Year: 2017
Journal: Cell Rep
Title: An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling.
Volume: 19
Issue: 13
Pages: 2853-2866
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Publication
12819136 | J:84168
First Author: Reed JC
Year: 2003
Journal: Genome Res
Title: Comparative analysis of apoptosis and inflammation genes of mice and humans.
Volume: 13
Issue: 6B
Pages: 1376-88
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
29728508 | J:263319
First Author: Li J
Year: 2018
Journal: J Immunol
Title: Small Molecule Mimetics of α-Helical Domain of IRAK2 Attenuate the Proinflammatory Effects of IL-33 in Asthma-like Mouse Models.
Volume: 200
Issue: 12
Pages: 4036-4043
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Publication
18490904 | -
First Author: Meylan E
Year: 2008
Journal: Nat Immunol
Title: IRAK2 takes its place in TLR signaling.
Volume: 9
Issue: 6
Pages: 581-2
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Allele
Irak2<em1Smoc> | MGI:7290566
Name: interleukin-1 receptor-associated kinase 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Pathway
R-MMU-937042 | IRAK2 mediated activation of TAK1 complex
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Strain
MGI:6429000 | C57BL/6JSmoc-Irak2<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Pathway
R-MMU-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
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Publication
18845156 | -
First Author: Kalverda AP
Year: 2009
Journal: J Mol Biol
Title: Poxvirus K7 protein adopts a Bcl-2 fold: biochemical mapping of its interactions with human DEAD box RNA helicase DDX3.
Volume: 385
Issue: 3
Pages: 843-53
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Publication
18636090 | -
First Author: Schröder M
Year: 2008
Journal: EMBO J
Title: Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation.
Volume: 27
Issue: 15
Pages: 2147-57
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Publication
28257484 | -
First Author: Teferi WM
Year: 2017
Journal: PLoS One
Title: The vaccinia virus K7 protein promotes histone methylation associated with heterochromatin formation.
Volume: 12
Issue: 3
Pages: e0173056
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Publication
23580427 | -
First Author: Benfield CTO
Year: 2013
Journal: J Gen Virol
Title: Vaccinia virus protein K7 is a virulence factor that alters the acute immune response to infection.
Volume: 94
Issue: Pt 7
Pages: 1647-1657
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Protein Domain
IPR009174 | Orthopox_K7
Type: Family
Description: This family represents Protein K7 from Orthopoxvirus. K7 is Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation []. It contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation and affects the acute immune response to infection [, , ]. In vaccinia virus, this protein has been related to the increase in cellular histone methylation during infection [].
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Publication
38605168 | J:349807
First Author: Liu Y
Year: 2024
Journal: Cell Death Differ
Title: OTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation.
Volume: 31
Issue: 6
Pages: 753-767
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Protein Coding Gene
MGI:1341909 | Ly96
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2147032 | Ticam1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88318 | Cd14
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3040056 | Ticam2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96824 | Tlr4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9JHF9
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: false
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Protein
P10810
Organism: Mus musculus/domesticus
Length: 366  
Fragment?: false
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Protein
Q80UF7
Organism: Mus musculus/domesticus
Length: 732  
Fragment?: false
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Protein
Q9QUK6
Organism: Mus musculus/domesticus
Length: 835  
Fragment?: false
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Protein
Q8BJQ4
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: false
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Publication
33932090 | J:329411
First Author: Petrova T
Year: 2021
Journal: FEBS J
Title: HOIL-1-catalysed, ester-linked ubiquitylation restricts IL-18 signaling in cytotoxic T cells but promotes TLR signalling in macrophages.
Volume: 288
Issue: 20
Pages: 5909-5924
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Publication
24114841 | J:209336
First Author: Stack J
Year: 2013
Journal: J Biol Chem
Title: Poxviral protein A52 stimulates p38 mitogen-activated protein kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor β-activated kinase 1 (TAK1) recruitment.
Volume: 288
Issue: 47
Pages: 33642-53
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Publication
36408944 | J:332170
First Author: McCrory EH
Year: 2022
Journal: Biochem J
Title: Identification of ester-linked ubiquitylation sites during TLR7 signalling increases the number of inter-ubiquitin linkages from 8 to 12.
Volume: 479
Issue: 23
Pages: 2419-2431
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Publication
19913487 | -
First Author: Oda S
Year: 2009
Journal: Structure
Title: Structural basis for targeting of human RNA helicase DDX3 by poxvirus protein K7.
Volume: 17
Issue: 11
Pages: 1528-37
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Publication
23166766 | -
First Author: Gosu V
Year: 2012
Journal: PLoS One
Title: Molecular evolution and structural features of IRAK family members.
Volume: 7
Issue: 11
Pages: e49771
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Protein Domain
IPR042151 | Death_IRAK2
Type: Domain
Description: This entry represents the death domain found in interleukin-1 receptor-associated kinase-like 2 (IRAK2) []. IRAK2 is an essential component of several signaling pathways, including NF-kappaB and the IL-1 signaling pathways. It is an inactive kinase that participates in septic shock mediated by TLR4 and TLR9 []. It plays a redundant role with IRAK1 in early NF-kB and MAPK responses, and remains present at later stages whereas IRAK1 disappears [, ].Interleukin-1 receptor-associated kinases (IRAKs) are essential components of innate immunity and inflammation in mammals and other vertebrates []. They are involved in signal transduction pathways involving IL-1 and IL-18 receptors, Toll-like receptors, nuclear factor-kappaB (NF-kB), and mitogen-activated protein kinases (MAPKs). IRAKs contain an N-terminal death domain (DD) and a C-terminal kinase domain [, , , ].Death domains (DDs) are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [].
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Protein Coding Gene
MGI:1915902 | Tab2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913763 | Tab1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1346877 | Map3k7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913974 | Tab3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q62073
Organism: Mus musculus/domesticus
Length: 579  
Fragment?: false
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Protein
Q571K4
Organism: Mus musculus/domesticus
Length: 716  
Fragment?: false
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Protein
Q8CF89
Organism: Mus musculus/domesticus
Length: 502  
Fragment?: false
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Protein
Q99K90
Organism: Mus musculus/domesticus
Length: 693  
Fragment?: false
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Protein
P70196-2
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: false
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Publication
16212909 | -
First Author: Huang YS
Year: 2005
Journal: Cell Mol Immunol
Title: Novel role and regulation of the interleukin-1 receptor associated kinase (IRAK) family proteins.
Volume: 2
Issue: 1
Pages: 36-9
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Publication
17172653 | -
First Author: Gan L
Year: 2006
Journal: Immunol Res
Title: Regulations and roles of the interleukin-1 receptor associated kinases (IRAKs) in innate and adaptive immunity.
Volume: 35
Issue: 3
Pages: 295-302
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Publication
18249132 | -
First Author: Ringwood L
Year: 2008
Journal: Cytokine
Title: The involvement of the interleukin-1 receptor-associated kinases (IRAKs) in cellular signaling networks controlling inflammation.
Volume: 42
Issue: 1
Pages: 1-7
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Protein Coding Gene
MGI:1925544 | Rps27a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98887 | Uba52
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98888 | Ubb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98889 | Ubc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P62984
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Protein
P0CG50
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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Protein
P62983
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
P0CG49
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
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Publication
7482697 | -
First Author: Feinstein E
Year: 1995
Journal: Trends Biochem Sci
Title: The death domain: a module shared by proteins with diverse cellular functions.
Volume: 20
Issue: 9
Pages: 342-4
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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